9.75349 % | Soleus Capital Management, L.P. | 4,327,622 | 40,528 | |
9.43200 % | Morgan Stanley & Co. LLC | 4,184,978 | 3,795 | |
7.35294 % | PFM Health Sciences, LP | 3,262,500 | -936,753 | |
5.18067 % | RTW Investments L.P. | 2,298,662 | 2,298,662 | |
2.56013 % | Adage Capital Management, L.P. | 1,135,931 | 93,400 | |
2.45545 % | Janus Henderson Investors | 1,089,482 | 1,089,482 | |
19.71744 % | BVF Partners L.P. | 8,748,629 | 0 | |
17.80163 % | Bellevue Asset Management AG | 7,898,583 | 0 | |
1.76787 % | Berger (Franklin Milan) | 784,404 | 22,770 | |
1.52582 % | Rock Springs Capital Management LP | 677,005 | 0 | |
0.80347 % | Rhenman & Partners Asset Management AB | 356,500 | 0 | |
0.59411 % | Citadel Advisors LLC | 263,607 | 258,132 | |
0.44997 % | D. E. Shaw & Co., L.P. | 199,653 | 31,603 | |
0.25175 % | CIBC World Markets Inc. | 111,700 | -37,443 | |
0.14822 % | Parkinson (David Ross M.D.) | 65,765 | 0 | |
0.12952 % | BNP Paribas Securities Corp. North America | 57,466 | 35,771 | |
0.12714 % | Glickman (Richard M) | 56,410 | 8,460 | |
0.10407 % | Avantis Investors | 46,176 | 26,132 | |
0.07515 % | Wood (David Sidney) | 33,343 | 0 | |
0.06762 % | Requadt (Scott) | 30,002 | 0 | |
0.06761 % | RBC Capital Markets Wealth Management | 30,000 | 30,000 | |
0.06053 % | Geode Capital Management, L.L.C. | 26,858 | 7,819 | |
0.05462 % | Renaissance Technologies LLC | 24,234 | 24,234 | |
0.04517 % | American Century Investment Management, Inc. | 20,044 | 20,044 | |
0.04515 % | Privium Fund Management (UK) Ltd | 20,032 | 0 | |
0.03207 % | Martin (John Alexander) | 14,229 | 0 | |
0.02691 % | Virsik (Peter) | 11,940 | -694 | |
0.02519 % | Group One Trading, L.P. | 11,175 | -30,685 | |
0.01730 % | BlackRock Financial Management, Inc. | 7,677 | 0 | |
0.01352 % | Osaic Holdings, Inc. | 6,000 | -6,000 | |
0.01155 % | Cesano (Alessandra) | 5,124 | 0 | |
0.01103 % | UBS Financial Services, Inc. | 4,895 | 4,730 | |
0.00943 % | Simplex Trading, LLC | 4,182 | 513 | |
0.00902 % | Blackstone Alternative Investment Advisors LLC | 4,000 | 800 | |
0.00649 % | Thorell (Marella) | 2,881 | 0 | |
0.00361 % | Morgan Stanley Smith Barney LLC | 1,600 | 100 | |
0.00219 % | Barclays Bank PLC | 971 | -317 | |
0.00203 % | TD Waterhouse Canada, Inc. | 900 | 0 | |
0.00175 % | RBC Dominion Securities, Inc. | 775 | 0 | |
0.00135 % | Laurel Wealth Advisors, LLC | 600 | 0 | |
0.00011 % | TD Securities, Inc. | 48 | 0 | |
0.00005 % | J.P. Morgan Securities plc | 21 | 0 | |
0.00002 % | BofA Global Research (US) | 8 | 0 | |
0 % | ACCI Capital Investments SGIIC, SA | 0 | -47,500 | |
0 % | Qube Research & Technologies Ltd | 0 | -11,353 | |
0 % | One Wealth Advisors, LLC | 0 | -8,333 | |
0 % | Crewe Advisors LLC | 0 | -265 | |
