11.29074 % | Baillie Gifford & Co. | 43,449,041 | -1,206,776 | |
10.24460 % | The Vanguard Group, Inc. | 39,423,276 | 524,278 | |
5.38921 % | Fidelity Management & Research Company LLC | 20,738,752 | 7,549,331 | |
4.45284 % | BlackRock Institutional Trust Company, N.A. | 17,135,427 | 548 | |
3.90415 % | State Street Global Advisors (US) | 15,023,936 | 571,901 | |
2.99084 % | Langer (Robert S Jr.) | 11,509,357 | 0 | |
2.35185 % | Boston Biotech Ventures, L.L.C. | 9,050,372 | 0 | |
1.93768 % | Invesco Capital Management (QQQ Trust) | 7,456,589 | 57,886 | |
1.87798 % | Theleme Partners LLP | 7,226,861 | -94,936 | |
1.79083 % | Geode Capital Management, L.L.C. | 6,891,465 | 140,986 | |
1.70596 % | OCHA, L.L.C. | 6,564,880 | 0 | |
1.42588 % | Bancel (Stephane J) | 5,487,064 | 26,840 | |
1.20372 % | Flagship Ventures | 4,632,149 | -5,033,889 | |
1.12223 % | Wellington Management Company, LLP | 4,318,571 | -1,286,132 | |
0.95296 % | Capital World Investors | 3,667,171 | 19,054 | |
0.87074 % | Norges Bank Investment Management (NBIM) | 3,350,793 | -144,081 | |
0.81997 % | Banque Pictet & Cie S.A. | 3,155,399 | 970 | |
0.75230 % | Manulife Investment Management (North America) Limited | 2,894,995 | -583,417 | |
0.73403 % | BlackRock Asset Management Ireland Limited | 2,824,702 | 92,890 | |
0.67994 % | Legal & General Investment Management Ltd. | 2,616,531 | -186,341 | |
0.55595 % | Morgan Stanley & Co. LLC | 2,139,424 | -544,930 | |
0.55541 % | Invesco Capital Management LLC | 2,137,328 | -181,137 | |
0.53264 % | Charles Schwab Investment Management, Inc. | 2,049,695 | 82,106 | |
0.51532 % | Northern Trust Investments, Inc. | 1,983,054 | 6,120 | |
0.49460 % | Mawer Investment Management Ltd. | 1,903,326 | -13,244 | |
0.47865 % | Afeyan (Noubar Boghos) | 1,841,931 | -60,000 | |
0.44297 % | Baillie Gifford Overseas Ltd. | 1,704,623 | -5,634 | |
0.44105 % | Goldman Sachs Bank AG | 1,697,235 | -353 | |
0.44001 % | UBS Asset Management (Switzerland) | 1,693,229 | 21,977 | |
0.41553 % | Hoge (Stephen) | 1,599,051 | -318 | |
0.40635 % | Bellevue Asset Management AG | 1,563,735 | -147,354 | |
0.39695 % | Parametric Portfolio Associates LLC | 1,527,526 | 247,321 | |
0.39461 % | BlackRock Investment Management (UK) Ltd. | 1,518,544 | 40,842 | |
0.37595 % | Sumitomo Mitsui Trust Bank, Limited | 1,446,717 | -99,112 | |
0.37090 % | Dimensional Fund Advisors, L.P. | 1,427,300 | 29,566 | |
0.35366 % | Goldman Sachs Asset Management, L.P. | 1,360,965 | 22,363 | |
0.34550 % | BlackRock Financial Management, Inc. | 1,329,539 | -52,500 | |
0.34159 % | Jane Street Capital, L.L.C. | 1,314,499 | 820,909 | |
0.32818 % | Mellon Investments Corporation | 1,262,915 | -39,357 | |
0.29483 % | T. Rowe Price Associates, Inc. | 1,134,567 | 571,403 | |
0.28953 % | Pictet Asset Management Ltd. | 1,114,162 | -1,507,475 | |
0.28915 % | UBS Asset Management (Americas), Inc. | 1,112,693 | -16,365 | |
0.28630 % | Goldman Sachs & Company, Inc. | 1,101,744 | 232,086 | |
0.27392 % | ARK Investment Management LLC | 1,054,094 | -163,289 | |
0.26067 % | California Public Employees' Retirement System | 1,003,122 | -126,817 | |
0.25788 % | UBS Financial Services, Inc. | 992,378 | 15,870 | |
0.25040 % | Schweizerische Nationalbank | 963,600 | -7,000 | |
0.24185 % | Barclays Bank PLC | 930,684 | -16,607 | |
0.22584 % | BNY Mellon Asset Management | 869,062 | -4,597 | |
