6.44751 % | BlackRock Institutional Trust Company, N.A. | 6,717,017 | 777,768 | |
6.28796 % | Teoxane SA | 6,550,800 | 2,105,000 | |
5.59213 % | GIC Private Limited | 5,825,881 | 332,916 | |
5.02715 % | Palo Alto Investors LP | 5,237,284 | 8,675 | |
4.85144 % | The Vanguard Group, Inc. | 5,054,228 | 278,166 | |
4.51684 % | Franklin Advisers, Inc. | 4,705,640 | 708,644 | |
3.04208 % | Polar Capital LLP | 3,169,239 | -991,072 | |
2.45611 % | JP Morgan Asset Management | 2,558,779 | -32,486 | |
2.42052 % | State Street Global Advisors (US) | 2,521,693 | 188,585 | |
11.46005 % | Capital World Investors | 11,939,076 | -21,744 | |
1.84721 % | Geode Capital Management, L.L.C. | 1,924,421 | 144,144 | |
1.81845 % | JPMorgan Asset Management U.K. Limited | 1,894,458 | -35,132 | |
1.49458 % | Invesco Advisers, Inc. | 1,557,055 | -1,301,085 | |
1.40284 % | Rubric Capital Management LP | 1,461,474 | -138,526 | |
1.10126 % | CIBC Asset Management Inc. | 1,147,294 | 820,587 | |
1.06148 % | Foley (Mark J) | 1,105,848 | 185,116 | |
0.99093 % | Jennison Associates LLC | 1,032,352 | 34,736 | |
0.98259 % | Baron Capital Management, Inc. | 1,023,663 | 3,429 | |
0.89059 % | Walleye Capital LLC | 927,814 | 622,022 | |
0.74942 % | Northern Trust Investments, Inc. | 780,746 | 63,871 | |
0.72763 % | Rice Hall James & Associates, LLC | 758,048 | 74,111 | |
0.65995 % | Goldman Sachs & Company, Inc. | 687,534 | -353,120 | |
0.65019 % | Charles Schwab Investment Management, Inc. | 677,364 | 13,826 | |
0.60472 % | EULAV Asset Management | 630,000 | 30,000 | |
0.59099 % | Morgan Stanley & Co. LLC | 615,697 | 305,886 | |
0.51180 % | Nuveen LLC | 533,196 | -65,438 | |
0.48366 % | Qube Research & Technologies Ltd | 503,874 | 389,624 | |
0.45678 % | Rhenman & Partners Asset Management AB | 475,872 | 114,193 | |
0.43875 % | EW Healthcare Partners | 457,085 | 0 | |
0.43194 % | Integral Health Asset Management, LLC | 450,000 | 350,000 | |
0.43164 % | Wellington Management Company, LLP | 449,685 | -632,735 | |
0.39523 % | D. E. Shaw & Co., L.P. | 411,750 | -370,266 | |
0.39011 % | Hightower Advisors, LLC | 406,421 | 116,920 | |
0.35995 % | Ghost Tree Capital, LLC | 375,000 | 25,000 | |
0.34821 % | Balyasny Asset Management LP | 362,760 | -107,089 | |
0.33947 % | Citadel Advisors LLC | 353,662 | 227,280 | |
0.29319 % | Cubist Systematic Strategies, LLC | 305,447 | 85,234 | |
0.28120 % | William Blair & Company, L.L.C. (Research) | 292,949 | -33,357 | |
0.27714 % | Schroder Investment Management Ltd. (SIM) | 288,726 | 288,726 | |
0.27714 % | International Biotechnology Trust PLC | 288,726 | 0 | |
0.26094 % | Voloridge Investment Management, LLC | 271,852 | -272,595 | |
0.25890 % | Principal Global Investors (Equity) | 269,718 | -693,311 | |
0.25536 % | Schonfeld Strategic Advisors LLC | 266,039 | 64,405 | |
0.24657 % | DCF Advisers, LLC | 256,872 | 230,372 | |
0.22457 % | Great Lakes Advisors, LLC | 233,958 | 11,881 | |
0.22111 % | BNY Mellon Asset Management | 230,350 | 4,368 | |
0.21611 % | BlackRock Financial Management, Inc. | 225,141 | -100,477 | |
0.21117 % | AlphaCentric Advisors LLC. | 220,000 | 30,000 | |
0.21117 % | LifeSci Fund Management LLC | 220,000 | 30,000 | |
0.20726 % | BlackRock Investment Management, LLC | 215,923 | 8,426 | |
