7.78773 % | The Vanguard Group, Inc. | 14,354,342 | -381,474 | |
7.41113 % | Wellington Management Company, LLP | 13,660,196 | -1,054,530 | |
5.91511 % | BlackRock Institutional Trust Company, N.A. | 10,902,738 | 779,058 | |
5.29389 % | Farallon Capital Management, L.L.C. | 9,757,692 | 2,249,820 | |
4.10649 % | Baker Bros. Advisors LP | 7,569,090 | 19,841 | |
3.41620 % | Nextech Invest, Ltd. | 6,296,740 | 0 | |
3.24502 % | BVF Partners L.P. | 5,981,212 | 0 | |
3.05178 % | Fidelity Management & Research Company LLC | 5,625,035 | 1,458,597 | |
2.87927 % | Alphabet, Inc. | 5,307,075 | 5,563 | |
2.85324 % | Paradigm BioCapital Advisors LP | 5,259,089 | 2,344,114 | |
2.75123 % | State Street Global Advisors (US) | 5,071,068 | -314,952 | |
2.74664 % | T. Rowe Price Associates, Inc. | 5,062,599 | 391,615 | |
2.72846 % | Bellevue Asset Management AG | 5,029,100 | -44,500 | |
2.51748 % | Janus Henderson Investors | 4,640,218 | 728,099 | |
2.39088 % | Casdin Capital, LLC | 4,406,875 | -1,210,724 | |
2.32176 % | Boxer Capital, L.L.C. | 4,279,464 | 0 | |
1.80971 % | Geode Capital Management, L.L.C. | 3,335,656 | 282,965 | |
1.78537 % | Woodline Partners LP | 3,290,791 | -506,357 | |
1.67647 % | Deerfield Management Company, L.P. | 3,090,073 | 0 | |
1.49117 % | Andreessen Horowitz | 2,748,523 | 0 | |
1.28233 % | Balyasny Asset Management LP | 2,363,584 | 708,689 | |
1.26440 % | Borisy (Alexis) | 2,330,542 | 4,248 | |
1.20675 % | JP Morgan Asset Management | 2,224,283 | -182,612 | |
1.19546 % | Holocene Advisors, LP | 2,203,474 | -218,937 | |
1.00296 % | Norges Bank Investment Management (NBIM) | 1,848,647 | 1,566,942 | |
0.90306 % | Lord, Abbett & Co. LLC | 1,664,516 | -13,315 | |
0.65104 % | Logos Global Management LLC | 1,200,000 | 1,200,000 | |
0.62004 % | BlackRock Financial Management, Inc. | 1,142,863 | 79,755 | |
0.60204 % | Charles Schwab Investment Management, Inc. | 1,109,684 | 57,421 | |
0.58163 % | Northern Trust Investments, Inc. | 1,072,055 | -37,405 | |
0.56151 % | Goldman Sachs & Company, Inc. | 1,034,972 | 334,291 | |
0.55109 % | Invus Public Equities Advisors, LLC | 1,015,776 | -302,873 | |
0.54115 % | Frazier Life Sciences Management, L.P. | 997,455 | 0 | |
0.51172 % | Rock Springs Capital Management LP | 943,195 | 19,514 | |
0.49588 % | Hood River Capital Management LLC | 914,003 | 914,003 | |
0.46451 % | Soleus Capital Management, L.P. | 856,178 | 127,478 | |
0.46089 % | Morgan Stanley & Co. LLC | 849,505 | 6,716 | |
0.44274 % | Marshall Wace LLP | 816,055 | -719,885 | |
0.40961 % | Avidity Partners Management LP | 755,000 | 120,000 | |
0.39576 % | Finepoint Capital LP | 729,464 | 52,364 | |
0.35946 % | Candriam Luxembourg S.A. | 662,564 | 0 | |
0.35310 % | Eventide Asset Management, LLC | 650,826 | 289,826 | |
0.34468 % | Columbia Threadneedle Investments (UK) | 635,319 | -245,391 | |
0.33732 % | JPMorgan Asset Management U.K. Limited | 621,752 | -218,680 | |
