14.02314 % | BlackRock Institutional Trust Company, N.A. | 23,726,864 | -251,670 | |
10.90631 % | The Vanguard Group, Inc. | 18,453,262 | 290,400 | |
5.82871 % | T. Rowe Price Associates, Inc. | 9,862,062 | -1,757,670 | |
4.85127 % | State Street Global Advisors (US) | 8,208,256 | 185,586 | |
3.78882 % | Baker Bros. Advisors LP | 6,410,603 | 1,927,318 | |
3.43394 % | Renaissance Technologies LLC | 5,810,160 | 71,332 | |
2.76734 % | RTW Investments L.P. | 4,682,289 | -2,202,409 | |
2.37801 % | Geode Capital Management, L.L.C. | 4,023,552 | 83,858 | |
2.33200 % | JP Morgan Asset Management | 3,945,689 | -179,847 | |
2.16150 % | American Century Investment Management, Inc. | 3,657,223 | 191,549 | |
1.83019 % | Dimensional Fund Advisors, L.P. | 3,096,637 | 105,632 | |
1.71545 % | PRIMECAP Management Company | 2,902,510 | -101,585 | |
1.71397 % | Avoro Capital Advisors LLC | 2,900,000 | 450,000 | |
1.68664 % | Holocene Advisors, LP | 2,853,768 | 679,166 | |
1.44801 % | Commodore Capital LP | 2,450,000 | 500,000 | |
1.24700 % | Loomis, Sayles & Company, L.P. | 2,109,894 | -330,389 | |
1.23645 % | Charles Schwab Investment Management, Inc. | 2,092,049 | 44,646 | |
1.10161 % | Norges Bank Investment Management (NBIM) | 1,863,895 | -107,046 | |
1.09270 % | BofA Global Research (US) | 1,848,831 | 595,273 | |
1.00480 % | Wellington Management Company, LLP | 1,700,103 | -1,396,776 | |
0.91558 % | Nuveen LLC | 1,549,147 | -114,867 | |
0.91124 % | Artisan Partners Limited Partnership | 1,541,807 | -94,462 | |
0.90781 % | Northern Trust Investments, Inc. | 1,535,992 | -68,027 | |
0.84629 % | BlackRock Financial Management, Inc. | 1,431,910 | 141,198 | |
0.82583 % | First Trust Advisors L.P. | 1,397,281 | -223,765 | |
0.81299 % | Paradigm BioCapital Advisors LP | 1,375,569 | 1,375,569 | |
0.79339 % | UBS Financial Services, Inc. | 1,342,402 | -1,700,807 | |
0.76265 % | Pops (Richard F) | 1,290,390 | 0 | |
0.67109 % | BNP Paribas Securities Corp. North America | 1,135,478 | 1,007,488 | |
0.59141 % | Frazier Life Sciences Management, L.P. | 1,000,647 | 399,518 | |
0.59102 % | Affinity Asset Advisors LLC | 1,000,000 | 0 | |
0.58701 % | Mellon Investments Corporation | 993,214 | -109,887 | |
0.54067 % | Principal Global Investors (Equity) | 914,795 | -14,070 | |
0.53603 % | Pacer Advisors, Inc. | 906,957 | 16,813 | |
0.52698 % | Parametric Portfolio Associates LLC | 891,642 | 38,933 | |
0.52198 % | Pictet Asset Management (Japan) Ltd. | 883,172 | -369,877 | |
0.51843 % | PanAgora Asset Management Inc. | 877,174 | 17,192 | |
0.50978 % | Fidelity Institutional Asset Management | 862,545 | 862,243 | |
0.49341 % | BlackRock Asset Management Ireland Limited | 834,838 | -19,443 | |
0.49068 % | Goldman Sachs Asset Management, L.P. | 830,224 | 137,694 | |
0.48866 % | Driehaus Capital Management, LLC | 826,811 | 33,980 | |
0.48470 % | D. E. Shaw & Co., L.P. | 820,096 | 351,615 | |
0.48269 % | Goldman Sachs & Company, Inc. | 816,709 | 52,315 | |
0.46599 % | Candriam Luxembourg S.A. | 788,447 | 0 | |
0.43909 % | JPMorgan Asset Management U.K. Limited | 742,939 | -22,435 | |
0.41749 % | Morgan Stanley & Co. LLC | 706,379 | -455,460 | |
0.41727 % | Columbia Threadneedle Investments (US) | 706,007 | 175,235 | |
0.40879 % | Farallon Capital Management, L.L.C. | 691,663 | -698,137 | |
0.40680 % | Barclays Bank PLC | 688,294 | 271,960 | |
