6.69 % | Deerfield Management Company, L.P. | 5,788,024 | -1,109,582 | |
6.01 % | Armistice Capital LLC | 5,200,000 | 588,000 | |
5.55 % | Redmile Group, LLC | 4,801,540 | 326,156 | |
5.53 % | BlackRock Institutional Trust Company, N.A. | 4,785,332 | 483,317 | |
5.08 % | The Vanguard Group, Inc. | 4,394,354 | 38,654 | |
27.72 % | Brightstar Associates LLC | 23,973,709 | 914,001 | |
2.86 % | State Street Global Advisors (US) | 2,470,813 | 159,695 | |
2.14 % | Polar Capital LLP | 1,850,000 | 100,000 | |
2.10 % | Goldman Sachs & Company, Inc. | 1,817,391 | 389,957 | |
1.90 % | Morgan Stanley & Co. LLC | 1,646,030 | 443,104 | |
1.81 % | Dimensional Fund Advisors, L.P. | 1,561,654 | 92,410 | |
1.63 % | Nuveen LLC | 1,410,239 | 97,103 | |
1.41 % | Geode Capital Management, L.L.C. | 1,221,308 | 84,701 | |
1.38 % | Emerald Advisers LLC | 1,197,526 | 1,126,978 | |
1.35 % | Braidwell LP | 1,169,490 | -2,166,731 | |
1.18 % | Frazier Healthcare Partners | 1,021,800 | 651,800 | |
1.06 % | Jefferies LLC | 917,515 | 178,772 | |
0.97 % | Two Sigma Investments, LP | 840,332 | 626,526 | |
0.94 % | Assenagon Asset Management S.A. | 809,923 | 0 | |
0.80 % | BlackRock Financial Management, Inc. | 695,434 | 44,019 | |
0.75 % | Millennium Management LLC | 652,254 | 298,064 | |
0.67 % | New Leaf Venture Partners LLC | 576,975 | -632,596 | |
0.65 % | Parkman Healthcare Partners LLC | 561,025 | -36,378 | |
0.60 % | Charles Schwab Investment Management, Inc. | 515,301 | 13,716 | |
0.57 % | Goldman Sachs Asset Management, L.P. | 490,084 | -98,989 | |
0.54 % | Northern Trust Investments, Inc. | 467,266 | 15,720 | |
0.52 % | Morgan Stanley Investment Management Inc. (US) | 450,972 | 343,749 | |
0.52 % | Medical Strategy GmbH | 450,450 | 15,000 | |
0.51 % | Jacobs Levy Equity Management, Inc. | 445,056 | -283,670 | |
0.51 % | Renaissance Technologies LLC | 437,300 | 125,900 | |
0.46 % | Woodline Partners LP | 396,239 | 396,239 | |
0.45 % | D. E. Shaw & Co., L.P. | 388,663 | 71,702 | |
0.41 % | Norges Bank Investment Management (NBIM) | 352,000 | 352,000 | |
0.39 % | Flynn (Daniel Lee) | 335,600 | -1,655 | |
0.38 % | Walleye Capital LLC | 331,632 | 331,632 | |
0.36 % | UBS Asset Management (Americas), Inc. | 314,975 | -2,132 | |
0.32 % | Schonfeld Strategic Advisors LLC | 279,511 | 46,611 | |
0.32 % | Cubist Systematic Strategies, LLC | 278,385 | 58,761 | |
0.31 % | Algert Global LLC | 271,671 | 178,261 | |
0.30 % | Citadel Advisors LLC | 261,288 | 26,264 | |
0.29 % | Connor, Clark & Lunn Investment Management Ltd. | 251,145 | 178,973 | |
0.28 % | DWS Investment GmbH | 246,400 | 14,529 | |
0.28 % | DWS Investments UK Limited | 239,253 | 216,880 | |
0.27 % | PanAgora Asset Management Inc. | 235,845 | 144,097 | |
0.26 % | Ghost Tree Capital, LLC | 225,000 | -100,000 | |
0.25 % | Parametric Portfolio Associates LLC | 218,136 | -63,588 | |
0.25 % | PSP Investments | 214,000 | 0 | |
0.24 % | BlackRock Asset Management Ireland Limited | 211,478 | -9,155 | |
0.22 % | Voloridge Investment Management, LLC | 194,229 | 194,229 | |
