7.74992 % | T. Rowe Price Associates, Inc. | 4,167,909 | 403,654 | |
6.51261 % | Scully (William P) | 3,502,481 | 1,039,481 | |
6.01062 % | BlackRock Institutional Trust Company, N.A. | 3,232,512 | 357,674 | |
5.84131 % | Fennell (Todd W.) | 3,141,459 | 3,141,459 | |
5.12935 % | State Street Global Advisors (US) | 2,758,564 | 648,331 | |
4.82354 % | Wellington Management Company, LLP | 2,594,102 | 452,455 | |
3.78576 % | Janus Henderson Investors | 2,035,984 | 209,375 | |
3.08676 % | Palo Alto Investors LP | 1,660,057 | 2,599 | |
21.54013 % | EcoR1 Capital, LLC | 11,584,280 | 0 | |
2.02455 % | First Light Asset Management, LLC | 1,088,801 | -405,238 | |
14.96768 % | Fidelity Management & Research Company LLC | 8,049,620 | 19,506 | |
1.97443 % | The Vanguard Group, Inc. | 1,061,850 | 38,191 | |
1.68301 % | Geode Capital Management, L.L.C. | 905,125 | 46,065 | |
1.61330 % | Dimensional Fund Advisors, L.P. | 867,635 | -235,227 | |
1.23652 % | Boxer Capital, L.L.C. | 665,000 | 40,000 | |
1.16223 % | Rock Springs Capital Management LP | 625,048 | 10,750 | |
0.93224 % | Invus Public Equities Advisors, LLC | 501,360 | 501,360 | |
0.82773 % | Eventide Asset Management, LLC | 445,155 | 0 | |
0.77567 % | Granahan Investment Management, LLC | 417,157 | 69,092 | |
0.69465 % | Maple Rock Capital Partners, Inc. | 373,584 | 139,000 | |
0.65050 % | Morgan Stanley & Co. LLC | 349,838 | 147,440 | |
0.64950 % | Finepoint Capital LP | 349,300 | 0 | |
0.64945 % | Northern Trust Investments, Inc. | 349,274 | -2,196 | |
0.62440 % | Renaissance Technologies LLC | 335,800 | 75,200 | |
0.58243 % | Charles Schwab Investment Management, Inc. | 313,230 | 4,693 | |
0.55671 % | Nuveen LLC | 299,397 | -128,073 | |
0.54935 % | JP Morgan Asset Management | 295,440 | -10,124 | |
0.51692 % | Armistice Capital LLC | 278,000 | 278,000 | |
0.51660 % | BofA Global Research (US) | 277,828 | 177,954 | |
0.51426 % | Goldman Sachs & Company, Inc. | 276,571 | 83,778 | |
0.48463 % | Mellon Investments Corporation | 260,634 | -44,776 | |
0.46372 % | BlackRock Financial Management, Inc. | 249,390 | -68,629 | |
0.42681 % | Prosight Capital | 229,539 | 103,337 | |
0.38568 % | Rafferty Asset Management LLC | 207,419 | 50,579 | |
0.37873 % | Qube Research & Technologies Ltd | 203,682 | 119,029 | |
0.37577 % | UBS Asset Management (Switzerland) | 202,090 | 25,737 | |
0.35282 % | PFM Health Sciences, LP | 189,744 | -646,827 | |
0.34436 % | Jane Street Capital, L.L.C. | 185,195 | 178,939 | |
0.33177 % | Mariner Wealth Advisors | 178,424 | 10,492 | |
0.31531 % | Birchview Capital, LP | 169,574 | 0 | |
0.30984 % | Amundi Asset Management US, Inc. | 166,631 | -7,160 | |
0.28996 % | Connor, Clark & Lunn Investment Management Ltd. | 155,942 | 28,167 | |
0.27847 % | Systematic Financial Management, L.P. | 149,759 | 130,009 | |
0.27296 % | Two Sigma Investments, LP | 146,800 | -193,203 | |
0.27248 % | TD Asset Management Inc. | 146,538 | -26,144 | |
0.26414 % | Barclays Bank PLC | 142,053 | 56,572 | |
0.25769 % | Citadel Advisors LLC | 138,587 | -10,348 | |
0.25262 % | SG Americas Securities, L.L.C. | 135,857 | 43,363 | |
0.24637 % | UBS Financial Services, Inc. | 132,497 | 87,245 | |
0.23382 % | Pinnacle Associates Ltd. | 125,747 | 741 | |
