9.65345 % | BVF Partners L.P. | 6,851,051 | 0 | |
8.61970 % | EcoR1 Capital, LLC | 6,117,400 | 0 | |
7.49045 % | Rubric Capital Management LP | 5,315,969 | -129,941 | |
5.55738 % | BlackRock Institutional Trust Company, N.A. | 3,944,073 | 748,785 | |
5.14608 % | Levin (Jeremy M) | 3,652,176 | 18,248 | |
5.14092 % | Madison Avenue Partners LP | 3,648,509 | 0 | |
4.21273 % | The Vanguard Group, Inc. | 2,989,777 | 23,360 | |
3.52262 % | Invus Public Equities Advisors, LLC | 2,500,000 | 0 | |
2.33320 % | Acadian Asset Management LLC | 1,655,871 | -45,357 | |
2.07871 % | JP Morgan Asset Management | 1,475,260 | -30,973 | |
10.61293 % | Takeda Pharmaceutical Co Ltd | 7,531,996 | 1,250,000 | |
1.85949 % | TLS Advisors LLC | 1,319,679 | 0 | |
1.73725 % | Geode Capital Management, L.L.C. | 1,232,923 | 32,146 | |
1.57862 % | State Street Global Advisors (US) | 1,120,347 | 11,288 | |
1.21857 % | Cowen Investment Management LLC | 864,822 | 0 | |
1.21857 % | Blue Owl Capital Holdings LP | 864,822 | 864,822 | |
0.63407 % | Northern Trust Investments, Inc. | 449,998 | 14,862 | |
0.61906 % | Bridgeway Capital Management, LLC | 439,345 | -19,355 | |
0.60624 % | Wells Fargo Advisors | 430,247 | 0 | |
0.55766 % | FFT Wealth Management LLC | 395,774 | 395,774 | |
0.44403 % | Medical Strategy GmbH | 315,131 | 48,816 | |
0.35226 % | ARIAD Asset Management GmbH | 250,000 | -94,634 | |
0.34281 % | Dimensional Fund Advisors, L.P. | 243,295 | 100,437 | |
0.23976 % | BlackRock Investment Management, LLC | 170,159 | -1,630 | |
0.23093 % | BNY Mellon Asset Management | 163,890 | -1,769 | |
0.22799 % | Charles Schwab Investment Management, Inc. | 161,808 | -8,228 | |
0.22578 % | BlackRock Financial Management, Inc. | 160,236 | 6,969 | |
0.21681 % | JPMorgan Private Bank (United States) | 153,873 | 47,058 | |
0.20361 % | UBS O'Connor LLC | 144,500 | -5,500 | |
0.17465 % | Morgan Stanley & Co. LLC | 123,948 | 93,237 | |
0.16689 % | ETF Architect | 118,445 | 10,645 | |
0.16075 % | Nuveen LLC | 114,085 | 0 | |
0.12037 % | Vestal Point Capital, LP | 85,429 | 85,429 | |
0.12009 % | Fidelity Management & Research Company LLC | 85,225 | -6,281 | |
0.11563 % | Barclays Bank PLC | 82,060 | 71,280 | |
0.11438 % | Connor, Clark & Lunn Investment Management Ltd. | 81,175 | 2 | |
0.11225 % | Rhumbline Advisers Ltd. Partnership | 79,666 | -3,125 | |
0.11058 % | Assenagon Asset Management S.A. | 78,479 | 77,447 | |
0.11028 % | D. E. Shaw & Co., L.P. | 78,267 | -6,041 | |
0.10308 % | Tejara Capital Ltd. | 73,153 | 73,153 | |
0.10136 % | UBS Financial Services, Inc. | 71,933 | 23,826 | |
0.08784 % | Jacobs Levy Equity Management, Inc. | 62,341 | 0 | |
0.07652 % | BofA Global Research (US) | 54,308 | 14,612 | |
0.07366 % | Newton Investment Management North America, LLC | 52,280 | 0 | |
0.07214 % | Renaissance Technologies LLC | 51,200 | -29,600 | |
0.07172 % | Jane Street Capital, L.L.C. | 50,901 | 50,901 | |
0.06404 % | BlackRock Asset Management Ireland Limited | 45,450 | 45,450 | |
0.06308 % | Dimensional Fund Advisors, Ltd. | 44,768 | 3,357 | |
0.06221 % | Bank of Nova Scotia | 44,152 | 0 | |
0.05787 % | Perone (Thomas Michael) | 41,067 | 41,067 | |
