8.20280 % | The Vanguard Group, Inc. | 14,096,512 | -313,844 | |
6.13315 % | T. Rowe Price Associates, Inc. | 10,539,825 | 378,043 | |
6.01113 % | BlackRock Institutional Trust Company, N.A. | 10,330,132 | 1,036,607 | |
3.45064 % | State Street Global Advisors (US) | 5,929,933 | 875,550 | |
3.40448 % | T. Rowe Price Investment Management, Inc. | 5,850,606 | -2,474,278 | |
3.20729 % | Palo Alto Investors LP | 5,511,721 | -377,770 | |
3.11318 % | Deep Track Capital LP | 5,350,000 | -650,000 | |
2.70672 % | Macquarie Investment Management | 4,651,492 | -2,280 | |
2.66069 % | Fidelity Management & Research Company LLC | 4,572,391 | 783,250 | |
2.47698 % | William Blair Investment Management, LLC | 4,256,687 | 14,752 | |
1.96070 % | Franklin Advisers, Inc. | 3,369,461 | -16,215 | |
1.78608 % | Geode Capital Management, L.L.C. | 3,069,378 | 195,681 | |
1.56211 % | Suvretta Capital Management, LLC | 2,684,487 | -761,847 | |
1.35671 % | Loomis, Sayles & Company, L.P. | 2,331,505 | -51,534 | |
1.33311 % | Bellevue Asset Management AG | 2,290,958 | -871,777 | |
1.24987 % | AllianceBernstein L.P. | 2,147,902 | -146,894 | |
1.14158 % | Pictet Asset Management Ltd. | 1,961,801 | -451,637 | |
1.08531 % | RTW Investments L.P. | 1,865,108 | 0 | |
0.97713 % | Emerald Advisers LLC | 1,679,193 | -3,056 | |
0.94316 % | Capital Research Global Investors | 1,620,814 | 1,620,814 | |
0.93969 % | Holocene Advisors, LP | 1,614,862 | -193,626 | |
0.93395 % | Millennium Management LLC | 1,605,001 | -569,828 | |
0.88367 % | Columbia Threadneedle Investments (US) | 1,518,588 | -23,104 | |
0.85734 % | Mellon Investments Corporation | 1,473,331 | -73,223 | |
0.84552 % | Norges Bank Investment Management (NBIM) | 1,453,025 | 109,192 | |
0.83781 % | Marshall Wace LLP | 1,439,769 | 874,006 | |
0.81646 % | Janus Henderson Investors | 1,403,091 | -511,711 | |
0.79113 % | Principal Global Investors (Equity) | 1,359,563 | 69,281 | |
0.77934 % | Novo Holdings A/S | 1,339,304 | 0 | |
0.75169 % | GW&K Investment Management, LLC | 1,291,772 | -60,497 | |
0.74883 % | Samlyn Capital, LLC | 1,286,868 | -94,189 | |
0.74716 % | Octagon Capital Advisors LP | 1,284,000 | 0 | |
0.71451 % | Northern Trust Investments, Inc. | 1,227,888 | 71,300 | |
0.65664 % | Charles Schwab Investment Management, Inc. | 1,128,436 | 28,629 | |
0.61761 % | Morgan Stanley & Co. LLC | 1,061,370 | 769,196 | |
0.60879 % | Citadel Advisors LLC | 1,046,214 | 466,832 | |
0.57132 % | Two Sigma Investments, LP | 981,812 | -437,748 | |
0.54899 % | Balyasny Asset Management LP | 943,431 | 862,055 | |
0.52710 % | Hood River Capital Management LLC | 905,819 | 905,819 | |
0.52371 % | Vestal Point Capital, LP | 900,000 | 900,000 | |
0.50484 % | FIL Investment Management (Hong Kong) Limited | 867,561 | -307,247 | |
0.48208 % | BNP Paribas Asset Management USA, Inc. | 828,460 | 39,516 | |
0.45909 % | BNP Paribas Asset Management UK Limited | 788,944 | 0 | |
0.43648 % | Medical Strategy GmbH | 750,096 | 0 | |
0.40235 % | Fidelity International | 691,431 | -139,771 | |
0.38534 % | American Century Investment Management, Inc. | 662,200 | 47,674 | |
0.37644 % | D. E. Shaw & Co., L.P. | 646,907 | 450,180 | |
0.37594 % | First Light Asset Management, LLC | 646,057 | 2,469 | |
0.36962 % | Eventide Asset Management, LLC | 635,185 | 0 | |
