11,79559 % | Satter Management Co., L.P. | 5 621 835 | 0 | 31.03.2021 |
10,89780 % | OrbiMed Advisors, LLC | 5 193 946 | 0 | 31.03.2021 |
9,44178 % | Avoro Capital Advisors LLC | 4 500 000 | 4 500 000 | 3.06.2021 |
5,56245 % | Ikarian Capital LLC | 2 651 093 | 2 175 315 | 31.03.2021 |
4,34906 % | EcoR1 Capital, LLC | 2 072 782 | 2 072 782 | 31.03.2021 |
4,21511 % | BML Capital Management LLC | 2 008 942 | -131 289 | 31.12.2020 |
4,07368 % | Renaissance Technologies LLC | 1 941 538 | 142 494 | 31.03.2021 |
4,01061 % | Acadian Asset Management LLC | 1 911 478 | 401 968 | 31.03.2021 |
3,82917 % | Point72 Asset Management, L.P. | 1 825 000 | 1 825 000 | 17.05.2021 |
3,61978 % | The Vanguard Group, Inc. | 1 725 207 | -986 372 | 31.03.2021 |
3,30422 % | RA Capital Management, LP | 1 574 806 | 1 574 806 | 30.06.2021 |
2,10067 % | Parkman Healthcare Partners LLC | 1 001 189 | 736 807 | 31.03.2021 |
2,09817 % | Opaleye Management Inc. | 1 000 000 | 1 000 000 | 31.03.2021 |
2,09817 % | Scion Asset Management, LLC | 1 000 000 | 1 000 000 | 31.03.2021 |
1,33284 % | Novartis AG | 635 236 | -2 512 431 | 14.05.2020 |
1,26524 % | Gardner (Joseph H) | 603 019 | 0 | 14.06.2021 |
0,83927 % | Ally Bridge Group (HK) Limited | 400 000 | 0 | 31.03.2021 |
0,67254 % | Johnson Investment Counsel, Inc. | 320 536 | 0 | 31.03.2021 |
0,67254 % | Peters (Kevin G M.D.) | 320 536 | 0 | 14.06.2021 |
0,63564 % | Boothbay Fund Management, LLC | 302 949 | 252 755 | 31.03.2021 |
0,61983 % | Castelein (Caley M.) | 295 414 | 15 507 | 30.06.2021 |
0,54337 % | Geode Capital Management, L.L.C. | 258 974 | 107 136 | 31.03.2021 |
0,53231 % | T. Rowe Price Associates, Inc. | 253 700 | 253 700 | 31.03.2021 |
0,26305 % | BlackRock Institutional Trust Company, N.A. | 125 370 | 6976 | 31.03.2021 |
0,25759 % | Citadel Advisors LLC | 122 770 | 40 661 | 31.03.2021 |
0,21192 % | Leonard (Braden Michael) | 101 000 | -49 000 | 31.12.2020 |
0,20982 % | Neville, Rodie & Shaw, Inc. | 100 000 | 0 | 30.06.2021 |
0,17269 % | Virtu Americas LLC | 82 306 | -88 783 | 31.03.2021 |
0,16385 % | Columbia Threadneedle Investments (US) | 78 092 | -5502 | 31.03.2021 |
0,15002 % | Schonfeld Strategic Advisors LLC | 71 500 | 59 600 | 31.03.2021 |
0,11666 % | Northern Trust Investments, Inc. | 55 602 | 0 | 31.03.2021 |
0,10491 % | U.S. Bancorp Asset Management, Inc. | 50 000 | 0 | 31.03.2021 |
0,10491 % | CSS, LLC | 50 000 | 50 000 | 31.03.2021 |
0,05137 % | Prelack (Steven) | 24 485 | 24 485 | 30.06.2021 |
0,03571 % | Squarepoint Capital LLP | 17 019 | 17 019 | 31.03.2021 |
0,03558 % | Dalal Anupam | 16 959 | 14 690 | 30.06.2021 |
