| 14,94778 % | BlackRock Institutional Trust Company, N.A. | 10.674.208 | -68.432 | |
| 14,74208 % | PRIMECAP Management Company | 10.527.322 | 766.310 | |
| 9,94785 % | The Vanguard Group, Inc. | 7.103.758 | -1.505.751 | |
| 8,60491 % | EcoR1 Capital, LLC | 6.144.767 | 0 | |
| 6,46876 % | BVF Partners L.P. | 4.619.341 | 1.879.200 | |
| 5,34604 % | State Street Investment Management (US) | 3.817.610 | 133.895 | |
| 5,11638 % | T. Rowe Price Associates, Inc. | 3.653.607 | -176.241 | |
| 3,43389 % | TCG Crossover Management, LLC | 2.452.138 | 0 | |
| 3,36491 % | RTW Investments L.P. | 2.402.883 | 0 | |
| 2,49345 % | Dimensional Fund Advisors, L.P. | 1.780.570 | 43.182 | |
| 2,38575 % | Geode Capital Management, L.L.C. | 1.703.664 | 29.316 | |
| 2,31857 % | Braidwell LP | 1.655.690 | 0 | |
| 1,75046 % | Logos Global Management LP | 1.250.000 | 1.250.000 | |
| 1,42717 % | Two Sigma Investments, LP | 1.019.143 | 315.712 | |
| 1,31493 % | BofA Global Research (US) | 938.993 | 456.302 | |
| 1,18092 % | Woodline Partners LP | 843.296 | 0 | |
| 1,14844 % | Nantahala Capital Management, LLC | 820.103 | 363.362 | |
| 1,08696 % | UBS Financial Services, Inc. | 776.196 | -165.646 | |
| 1,04756 % | Johnson & Johnson Innovation-JJDC, Inc. | 748.062 | 0 | |
| 0,93885 % | Baker Bros. Advisors LP | 670.431 | 0 | |
| 0,91633 % | Barclays Bank PLC | 654.353 | 478.251 | |
| 0,89894 % | Goldman Sachs & Company, Inc. | 641.930 | -45.039 | |
| 0,85038 % | Northern Trust Investments, Inc. | 607.258 | 334 | |
| 0,84312 % | BlackRock Financial Management, Inc. | 602.072 | 38.399 | |
| 0,84002 % | Morgan Stanley & Co. LLC | 599.859 | -38.042 | |
| 0,83887 % | Charles Schwab Investment Management, Inc. | 599.039 | -37.617 | |
| 0,78254 % | abrdn Inc. | 558.810 | 181.698 | |
| 0,76941 % | Deep Track Capital LP | 549.439 | 0 | |
| 0,73052 % | Jacobs Levy Equity Management, Inc. | 521.667 | -382.818 | |
| 0,68463 % | PanAgora Asset Management Inc. | 488.892 | 198.564 | |
| 0,67918 % | Hudson Bay Capital Management LP | 485.000 | 24.110 | |
| 0,58878 % | Parametric Portfolio Associates LLC | 420.449 | 206.056 | |
| 0,56340 % | Dahiyat (Bassil Ishmael) | 402.326 | 90.029 | |
| 0,53242 % | Erste Asset Management GmbH | 380.200 | 0 | |
| 0,50855 % | Squarepoint Capital LLP | 363.153 | 351.979 | |
| 0,49410 % | Principal Global Investors (Equity) | 352.839 | 4.113 | |
| 0,48583 % | Millennium Management LLC | 346.934 | 287.551 | |
| 0,46981 % | Cubist Systematic Strategies, LLC | 335.493 | 179.913 | |
| 0,44091 % | Columbia Threadneedle Investments (US) | 314.853 | 5.895 | |
| 0,41282 % | ExodusPoint Capital Management, LP | 294.798 | 128.109 | |
| 0,37868 % | Mellon Investments Corporation | 270.412 | 10.343 | |
| 0,37481 % | J.P. Morgan Securities LLC | 267.653 | 265.161 | |
| 0,36417 % | BlackRock Investment Management, LLC | 260.055 | 54.123 | |
| 0,34828 % | Walleye Capital LLC | 248.706 | 248.706 | |
| 0,33980 % | PSP Investments | 242.652 | 20.681 | |
| 0,30846 % | Citadel Advisors LLC | 220.268 | 161.784 | |
| 0,29823 % | Desjarlais (John R) | 212.963 | 20.154 | |
| 0,29130 % | BlackRock Advisors (UK) Limited | 208.016 | -1.564 | |
| 0,28007 % | Macquarie Investment Management | 200.000 | 0 | |
| 0,26755 % | BlackRock Asset Management Ireland Limited | 191.055 | -124.676 | |
