9.87331 % | Artisan Partners Limited Partnership | 5,749,227 | -246,181 | |
8.19423 % | Fidelity Management & Research Company LLC | 4,771,502 | -21,813 | |
6.92192 % | Westfield Capital Management Company, L.P. | 4,030,634 | 228,457 | |
6.86036 % | Janus Henderson Investors | 3,994,785 | 140,252 | |
6.85185 % | T. Rowe Price Investment Management, Inc. | 3,989,830 | 5,327 | |
6.44952 % | Avoro Capital Advisors LLC | 3,755,555 | 85,555 | |
5.57838 % | Wellington Management Company, LLP | 3,248,293 | -28,879 | |
3.74595 % | Capital International Investors | 2,181,268 | 12,825 | |
2.60752 % | MFS Investment Management | 1,518,356 | 254,634 | |
2.48145 % | T. Rowe Price Associates, Inc. | 1,444,950 | -192,898 | |
17.35772 % | RA Capital Management, LP | 10,107,400 | -612,155 | |
1.81854 % | Franklin Advisers, Inc. | 1,058,937 | -148,698 | |
1.47038 % | Invesco Advisers, Inc. | 856,203 | 237,928 | |
1.36175 % | TimesSquare Capital Management, LLC | 792,945 | -49,856 | |
1.29492 % | Sofinnova Investments, Inc | 754,032 | 0 | |
1.24618 % | Putnam Investment Management, L.L.C. | 725,651 | -46,711 | |
1.07333 % | Vestal Point Capital, LP | 625,000 | 625,000 | |
1.01140 % | AllianceBernstein L.P. | 588,936 | -13,938 | |
0.92727 % | Spyglass Capital Management LLC | 539,948 | -74,670 | |
0.91346 % | Capital World Investors | 531,910 | 3,296 | |
0.86888 % | Brown Advisory | 505,947 | -4,162 | |
0.72691 % | Mikkelsen Jan Moller | 423,279 | 423,279 | |
0.72618 % | Goldman Sachs & Company, Inc. | 422,854 | 12,881 | |
0.71184 % | Medical Strategy GmbH | 414,506 | -6,000 | |
0.62138 % | SEI Investments Management Corporation | 361,830 | -34,610 | |
0.62001 % | DWS Investment GmbH | 361,029 | 0 | |
0.60398 % | Paradigm BioCapital Advisors LP | 351,700 | 351,700 | |
0.58882 % | Fidelity Institutional Asset Management | 342,867 | -100 | |
0.52849 % | American Century Investment Management, Inc. | 307,737 | -21,537 | |
0.52355 % | BlackRock Institutional Trust Company, N.A. | 304,862 | 12,231 | |
0.50531 % | Florida State Board of Administration | 294,243 | 128,050 | |
0.49803 % | Rock Springs Capital Management LP | 290,000 | -135,500 | |
0.48944 % | Q Global Advisors, LLC | 285,000 | 0 | |
0.48556 % | ARS Investment Partners LLC | 282,744 | -3,174 | |
0.45536 % | D. E. Shaw & Co., L.P. | 265,157 | 44,604 | |
0.42002 % | TD Asset Management Inc. | 244,578 | -22,782 | |
0.35128 % | New York State Common Retirement Fund | 204,548 | -152 | |
0.34974 % | Pictet Asset Management Ltd. | 203,654 | 32,784 | |
0.34261 % | The Vanguard Group, Inc. | 199,499 | -233,494 | |
0.33231 % | Fred Alger Management, LLC | 193,502 | -76,503 | |
0.32493 % | Allspring Global Investments, LLC | 189,208 | -13,964 | |
0.31059 % | Eventide Asset Management, LLC | 180,857 | -394,581 | |
0.29464 % | Citadel Advisors LLC | 171,571 | 171,323 | |
0.29003 % | Rice Hall James & Associates, LLC | 168,883 | -904 | |
0.28336 % | Camber Capital Management LP | 165,000 | 165,000 | |
0.28125 % | Finepoint Capital LP | 163,772 | 0 | |
0.27671 % | Mellon Investments Corporation | 161,126 | -16,274 | |
0.26032 % | First Turn Management, LLC | 151,587 | 151,587 | |
0.24730 % | Adage Capital Management, L.P. | 144,000 | -382,371 | |