0.22770 % | BNY Mellon Asset Management | 122,456 | -4,112 | |
0.22428 % | AXA Investment Managers UK Ltd. | 120,617 | 7,704 | |
0.21566 % | BlackRock Advisors (UK) Limited | 115,984 | 3,518 | |
0.20655 % | BlackRock Investment Management, LLC | 111,084 | 2,782 | |
0.19443 % | Norges Bank Investment Management (NBIM) | 104,564 | 45,305 | |
0.17293 % | BNP Paribas Securities Corp. North America | 93,004 | -12,212 | |
0.16645 % | BlackRock Asset Management Ireland Limited | 89,518 | 13,157 | |
0.16285 % | Citi Investment Research (US) | 87,581 | 19,651 | |
0.15921 % | Manulife Investment Management (North America) Limited | 85,622 | 3,591 | |
0.15619 % | DCF Advisers, LLC | 84,000 | 1,050 | |
0.15247 % | Candriam Luxembourg S.A. | 82,000 | 0 | |
0.15030 % | Ensign Peak Advisors, Inc. | 80,834 | -45,388 | |
0.14727 % | Schweizerische Nationalbank | 79,200 | -7,800 | |
0.14204 % | Morgan Stanley Smith Barney LLC | 76,391 | 63,265 | |
0.13765 % | Squarepoint Capital LLP | 74,030 | 41,691 | |
0.12912 % | T. Rowe Price International Ltd | 69,442 | 13,684 | |
0.12664 % | UBS Asset Management (Americas), Inc. | 68,108 | -799 | |
0.12585 % | Trexquant Investment LP | 67,683 | 10,840 | |
0.12368 % | Putnam Investment Management, L.L.C. | 66,516 | 9,903 | |
0.11514 % | Rhumbline Advisers Ltd. Partnership | 61,920 | -531 | |
0.11417 % | Handelsbanken Kapitalförvaltning AB | 61,400 | 2,500 | |
0.11027 % | Credit Suisse Funds AG | 59,304 | 8,641 | |
0.10803 % | TwinBeech Capital LP | 58,096 | 39,720 | |
0.10589 % | Seven Eight Capital, LP | 56,946 | 56,946 | |
0.10567 % | Pier Capital, LLC | 56,829 | -627 | |
0.10392 % | Newton Investment Management North America, LLC | 55,886 | -6,525 | |
0.10179 % | Parametric Portfolio Associates LLC | 54,742 | 2,731 | |
0.10118 % | JPMorgan Private Bank (United States) | 54,417 | 33,992 | |
0.09394 % | Edgestream Partners, L.P. | 50,522 | 50,522 | |
0.09171 % | Goldman Sachs Asset Management, L.P. | 49,321 | -410 | |
0.09159 % | Algert Global LLC | 49,258 | 21,258 | |
0.08929 % | Northern Trust Global Investments | 48,018 | 2,353 | |
0.08698 % | Sectoral Asset Management Inc. | 46,777 | -125,630 | |
0.08692 % | AllianceBernstein L.P. | 46,746 | 1,000 | |
0.08602 % | Voya Investment Management LLC | 46,262 | -44,449 | |
0.08533 % | Caption Management, LLC | 45,892 | 45,892 | |
0.08435 % | RBF Capital, LLC | 45,362 | -9,000 | |
0.07942 % | California State Teachers Retirement System | 42,710 | -1,422 | |
0.07718 % | Platinum Asset Management | 41,508 | 0 | |
0.07140 % | Legal & General Investment Management Ltd. | 38,397 | -105 | |
0.07002 % | Millennium Management LLC | 37,656 | -227,869 | |
0.06830 % | Assenagon Asset Management S.A. | 36,730 | 2,663 | |
0.06792 % | Alps Advisors, Inc. | 36,530 | -2,994 | |
0.06791 % | Engineers Gate Manager, L.P. | 36,523 | 25,139 | |
0.06765 % | Exome Asset Management LLC | 36,384 | 36,384 | |
0.06693 % | BlackRock Investment Management (UK) Ltd. | 35,993 | -82,716 | |
0.06628 % | Monarch Partners Asset Management LLC | 35,645 | 2,285 | |
0.06480 % | GSA Capital Partners LLP | 34,850 | 34,850 | |
0.06470 % | Wells Fargo Advisors | 34,793 | 15,803 | |
0.06469 % | Allianz Global Investors U.S. LLC_NLE | 34,790 | 0 | |