| 0,25333 % | Legal & General Investment Management Ltd. | 180.905 | -2.722 | |
| 0,24703 % | Rhumbline Advisers Ltd. Partnership | 176.404 | 12.547 | |
| 0,24138 % | Invesco Capital Management LLC | 172.371 | -439.144 | |
| 0,24005 % | Trexquant Investment LP | 171.420 | 38.060 | |
| 0,23211 % | Rhenman & Partners Asset Management AB | 165.750 | -30.000 | |
| 0,21842 % | American Century Investment Management, Inc. | 155.973 | 16.731 | |
| 0,19605 % | DCF Advisers, LLC | 140.000 | -62.167 | |
| 0,18908 % | BNY Mellon Asset Management | 135.020 | 5.755 | |
| 0,18571 % | Nuveen LLC | 132.618 | -27.098 | |
| 0,18491 % | Algert Global LLC | 132.045 | 132.045 | |
| 0,18084 % | Kuch John J | 129.136 | 36.542 | |
| 0,18058 % | Verition Fund Management LLC | 128.949 | 100.917 | |
| 0,17781 % | Jump Financial, LLC | 126.972 | 76.499 | |
| 0,17725 % | UBS Asset Management (Switzerland) | 126.575 | 43.552 | |
| 0,17244 % | Y-Intercept (Hong Kong) Ltd | 123.138 | 27.393 | |
| 0,16964 % | Thrivent Asset Management, LLC | 121.137 | 930 | |
| 0,16660 % | BNP Paribas Securities Corp. North America | 118.970 | 81.640 | |
| 0,16146 % | Schweizerische Nationalbank | 115.300 | 0 | |
| 0,14925 % | T. Rowe Price International Ltd | 106.577 | 5.778 | |
| 0,14655 % | Manulife Investment Management (North America) Limited | 104.650 | 3.243 | |
| 0,14245 % | TD Asset Management Inc. | 101.722 | 0 | |
| 0,13984 % | Essex LLC | 99.861 | -6.100 | |
| 0,13889 % | Citi Investment Research (US) | 99.184 | -65.995 | |
| 0,13827 % | Los Angeles Capital Management LLC | 98.738 | 2.891 | |
| 0,13486 % | AQR Capital Management, LLC | 96.301 | 55.174 | |
| 0,13042 % | Susquehanna International Group, LLP | 93.130 | -6.448 | |
| 0,12969 % | Acadian Asset Management LLC | 92.614 | 92.614 | |
| 0,12777 % | Winton Capital Management Ltd. | 91.241 | 5.271 | |
| 0,12687 % | Rafferty Asset Management LLC | 90.599 | 3.858 | |
| 0,12673 % | SG Americas Securities, L.L.C. | 90.501 | 90.501 | |
| 0,12019 % | Adar1 Capital Management LLC | 85.826 | -312.326 | |
| 0,10427 % | Goldman Sachs Asset Management, L.P. | 74.462 | 34.697 | |
| 0,10095 % | AllianceBernstein L.P. | 72.090 | 0 | |
| 0,10081 % | PGIM Quantitative Solutions LLC | 71.990 | 3.715 | |
| 0,09895 % | Aperio Group, LLC | 70.660 | 21.280 | |
| 0,09805 % | Canada Life Asset Management Limited | 70.015 | 2.256 | |
| 0,09803 % | Birchview Capital, LP | 70.000 | 44.000 | |
| 0,09637 % | Fubon Asset Management Company Ltd. | 68.816 | 2.329 | |
| 0,09613 % | Polen Capital Management, LLC | 68.646 | -48.291 | |
| 0,09568 % | Fidelity Management & Research Company LLC | 68.327 | -8.325 | |
| 0,09541 % | Dimensional Fund Advisors, Ltd. | 68.134 | -21.513 | |
| 0,09182 % | State of Wisconsin Investment Board | 65.566 | 28.537 | |
| 0,08988 % | Susquehanna Fundamental Investments, LLC | 64.184 | -37.208 | |
| 0,08648 % | Numeric Investors LLC | 61.752 | 61.752 | |
| 0,08595 % | INTECH Investment Management LLC | 61.376 | -3.305 | |
| 0,08350 % | New York State Teachers' Retirement System | 59.626 | 200 | |
| 0,08319 % | UBS Fund Management (Switzerland) AG | 59.408 | -12.954 | |
| 0,07786 % | Renaissance Technologies LLC | 55.600 | -96.800 | |
| 0,07589 % | California State Teachers Retirement System | 54.193 | -4.937 | |
| 0,07571 % | Northern Trust Global Investments Limited | 54.061 | 138 | |