11.34711 % | Jennison Associates LLC | 5,546,467 | 376,232 | |
7.93414 % | T. Rowe Price Investment Management, Inc. | 3,878,210 | 1,407,717 | |
6.77139 % | BlackRock Institutional Trust Company, N.A. | 3,309,856 | 553,132 | |
6.21245 % | Adage Capital Management, L.P. | 3,036,645 | 0 | |
5.64830 % | Bain Capital Life Sciences Investors, LLC | 2,760,888 | 1,110,924 | |
5.16138 % | Fred Alger Management, LLC | 2,522,882 | -587,432 | |
4.82866 % | The Vanguard Group, Inc. | 2,360,250 | 89,835 | |
4.53488 % | Alkeon Capital Management LLC | 2,216,650 | 1,799,640 | |
3.19957 % | VR Adviser, LLC | 1,563,952 | 0 | |
2.76081 % | Nichtberger (Steven) | 1,349,483 | 0 | |
2.56444 % | Polar Capital LLP | 1,253,500 | 3,500 | |
2.49673 % | Sofinnova Investments, Inc | 1,220,400 | 790,654 | |
2.43500 % | BlackRock Financial Management, Inc. | 1,190,229 | 109,677 | |
2.41020 % | StemPoint Capital LP | 1,178,105 | 174,189 | |
2.25041 % | Commodore Capital LP | 1,100,000 | 0 | |
1.98562 % | Geode Capital Management, L.L.C. | 970,573 | 197,483 | |
1.83331 % | State Street Global Advisors (US) | 896,123 | -1,109,678 | |
1.42864 % | Millennium Management LLC | 698,317 | 238,950 | |
1.29750 % | Victory Capital Management Inc. | 634,217 | 262,594 | |
1.29135 % | JP Morgan Asset Management | 631,211 | 630,368 | |
1.19690 % | Perceptive Advisors LLC | 585,045 | -1,131,615 | |
1.14795 % | T. Rowe Price Associates, Inc. | 561,120 | -34,064 | |
1.00676 % | Lynx1 Capital Advisors LLC | 492,103 | -1,590,870 | |
0.95732 % | Two Sigma Investments, LP | 467,937 | 431,263 | |
0.94978 % | Deerfield Management Company, L.P. | 464,252 | -794,398 | |
0.90595 % | Redmile Group, LLC | 442,826 | 0 | |
0.86948 % | Integral Health Asset Management, LLC | 425,000 | 0 | |
0.82109 % | Oppenheimer Asset Management Inc. | 401,350 | 318,360 | |
0.76557 % | Goldman Sachs & Company, Inc. | 374,210 | -15,066 | |
0.75880 % | Ghost Tree Capital, LLC | 370,899 | -4,101 | |
0.67551 % | Marshall Wace LLP | 330,187 | 159,000 | |
0.66980 % | Artisan Partners Limited Partnership | 327,397 | -7,416 | |
0.65374 % | Citadel Advisors LLC | 319,546 | 317,305 | |
0.64521 % | Squarepoint Capital LLP | 315,379 | 272,948 | |
0.62371 % | UBS Asset Management (Americas), Inc. | 304,870 | 278,080 | |
0.62055 % | Qube Research & Technologies Ltd | 303,326 | -131,174 | |
0.61416 % | Exome Asset Management LLC | 300,200 | 300,200 | |
0.61334 % | PanAgora Asset Management Inc. | 299,801 | 299,801 | |
0.60682 % | Jane Street Capital, L.L.C. | 296,615 | 245,896 | |
0.58597 % | E Fund Management Co. Ltd. | 286,424 | 269,675 | |
0.58210 % | Northern Trust Investments, Inc. | 284,529 | 3,009 | |
0.58101 % | PGIM Securities Investment Trust Enterprise | 284,000 | -199,265 | |
0.55396 % | AXA Investment Managers UK Ltd. | 270,778 | 92,616 | |
0.53555 % | JPMorgan Asset Management U.K. Limited | 261,777 | -28,603 | |
0.49710 % | Woodline Partners LP | 242,981 | 318 | |
0.44991 % | Weatherbie Capital, LLC | 219,916 | 53,307 | |
0.39697 % | Schonfeld Strategic Advisors LLC | 194,037 | -123,483 | |
0.38862 % | Walleye Capital LLC | 189,957 | 189,957 | |
0.37262 % | Jump Financial, LLC | 182,135 | 182,135 | |
0.35933 % | Morgan Stanley Smith Barney LLC | 175,640 | 44,145 | |
