4.18792 % | BVF Partners L.P. | 1,685,219 | 0 | |
4.12847 % | Soleus Capital Management, L.P. | 1,661,297 | 120,663 | |
3.82321 % | Vivo Capital, LLC | 1,538,461 | 0 | |
3.79999 % | OrbiMed Advisors, LLC | 1,529,115 | 0 | |
3.71471 % | BlackRock Institutional Trust Company, N.A. | 1,494,800 | 1,191,664 | |
3.39390 % | The Vanguard Group, Inc. | 1,365,705 | 204,774 | |
3.31345 % | Stonepine Capital Management, LLC | 1,333,333 | 1,333,333 | |
2.27386 % | Opaleye Management Inc. | 915,000 | 703,600 | |
1.73956 % | Alyeska Investment Group, L.P. | 700,000 | 700,000 | |
1.34571 % | Tang Capital Management, LLC | 541,514 | 0 | |
1.32092 % | Geode Capital Management, L.L.C. | 531,539 | 282,587 | |
0.99404 % | Nantahala Capital Management, LLC | 400,000 | 400,000 | |
0.89214 % | State Street Global Advisors (US) | 358,999 | 271,512 | |
0.52734 % | Kennedy Capital Management LLC | 212,203 | 212,203 | |
0.47154 % | Paterson (Daniel W) | 189,747 | -430 | |
0.33154 % | Sio Capital Management, LLC | 133,412 | 133,412 | |
0.29430 % | Parametric Portfolio Associates LLC | 118,425 | 118,425 | |
0.24948 % | UBS O'Connor LLC | 100,389 | 54,157 | |
0.22333 % | Susquehanna International Group, LLP | 89,870 | -143,413 | |
0.19805 % | Stuglik (Brian M) | 79,696 | -936 | |
0.18592 % | Marshall Wace LLP | 74,814 | 2,549 | |
0.17597 % | Charles Schwab Investment Management, Inc. | 70,810 | 59,651 | |
0.17348 % | BlackRock Investment Management, LLC | 69,809 | 67,245 | |
0.15051 % | BNY Mellon Asset Management | 60,565 | 60,565 | |
0.14313 % | BlackRock Financial Management, Inc. | 57,594 | 57,594 | |
0.14199 % | Northern Trust Investments, Inc. | 57,137 | 12,264 | |
0.13601 % | RBC Capital Markets Wealth Management | 54,730 | 1,391 | |
0.11455 % | Dimensional Fund Advisors, L.P. | 46,094 | 2,441 | |
0.11127 % | Calkins (Daniel) | 44,774 | -6 | |
0.09568 % | OMERS Administration Corporation | 38,500 | 38,500 | |
0.09485 % | Goldman Sachs & Company, Inc. | 38,168 | -135,568 | |
0.09046 % | Walleye Capital LLC | 36,401 | 36,401 | |
0.08548 % | Nuveen LLC | 34,399 | 34,399 | |
0.08035 % | BMO Capital Markets (US) | 32,334 | 19,134 | |
0.07952 % | Jane Street Capital, L.L.C. | 31,998 | 20,702 | |
0.07555 % | Citadel Advisors LLC | 30,400 | -9,408 | |
0.07455 % | Abaris Investment Management AG | 30,000 | 15,000 | |
0.07155 % | Rhumbline Advisers Ltd. Partnership | 28,793 | 28,119 | |
0.07062 % | Gagnon (Robert E) | 28,419 | -418 | |
0.06935 % | Morgan Stanley & Co. LLC | 27,906 | -14,218 | |
0.06881 % | Acadian Asset Management LLC | 27,689 | 27,689 | |
0.06433 % | NewEdge Wealth, LLC | 25,885 | 0 | |
0.06229 % | CornerCap Investment Counsel, Inc. | 25,064 | -210 | |
0.05979 % | Alpine Global Management, LLC | 24,058 | 24,058 | |
0.05621 % | DWS Investments UK Limited | 22,620 | 22,620 | |
0.05165 % | Millennium Management LLC | 20,784 | -605,158 | |
0.04944 % | Morgan Stanley Smith Barney LLC | 19,893 | 8,584 | |
0.04615 % | Stifel, Nicolaus & Company, Incorporated | 18,572 | 1,394 | |
0.04063 % | BofA Global Research (US) | 16,348 | -2,476 | |