0,03391 % | Cohen (Cheryl L) | 16 160 | 16 160 | 30.06.2021 |
0,03269 % | Jane Street Capital, L.L.C. | 15 581 | -4738 | 31.03.2021 |
0,03230 % | Dimensional Fund Advisors, L.P. | 15 393 | -8719 | 31.03.2021 |
0,02693 % | Charles Schwab Investment Management, Inc. | 12 835 | 0 | 31.03.2021 |
0,02686 % | Two Sigma Investments, LP | 12 800 | 12 800 | 31.03.2021 |
0,02669 % | Lakeview Capital Partners, Llc | 12 722 | -4778 | 31.03.2021 |
0,02637 % | Dugel (Pravin U) | 12 568 | 12 568 | 30.06.2021 |
0,02521 % | Qube Research & Technologies Ltd | 12 016 | -56 029 | 31.03.2021 |
0,02444 % | Barclays Bank PLC | 11 648 | 11 648 | 31.03.2021 |
0,02439 % | Marek (Regina) | 11 625 | 0 | 14.06.2021 |
0,02144 % | Truepoint Wealth Counsel LLC | 10 219 | 0 | 31.03.2021 |
0,02098 % | Ascent Wealth Partners, LLC | 10 000 | 0 | 31.03.2021 |
0,01049 % | Lindbrook Capital, LLC | 5000 | 5000 | 30.06.2021 |
0,00690 % | Tower Research Capital LLC | 3288 | -117 | 31.03.2021 |
0,00664 % | UBS Financial Services, Inc. | 3166 | -18 638 | 31.03.2021 |
0,00420 % | BofA Global Research (US) | 2000 | 2000 | 31.03.2021 |
0,00315 % | NEXT Financial Group, Inc. | 1500 | 1500 | 30.06.2021 |
0,00315 % | Advisor Group, Inc | 1500 | 0 | 31.03.2021 |
0,00210 % | Wells Fargo Advisors | 1000 | 0 | 31.03.2021 |
0,00076 % | O'Shaughnessy Asset Management, LLC | 363 | 135 | 31.03.2021 |
0,00045 % | Wells Fargo Bank, N.A. | 214 | -1 | 31.03.2021 |
0,00026 % | Parallel Advisors, LLC | 125 | 0 | 31.03.2021 |
0 % | Keudell Morrison Wealth Management, LLC | 0 | -30 694 | 30.06.2021 |
0 % | J.P. Morgan Securities LLC | 0 | -6400 | 31.12.2020 |
0 % | PanAgora Asset Management Inc. | 0 | -44 630 | 31.03.2021 |
0 % | Tekla Capital Management LLC | 0 | -257 554 | 30.09.2020 |
0 % | Deutsche Asset Management Americas | 0 | -6712 | 31.03.2020 |
0 % | Goldman Sachs & Company, Inc. | 0 | -29 407 | 30.09.2020 |
0 % | BlackRock Investment Management, LLC | 0 | -4797 | 30.06.2020 |
0 % | Morgan Stanley & Co. LLC | 0 | -25 062 | 31.03.2021 |
0 % | Raymond James & Associates, Inc. | 0 | -12 000 | 31.03.2020 |
0 % | Arrowstreet Capital, Limited Partnership | 0 | -35 725 | 31.03.2021 |
0 % | Millennium Management LLC | 0 | -59 587 | 31.12.2020 |
0 % | GSA Capital Partners LLP | 0 | -17 895 | 31.03.2021 |
0 % | Hightower Advisors, LLC | 0 | -35 500 | 30.09.2020 |
0 % | Blackstone Alternative Investment Advisors LLC | 0 | -1100 | 31.12.2020 |
0 % | Alambic Investment Management, L.P. | 0 | -35 264 | 31.12.2019 |
0 % | Susquehanna Fundamental Investments, LLC | 0 | -11 000 | 31.03.2021 |