0.34914 % | Adage Capital Management, L.P. | 600,000 | 0 | |
0.33794 % | BofA Global Research (US) | 580,758 | -162,406 | |
0.33459 % | Cormorant Asset Management, LP | 575,000 | 0 | |
0.31925 % | Eagle Asset Management, Inc. | 548,633 | 29,555 | |
0.30733 % | BioImpact Capital LLC | 528,150 | 692 | |
0.30214 % | Fidelity Institutional Asset Management | 519,223 | 3,410 | |
0.29344 % | Polar Capital LLP | 504,275 | -357,125 | |
0.29117 % | BlackRock Financial Management, Inc. | 500,383 | 36,084 | |
0.28753 % | Voya Investment Management LLC | 494,116 | 6,916 | |
0.28358 % | BNY Mellon Asset Management | 487,331 | 6,256 | |
0.27774 % | ClearBridge Investments, LLC | 477,300 | 477,300 | |
0.27204 % | Hudson Bay Capital Management LP | 467,500 | -380,000 | |
0.27063 % | Goldman Sachs & Company, Inc. | 465,084 | -113,722 | |
0.26973 % | TD Asset Management Inc. | 463,532 | -59,600 | |
0.26376 % | Lewis (William H) | 453,266 | 90,918 | |
0.24964 % | PanAgora Asset Management Inc. | 429,003 | -3,576 | |
0.24062 % | Cutter Capital Management, LP | 413,499 | 413,499 | |
0.23567 % | Kingdon Capital Management, L.L.C. | 405,000 | 405,000 | |
0.22559 % | Putnam Investment Management, L.L.C. | 387,674 | 387,674 | |
0.21626 % | Long Focus Capital Management LLC | 371,649 | 0 | |
0.21504 % | Columbia Wanger Asset Management, LLC | 369,550 | 0 | |
0.20864 % | Columbia Threadneedle Investments (UK) | 358,548 | 23,527 | |
0.20854 % | Nuveen LLC | 358,377 | 9,611 | |
0.20486 % | AXA Investment Managers UK Ltd. | 352,046 | -8,515 | |
0.20367 % | Integral Health Asset Management, LLC | 350,000 | 350,000 | |
0.20102 % | BlackRock Investment Management, LLC | 345,451 | 9,231 | |
0.19966 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 343,110 | 0 | |
0.19959 % | Baker Bros. Advisors LP | 343,000 | 0 | |
0.19928 % | Sharoky (Melvin A) | 342,458 | 19,198 | |
0.19697 % | Summit Partners Public Asset Management, LLC | 338,491 | 338,491 | |
0.19466 % | Barclays Bank PLC | 334,529 | 162,728 | |
0.19338 % | Managed Account Advisors LLC | 332,318 | -133,544 | |
0.18912 % | Bleichroeder LP | 325,000 | 0 | |
0.18684 % | Rafferty Asset Management LLC | 321,087 | 47,563 | |
0.18335 % | Newton Investment Management North America, LLC | 315,084 | -103,311 | |
0.18051 % | Candriam Belgium S.A. | 310,200 | -15,000 | |
0.18051 % | Candriam Luxembourg S.A. | 310,200 | 0 | |
0.17468 % | UBS Financial Services, Inc. | 300,181 | 177,981 | |
0.17185 % | WCM Investment Management | 295,328 | 5,592 | |
0.17061 % | Scout Investments, Inc. | 293,197 | -4,600 | |
0.16880 % | Peregrine Capital Management, LLC | 290,088 | -50,037 | |
0.16556 % | Assenagon Asset Management S.A. | 284,520 | 22,384 | |
0.16474 % | Goldman Sachs Asset Management, L.P. | 283,099 | 11,457 | |
0.15788 % | Connor, Clark & Lunn Investment Management Ltd. | 271,312 | -174,792 | |
0.15665 % | Schweizerische Nationalbank | 269,200 | -30,700 | |
0.13696 % | JP Morgan Asset Management | 235,371 | -37,358 | |
0.13313 % | Knights of Columbus | 228,783 | 114,987 | |
0.13146 % | Great Point Partners, LLC | 225,912 | -168,960 | |
0.13031 % | T. Rowe Price International Ltd | 223,946 | -21,488 | |
0.12893 % | BNP Paribas Securities Corp. North America | 221,572 | 98,417 | |
0.12876 % | Rice Hall James & Associates, LLC | 221,270 | -3,195 | |