0.24159 % | BofA Global Research (US) | 140,677 | -94,453 | |
0.23835 % | Tekla Capital Management LLC_NLE | 138,791 | 15,000 | |
0.23835 % | abrdn Inc. | 138,791 | 138,791 | |
0.22699 % | Perceptive Advisors LLC | 132,176 | 132,176 | |
0.22627 % | Saturn V Capital Management LLC | 131,759 | 19,286 | |
0.21450 % | Schonfeld Strategic Advisors LLC | 124,901 | 86,001 | |
0.21204 % | Dafna Capital Management, LLC | 123,472 | -12,740 | |
0.19451 % | Thrivent Asset Management, LLC | 113,264 | -2,190 | |
0.19081 % | HSBC Global Asset Management (UK) Limited | 111,107 | 111,107 | |
0.17227 % | Principal Global Investors (Equity) | 100,313 | 15,598 | |
0.17096 % | Tri Locum Partners LP | 99,550 | 99,550 | |
0.17066 % | Candriam Luxembourg S.A. | 99,375 | 0 | |
0.17066 % | Candriam Belgium S.A. | 99,375 | -40,000 | |
0.14804 % | BNP Paribas Asset Management USA, Inc. | 86,202 | 41,334 | |
0.14025 % | Baillie Gifford & Co. | 81,670 | -4,651 | |
0.13945 % | Pictet Asset Management (Japan) Ltd. | 81,199 | 81,199 | |
0.12594 % | Voloridge Investment Management, LLC | 73,335 | 53,427 | |
0.12021 % | Tang Capital Management, LLC | 70,000 | 60,000 | |
0.11600 % | Ensign Peak Advisors, Inc. | 67,544 | 0 | |
0.11415 % | Morgan Stanley & Co. LLC | 66,470 | 44,517 | |
0.10701 % | Columbia Threadneedle Investments (US) | 62,310 | 1,734 | |
0.09461 % | Geode Capital Management, L.L.C. | 55,090 | 535 | |
0.09300 % | AEGON Investment Management B.V. | 54,156 | -2,390 | |
0.08879 % | Gray Foundation | 51,700 | 51,700 | |
0.07880 % | Adar1 Capital Management LLC | 45,884 | 45,884 | |
0.07758 % | JPMorgan Private Bank (United States) | 45,172 | -6,802 | |
0.07439 % | INVESCO Asset Management Limited | 43,320 | -2,486 | |
0.06546 % | Assenagon Asset Management S.A. | 38,120 | 2,800 | |
0.06251 % | Resolute Capital Asset Partners LLC | 36,400 | -1,100 | |
0.06144 % | Baillie Gifford Overseas Ltd. | 35,774 | 1,418 | |
0.05948 % | Matisse Capital | 34,635 | 8,380 | |
0.05877 % | Parametric Portfolio Associates LLC | 34,224 | 857 | |
0.05431 % | Newton Investment Management North America, LLC | 31,627 | -1,397 | |
0.05404 % | Jane Street Capital, L.L.C. | 31,468 | 6,751 | |
0.05367 % | State Street Global Advisors (US) | 31,252 | 525 | |
0.05313 % | BlackRock Advisors (UK) Limited | 30,939 | 1,697 | |
0.05225 % | Goldman Sachs Asset Management International | 30,423 | 0 | |
0.05152 % | Deka Vermögensmanagement GmbH | 30,000 | 0 | |
0.04840 % | BlackRock Asset Management Ireland Limited | 28,183 | 3,454 | |
0.04817 % | CAPTRUST Financial Advisors | 28,051 | 4,022 | |
0.04809 % | Jefferies LLC | 28,000 | 25,500 | |
0.04796 % | UBS Financial Services, Inc. | 27,927 | -15,304 | |
0.04649 % | Evoke Advisors | 27,069 | 27,069 | |
0.04293 % | Altium Capital Management LP | 25,000 | 25,000 | |
0.04207 % | Henry James International Management, Inc. | 24,495 | 0 | |
0.04139 % | Wellington Management Japan Pte Ltd | 24,099 | 3,863 | |
0.03913 % | Manulife Investment Management (North America) Limited | 22,788 | -2,785 | |
0.03845 % | Millennium Management LLC | 22,391 | -20,461 | |
0.03512 % | Morgan Stanley Smith Barney LLC | 20,450 | -180 | |
0.03435 % | Deka Investment GmbH | 20,000 | 4,940 | |
0.03435 % | Ghost Tree Capital, LLC | 20,000 | -65,000 | |