0.22355 % | UBS Asset Management (UK) Ltd. | 860,249 | -12,484 | |
0.21831 % | Morgan Stanley Smith Barney LLC | 840,092 | -59,156 | |
0.21150 % | National Pension Service | 813,893 | 75,817 | |
0.19181 % | BNP Paribas Securities Corp. North America | 738,116 | -8,776 | |
0.18981 % | Nuveen LLC | 730,429 | -61,814 | |
0.18451 % | Candriam Luxembourg S.A. | 710,042 | -73,880 | |
0.17898 % | BofA Global Research (US) | 688,754 | 86,860 | |
0.17880 % | Amundi Asset Management, SAS | 688,069 | 93,960 | |
0.17698 % | BlackRock (Netherlands) B.V. | 681,044 | 61,402 | |
0.17565 % | Mitsubishi UFJ Trust and Banking Corporation | 675,927 | -88,049 | |
0.16292 % | J.P. Morgan Securities LLC | 626,945 | 249,724 | |
0.15764 % | Northern Trust Global Investments | 606,628 | -34,240 | |
0.15356 % | J.P. Morgan Securities plc | 590,933 | 19,033 | |
0.15228 % | Rhumbline Advisers Ltd. Partnership | 585,992 | -2,900 | |
0.14289 % | Pictet Asset Management (Japan) Ltd. | 549,882 | 97,533 | |
0.13765 % | Pictet & Cie (Europe) S.A. | 529,686 | 7,060 | |
0.13527 % | California State Teachers Retirement System | 520,535 | -669 | |
0.13272 % | DWS Investments UK Limited | 510,746 | -48,790 | |
0.13223 % | First Trust Advisors L.P. | 508,832 | -95,514 | |
0.12830 % | BlackRock Investment Management, LLC | 493,739 | -42,576 | |
0.12527 % | Candriam Belgium S.A. | 482,052 | 40,007 | |
0.12420 % | Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 477,941 | 31,468 | |
0.12346 % | Douglas C. Lane & Associates | 475,089 | 70,889 | |
0.12279 % | RBC Capital Markets Wealth Management | 472,532 | -40,825 | |
0.12088 % | T. Rowe Price International Ltd | 465,161 | 9,128 | |
0.12019 % | Sagan (Paul L) | 462,513 | 0 | |
0.11965 % | Citadel Advisors LLC | 460,456 | 188,119 | |
0.11786 % | Citi Investment Research (US) | 453,532 | 25,335 | |
0.10980 % | Fidelity Institutional Asset Management | 422,533 | 12,117 | |
0.10543 % | AllianceBernstein L.P. | 405,705 | 20,343 | |
0.10435 % | ProShare Advisors LLC | 401,548 | -43,073 | |
0.10413 % | New York State Common Retirement Fund | 400,732 | -20,030 | |
0.10366 % | BlackRock Japan Co., Ltd. | 398,888 | -104,029 | |
0.10076 % | Aperio Group, LLC | 387,741 | 65,729 | |
0.10050 % | Mirae Asset Global Investments (USA) LLC | 386,740 | 5,318 | |
0.09724 % | Invesco Advisers, Inc. | 374,214 | -49,499 | |
0.09465 % | Principal Global Investors (Equity) | 364,233 | 328 | |
0.09171 % | BlackRock Asset Management Canada Limited | 352,906 | 87,853 | |
0.09046 % | Lingotto Investment Management LLP | 348,095 | 45,000 | |
0.08930 % | Boston Management and Research | 343,661 | 0 | |
0.08803 % | HSBC Global Asset Management (UK) Limited | 338,755 | -75,257 | |
0.08713 % | Royal London Asset Management Ltd. | 335,309 | -51,219 | |
0.08701 % | Florida State Board of Administration | 334,826 | -41,291 | |
0.08239 % | Ostrum Asset Management | 317,039 | 285,662 | |
0.08196 % | Letko, Brosseau & Associates Inc. | 315,400 | -4,650 | |
0.08065 % | State Street Global Advisors Ireland Limited | 310,341 | 6,673 | |
0.08002 % | Wells Fargo Advisors | 307,946 | 55,712 | |
0.07628 % | DWS Investment GmbH | 293,553 | 125,119 | |
0.07434 % | Managed Account Advisors LLC | 286,067 | -16,010 | |
0.07389 % | Victory Capital Management Inc. | 284,337 | -15,173 | |
0.07378 % | Kentucky Teachers' Retirement System | 283,909 | 11,828 | |