0.05731 % | Northern Trust Global Investments | 40,674 | -3,000 | |
0.05607 % | SG Americas Securities, L.L.C. | 39,792 | 13,728 | |
0.05476 % | Goldman Sachs & Company, Inc. | 38,862 | 5,194 | |
0.05283 % | BlackRock Advisors (UK) Limited | 37,490 | 1,800 | |
0.04790 % | Mirae Asset Global Investments (USA) LLC | 33,996 | 1,765 | |
0.04599 % | Mellon Investments Corporation | 32,639 | 498 | |
0.04469 % | MetLife Investment Management, LLC | 31,717 | 0 | |
0.04352 % | Tardio (Jason) | 30,886 | 28,125 | |
0.04321 % | Rona (Jeffrey A) | 30,666 | 28,125 | |
0.04176 % | SunAmerica Asset Management, LLC | 29,639 | -120 | |
0.03863 % | Invesco Advisers, Inc. | 27,416 | 5,463 | |
0.03776 % | Voya Investment Management LLC | 26,797 | 972 | |
0.03664 % | First Manhattan Co. LLC | 26,000 | 0 | |
0.03626 % | Vaughan Nelson Investment Management, L.P. | 25,732 | 0 | |
0.03501 % | Manulife Investment Management (North America) Limited | 24,850 | 0 | |
0.03419 % | Virtu Americas LLC | 24,264 | 24,264 | |
0.03231 % | Goldman Sachs Asset Management, L.P. | 22,933 | -155 | |
0.03224 % | DWS Investments UK Limited | 22,884 | -1,136 | |
0.03131 % | Susquehanna International Group, LLP | 22,220 | 22,220 | |
0.03054 % | William Blair & Company, L.L.C. (Research) | 21,676 | -401 | |
0.02818 % | Bernstein (Karen) | 20,000 | 0 | |
0.02675 % | New York State Common Retirement Fund | 18,982 | -128 | |
0.02639 % | DCF Advisers, LLC | 18,730 | -11,700 | |
0.02593 % | BNP Paribas Securities Corp. North America | 18,406 | 9,756 | |
0.02585 % | Wells Fargo Bank, N.A. | 18,344 | 3,625 | |
0.02428 % | Florida State Board of Administration | 17,230 | 0 | |
0.02328 % | Newman, Dignan & Sheerar, Inc. | 16,522 | 16,522 | |
0.02027 % | ProShare Advisors LLC | 14,385 | 6,681 | |
0.02008 % | T. Rowe Price International Ltd | 14,251 | 837 | |
0.01866 % | Adar1 Capital Management LLC | 13,246 | 13,246 | |
0.01792 % | RBC Wealth Management, International | 12,720 | 2,709 | |
0.01775 % | Bailard, Inc. | 12,600 | 0 | |
0.01604 % | Squarepoint Capital LLP | 11,381 | 11,381 | |
0.01578 % | Citadel Advisors LLC | 11,202 | 11,202 | |
0.01494 % | RBC Capital Partners | 10,602 | 7,794 | |
0.01413 % | Citi Investment Research (US) | 10,026 | 9,997 | |
0.01383 % | California State Teachers Retirement System | 9,815 | -3,342 | |
0.01263 % | Avantis Investors | 8,962 | 45 | |
0.01241 % | Parametric Portfolio Associates LLC | 8,807 | -886 | |
0.01230 % | Horizon Kinetics LLC | 8,731 | 0 | |
0.01152 % | China Universal Asset Management Co., Ltd. | 8,178 | 8,178 | |
0.00959 % | Principal Global Investors (Equity) | 6,809 | -247 | |
0.00911 % | Mackenzie Financial Corporation | 6,468 | -24 | |
0.00826 % | AllianceBernstein L.P. | 5,860 | 0 | |
0.00813 % | DFA Australia Ltd. | 5,768 | 10 | |
0.00733 % | Amalgamated Bank Institutional Asset Management & Custody | 5,202 | -598 | |
0.00733 % | Legal & General Investment Management Ltd. | 5,201 | 588 | |
0.00694 % | Ameritas Investment Partners, Inc. | 4,924 | 0 | |
0.00659 % | Wellington Management Company, LLP | 4,674 | -148 | |
0.00618 % | Tower Research Capital LLC | 4,383 | 346 | |