0 % | Trexquant Investment LP | 0 | -19,147 | |
0 % | HRT Financial LP | 0 | -53,443 | |
0 % | Cubist Systematic Strategies, LLC | 0 | -34,086 | |
0 % | Hunting Hill Global Capital, LLC | 0 | -10,000 | |
0 % | Omega Fund Management, LLC | 0 | -328,196 | |
0 % | Kapitalo Investimentos Ltda | 0 | -33,400 | |
0 % | Quantbot Technologies, LP | 0 | -1,751 | |
0 % | KLP Fondsforvaltning AS | 0 | -3,200 | |
0 % | Boxer Capital, L.L.C. | 0 | -724,500 | |
0 % | Eventide Asset Management, LLC | 0 | -1,561,251 | |
0 % | Managed Account Advisors LLC | 0 | -6,968 | |
0 % | Alps Advisors, Inc. | 0 | -24,052 | |
0 % | Clarus Ventures, LLC | 0 | -2,003,103 | |
0 % | Jane Street Capital, L.L.C. | 0 | -40,421 | |
0 % | Susquehanna International Group, LLP | 0 | -95,758 | |
0 % | Tower Research Capital LLC | 0 | -27 | |
0 % | Frazier Healthcare Partners | 0 | -605,141 | |
0 % | Northern Trust Global Investments | 0 | -4,661 | |
0 % | Newbridge Capital Management | 0 | -31 | |
0 % | Two Sigma Investments, LP | 0 | -72,088 | |
0 % | Apo Asset Management GmbH | 0 | -11,423 | |
0 % | AlpInvest Partners B.V. | 0 | -39,930 | |
0 % | RBC Capital Partners | 0 | -723 | |
0 % | Medical Strategy GmbH | 0 | -413,492 | |
0 % | Marshall Wace LLP | 0 | -115,122 | |
0 % | Millennium Management LLC | 0 | -473,556 | |
0 % | OrbiMed Advisors, LLC | 0 | -842,366 | |
0 % | City National Rochdale, LLC | 0 | -5,000 | |
0 % | Acadian Asset Management LLC | 0 | -15,903 | |
0 % | Driehaus Capital Management, LLC | 0 | -28,300 | |
0 % | APG Asset Management N.V. | 0 | -332,761 | |
0 % | Candriam Belgium S.A. | 0 | -417,532 | |
0 % | Candriam Luxembourg S.A. | 0 | -417,497 | |
0 % | Wellington Management Company, LLP | 0 | -562 | |
0 % | State Street Global Advisors (US) | 0 | -24,414 | |
0 % | Citi Investment Research (US) | 0 | -599 | |
0 % | Rockefeller Capital Management | 0 | -132 | |
0 % | Raymond James & Associates, Inc. | 0 | -40,619 | |
0 % | T. Rowe Price Associates, Inc. | 0 | -44,832 | |
0 % | Ensign Peak Advisors, Inc. | 0 | -26,282 | |
0 % | Morgan Stanley Investment Management Inc. (US) | 0 | -7 | |
0 % | Thrivent Asset Management, LLC | 0 | -33,389 | |
0 % | Goldman Sachs & Company, Inc. | 0 | -24,531 | |
0 % | JPMorgan Private Bank (United States) | 0 | -2,950 | |
0 % | Bessemer Trust Company, N.A. (US) | 0 | -6,852 | |
0 % | Northern Trust Investments, Inc. | 0 | -7,828 | |
0 % | Parametric Portfolio Associates LLC | 0 | -799 | |
0 % | J.P. Morgan Securities LLC | 0 | -29,406 | |
0 % | JP Morgan Asset Management | 0 | -73,643 | |
0 % | Values First Advisors, Inc. | 0 | -14,605 | |
0 % | Aquatic Capital Management LLC | 0 | -3,300 | |
0 % | Alta Wealth Advisors LLC | 0 | -11,285 | |
0 % | Ally Bridge Group NY LLC | 0 | -236,583 | |