0.03589 % | SG Americas Securities, L.L.C. | 14,444 | 14,444 | |
0.03491 % | Mirae Asset Global Investments (USA) LLC | 14,049 | -627 | |
0.03449 % | AllianceBernstein L.P. | 13,880 | 13,880 | |
0.03397 % | SunAmerica Asset Management, LLC | 13,668 | 0 | |
0.03397 % | Corebridge Financial Inc | 13,668 | 13,668 | |
0.03251 % | Aries Wealth Management, LLC | 13,081 | 0 | |
0.03104 % | Goldman Sachs Asset Management, L.P. | 12,491 | 12,491 | |
0.03068 % | Avantis Investors | 12,345 | 6,972 | |
0.02930 % | Invesco Advisers, Inc. | 11,790 | 11,790 | |
0.02691 % | JPMorgan Private Bank (United States) | 10,828 | 10,828 | |
0.02506 % | Two Sigma Investments, LP | 10,085 | -1,997 | |
0.02485 % | Apollon Wealth Management, LLC | 10,000 | 10,000 | |
0.02208 % | Kauffman (Michael G) | 8,883 | 8,333 | |
0.02141 % | Barclays Bank PLC | 8,614 | -22,447 | |
0.02071 % | Kapur (Anil) | 8,333 | 8,333 | |
0.02071 % | Tollefson (Karin Anna) | 8,333 | 8,333 | |
0.02071 % | Robertson (Michelle) | 8,333 | 8,333 | |
0.02071 % | Rowinsky (Eric K.) | 8,333 | 8,333 | |
0.02071 % | Johnson (John H.) | 8,333 | 8,333 | |
0.02071 % | Bunn (Paul A) | 8,333 | 8,333 | |
0.02021 % | Wells Fargo Bank, N.A. | 8,134 | 7,948 | |
0.01908 % | UBS Financial Services, Inc. | 7,676 | 5,981 | |
0.01903 % | Mellon Investments Corporation | 7,659 | 7,659 | |
0.01781 % | ProShare Advisors LLC | 7,165 | 2,283 | |
0.01777 % | BMO Family Office, LLC | 7,150 | 7,150 | |
0.01752 % | Simplex Trading, LLC | 7,050 | 6,761 | |
0.01519 % | Dimensional Fund Advisors, Ltd. | 6,114 | 0 | |
0.01478 % | Loring, Wolcott & Coolidge Fiduciary Advisors, LLP | 5,949 | 3,000 | |
0.01374 % | Citi Investment Research (US) | 5,528 | -71,692 | |
0.01292 % | New York State Common Retirement Fund | 5,200 | -29,300 | |
0.00982 % | Osaic Holdings, Inc. | 3,952 | 1,956 | |
0.00856 % | Wells Fargo Advisors | 3,445 | -3,373 | |
0.00853 % | Principal Global Investors (Equity) | 3,432 | 0 | |
0.00698 % | Legal & General Investment Management Ltd. | 2,808 | 2,808 | |
0.00619 % | Ameritas Investment Partners, Inc. | 2,489 | 2,489 | |
0.00594 % | RBC Wealth Management, International | 2,390 | 2,390 | |
0.00520 % | Group One Trading, L.P. | 2,092 | 2,000 | |
0.00458 % | California State Teachers Retirement System | 1,841 | 1,841 | |
0.00446 % | Assenagon Asset Management S.A. | 1,795 | 449 | |
0.00434 % | Franklin Mutual Advisers, LLC | 1,746 | 0 | |
0.00227 % | IFAM Capital | 915 | -371 | |
0.00224 % | International Assets Investment Management, LLC | 900 | 900 | |
0.00218 % | Amalgamated Bank Institutional Asset Management & Custody | 879 | 879 | |
0.00201 % | Blackstone Alternative Investment Advisors LLC | 808 | -300 | |
0.00182 % | Carson Wealth Management Group | 733 | 733 | |
0.00144 % | Tower Research Capital LLC | 581 | -992 | |
0.00117 % | Invesco Capital Management LLC | 470 | 470 | |
0.00114 % | Guggenheim Investments | 457 | 0 | |
0.00103 % | Clearstead Advisors LLC | 416 | 416 | |
0.00101 % | Manulife Investment Management (North America) Limited | 405 | 0 | |
0.00040 % | ProFund Advisors LLC | 161 | 161 | |