8.59771 % | Wellington Management Company, LLP | 7,339,004 | -97,612 | |
7.65327 % | BlackRock Institutional Trust Company, N.A. | 6,532,828 | 283,661 | |
6.70344 % | Kynam Capital Management LP | 5,722,057 | 62,057 | |
5.60230 % | The Vanguard Group, Inc. | 4,782,124 | -129,895 | |
4.55534 % | Avoro Capital Advisors LLC | 3,888,437 | -333,785 | |
4.41756 % | State Street Global Advisors (US) | 3,770,826 | 148,491 | |
4.23340 % | Eversept Partners, LP | 3,613,631 | 480,518 | |
3.90698 % | Avidity Partners Management LP | 3,335,000 | 922,500 | |
3.26014 % | Point72 Asset Management, L.P. | 2,782,853 | 716,168 | |
2.52304 % | Sofinnova Investments, Inc | 2,153,669 | 545,129 | |
2.25551 % | OrbiMed Advisors, LLC | 1,925,300 | 176,300 | |
2.23831 % | Geode Capital Management, L.L.C. | 1,910,623 | 132,075 | |
2.14436 % | Marshall Wace LLP | 1,830,427 | -201,632 | |
1.81841 % | Two Sigma Investments, LP | 1,552,199 | 377,795 | |
1.81345 % | Franklin Advisers, Inc. | 1,547,963 | 72,729 | |
1.81060 % | Woodline Partners LP | 1,545,528 | 1,241 | |
1.65438 % | StemPoint Capital LP | 1,412,176 | 311,188 | |
1.38968 % | Candriam Luxembourg S.A. | 1,186,228 | 0 | |
1.32315 % | Goldman Sachs & Company, Inc. | 1,129,438 | 30,137 | |
1.24825 % | Millennium Management LLC | 1,065,508 | 383,634 | |
1.20080 % | Aisling Capital Management LP | 1,025,000 | 0 | |
1.13649 % | Candriam Belgium S.A. | 970,106 | -74,926 | |
1.04849 % | Kingdon Capital Management, L.L.C. | 894,993 | 0 | |
1.02507 % | Foresite Capital Management, LLC | 875,000 | 0 | |
1.00750 % | Adage Capital Management, L.P. | 860,000 | -40,000 | |
0.96825 % | Soleus Capital Management, L.P. | 826,500 | 457,500 | |
0.96649 % | Commodore Capital LP | 825,000 | 506,149 | |
0.96578 % | BlackRock Financial Management, Inc. | 824,394 | 38,560 | |
0.96304 % | Sphera Funds Management Ltd. | 822,047 | 9,083 | |
0.95177 % | BofA Global Research (US) | 812,433 | -805,740 | |
0.92290 % | BNP Paribas Asset Management USA, Inc. | 787,785 | 69,345 | |
0.76977 % | Dafna Capital Management, LLC | 657,074 | -2,500 | |
0.76880 % | Federated Hermes Global Investment Management Corp. | 656,250 | 117,536 | |
0.76674 % | Charles Schwab Investment Management, Inc. | 654,489 | 19,282 | |
0.75022 % | First Turn Management, LLC | 640,389 | 640,389 | |
0.74384 % | Northern Trust Investments, Inc. | 634,946 | -41,048 | |
0.73304 % | ExodusPoint Capital Management, LP | 625,723 | 339,393 | |
0.70372 % | Parkman Healthcare Partners LLC | 600,698 | -184,113 | |
0.69633 % | Granahan Investment Management, LLC | 594,386 | 197,508 | |
0.64806 % | Nuveen LLC | 553,187 | 162,265 | |
0.64614 % | Prosight Capital | 551,544 | 551,544 | |
0.64306 % | JP Morgan Asset Management | 548,917 | -44,379 | |
0.60788 % | Ensign Peak Advisors, Inc. | 518,885 | 4,033 | |
0.56667 % | Columbia Threadneedle Investments (US) | 483,712 | 2,811 | |
0.54596 % | Assenagon Asset Management S.A. | 466,028 | 37,079 | |
0.53097 % | Nantahala Capital Management, LLC | 453,232 | -12,027 | |
0.51915 % | Morgan Stanley & Co. LLC | 443,145 | -1,088,823 | |
0.50624 % | Algert Global LLC | 432,128 | 6,455 | |
0.49163 % | Saturn V Capital Management LP | 419,654 | 21,657 | |
0.47469 % | Palo Alto Investors LP | 405,193 | 0 | |
