9,82072 % | RA Capital Management, LP | 12 452 574 | 1 067 000 | 2022. 12. 31. |
7,01191 % | Perceptive Advisors LLC | 8 891 027 | -1 356 046 | 2022. 12. 31. |
6,37161 % | Goldman Sachs & Company, Inc. | 8 079 140 | 882 090 | 2022. 12. 31. |
5,27497 % | Pictet Asset Management Ltd. | 6 688 609 | -1 674 685 | 2022. 12. 31. |
4,18265 % | Commodore Capital LP | 5 303 557 | 175 000 | 2022. 12. 31. |
3,89414 % | Power Corporation of Canada | 4 937 730 | 0 | 2022. 12. 31. |
3,71367 % | OrbiMed Advisors, LLC | 4 708 900 | 74 000 | 2022. 12. 31. |
3,62779 % | Avidity Partners Management LP | 4 599 998 | 253 298 | 2022. 12. 31. |
3,60004 % | Rocabe Investments, Inc. | 4 564 810 | 0 | 2022. 03. 23. |
3,28751 % | Citadel Advisors LLC | 4 168 529 | 221 755 | 2022. 12. 31. |
3,24332 % | Braidwell LP | 4 112 494 | 4 112 494 | 2022. 12. 31. |
2,91800 % | Invus Public Equities Advisors, LLC | 3 700 000 | -2 300 000 | 2022. 12. 31. |
2,82415 % | Deerfield Management Company, L.P. | 3 581 000 | 500 000 | 2022. 12. 31. |
2,52368 % | Boxer Capital, L.L.C. | 3 200 000 | 0 | 2022. 12. 31. |
2,39531 % | Polar Capital LLP | 3 037 225 | -500 000 | 2022. 12. 31. |
1,85881 % | First Light Asset Management, LLC | 2 356 950 | -24 907 | 2022. 12. 31. |
1,48092 % | Fidelity Management & Research Company LLC | 1 877 796 | -848 668 | 2022. 12. 31. |
1,36364 % | Franklin Advisers, Inc. | 1 729 081 | -1092 | 2022. 12. 31. |
1,34652 % | SilverArc Capital Management, LLC | 1 707 370 | 51 595 | 2022. 12. 31. |
1,33919 % | Novo Holdings A/S | 1 698 084 | 1 698 084 | 2022. 12. 31. |
1,24777 % | Marshall Wace LLP | 1 582 165 | -76 817 | 2022. 12. 31. |
1,22396 % | Laurion Capital Management LP | 1 551 966 | -46 679 | 2022. 12. 31. |
1,07624 % | Balyasny Asset Management LP | 1 364 662 | -26 537 | 2022. 12. 31. |
1,04745 % | Millennium Management LLC | 1 328 161 | 296 392 | 2022. 12. 31. |
1,01007 % | Asymmetry Capital Management, L.P | 1 280 757 | 208 059 | 2021. 12. 31. |
0,97752 % | Lord, Abbett & Co. LLC | 1 239 489 | -22 623 | 2022. 12. 31. |
0,89275 % | Altium Capital Management LP | 1 132 000 | 0 | 2022. 12. 31. |
0,87264 % | Connor, Clark & Lunn Investment Management Ltd. | 1 106 500 | 400 | 2022. 12. 31. |
0,86270 % | Lynx1 Capital Advisors LLC | 1 093 900 | -1 288 227 | 2022. 12. 31. |
0,84163 % | National Bank of Canada | 1 067 180 | 1 045 639 | 2022. 12. 31. |
0,80218 % | Vivo Capital, LLC | 1 017 152 | 0 | 2022. 12. 31. |
0,79169 % | Janus Henderson Investors | 1 003 861 | 221 938 | 2022. 12. 31. |
0,69822 % | Ikarian Capital LLC | 885 334 | 35 200 | 2022. 12. 31. |
0,68034 % | BlackRock Institutional Trust Company, N.A. | 862 664 | 67 469 | 2022. 12. 31. |
0,60337 % | Bellini (Roberto) | 765 061 | 135 000 | 2022. 11. 25. |
0,55755 % | Medical Strategy GmbH | 706 970 | 0 | 2022. 09. 30. |
0,55120 % | Berger (Franklin Milan) | 698 918 | 0 | 2022. 03. 23. |
0,52763 % | Sectoral Asset Management Inc. | 669 029 | 54 600 | 2022. 12. 31. |
0,51833 % | FMRC Family Trust | 657 239 | 0 | 2022. 03. 23. |
0,51349 % | Nomura Asset Management Co., Ltd. | 651 097 | 651 097 | 2022. 11. 30. |
0,49882 % | Acuta Capital Partners, LLC | 632 500 | -806 000 | 2022. 12. 31. |
0,45243 % | Affinity Asset Advisors LLC | 573 678 | 100 081 | 2022. 12. 31. |
0,39628 % | ExodusPoint Capital Management, LP | 502 484 | 297 614 | 2022. 12. 31. |
0,38633 % | Sphera Funds Management Ltd. | 489 860 | 25 000 | 2022. 12. 31. |
0,35988 % | Assenagon Asset Management S.A. | 456 321 | -351 676 | 2022. 12. 31. |
0,34331 % | D. E. Shaw & Co., L.P. | 435 313 | -133 708 | 2022. 12. 31. |
0,34030 % | Tenax Capital Ltd. | 431 497 | 68 120 | 2022. 12. 31. |
0,32249 % | Ensign Peak Advisors, Inc. | 408 916 | 0 | 2022. 12. 31. |
0,29969 % | AWM Investment Company, Inc. | 380 000 | 0 | 2022. 12. 31. |
0,28882 % | Driehaus Capital Management, LLC | 366 226 | -4874 | 2022. 12. 31. |
