8.43569 % | The Vanguard Group, Inc. | 3,218,215 | 21,201 | 31.12.2023 |
7.51056 % | Fidelity Management & Research Company LLC | 2,865,278 | -2,691,695 | 31.12.2023 |
7.10257 % | T. Rowe Price Investment Management, Inc. | 2,709,629 | -32,828 | 31.12.2023 |
5.03766 % | T. Rowe Price Associates, Inc. | 1,921,869 | -777,197 | 31.12.2023 |
4.44435 % | BlackRock Institutional Trust Company, N.A. | 1,695,518 | 50,701 | 31.12.2023 |
4.01458 % | PureTech Health, L.L.C. | 1,531,564 | -125,000 | 12.8.2022 |
3.62031 % | Sofinnova Investments, Inc | 1,381,149 | 0 | 17.1.2024 |
2.97260 % | Wellington Management Company, LLP | 1,134,046 | -151,462 | 31.12.2023 |
2.79476 % | Pentwater Capital Management LP | 1,066,200 | 1,037,700 | 31.12.2023 |
2.58640 % | General Atlantic LLC | 986,710 | 0 | 31.12.2023 |
2.55477 % | State Street Global Advisors (US) | 974,643 | 45,673 | 31.12.2023 |
2.08914 % | Pivotal Bioventure Partners Investment Advisor LLC | 797,008 | 0 | 31.12.2023 |
1.49337 % | Geode Capital Management, L.L.C. | 569,722 | 24,649 | 31.12.2023 |
1.35000 % | Rock Springs Capital Management LP | 515,024 | 9,591 | 31.12.2023 |
1.17658 % | Capital International Investors | 448,866 | -3,778,236 | 31.1.2024 |
1.10663 % | UBS Financial Services, Inc. | 422,178 | 419,217 | 31.12.2023 |
0.98861 % | AllianceBernstein L.P. | 377,155 | 13,787 | 31.12.2023 |
0.93702 % | Woodline Partners LP | 357,473 | 334,751 | 31.12.2023 |
0.87325 % | Brown Advisory | 333,144 | 11,059 | 31.12.2023 |
0.85994 % | Norges Bank Investment Management (NBIM) | 328,067 | 16,582 | 31.12.2023 |
0.82803 % | Balyasny Asset Management LP | 315,892 | 208,093 | 31.12.2023 |
0.77939 % | Invesco Advisers, Inc. | 297,336 | -15,709 | 31.12.2023 |
0.75239 % | First Light Asset Management, LLC | 287,037 | -16,100 | 31.12.2023 |
0.65531 % | Boxer Capital, L.L.C. | 250,000 | 0 | 31.12.2023 |
0.62295 % | Fiera Capital Corporation | 237,656 | 199 | 31.12.2023 |
0.59158 % | Nan Fung Life Sciences | 225,688 | 0 | 31.12.2023 |
0.58993 % | Charles Schwab Investment Management, Inc. | 225,060 | 6,721 | 31.12.2023 |
0.58453 % | Alpine Associates Management Inc. | 223,000 | 223,000 | 31.12.2023 |
0.53997 % | Avidity Partners Management LP | 206,000 | -80,700 | 31.12.2023 |
0.52992 % | Magnetar Capital Partners LP | 202,165 | 198,264 | 31.12.2023 |
0.52701 % | Kryger Capital Limited | 201,053 | 201,053 | 31.12.2023 |
0.49901 % | Goldman Sachs Asset Management, L.P. | 190,371 | 169,488 | 31.12.2023 |
0.49803 % | Eventide Asset Management, LLC | 190,000 | -149,840 | 31.12.2023 |
0.49630 % | TD Asset Management Inc. | 189,340 | -38,378 | 31.12.2023 |
0.46880 % | Eagle Asset Management, Inc. | 178,849 | -26,930 | 31.12.2023 |
0.45660 % | SG Americas Securities, L.L.C. | 174,193 | 167,448 | 31.12.2023 |
0.42724 % | Millennium Management LLC | 162,991 | 64,988 | 31.12.2023 |
0.41419 % | Citadel Advisors LLC | 158,012 | -31,585 | 31.12.2023 |
0.38599 % | AQR Capital Management, LLC | 147,256 | 143,172 | 31.12.2023 |
0.38392 % | Ensign Peak Advisors, Inc. | 146,467 | 5,129 | 31.12.2023 |
0.37153 % | Citi Investment Research (US) | 141,738 | 104,913 | 31.12.2023 |
0.35946 % | Northern Trust Investments, Inc. | 137,134 | 6,670 | 31.12.2023 |
0.34153 % | PFM Health Sciences, LP | 130,293 | -7,916 | 31.12.2023 |
0.33451 % | Nuveen LLC | 127,614 | -22,405 | 31.12.2023 |
0.33082 % | Twin Capital Management, LLC | 126,206 | 126,206 | 31.12.2023 |
0.33029 % | BlackRock Financial Management, Inc. | 126,004 | -168 | 31.12.2023 |
0.32765 % | Avoro Capital Advisors LLC | 125,000 | 125,000 | 31.12.2023 |
0.32146 % | Franklin Advisers, Inc. | 122,636 | -77,897 | 31.12.2023 |
0.31679 % | BlackRock Asset Management Ireland Limited | 120,857 | -2,911 | 31.12.2023 |