0.40618 % | Acadian Asset Management LLC | 687,252 | -194,575 | |
0.38809 % | MetLife Investment Management, LLC | 656,648 | 89,027 | |
0.38615 % | BlackRock Investment Management, LLC | 653,355 | 198,115 | |
0.37643 % | PSP Investments | 636,913 | 51,651 | |
0.35103 % | Segall Bryant & Hamill, LLC | 593,938 | 65,117 | |
0.33474 % | JPMorgan Asset Management (Europe) S.à.r.l. | 566,380 | -4,103 | |
0.33007 % | Woodline Partners LP | 558,465 | -185,535 | |
0.32463 % | MPM BioImpact LLC | 549,262 | 211,659 | |
0.31640 % | Legal & General Investment Management Ltd. | 535,342 | -17,227 | |
0.29763 % | Voya Investment Management LLC | 503,585 | 26,402 | |
0.29551 % | EcoR1 Capital, LLC | 500,000 | 500,000 | |
0.29488 % | Nuveen Asset Management, LLC | 498,926 | 143,272 | |
0.28568 % | Glenmede Investment Management LP | 483,363 | -15,656 | |
0.27947 % | Rhumbline Advisers Ltd. Partnership | 472,857 | 17,660 | |
0.27309 % | Invesco Capital Management LLC | 462,069 | -128,564 | |
0.26745 % | AQR Capital Management, LLC | 452,522 | -79,743 | |
0.24934 % | Rice Hall James & Associates, LLC | 421,885 | -4,700 | |
0.24555 % | Fidelity Management & Research Company LLC | 415,461 | -1,127,295 | |
0.22945 % | Eagle Asset Management, Inc. | 388,221 | 17,557 | |
0.22316 % | BlackRock Investment Management (UK) Ltd. | 377,587 | 64,373 | |
0.22274 % | Mesirow Institutional Investment Management, Inc. | 376,867 | 376,867 | |
0.22123 % | Macquarie Investment Management | 374,324 | 74,324 | |
0.21921 % | CPP Investment Board | 370,900 | 65,400 | |
0.21105 % | Jane Street Capital, L.L.C. | 357,097 | -167,590 | |
0.20882 % | UBS Asset Management (Switzerland) | 353,313 | 159,268 | |
0.20752 % | StemPoint Capital LP | 351,124 | 158,772 | |
0.19723 % | Two Sigma Investments, LP | 333,703 | -443,937 | |
0.19239 % | BNY Mellon Asset Management | 325,526 | 5,268 | |
0.18818 % | Handelsbanken Kapitalförvaltning AB | 318,400 | 101,400 | |
0.18236 % | California Public Employees' Retirement System | 308,542 | 15,352 | |
0.18100 % | Managed Account Advisors LLC | 306,256 | 52,632 | |
0.17689 % | Schweizerische Nationalbank | 299,300 | 1,500 | |
0.17432 % | Dimensional Fund Advisors, Ltd. | 294,952 | -35 | |
0.17255 % | Fisher Investments | 291,947 | -29,734 | |
0.17159 % | Mackenzie Investments | 290,327 | 53,323 | |
0.16728 % | Aperio Group, LLC | 283,029 | -22,718 | |
0.16651 % | Landine (Michael J) | 281,730 | 31,288 | |
0.15909 % | Pictet Asset Management Ltd. | 269,170 | -142,151 | |
0.15640 % | Peregrine Capital Management, LLC | 264,620 | 75,821 | |
0.14776 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 250,000 | 0 | |
0.14211 % | Victory Capital Management Inc. | 240,453 | 119,456 | |
0.13959 % | AXA Investment Managers UK Ltd. | 236,189 | 380 | |
0.13429 % | Healthinvest Partners AB | 227,224 | 12,446 | |
0.13063 % | Palo Alto Investors LP | 221,021 | -492 | |
0.13037 % | S & Company, Inc. | 220,585 | -1,375 | |
0.12820 % | SEI Investments Management Corporation | 216,906 | 25,134 | |
0.12792 % | TD Asset Management Inc. | 216,442 | 10,800 | |
0.12298 % | Manulife Investment Management (North America) Limited | 208,088 | 13,096 | |
0.12283 % | Krensavage Asset Management, LLC | 207,822 | 0 | |
0.12264 % | Marshall Wace LLP | 207,511 | 207,511 | |
0.12138 % | Gaffin (David Joseph) | 205,374 | 1,119 | |