0,27968 % | J.P. Morgan Securities LLC | 354 633 | -168 022 | 2022. 12. 31. |
0,22915 % | Walleye Capital LLC | 290 565 | 107 638 | 2022. 12. 31. |
0,22882 % | Industrial Alliance Investment Management Inc. | 290 140 | 19 670 | 2022. 12. 31. |
0,22153 % | Bellini (Francesco) | 280 894 | 0 | 2022. 11. 25. |
0,21082 % | BMO Asset Management Inc. | 267 317 | -11 114 | 2022. 12. 31. |
0,20840 % | UBS O'Connor LLC | 264 249 | 24 881 | 2022. 12. 31. |
0,20602 % | TD Asset Management Inc. | 261 237 | -6820 | 2022. 12. 31. |
0,19696 % | Qube Research & Technologies Ltd | 249 746 | 74 625 | 2022. 12. 31. |
0,19322 % | Monashee Investment Management, LLC | 245 000 | 215 000 | 2022. 12. 31. |
0,17185 % | Barclays Capital Inc. | 217 902 | -12 099 | 2022. 12. 31. |
0,17125 % | Moore Capital Management, LP | 217 138 | -202 764 | 2022. 12. 31. |
0,17033 % | State Street Global Advisors (US) | 215 982 | 693 | 2023. 02. 28. |
0,16650 % | PSP Investments | 211 120 | -60 320 | 2022. 12. 31. |
0,15831 % | Renaissance Technologies LLC | 200 738 | 200 738 | 2022. 12. 31. |
0,15331 % | Schweizerische Nationalbank | 194 400 | 2700 | 2022. 12. 31. |
0,14635 % | J. Goldman & Co., L.P. | 185 575 | 106 717 | 2022. 12. 31. |
0,11830 % | Lion Point Capital, L.P. | 150 000 | 0 | 2022. 12. 31. |
0,11372 % | Two Sigma Investments, LP | 144 194 | 11 594 | 2022. 12. 31. |
0,11049 % | Morgan Stanley & Co. LLC | 140 099 | -110 701 | 2022. 12. 31. |
0,10376 % | Larochelle (Pierre) | 131 570 | 0 | 2022. 11. 30. |
0,10319 % | British Columbia Investment Management Corp. | 130 844 | 57 044 | 2022. 12. 31. |
0,10061 % | J O Hambro Capital Management Limited | 127 569 | 99 241 | 2022. 12. 31. |
0,09916 % | TLS Advisors LLC | 125 731 | 125 731 | 2022. 12. 31. |
0,09402 % | Boothbay Fund Management, LLC | 119 215 | 4876 | 2022. 12. 31. |
0,08932 % | Geode Capital Management, L.L.C. | 113 260 | 0 | 2022. 12. 31. |
0,08647 % | Bennani (Youssef Laafiret) | 109 649 | 0 | 2022. 03. 23. |
0,08480 % | BlackRock Advisors (UK) Limited | 107 521 | 4433 | 2023. 02. 28. |
0,07912 % | CIBC Asset Management Inc. | 100 329 | 6344 | 2022. 12. 31. |
0,07886 % | Velan Capital Investment Management LP | 100 000 | 0 | 2022. 12. 31. |
0,07438 % | RBC Capital Markets Wealth Management | 94 308 | 91 158 | 2022. 12. 31. |
0,07325 % | EAM Global Investors LLC | 92 884 | -490 709 | 2022. 12. 31. |
0,07216 % | HighVista Strategies LLC | 91 493 | 14 649 | 2022. 12. 31. |
0,07097 % | BofA Global Research (US) | 89 992 | 23 055 | 2022. 12. 31. |
0,06996 % | California State Teachers Retirement System | 88 708 | 88 708 | 2022. 06. 30. |
0,06827 % | Morgan Stanley Canada Limited | 86 560 | -42 481 | 2022. 12. 31. |
0,06793 % | Nuveen LLC | 86 129 | -34 191 | 2023. 01. 31. |
0,06750 % | RBC Global Asset Management Inc. | 85 594 | 14 100 | 2022. 12. 31. |
0,06700 % | Alps Advisors, Inc. | 84 953 | 16 578 | 2022. 12. 31. |
0,06467 % | First Wilshire Securities Management, Inc. | 82 000 | 0 | 2022. 12. 31. |
0,06290 % | Manulife Investment Management (North America) Limited | 79 757 | -2957 | 2022. 12. 31. |
0,06240 % | Credit Suisse Asset Management | 79 125 | 20 329 | 2022. 12. 31. |
0,05939 % | Sun Life Global Investments (Canada) Inc. | 75 311 | 75 311 | 2022. 09. 30. |
0,05938 % | Mackenzie Financial Corporation | 75 289 | 1759 | 2022. 12. 31. |
0,05901 % | Cubist Systematic Strategies, LLC | 74 819 | -120 044 | 2022. 12. 31. |
0,05256 % | Vestcor Inc | 66 648 | -107 074 | 2021. 12. 31. |
0,05237 % | Jump Financial, LLC | 66 400 | -30 900 | 2022. 12. 31. |
0,05037 % | PFM Health Sciences, LP | 63 864 | 63 864 | 2022. 12. 31. |
0,04602 % | BlackRock Asset Management Ireland Limited | 58 355 | 2470 | 2022. 12. 31. |
0,04516 % | Jane Street Capital, L.L.C. | 57 263 | 26 118 | 2022. 12. 31. |
0,04465 % | Addenda Capital, Inc. | 56 617 | 56 617 | 2022. 12. 31. |