9.82 % | The Vanguard Group, Inc. | 26,740,681 | 3,514,792 | |
7.27 % | BlackRock Institutional Trust Company, N.A. | 19,808,397 | 2,231,604 | |
6.46 % | Madrone Advisors, LLC | 17,591,915 | 1,175,982 | |
4.71 % | Nikko Asset Management Co., Ltd. | 12,824,385 | -375,990 | |
3.86 % | Morgan Stanley & Co. LLC | 10,504,642 | 8,821,652 | |
3.56 % | Jackson Square Partners, LLC | 9,704,766 | 2,770,901 | |
2.85 % | T. Rowe Price Investment Management, Inc. | 7,753,781 | 338,257 | |
2.69 % | Bellevue Asset Management AG | 7,317,128 | 71,940 | |
2.57 % | Deep Track Capital LP | 7,000,000 | 1,000,000 | |
2.27 % | Farallon Capital Management, L.L.C. | 6,191,370 | -4,032,750 | |
2.07 % | State Street Global Advisors (US) | 5,624,329 | 252,447 | |
2.03 % | Geode Capital Management, L.L.C. | 5,516,386 | 412,150 | |
12.22 % | ARK Investment Management LLC | 33,290,137 | -1,214,136 | |
1.96 % | Point72 Asset Management, L.P. | 5,349,146 | 2,720,058 | |
1.83 % | Macquarie Investment Management | 4,971,504 | 723,785 | |
1.29 % | Shimoda Holdings LLC | 3,500,000 | 0 | |
1.27 % | T. Rowe Price Associates, Inc. | 3,461,836 | -399,071 | |
1.24 % | Capital World Investors | 3,390,000 | 0 | |
1.14 % | Capital International Investors | 3,113,749 | 0 | |
1.12 % | Dimensional Fund Advisors, L.P. | 3,057,262 | -98,944 | |
1.12 % | Assenagon Asset Management S.A. | 3,041,624 | 2,909,439 | |
1.08 % | Decheng Capital LLC | 2,940,361 | 1,476,489 | |
1.07 % | Mellon Investments Corporation | 2,923,690 | 45,820 | |
1.04 % | Fidelity Institutional Asset Management | 2,834,126 | 309,123 | |
0.97 % | VK Services, LLC | 2,632,784 | 0 | |
0.90 % | Lord, Abbett & Co. LLC | 2,442,956 | -1,222,921 | |
0.82 % | BlackRock Financial Management, Inc. | 2,223,181 | 133,067 | |
0.78 % | Northern Trust Investments, Inc. | 2,126,194 | 82,432 | |
0.72 % | Charles Schwab Investment Management, Inc. | 1,966,837 | 127,855 | |
0.68 % | Woodline Partners LP | 1,854,107 | -527,600 | |
0.68 % | Iron Triangle Partners LP | 1,843,278 | 43,278 | |
0.68 % | SEI Investments Management Corporation | 1,840,073 | 642,400 | |
0.57 % | Henry (Christian O) | 1,538,858 | -14,177 | |
0.56 % | Eagle Health Investments LP | 1,522,721 | 1,522,721 | |
0.51 % | Oracle Investment Management, Inc. | 1,376,795 | -261,600 | |
0.50 % | Norges Bank Investment Management (NBIM) | 1,374,715 | -322,812 | |
0.46 % | Senator Investment Group LP | 1,250,000 | 1,250,000 | |
0.40 % | Victory Capital Management Inc. | 1,094,724 | 442,250 | |
0.38 % | Casdin Capital, LLC | 1,035,859 | 0 | |
0.37 % | Columbia Threadneedle Investments (US) | 1,013,242 | 910,851 | |
0.37 % | BlackRock Asset Management Ireland Limited | 1,011,533 | 11,429 | |
0.37 % | Edmond de Rothschild Asset Management (France) S.A. | 995,500 | 188,600 | |
0.35 % | Newton Investment Management North America, LLC | 939,978 | 301,410 | |
0.34 % | Mirae Asset Global Investments (USA) LLC | 926,988 | -507,572 | |
0.34 % | Nikko Asset Management Americas, Inc. | 921,442 | 109,649 | |
0.34 % | HHLR Advisors, Ltd. | 918,892 | 0 | |
0.33 % | Alyeska Investment Group, L.P. | 908,107 | -1,195,862 | |
0.33 % | BNY Mellon Asset Management | 901,082 | 38,770 | |
