9.07323 % | Baker Bros. Advisors LP | 1,969,798 | 0 | |
8.70054 % | Avoro Capital Advisors LLC | 1,888,888 | 333,888 | |
7.24360 % | The Vanguard Group, Inc. | 1,572,586 | 1,404 | |
5.09323 % | Paulson & Co. Inc. | 1,105,741 | 105,741 | |
5.01801 % | BlackRock Institutional Trust Company, N.A. | 1,089,409 | 160,817 | |
3.75491 % | RTW Investments L.P. | 815,191 | 505,706 | |
3.22772 % | State Street Global Advisors (US) | 700,739 | 58,473 | |
3.01953 % | SQN, L.L.C. | 655,540 | 0 | |
2.56251 % | Fidelity Management & Research Company LLC | 556,322 | 115,958 | |
2.24977 % | Craves (Frederick B) | 488,424 | 17,868 | |
2.02210 % | Taub (Rebecca A) | 438,998 | 0 | |
13.36734 % | Janus Henderson Investors | 2,902,050 | -140,611 | |
1.74034 % | T. Rowe Price Associates, Inc. | 377,827 | 215,394 | |
1.56497 % | AllianceBernstein L.P. | 339,754 | -21,223 | |
1.54885 % | Geode Capital Management, L.L.C. | 336,255 | 39,817 | |
1.49525 % | Bain Capital Life Sciences Investors, LLC | 324,619 | 324,619 | |
1.36564 % | Artisan Partners Limited Partnership | 296,480 | 16,390 | |
0.99870 % | Jane Street Capital, L.L.C. | 216,818 | 113,432 | |
0.97415 % | AlpInvest Partners B.V. | 211,488 | 211,488 | |
0.94196 % | RA Capital Management, LP | 204,500 | 0 | |
0.91280 % | Rock Springs Capital Management LP | 198,169 | 1,800 | |
0.88407 % | Group One Trading, L.P. | 191,931 | 116,243 | |
0.82873 % | TCG Crossover Management, LLC | 179,917 | 0 | |
0.78842 % | Pictet Asset Management Ltd. | 171,165 | 59,740 | |
0.74307 % | Friedman (Paul A) | 161,321 | 0 | |
0.69623 % | Perceptive Advisors LLC | 151,151 | 26,514 | |
0.67061 % | Norges Bank Investment Management (NBIM) | 145,589 | 29,289 | |
0.60124 % | Tao Capital Management LP | 130,529 | 52,872 | |
0.57151 % | Northern Trust Investments, Inc. | 124,075 | 12,833 | |
0.55372 % | Charles Schwab Investment Management, Inc. | 120,212 | 10,711 | |
0.50767 % | Rheos Capital Works Inc. | 110,215 | 110,215 | |
0.46062 % | Affinity Asset Advisors LLC | 100,000 | 15,000 | |
0.40708 % | UBS Financial Services, Inc. | 88,377 | 32,192 | |
0.40075 % | Emerald Advisers LLC | 87,002 | 86,124 | |
0.37903 % | Summit Partners Public Asset Management, LLC | 82,287 | 82,287 | |
0.36668 % | Morgan Stanley & Co. LLC | 79,607 | 18,406 | |
0.36000 % | Managed Account Advisors LLC | 78,157 | -2,176 | |
0.34948 % | American Century Investment Management, Inc. | 75,873 | 12,264 | |
0.33849 % | University of Wisconsin Foundation | 73,487 | 33,354 | |
0.31970 % | Frazier Healthcare Partners | 69,406 | 69,406 | |
0.31710 % | Fidelity Institutional Asset Management | 68,843 | 68,827 | |
0.31534 % | Goldman Sachs & Company, Inc. | 68,460 | 13,348 | |
0.28914 % | Susquehanna International Group, LLP | 62,773 | 18,654 | |
0.28673 % | Sibold (William John) | 62,250 | 12,250 | |
0.28332 % | Mirae Asset Global Investments (USA) LLC | 61,508 | -767 | |
0.28287 % | Ensign Peak Advisors, Inc. | 61,412 | 10,365 | |
0.27845 % | Gollust (Keith R) | 60,452 | 0 | |
0.25701 % | Wells Fargo Advisors | 55,797 | 46,812 | |
0.25510 % | Morgan Stanley Smith Barney LLC | 55,382 | 14,944 | |
0.25497 % | Pictet Asset Management (Japan) Ltd. | 55,355 | 4,491 | |