0.20030 % | BofA Global Research (US) | 208,673 | 118,712 | |
0.19504 % | Susquehanna Portfolio Strategies, LLC | 203,192 | 203,192 | |
0.19229 % | Barclays Capital Inc. | 200,332 | -183,202 | |
0.19087 % | Assenagon Asset Management S.A. | 198,846 | -215,209 | |
0.18636 % | UBS Financial Services, Inc. | 194,153 | 76,108 | |
0.18494 % | Schilke (Tobin C) | 192,666 | 29,166 | |
0.17266 % | BlackRock Advisors (UK) Limited | 179,873 | 5,486 | |
0.17096 % | Columbia Threadneedle Investments (US) | 178,103 | 52,284 | |
0.16511 % | Credit Suisse Funds AG | 172,007 | 31,392 | |
0.16441 % | JPMorgan Private Bank (United States) | 171,284 | 76,104 | |
0.16239 % | Parametric Portfolio Associates LLC | 169,180 | -69,670 | |
0.16083 % | Sjuts (Dustin S) | 167,550 | 40,217 | |
0.15804 % | Schweizerische Nationalbank | 164,650 | -20,100 | |
0.15585 % | Conestoga Capital Advisors, LLC | 162,368 | -4,453 | |
0.15454 % | Norges Bank Investment Management (NBIM) | 161,000 | 0 | |
0.15113 % | Group One Trading, L.P. | 157,445 | 73,327 | |
0.15092 % | Barclays Bank PLC | 157,224 | 6,436 | |
0.14398 % | Moore Capital Management, LP | 150,000 | -10,000 | |
0.14045 % | BlackRock Asset Management Ireland Limited | 146,321 | 15,843 | |
0.13826 % | Algert Global LLC | 144,040 | 144,040 | |
0.13229 % | Moxie (Dwight) | 137,815 | 30,955 | |
0.11751 % | Essex Investment Management Company, LLC | 122,419 | 38,671 | |
0.11466 % | Rhumbline Advisers Ltd. Partnership | 119,457 | 1,678 | |
0.11026 % | Jordan (Erica) | 114,864 | -2,392 | |
0.10673 % | Landscape Capital Management, L.L.C. | 111,194 | 111,194 | |
0.10668 % | Commonwealth Financial Network | 111,144 | 12,015 | |
0.10527 % | UBS O'Connor LLC | 109,667 | 20,867 | |
0.10449 % | Hollander (David) | 108,853 | 0 | |
0.10311 % | State of Wisconsin Investment Board | 107,418 | 29,386 | |
0.10107 % | Nebula Research & Development LLC | 105,295 | 105,295 | |
0.09776 % | Legato Capital Management LLC | 101,842 | 44,190 | |
0.09224 % | Goldman Sachs Asset Management, L.P. | 96,094 | -7,896 | |
0.08919 % | Los Angeles Capital Management LLC | 92,918 | 92,918 | |
0.08890 % | Morgan Stanley Smith Barney LLC | 92,617 | 40,937 | |
0.08763 % | Citi Investment Research (US) | 91,288 | 42,063 | |
0.08735 % | AllianceBernstein L.P. | 91,000 | 0 | |
0.08526 % | California State Teachers Retirement System | 88,825 | -3,850 | |
0.08295 % | Sierra Summit Advisors LLC | 86,421 | 86,421 | |
0.08265 % | Deka Investment GmbH | 86,100 | 86,100 | |
0.08265 % | Deka Vermögensmanagement GmbH | 86,100 | 0 | |
0.08011 % | Legal & General Investment Management Ltd. | 83,463 | 163 | |
0.07698 % | UBS Asset Management (Switzerland) | 80,201 | 8,686 | |
0.07546 % | UBS Switzerland AG | 78,610 | 0 | |
0.07199 % | CM Management, LLC | 75,000 | 75,000 | |
0.07145 % | TwinBeech Capital LP | 74,438 | 74,438 | |
0.07135 % | Point72 Asset Management, L.P. | 74,330 | -1,290,923 | |
0.07015 % | Federated Hermes Global Investment Management Corp. | 73,087 | 73,087 | |
0.07015 % | Federated Hermes Equity Management Company of Pennsylvania | 73,087 | 38,441 | |
0.06498 % | Tekla Capital Management LLC_NLE | 67,699 | 67,699 | |
0.06312 % | Trexquant Investment LP | 65,759 | 65,759 | |