0.20 % | BlackRock Advisors (UK) Limited | 176,081 | 2,818 | |
0.19 % | BlackRock Investment Management, LLC | 164,328 | 9,593 | |
0.19 % | Barclays Bank PLC | 163,913 | 49,872 | |
0.18 % | Dhanak (Dashyant) | 158,175 | 17,275 | |
0.18 % | HOOPP Investment Management | 152,000 | 39,000 | |
0.17 % | BNY Mellon Asset Management | 147,373 | -2,891 | |
0.16 % | Rafferty Asset Management LLC | 139,582 | -158 | |
0.16 % | Trexquant Investment LP | 135,994 | 135,994 | |
0.15 % | GSA Capital Partners LLP | 132,130 | -30,569 | |
0.15 % | UBS Financial Services, Inc. | 126,323 | 68,064 | |
0.14 % | Qube Research & Technologies Ltd | 119,760 | 44,004 | |
0.14 % | UBS O'Connor LLC | 117,920 | -35,817 | |
0.14 % | ExodusPoint Capital Management, LP | 116,932 | -218,953 | |
0.13 % | LifeSci Fund Management LLC | 112,500 | -19,500 | |
0.12 % | Point72 Asset Management, L.P. | 106,800 | -515,633 | |
0.12 % | HRT Financial LP | 103,651 | 46,153 | |
0.12 % | Pictet Asset Management (Japan) Ltd. | 99,666 | 99,666 | |
0.11 % | Sunesis Advisors, LLC | 96,299 | 0 | |
0.11 % | Jane Street Capital, L.L.C. | 91,573 | -6,244 | |
0.10 % | Jupiter Asset Management Ltd. | 87,543 | 25,383 | |
0.10 % | BofA Global Research (US) | 86,250 | -82,407 | |
0.09 % | Susquehanna International Group, LLP | 81,717 | 9,192 | |
0.09 % | Virginia Retirement System | 81,000 | 6,000 | |
0.09 % | Rhumbline Advisers Ltd. Partnership | 80,785 | -10 | |
0.09 % | Columbia Threadneedle Investments (US) | 78,165 | -48,644 | |
0.09 % | Thrivent Asset Management, LLC | 77,720 | -8,931 | |
0.09 % | BNP Paribas Securities Corp. North America | 77,653 | 42,051 | |
0.08 % | Hoerter (Steven L) | 72,763 | 31,836 | |
0.08 % | Aperio Group, LLC | 71,526 | -7,645 | |
0.08 % | Voya Investment Management LLC | 71,517 | 50,166 | |
0.08 % | PDT Partners, LLC | 71,365 | 35,863 | |
0.08 % | Martingale Asset Management, L.P. | 70,526 | 5 | |
0.08 % | Schweizerische Nationalbank | 69,900 | -16,500 | |
0.08 % | UBS Asset Management (Switzerland) | 68,083 | -722 | |
0.08 % | Dimensional Fund Advisors, Ltd. | 66,745 | 0 | |
0.07 % | Nebula Research & Development LLC | 64,159 | 30,990 | |
0.07 % | Citi Investment Research (US) | 62,580 | 2,000 | |
0.07 % | Fisher Investments | 62,372 | 62,372 | |
0.07 % | AQR Capital Management, LLC | 59,070 | 3,422 | |
0.07 % | Goldman Sachs Asset Management International | 57,745 | -7,943 | |
0.07 % | Sherman (Matthew L) | 57,686 | 14,660 | |
0.06 % | Pitman (Jama) | 53,900 | 17,458 | |
0.06 % | Legato Capital Management LLC | 52,636 | 52,636 | |
0.06 % | Northern Trust Global Investments | 52,187 | -2,402 | |
0.06 % | Avantis Investors | 51,474 | 13,440 | |
0.06 % | Campbell & Company, Inc. | 50,735 | 50,735 | |
0.06 % | Deka Vermögensmanagement GmbH | 50,000 | 50,000 | |
0.06 % | Allianz Global Investors GmbH | 49,880 | 0 | |
0.06 % | AllianceBernstein L.P. | 49,700 | -343 | |
0.06 % | Alps Advisors, Inc. | 49,699 | -8,516 | |
0.06 % | Wellington Management Company, LLP | 48,546 | 48,546 | |