9.35333 % | RTW Investments L.P. | 4,489,596 | 0 | |
7.68756 % | The Vanguard Group, Inc. | 3,690,027 | -32,360 | |
5.83802 % | BlackRock Institutional Trust Company, N.A. | 2,802,249 | 267,537 | |
4.91683 % | Fairmount Funds Management LLC | 2,360,077 | 0 | |
4.12729 % | BVF Partners L.P. | 1,981,100 | -150,000 | |
2.26893 % | Citadel Advisors LLC | 1,089,085 | -206,539 | |
2.16254 % | Perceptive Advisors LLC | 1,038,019 | 556,370 | |
2.08333 % | Deep Track Capital LP | 1,000,000 | -140,745 | |
2.08333 % | RA Capital Management, LP | 1,000,000 | 0 | |
15.30104 % | Antecip Capital, L.L.C. | 7,344,500 | 0 | |
1.92540 % | State Street Global Advisors (US) | 924,190 | 56,543 | |
1.89576 % | Millennium Management LLC | 909,965 | 406,923 | |
1.74417 % | Point72 Asset Management, L.P. | 837,201 | 305,264 | |
1.71313 % | Geode Capital Management, L.L.C. | 822,304 | 43,809 | |
1.56676 % | Alethea Capital Management, LLC | 752,044 | -6,750 | |
1.45611 % | Pictet Asset Management Ltd. | 698,932 | 52,503 | |
1.32369 % | Bellevue Asset Management AG | 635,372 | 3,885 | |
1.17361 % | Jefferies LLC | 563,335 | 10,140 | |
1.17117 % | Woodline Partners LP | 562,163 | 110,056 | |
1.12677 % | Fidelity Management & Research Company LLC | 540,849 | -981,224 | |
0.97381 % | PFM Health Sciences, LP | 467,427 | -55,783 | |
0.95708 % | Avidity Partners Management LP | 459,400 | 162,600 | |
0.93234 % | Coleman (Mark H) | 447,525 | 0 | |
0.83333 % | Boxer Capital, L.L.C. | 400,000 | 0 | |
0.81824 % | Hood River Capital Management LLC | 392,753 | 9,477 | |
0.76179 % | Morgan Stanley & Co. LLC | 365,660 | 314,379 | |
0.76042 % | Adage Capital Management, L.P. | 365,000 | 40,000 | |
0.72232 % | Eventide Asset Management, LLC | 346,712 | 0 | |
0.71079 % | Fidelity Institutional Asset Management | 341,178 | 4,695 | |
0.66667 % | Tang Capital Management, LLC | 320,000 | 0 | |
0.64997 % | Northern Trust Investments, Inc. | 311,985 | 8,356 | |
0.61604 % | Charles Schwab Investment Management, Inc. | 295,701 | 5,830 | |
0.61548 % | First Turn Management, LLC | 295,428 | 295,428 | |
0.55384 % | Driehaus Capital Management, LLC | 265,842 | 16,953 | |
0.49962 % | Wellington Management Company, LLP | 239,819 | 2,265 | |
0.48599 % | Nuveen LLC | 233,273 | 16,950 | |
0.44164 % | Morgan Stanley Smith Barney LLC | 211,986 | 7,285 | |
0.40651 % | Norges Bank Investment Management (NBIM) | 195,123 | -61,274 | |
0.39971 % | Barclays Bank PLC | 191,862 | 175,164 | |
0.34931 % | Jeffs (Roger A) | 167,668 | 0 | |
0.34375 % | Ghost Tree Capital, LLC | 165,000 | 55,000 | |
0.33445 % | BofA Global Research (US) | 160,534 | 136,659 | |
0.32554 % | Goldman Sachs & Company, Inc. | 156,261 | 48,311 | |
0.32364 % | Checkpoint Capital L.P. | 155,346 | 155,346 | |
0.31950 % | BlackRock Asset Management Ireland Limited | 153,360 | -6,457 | |
0.30379 % | BlackRock Advisors (UK) Limited | 145,817 | -1,580 | |
0.30057 % | BlackRock Financial Management, Inc. | 144,273 | 38,954 | |
0.29880 % | U.S. Bancorp Asset Management, Inc. | 143,424 | 4,653 | |
0.29132 % | Loomis, Sayles & Company, L.P. | 139,832 | 139,832 | |