0.31405 % | Bank of Nova Scotia | 119,810 | 119,810 | 31.12.2023 |
0.31164 % | Morgan Stanley & Co. LLC | 118,890 | 93,499 | 31.12.2023 |
0.29106 % | Mellon Investments Corporation | 111,039 | -8,865 | 31.12.2023 |
0.29068 % | Paul (Steven M) | 110,895 | -804 | 9.2.2024 |
0.27727 % | ClearBridge Investments, LLC | 105,780 | 11,390 | 31.12.2023 |
0.27374 % | UBS Asset Management (Switzerland) | 104,432 | -18,731 | 31.12.2023 |
0.26759 % | Allspring Global Investments, LLC | 102,086 | 1,057 | 31.12.2023 |
0.26518 % | Westchester Capital Management, LLC | 101,166 | 101,166 | 31.12.2023 |
0.25275 % | Driehaus Capital Management, LLC | 96,424 | 5,745 | 31.12.2023 |
0.24401 % | New York State Common Retirement Fund | 93,089 | -4,694 | 31.12.2023 |
0.23591 % | Logos Global Management LLC | 90,000 | -25,000 | 31.12.2023 |
0.23591 % | Carlson Capital, L.P. | 90,000 | 90,000 | 31.12.2023 |
0.22901 % | First Turn Management, LLC | 87,369 | 87,369 | 31.12.2023 |
0.22890 % | Water Island Capital, LLC | 87,325 | 87,325 | 31.12.2023 |
0.22068 % | Gabelli Funds, LLC | 84,190 | 84,190 | 31.12.2023 |
0.20408 % | Ignelzi (Troy A) | 77,855 | 56,018 | 17.1.2024 |
0.20408 % | Catalyst Private Wealth, L.L.C. | 77,855 | 56,018 | 31.12.2023 |
0.19558 % | Segantii Capital Management Limited | 74,613 | 74,613 | 31.12.2023 |
0.18194 % | Glazer Capital, LLC | 69,410 | 69,410 | 31.12.2023 |
0.18181 % | BNY Mellon Asset Management | 69,359 | -161 | 31.12.2023 |
0.18152 % | The Clarius Group, LLC | 69,248 | -29,973 | 31.12.2023 |
0.17956 % | Corient Private Wealth LLC | 68,504 | 19,912 | 31.12.2023 |
0.16941 % | Point72 Asset Management, L.P. | 64,630 | -283,170 | 31.12.2023 |
0.16847 % | SEB Investment Management AB | 64,273 | 55,374 | 31.12.2023 |
0.16540 % | Schweizerische Nationalbank | 63,100 | -6,900 | 31.12.2023 |
0.16514 % | P. Schoenfeld Asset Management LP | 63,000 | 63,000 | 31.12.2023 |
0.16182 % | Barclays Bank PLC | 61,734 | 33,152 | 31.12.2023 |
0.15697 % | Fidelity International | 59,885 | 0 | 31.12.2023 |
0.15625 % | AQR Arbitrage, LLC | 59,608 | 59,608 | 31.12.2023 |
0.15354 % | Tekla Capital Management LLC | 58,577 | 5,125 | 30.6.2023 |
0.15335 % | Neuberger Berman, LLC | 58,503 | 57,215 | 31.12.2023 |
0.14994 % | Candriam Belgium S.A. | 57,201 | -4,000 | 31.12.2023 |
0.14994 % | Candriam Luxembourg S.A. | 57,201 | 0 | 31.12.2023 |
0.14417 % | Picton Mahoney Asset Management | 55,000 | 55,000 | 31.12.2023 |
0.13966 % | BioImpact Capital LLC | 53,279 | 69 | 31.12.2023 |
0.13602 % | Dimensional Fund Advisors, L.P. | 51,891 | 10,334 | 31.12.2023 |
0.13289 % | California Public Employees' Retirement System | 50,696 | 0 | 31.12.2023 |
0.13179 % | HSBC Global Asset Management (UK) Limited | 50,277 | 50,277 | 31.12.2023 |
0.13157 % | Melqart Asset Management (UK) Limited | 50,194 | 50,194 | 31.12.2023 |
0.13151 % | Rice Hall James & Associates, LLC | 50,171 | 10,790 | 31.12.2023 |
0.13028 % | DWS Investment GmbH | 49,700 | 0 | 31.12.2023 |
0.12620 % | Dafna Capital Management, LLC | 48,145 | -4,728 | 31.12.2023 |
0.12558 % | Summit Partners Public Asset Management, LLC | 47,910 | -49,467 | 31.12.2023 |
0.12366 % | Rhumbline Advisers Ltd. Partnership | 47,175 | -312 | 31.12.2023 |
0.12320 % | Decheng Capital LLC | 47,000 | 47,000 | 31.12.2023 |
0.11812 % | American Century Investment Management, Inc. | 45,064 | 823 | 31.12.2023 |
0.11453 % | Rafferty Asset Management LLC | 43,693 | -4,667 | 31.12.2023 |
0.11194 % | BofA Global Research (US) | 42,705 | 22 | 31.12.2023 |
0.11153 % | Florida State Board of Administration | 42,548 | 1,485 | 31.12.2023 |
0.11085 % | Connor, Clark & Lunn Investment Management Ltd. | 42,289 | -10,401 | 31.12.2023 |
0.10940 % | Ostrum Asset Management | 41,737 | 41,737 | 31.12.2023 |