10.61293 % | Takeda Pharmaceutical Co Ltd | 7,531,996 | 0 | |
7.49045 % | Rubric Capital Management LP | 5,315,969 | 0 | |
5.75187 % | Madison Avenue Partners LP | 4,082,100 | 433,591 | |
5.43021 % | BVF Partners L.P. | 3,853,818 | 0 | |
5.17311 % | BlackRock Institutional Trust Company, N.A. | 3,671,358 | -142,139 | |
5.14611 % | Levin (Jeremy M) | 3,652,196 | 20 | |
4.35310 % | The Vanguard Group, Inc. | 3,089,393 | 113,085 | |
3.52262 % | Invus Public Equities Advisors, LLC | 2,500,000 | 0 | |
2.34543 % | Acadian Asset Management LLC | 1,664,552 | 8,681 | |
2.09747 % | Kennedy Capital Management LLC | 1,488,571 | 1,451,189 | |
1.97293 % | Driehaus Capital Management, LLC | 1,400,191 | 1,400,191 | |
1.90837 % | State Street Global Advisors (US) | 1,354,371 | 198,724 | |
1.87236 % | JP Morgan Asset Management | 1,328,813 | -69,742 | |
1.83530 % | Geode Capital Management, L.L.C. | 1,302,514 | 42,435 | |
1.58559 % | TLS Advisors LLC | 1,125,296 | -194,383 | |
1.51472 % | Prosight Capital | 1,075,000 | 91,800 | |
1.21857 % | Cowen Investment Management LLC | 864,822 | 0 | |
1.01844 % | Wells Fargo Advisors | 722,785 | 309,960 | |
0.70994 % | Medical Strategy GmbH | 503,846 | -99,418 | |
0.68980 % | FFT Wealth Management LLC | 489,552 | 75,530 | |
0.59397 % | Northern Trust Investments, Inc. | 421,538 | -15,335 | |
0.49622 % | Bridgeway Capital Management, LLC | 352,170 | -5,700 | |
0.40621 % | UBS O'Connor LLC | 288,290 | 28,790 | |
0.38746 % | Dimensional Fund Advisors, L.P. | 274,982 | -67,187 | |
0.35226 % | ARIAD Asset Management GmbH | 250,000 | 0 | |
0.22799 % | Charles Schwab Investment Management, Inc. | 161,808 | 0 | |
0.20980 % | BlackRock Investment Management, LLC | 148,896 | -20,676 | |
0.19896 % | Renaissance Technologies LLC | 141,200 | -15,600 | |
0.19475 % | BNY Mellon Asset Management | 138,215 | 1,267 | |
0.19441 % | ETF Architect | 137,970 | 9,900 | |
0.18865 % | BlackRock Financial Management, Inc. | 133,882 | -40,848 | |
0.18263 % | JPMorgan Private Bank (United States) | 129,609 | -5,068 | |
0.16839 % | GSA Capital Partners LLP | 119,507 | 119,507 | |
0.16784 % | Nuveen LLC | 119,113 | 0 | |
0.16321 % | Wellington Management Company, LLP | 115,832 | -107,061 | |
0.15943 % | Goldman Sachs & Company, Inc. | 113,146 | 76,979 | |
0.14820 % | DWS Investments UK Limited | 105,177 | 81,196 | |
0.13892 % | Jane Street Capital, L.L.C. | 98,590 | 45,010 | |
0.12159 % | Assenagon Asset Management S.A. | 86,289 | 86,289 | |
0.10994 % | Millennium Management LLC | 78,024 | -67,941 | |
0.09826 % | Rhumbline Advisers Ltd. Partnership | 69,733 | -12,851 | |
0.09654 % | Tejara Capital Ltd. | 68,517 | -4,636 | |
0.09198 % | Morgan Stanley & Co. LLC | 65,278 | -28,374 | |
0.07366 % | Newton Investment Management North America, LLC | 52,280 | 0 | |
0.07086 % | Dimensional Fund Advisors, Ltd. | 50,288 | 0 | |
0.06747 % | AllianceBernstein L.P. | 47,880 | 42,020 | |
0.06199 % | Northern Trust Global Investments | 43,994 | 0 | |
0.06182 % | Signal Iduna Asset Management GmbH | 43,874 | 114 | |
0.05883 % | DCF Advisers, LLC | 41,750 | 22,020 | |
0.05384 % | BlackRock Asset Management Ireland Limited | 38,210 | 720 | |