0.34805 % | Westwood Management Corp. (Texas) | 170,129 | 87,901 | |
0.34596 % | BofA Global Research (US) | 169,105 | -20,875 | |
0.32733 % | Raiffeisen Kapitalanlage-Gesellschaft mbH | 160,000 | 0 | |
0.32490 % | Wellington Management Company, LLP | 158,809 | -849,450 | |
0.30713 % | Nuveen LLC | 150,123 | -46,104 | |
0.30341 % | BlackRock Investment Management, LLC | 148,305 | 40,490 | |
0.29285 % | Simon (Mark) | 143,144 | 0 | |
0.28620 % | Superstring Capital Management LP | 139,895 | -150,902 | |
0.27420 % | TD Asset Management Inc. | 134,030 | 7,000 | |
0.26248 % | MFS Investment Management | 128,298 | 0 | |
0.24208 % | Charles Schwab Investment Management, Inc. | 118,327 | 24,802 | |
0.23902 % | Morgan Stanley & Co. LLC | 116,832 | -617,325 | |
0.22504 % | Medical Strategy GmbH | 110,000 | -15,000 | |
0.22453 % | BNY Mellon Asset Management | 109,751 | 23,972 | |
0.21421 % | Crestline Investors, Inc. | 104,705 | 19,705 | |
0.21191 % | Rafferty Asset Management LLC | 103,582 | -250,842 | |
0.19476 % | Prelude Capital Management, LLC | 95,200 | 95,200 | |
0.18143 % | BlackRock Asset Management Ireland Limited | 88,683 | 12,090 | |
0.17757 % | TCG Crossover Management, LLC | 86,795 | 0 | |
0.15653 % | Voloridge Investment Management, LLC | 76,513 | -201,610 | |
0.14321 % | LifeSci Fund Management LLC | 70,000 | 5,000 | |
0.14029 % | UBS Financial Services, Inc. | 68,573 | -140,903 | |
0.13702 % | Susquehanna International Group, LLP | 66,973 | 2,874 | |
0.13605 % | Schweizerische Nationalbank | 66,500 | 7,300 | |
0.13222 % | AllianceBernstein L.P. | 64,630 | 33,320 | |
0.13159 % | Healthinvest Partners AB | 64,321 | -13,219 | |
0.12856 % | RBC Capital Markets Wealth Management | 62,841 | -13,347 | |
0.12660 % | Rhumbline Advisers Ltd. Partnership | 61,880 | 16,274 | |
0.11789 % | Verition Fund Management LLC | 57,626 | 57,626 | |
0.11634 % | JPMorgan Private Bank (United States) | 56,867 | 43,365 | |
0.11626 % | Balyasny Asset Management LP | 56,828 | 41,865 | |
0.11543 % | Manulife Investment Management (North America) Limited | 56,424 | 4,191 | |
0.10209 % | UBS Asset Management (Switzerland) | 49,902 | 36,981 | |
0.10140 % | SEB Investment Management AB | 49,563 | 0 | |
0.09646 % | Nan Fung Life Sciences | 47,150 | 0 | |
0.08437 % | Barclays Bank PLC | 41,239 | -7,729 | |
0.08299 % | Mellon Investments Corporation | 40,566 | 20,184 | |
0.08163 % | Newton Investment Management North America, LLC | 39,900 | 0 | |
0.07180 % | SG Americas Securities, L.L.C. | 35,098 | 35,098 | |
0.06920 % | California State Teachers Retirement System | 33,825 | 3,397 | |
0.06863 % | Osaic Holdings, Inc. | 33,548 | 121 | |
0.06560 % | UBS Fund Management (Switzerland) AG | 32,064 | -1,324 | |
0.06533 % | Corton Capital Inc | 31,931 | 31,931 | |
0.06363 % | Aquatic Capital Management LLC | 31,100 | 31,100 | |
0.06143 % | Envestnet Asset Management, Inc. | 30,026 | -2,538 | |
0.06023 % | LPL Financial LLC | 29,441 | -5,492 | |
0.05839 % | Legal & General Investment Management Ltd. | 28,540 | 5,122 | |
0.05776 % | Trexquant Investment LP | 28,233 | -41,184 | |
0.05670 % | MetLife Investment Management, LLC | 27,714 | 9,399 | |
0.05632 % | BlackRock Advisors (UK) Limited | 27,527 | 609 | |