0.24923 % | Connor, Clark & Lunn Investment Management Ltd. | 54,107 | 2,421 | |
0.24284 % | Nuveen LLC | 52,720 | 15,533 | |
0.23899 % | LMR Partners LLP | 51,885 | 44,385 | |
0.23722 % | Erste Asset Management GmbH | 51,500 | -400 | |
0.23137 % | L1 Capital Pty Ltd. | 50,230 | 1,761 | |
0.23031 % | Armistice Capital LLC | 50,000 | -58,000 | |
0.22234 % | BlackRock Financial Management, Inc. | 48,271 | 11,713 | |
0.21981 % | DWS Investment GmbH | 47,721 | 11,149 | |
0.21110 % | Baillie Gifford & Co. | 45,830 | -723 | |
0.19852 % | Rafferty Asset Management LLC | 43,099 | -2,224 | |
0.18844 % | BioImpact Capital LLC | 40,910 | 51 | |
0.18511 % | BNY Mellon Asset Management | 40,188 | 2,878 | |
0.18024 % | JP Morgan Asset Management | 39,130 | -9,477 | |
0.17619 % | Barclays Bank PLC | 38,251 | 12,441 | |
0.16732 % | BlackRock Investment Management, LLC | 36,326 | 3,019 | |
0.16186 % | BofA Global Research (US) | 35,139 | 5,967 | |
0.15861 % | Tekla Capital Management LLC_NLE | 34,434 | 21,953 | |
0.15233 % | Marshall Wace LLP | 33,071 | -362,327 | |
0.15219 % | Rockefeller Capital Management | 33,040 | 14,926 | |
0.14886 % | Hennion & Walsh Asset Management, Inc. | 32,318 | 5,392 | |
0.13833 % | Propel Bio Management, LLC | 30,032 | 15,738 | |
0.13128 % | Macquarie Investment Management | 28,500 | 0 | |
0.12978 % | T. Rowe Price Investment Management, Inc. | 28,176 | 28,176 | |
0.12790 % | Sphera Funds Management Ltd. | 27,767 | -23,100 | |
0.12437 % | Candriam Belgium S.A. | 27,000 | -2,000 | |
0.11757 % | Tri Locum Partners LP | 25,524 | -8,237 | |
0.11515 % | Rosalind Advisors, Inc. | 25,000 | 25,000 | |
0.11055 % | Candriam Luxembourg S.A. | 24,000 | -11,000 | |
0.10488 % | BNP Paribas Securities Corp. North America | 22,769 | 6,148 | |
0.10364 % | Rhenman & Partners Asset Management AB | 22,500 | 22,500 | |
0.09857 % | Schweizerische Nationalbank | 21,400 | -700 | |
0.09822 % | Citi Investment Research (US) | 21,323 | -961 | |
0.09801 % | BlackRock Advisors (UK) Limited | 21,279 | 773 | |
0.09753 % | Capital Fund Management S.A. | 21,174 | 21,174 | |
0.09597 % | HSBC Private Bank (Suisse) S.A. | 20,835 | 868 | |
0.09500 % | Rhumbline Advisers Ltd. Partnership | 20,624 | 1,401 | |
0.09452 % | Wintrust Investments, LLC | 20,520 | -5,365 | |
0.09417 % | StemPoint Capital LP | 20,444 | 20,444 | |
0.09300 % | California Public Employees' Retirement System | 20,190 | -4,668 | |
0.09088 % | Raymond James & Associates, Inc. | 19,730 | -721 | |
0.09066 % | Mellon Investments Corporation | 19,682 | 401 | |
0.08789 % | Assenagon Asset Management S.A. | 19,082 | -23,294 | |
0.08451 % | New York State Common Retirement Fund | 18,347 | 1,753 | |
0.08429 % | International Biotechnology Trust PLC | 18,300 | 0 | |
0.08429 % | Schroder Investment Management Ltd. (SIM) | 18,300 | 18,300 | |
0.08336 % | Fred Alger Management, LLC | 18,097 | -1,767 | |
0.07963 % | BlackRock Asset Management Ireland Limited | 17,287 | 1,732 | |
0.07807 % | HSBC Global Asset Management (France) S.A. | 16,949 | 2,706 | |
0.07666 % | Goldman Sachs Asset Management, L.P. | 16,643 | -4,657 | |
0.07406 % | Manulife Investment Management (North America) Limited | 16,079 | 2,219 | |