0.05384 % | BlackRock Advisors (UK) Limited | 38,210 | 840 | |
0.04654 % | Mirae Asset Global Investments (USA) LLC | 33,031 | 33,031 | |
0.04464 % | Corebridge Financial Inc | 31,683 | 31,683 | |
0.04374 % | William Blair & Company, L.L.C. (Research) | 31,039 | 7,100 | |
0.04352 % | Tardio (Jason) | 30,886 | 28,125 | |
0.04161 % | BofA Global Research (US) | 29,534 | 10,946 | |
0.04141 % | SunAmerica Asset Management, LLC | 29,386 | -253 | |
0.03963 % | Alexander (Margaret A.) | 28,125 | 28,125 | |
0.03899 % | Mellon Investments Corporation | 27,668 | -12,657 | |
0.03685 % | XTX Markets LLC | 26,154 | 26,154 | |
0.03664 % | First Manhattan Co. LLC | 26,000 | 0 | |
0.03626 % | Vaughan Nelson Investment Management, L.P. | 25,732 | 0 | |
0.03571 % | Invesco Advisers, Inc. | 25,343 | -1,054 | |
0.02986 % | UBS Financial Services, Inc. | 21,192 | -52,230 | |
0.02885 % | Barclays Bank PLC | 20,473 | -21,663 | |
0.02883 % | SG Americas Securities, L.L.C. | 20,464 | 20,464 | |
0.02818 % | Bernstein (Karen) | 20,000 | 0 | |
0.02818 % | Knott Partners Management, LLC | 20,000 | 20,000 | |
0.02704 % | Adar1 Capital Management LLC | 19,190 | 2,744 | |
0.02675 % | New York State Common Retirement Fund | 18,986 | 0 | |
0.02657 % | Wells Fargo Bank, N.A. | 18,855 | -2,192 | |
0.02451 % | T. Rowe Price International Ltd | 17,396 | 0 | |
0.02017 % | Citi Investment Research (US) | 14,316 | 2,864 | |
0.01998 % | Tower Research Capital LLC | 14,177 | -9,958 | |
0.01938 % | Rona (Jeffrey A) | 13,756 | -16,910 | |
0.01928 % | Goldman Sachs Asset Management, L.P. | 13,680 | -9,137 | |
0.01923 % | China Universal Asset Management Co., Ltd. | 13,650 | 5,315 | |
0.01824 % | Perone (Thomas Michael) | 12,942 | -28,125 | |
0.01779 % | Two Sigma Investments, LP | 12,628 | -28,041 | |
0.01761 % | BBR Partners LLC | 12,495 | 12,495 | |
0.01742 % | ProShare Advisors LLC | 12,365 | -3,301 | |
0.01129 % | J.P. Morgan Securities plc | 8,011 | -8,691 | |
0.00927 % | Legal & General Investment Management Ltd. | 6,579 | 1,378 | |
0.00926 % | Principal Global Investors (Equity) | 6,570 | 0 | |
0.00906 % | Mackenzie Investments | 6,430 | -7 | |
0.00780 % | RBC Wealth Management, International | 5,539 | 4,204 | |
0.00734 % | BNP Paribas Securities Corp. North America | 5,212 | -26,950 | |
0.00694 % | Ameritas Investment Partners, Inc. | 4,924 | 0 | |
0.00601 % | California State Teachers Retirement System | 4,267 | -1,728 | |
0.00546 % | T. Rowe Price Associates, Inc. | 3,876 | 0 | |
0.00494 % | Invesco Capital Management LLC | 3,507 | 350 | |
0.00391 % | Mirae Asset Global Investments Co., Ltd. | 2,775 | 231 | |
0.00370 % | Franklin Mutual Advisers, LLC | 2,623 | 0 | |
0.00353 % | Fidelity Management & Research Company LLC | 2,502 | -83,705 | |
0.00336 % | Simplex Trading, LLC | 2,383 | 1,150 | |
0.00324 % | Sandy Spring Bank | 2,300 | 300 | |
0.00319 % | Parametric Portfolio Associates LLC | 2,262 | -3,152 | |
0.00317 % | Federated MDTA LLC | 2,250 | 2,250 | |
0.00283 % | Amalgamated Bank Institutional Asset Management & Custody | 2,011 | 0 | |
0.00238 % | Los Angeles Capital Management LLC | 1,686 | 1,686 | |