8.71460 % | Tang Capital Management, LLC | 4,800,000 | 297,143 | |
7.53736 % | Sofinnova Investments, Inc | 4,151,576 | 2,750,523 | |
7.22514 % | Woodline Partners LP | 3,979,605 | 2,792,824 | |
6.93539 % | Suvretta Capital Management, LLC | 3,820,012 | -1,288,508 | |
6.34194 % | Franklin Advisers, Inc. | 3,493,143 | 0 | |
5.08890 % | The Vanguard Group, Inc. | 2,802,965 | -2,955 | |
4.82666 % | abrdn Inc. | 2,658,527 | 1,578,329 | |
4.11707 % | Bain Capital Life Sciences Investors, LLC | 2,267,680 | 874,300 | |
3.83956 % | Lion Point Capital, L.P. | 2,114,827 | -4,309 | |
3.39953 % | Bleichroeder LP | 1,872,463 | 0 | |
2.66755 % | Jennison Associates LLC | 1,469,285 | -1,496,598 | |
2.47077 % | BlackRock Institutional Trust Company, N.A. | 1,360,898 | -2,523,903 | |
1.30461 % | Millennium Management LLC | 718,580 | 718,580 | |
1.28205 % | Ikarian Capital LLC | 706,154 | 168,229 | |
1.26357 % | Acadian Asset Management LLC | 695,972 | 695,972 | |
1.12859 % | Renaissance Technologies LLC | 621,625 | 621,625 | |
1.12091 % | Geode Capital Management, L.L.C. | 617,395 | -597,371 | |
0.93006 % | Goldman Sachs & Company, Inc. | 512,278 | 410,559 | |
0.91103 % | Susquehanna International Group, LLP | 501,797 | 397,907 | |
0.82613 % | BlackRock Financial Management, Inc. | 455,032 | -191,292 | |
0.80644 % | Assenagon Asset Management S.A. | 444,185 | 183,396 | |
0.69898 % | PGIM Securities Investment Trust Enterprise | 385,000 | 0 | |
0.67301 % | Northern Trust Investments, Inc. | 370,693 | -64,800 | |
0.53924 % | Jacobs Levy Equity Management, Inc. | 297,014 | 254,565 | |
0.52651 % | International Biotechnology Trust PLC | 290,000 | 200,000 | |
0.52651 % | Schroder Investment Management Ltd. (SIM) | 290,000 | 0 | |
0.47542 % | Superstring Capital Management LP | 261,861 | -303,689 | |
0.43706 % | Qube Research & Technologies Ltd | 240,734 | 169,962 | |
0.37487 % | State Street Global Advisors (US) | 206,476 | -975,268 | |
0.37071 % | Jane Street Capital, L.L.C. | 204,185 | 36,251 | |
0.36235 % | GSA Capital Partners LLP | 199,584 | 199,584 | |
0.35937 % | XTX Markets LLC | 197,940 | 197,940 | |
0.33768 % | Boothbay Fund Management, LLC | 185,996 | 44,783 | |
0.31905 % | Squarepoint Capital LLP | 175,735 | 175,735 | |
0.31166 % | Morgan Stanley & Co. LLC | 171,662 | -225,063 | |
0.26546 % | Graham Capital Management, L.P. | 146,215 | 125,651 | |
0.24446 % | Alpine Global Management, LLC | 134,646 | 134,646 | |
0.24052 % | Braunstein (Scott N.) | 132,479 | -12,145 | |
0.19416 % | Y-Intercept (Hong Kong) Ltd | 106,942 | 81,182 | |
0.16872 % | Centiva Capital, LP | 92,933 | 92,933 | |
0.15251 % | Hussman Strategic Advisors, Inc. | 84,000 | 10,500 | |
0.13680 % | BofA Global Research (US) | 75,350 | -15,324 | |
0.12676 % | Goldman Sachs Asset Management, L.P. | 69,819 | 35,221 | |
0.12238 % | Shafer (Christina) | 67,406 | -3,820 | |
0.12165 % | Values First Advisors, Inc. | 67,004 | 4,333 | |
0.11808 % | Simplex Trading, LLC | 65,041 | -27,230 | |
0.11329 % | Paloma Partners Management Company | 62,400 | 62,400 | |
0.10941 % | Manning (Martha E) | 60,263 | -3,621 | |