0.28820 % | Iridian Asset Management LLC | 138,337 | -6,696 | |
0.28750 % | Altium Capital Management LP | 138,000 | 46,000 | |
0.27237 % | Tri Locum Partners LP | 130,738 | -11,772 | |
0.26810 % | JP Morgan Asset Management | 128,688 | -24,497 | |
0.25539 % | T. Rowe Price Associates, Inc. | 122,586 | 115,719 | |
0.24790 % | Medical Strategy GmbH | 118,990 | -4,300 | |
0.22259 % | Schonfeld Strategic Advisors LLC | 106,842 | 39,144 | |
0.21963 % | BNY Mellon Asset Management | 105,421 | 230 | |
0.21835 % | WCM Investment Management | 104,808 | 8,845 | |
0.21193 % | Citi Investment Research (US) | 101,727 | -935 | |
0.21013 % | Ally Bridge Group NY LLC | 100,862 | -9,738 | |
0.19768 % | Frontier Capital Management Company, LLC | 94,888 | -65,788 | |
0.19456 % | BioImpact Capital LLC | 93,387 | -199 | |
0.19340 % | Jane Street Capital, L.L.C. | 92,831 | -32,750 | |
0.18427 % | BlackRock Investment Management, LLC | 88,450 | 1,660 | |
0.18302 % | Artia Global Partners LP | 87,848 | 0 | |
0.17726 % | Candriam Belgium S.A. | 85,084 | 35,000 | |
0.17670 % | Peregrine Capital Management, LLC | 84,817 | -6,274 | |
0.17518 % | Lindbrook Capital, LLC | 84,086 | -233 | |
0.17259 % | Cannell & Co. | 82,845 | -21,345 | |
0.17218 % | Nicholas Investment Partners, L.P. | 82,645 | -312,335 | |
0.16758 % | HSBC Global Asset Management (UK) Limited | 80,437 | -68,375 | |
0.16479 % | Rhenman & Partners Asset Management AB | 79,100 | 39,000 | |
0.16436 % | Jess S. Morgan & Company, Inc | 78,895 | -25,994 | |
0.15643 % | Candriam Luxembourg S.A. | 75,084 | 0 | |
0.15208 % | ACT Capital Management, L.L.C. | 73,000 | 73,000 | |
0.15007 % | Privium Fund Management BV | 72,032 | 0 | |
0.14564 % | First Trust Advisors L.P. | 69,909 | 794 | |
0.14476 % | Hennion & Walsh Asset Management, Inc. | 69,483 | 8,867 | |
0.13930 % | Moody Aldrich Partners, LLC | 66,866 | -6,767 | |
0.13896 % | Atika Capital Management LLC | 66,700 | -4,300 | |
0.12971 % | HighVista Strategies LLC | 62,263 | 5,299 | |
0.12604 % | Schweizerische Nationalbank | 60,500 | -11,200 | |
0.12583 % | ClearBridge Investments, LLC | 60,400 | 60,400 | |
0.12146 % | International Biotechnology Trust PLC | 58,300 | 0 | |
0.12146 % | Schroder Investment Management Ltd. (SIM) | 58,300 | 58,300 | |
0.11709 % | Lighthouse Partners | 56,202 | 56,202 | |
0.11181 % | DWS Investment Management Americas, Inc. | 53,670 | 10,661 | |
0.10565 % | WMS Partners LLC | 50,711 | -30,000 | |
0.10549 % | Rhumbline Advisers Ltd. Partnership | 50,637 | -208 | |
0.10417 % | Affinity Asset Advisors LLC | 50,000 | 50,000 | |
0.10353 % | Baldwin Brothers, LLC. | 49,695 | 700 | |
0.10324 % | Goldman Sachs Asset Management, L.P. | 49,554 | -1,745 | |
0.10203 % | Mellon Investments Corporation | 48,976 | -1,886 | |
0.09476 % | Putnam Investment Management, L.L.C. | 45,486 | -74,780 | |
0.09319 % | Invesco Advisers, Inc. | 44,733 | -16,436 | |
0.09232 % | Neuberger Berman, LLC | 44,315 | 40,050 | |
0.08965 % | Credit Suisse Funds AG | 43,033 | 182 | |
0.08808 % | Pizzie (Nick) | 42,277 | 0 | |
0.08602 % | AllianceBernstein L.P. | 41,290 | 0 | |
0.08359 % | UBS Financial Services, Inc. | 40,125 | 7,341 | |