0.45379 % | PFM Health Sciences, LP | 387,357 | -271,337 | |
0.43346 % | SilverArc Capital Management, LLC | 370,000 | 370,000 | |
0.41003 % | Ghost Tree Capital, LLC | 350,000 | 200,000 | |
0.35555 % | Goldman Sachs Asset Management, L.P. | 303,499 | 108,246 | |
0.34829 % | Qube Research & Technologies Ltd | 297,303 | 203,414 | |
0.33251 % | T. Rowe Price Investment Management, Inc. | 283,827 | -2,175,408 | |
0.31359 % | Parametric Portfolio Associates LLC | 267,682 | 26,396 | |
0.30562 % | Schonfeld Strategic Advisors LLC | 260,876 | -524,768 | |
0.28458 % | Macquarie Investment Management | 242,919 | -73 | |
0.27136 % | BlackRock Investment Management, LLC | 231,634 | 16,095 | |
0.26784 % | HOOPP Investment Management | 228,625 | -551,375 | |
0.26769 % | Rhenman & Partners Asset Management AB | 228,500 | 50,000 | |
0.25105 % | Renaissance Technologies LLC | 214,300 | 135,200 | |
0.24170 % | BNY Mellon Asset Management | 206,319 | 24,260 | |
0.23323 % | Peregrine Capital Management, LLC | 199,086 | 427 | |
0.22256 % | Citadel Advisors LLC | 189,981 | 156,172 | |
0.21515 % | Voya Investment Management LLC | 183,649 | -13,375 | |
0.20843 % | Rafferty Asset Management LLC | 177,920 | -195,318 | |
0.19648 % | TwinBeech Capital LP | 167,714 | 95,831 | |
0.19202 % | Metzger (Michael A) | 163,909 | 3,750 | |
0.18158 % | Zimmer Partners, LP | 155,000 | 0 | |
0.17961 % | Jane Street Capital, L.L.C. | 153,311 | 39,783 | |
0.17643 % | Schweizerische Nationalbank | 150,600 | 0 | |
0.17573 % | Casdin Capital, LLC | 150,000 | 0 | |
0.17179 % | D. E. Shaw & Co., L.P. | 146,643 | 138,119 | |
0.16936 % | Verition Fund Management LLC | 144,566 | -202,296 | |
0.16785 % | Crestline Investors, Inc. | 143,280 | 39,570 | |
0.16044 % | BlackRock Advisors (UK) Limited | 136,952 | 1,627 | |
0.14662 % | UBS Financial Services, Inc. | 125,152 | -144,659 | |
0.13974 % | Rhumbline Advisers Ltd. Partnership | 119,285 | 10,291 | |
0.13860 % | BlackRock Asset Management Ireland Limited | 118,312 | 1,362 | |
0.13417 % | Yelin Lapidot Mutual Funds Management Ltd | 114,530 | 114,530 | |
0.12940 % | UBS O'Connor LLC | 110,454 | 2,023 | |
0.12696 % | Yelin Lapidot Provident Funds Management Ltd | 108,377 | -6,153 | |
0.12163 % | Knott Partners Management, LLC | 103,826 | 38,351 | |
0.11953 % | Susquehanna International Group, LLP | 102,027 | -634,121 | |
0.11894 % | PGIM Quantitative Solutions LLC | 101,530 | 85,770 | |
0.11146 % | Axiom Investors | 95,140 | 1,075 | |
0.11049 % | New Jersey Division of Investment | 94,313 | -20,071 | |
0.11001 % | Trexquant Investment LP | 93,906 | 19,314 | |
0.10934 % | Podlesak (Dennis G) | 93,333 | -2,000 | |
0.10857 % | Aperio Group, LLC | 92,675 | 13,305 | |
0.09987 % | AllianceBernstein L.P. | 85,250 | 7,790 | |
0.09981 % | Wellington Management Singapore Pte. Ltd. | 85,200 | 85,200 | |
0.09981 % | Wellington Management Japan Pte Ltd | 85,200 | -54,891 | |
0.09879 % | Legal & General Investment Management Ltd. | 84,330 | 14,552 | |
0.09754 % | Propel Bio Management, LLC | 83,259 | 0 | |
0.09706 % | PanAgora Asset Management Inc. | 82,849 | -154,157 | |
0.09069 % | Mellon Investments Corporation | 77,412 | 19,883 | |
0.08900 % | Seven Eight Capital, LP | 75,971 | 66,332 | |