0.10270 % | Citi Investment Research (US) | 56,568 | 42,856 | |
0.09963 % | Point72 Asia (Singapore) Pte. Ltd. | 54,878 | 54,878 | |
0.08170 % | Abaris Investment Management AG | 45,000 | 4,000 | |
0.08025 % | T. Rowe Price International Ltd | 44,200 | 13,271 | |
0.07739 % | Two Sigma Investments, LP | 42,625 | -42,934 | |
0.07568 % | Jefferies LLC | 41,686 | -11,500 | |
0.07470 % | Prospera Financial Services, Inc. | 41,144 | 41,144 | |
0.06666 % | HRT Financial LP | 36,716 | 36,716 | |
0.06608 % | Barclays Bank PLC | 36,399 | -14,169 | |
0.06102 % | Grimes & Company, Inc. | 33,609 | 0 | |
0.05689 % | AQR Capital Management, LLC | 31,333 | 12,934 | |
0.05465 % | Schonfeld Strategic Advisors LLC | 30,100 | 30,100 | |
0.05356 % | BlackRock Advisors (UK) Limited | 29,502 | 651 | |
0.05356 % | BlackRock Asset Management Ireland Limited | 29,502 | 558 | |
0.05319 % | Mirae Asset Global Investments (USA) LLC | 29,299 | 29,299 | |
0.05212 % | Rhumbline Advisers Ltd. Partnership | 28,709 | -48,389 | |
0.04979 % | Northern Trust Global Investments | 27,424 | -976 | |
0.04899 % | SunAmerica Asset Management, LLC | 26,982 | 1,776 | |
0.04302 % | Point72 (DIFC) Ltd | 23,698 | 23,698 | |
0.03818 % | Engineers Gate Manager, L.P. | 21,028 | 21,028 | |
0.03776 % | Pfanstiel (Steven) | 20,796 | -4,657 | |
0.03726 % | Verition Fund Management LLC | 20,522 | 20,522 | |
0.03590 % | Mayleben (Timothy M) | 19,775 | 2,300 | |
0.03543 % | Tower Research Capital LLC | 19,517 | 19,159 | |
0.03458 % | UBS Financial Services, Inc. | 19,045 | -104,807 | |
0.03358 % | Hulihan (Joseph M.D.) | 18,498 | -4,828 | |
0.02869 % | Osaic Holdings, Inc. | 15,801 | 9,750 | |
0.02479 % | Aperio Group, LLC | 13,653 | -11,144 | |
0.02421 % | Jump Financial, LLC | 13,334 | 13,334 | |
0.02291 % | Commonwealth Financial Network | 12,618 | 985 | |
0.01997 % | Performance Wealth Partners LLC | 11,000 | 11,000 | |
0.01972 % | BlackRock Investment Management, LLC | 10,864 | -123,877 | |
0.01947 % | ProShare Advisors LLC | 10,724 | -2,938 | |
0.01943 % | Fidelity Management & Research Company LLC | 10,704 | 7,781 | |
0.01923 % | China Universal Asset Management Co., Ltd. | 10,594 | 4,139 | |
0.01570 % | Nochur (Saraswathy V) | 8,650 | 2,300 | |
0.01552 % | UBS Asset Management (Americas), Inc. | 8,550 | 0 | |
0.01512 % | Fischer (Seth H Z) | 8,326 | 2,300 | |
0.01434 % | Ezickson (Elan Z) | 7,900 | 2,300 | |
0.01380 % | Group One Trading, L.P. | 7,603 | 4,838 | |
0.01376 % | Austin (Charles) | 7,577 | 2,300 | |
0.01169 % | J.P. Morgan Securities plc | 6,439 | -5,894 | |
0.01058 % | Federated MDTA LLC | 5,826 | 5,826 | |
0.01016 % | Northern Trust Global Investments Limited | 5,594 | -111 | |
0.00972 % | Mackenzie Investments | 5,352 | -6 | |
0.00853 % | Silverstein (Christine Berni) | 4,699 | 2,300 | |
0.00853 % | Johnson (Marvin H.) | 4,699 | 2,300 | |
0.00853 % | Noonberg (Sarah B) | 4,699 | 2,300 | |
0.00815 % | Russell Investments Trust Company | 4,487 | 4,487 | |
0.00766 % | Parametric Portfolio Associates LLC | 4,221 | -6,695 | |
0.00647 % | Citadel Advisors LLC | 3,565 | -218,770 | |
0.00634 % | T. Rowe Price Associates, Inc. | 3,491 | 0 | |