0.33 % | Fidelity Management & Research Company LLC | 890,928 | -1,206,989 | |
0.31 % | BlackRock Advisors (UK) Limited | 832,046 | 32,618 | |
0.30 % | Granahan Investment Management, LLC | 821,306 | 123,680 | |
0.30 % | Van (Oene Mark D) | 813,712 | -9,186 | |
0.30 % | Goldman Sachs & Company, Inc. | 804,594 | -54,836 | |
0.28 % | Goldman Sachs Asset Management, L.P. | 770,015 | -45,400 | |
0.28 % | Susquehanna International Group, LLP | 766,165 | 520,223 | |
0.27 % | BlackRock Investment Management, LLC | 730,946 | 75,661 | |
0.25 % | Wellington Management Company, LLP | 691,068 | 147,630 | |
0.25 % | Atika Capital Management LLC | 690,000 | 690,000 | |
0.24 % | TD Asset Management Inc. | 661,300 | -43,400 | |
0.24 % | Nuveen LLC | 658,748 | 0 | |
0.24 % | Bourne Lent Asset Management Inc. | 654,415 | 62,200 | |
0.23 % | J.P. Morgan Securities LLC | 639,027 | 336,975 | |
0.23 % | BlackRock Investment Management (UK) Ltd. | 638,476 | -455,954 | |
0.23 % | Neuberger Berman, LLC | 621,771 | 143,661 | |
0.21 % | BNP Paribas Securities Corp. North America | 582,974 | 2,832 | |
0.20 % | Citadel Advisors LLC | 544,504 | -2,600,173 | |
0.19 % | Northern Trust Global Investments | 512,295 | -162,933 | |
0.19 % | Managed Account Advisors LLC | 512,293 | -83,592 | |
0.18 % | Vestmark Advisory Solutions, Inc | 494,790 | 494,790 | |
0.18 % | Jane Street Capital, L.L.C. | 487,185 | 236,487 | |
0.17 % | Schroder Investment Management Ltd. (SIM) | 471,464 | -182,380 | |
0.17 % | Schweizerische Nationalbank | 469,046 | -52,800 | |
0.17 % | Barclays Bank PLC | 465,793 | 344,584 | |
0.16 % | Kim (Susan G) | 435,988 | -5,275 | |
0.16 % | Eidel (Jeffrey) | 426,714 | 420,104 | |
0.15 % | Moody Aldrich Partners, LLC | 418,262 | 418,262 | |
0.15 % | Group One Trading, L.P. | 403,987 | 122,327 | |
0.14 % | New Jersey Division of Investment | 389,978 | 67,107 | |
0.14 % | Rhumbline Advisers Ltd. Partnership | 383,318 | 334 | |
0.14 % | Ordonez (Kathleen P) | 380,216 | 361,621 | |
0.13 % | Mediolanum International Funds Limited | 342,884 | -305,821 | |
0.12 % | Simplex Trading, LLC | 326,791 | 84,556 | |
0.12 % | Manulife Investment Management (North America) Limited | 326,477 | -5,569 | |
0.12 % | Polar Asset Management Partners Inc. | 322,800 | -510,200 | |
0.12 % | Credit Suisse Funds AG | 320,699 | 49,683 | |
0.12 % | Mirador Capital Partners LP | 318,373 | 265,835 | |
0.12 % | GTS Securities LLC | 316,535 | 95,943 | |
0.10 % | Brookfield BHS Advisors LLC | 282,763 | 15,179 | |
0.10 % | Morgan Stanley Smith Barney LLC | 279,230 | -308 | |
0.10 % | Nan Fung Life Sciences | 274,488 | 137,833 | |
0.10 % | AllianceBernstein L.P. | 270,730 | 6,900 | |
0.10 % | Parametric Portfolio Associates LLC | 270,441 | -12,558 | |
0.10 % | Seven Eight Capital, LP | 270,167 | 28,911 | |
0.10 % | JPMorgan Private Bank (United States) | 269,447 | 226,667 | |
0.09 % | California State Teachers Retirement System | 253,494 | -11,997 | |
0.09 % | Legal & General Investment Management Ltd. | 236,272 | 1,909 | |
0.09 % | ArrowMark Colorado Holdings, LLC | 233,186 | 0 | |
0.08 % | Two Sigma Investments, LP | 225,373 | -311,684 | |
0.08 % | J.P. Morgan Securities plc | 208,969 | -119,832 | |
0.08 % | Farmer (Michele) | 207,563 | -2,968 | |