0.32314 % | Goldsmith Mark A | 595,609 | 0 | |
0.30075 % | Candriam Belgium S.A. | 554,334 | -29,616 | |
0.29438 % | Victory Capital Management Inc. | 542,601 | -57,980 | |
0.29307 % | Pzena Investment Management, LLC | 540,194 | -160,971 | |
0.28174 % | American Century Investment Management, Inc. | 519,305 | 519,305 | |
0.27772 % | Dafna Capital Management, LLC | 511,894 | 0 | |
0.27592 % | MIC Capital Management UK LLP | 508,569 | 0 | |
0.26957 % | Columbia Threadneedle Investments (US) | 496,878 | 49,167 | |
0.26198 % | BlackRock Advisors (UK) Limited | 482,883 | 617 | |
0.24691 % | Sofinnova Investments, Inc | 455,099 | 455,099 | |
0.24516 % | BlackRock Asset Management Ireland Limited | 451,870 | 115,991 | |
0.22796 % | BlackRock Investment Management, LLC | 420,169 | 59,350 | |
0.22232 % | Nuveen LLC | 409,781 | 45,858 | |
0.22181 % | Citadel Advisors LLC | 408,842 | -179,246 | |
0.21674 % | Goldman Sachs Asset Management, L.P. | 399,489 | -13,221 | |
0.21237 % | BlackRock Investment Management (UK) Ltd. | 391,439 | 44,624 | |
0.21190 % | Dimensional Fund Advisors, L.P. | 390,583 | -940,676 | |
0.20673 % | BofA Global Research (US) | 381,041 | -140,355 | |
0.20649 % | Jane Street Capital, L.L.C. | 380,594 | 251,127 | |
0.19662 % | BNY Mellon Asset Management | 362,416 | 46,589 | |
0.18348 % | Partners HealthCare System, Inc | 338,191 | 0 | |
0.17878 % | First Turn Management, LLC | 329,519 | 329,519 | |
0.17632 % | Integral Health Asset Management, LLC | 325,000 | -95,000 | |
0.17340 % | AllianceBernstein L.P. | 319,618 | -3,746 | |
0.16677 % | Columbia Wanger Asset Management, LLC | 307,387 | 0 | |
0.15701 % | MPM BioImpact LLC | 289,396 | 16,179 | |
0.15340 % | AHL Partners LLP | 282,746 | 253,449 | |
0.15082 % | Mubadala Investment Company PJSC | 278,000 | 0 | |
0.14622 % | Ensign Peak Advisors, Inc. | 269,504 | 229,721 | |
0.14592 % | Mellon Investments Corporation | 268,962 | 65,210 | |
0.14273 % | Voya Investment Management LLC | 263,079 | -20,554 | |
0.13574 % | TD Asset Management Inc. | 250,194 | -4,400 | |
0.13519 % | Qube Research & Technologies Ltd | 249,188 | 81,708 | |
0.13208 % | Bessemer Trust Company, N.A. (US) | 243,442 | 0 | |
0.12401 % | Rhumbline Advisers Ltd. Partnership | 228,567 | 19,257 | |
0.12398 % | Susquehanna Fundamental Investments, LLC | 228,513 | 22,000 | |
0.12366 % | Point72 Asset Management, L.P. | 227,922 | 227,922 | |
0.12335 % | HSBC Private Bank (Suisse) S.A. | 227,365 | 19,081 | |
0.12306 % | Schweizerische Nationalbank | 226,831 | 26,700 | |
0.12161 % | Walleye Capital LLC | 224,143 | 189,186 | |
0.11951 % | TwinBeech Capital LP | 220,289 | 220,289 | |
0.11814 % | UBS Financial Services, Inc. | 217,763 | -87,216 | |
0.11522 % | Manulife Investment Management (North America) Limited | 212,368 | 13,318 | |
0.10336 % | Raymond James & Associates, Inc. | 190,505 | 116,135 | |
0.10071 % | Rafferty Asset Management LLC | 185,637 | -98,715 | |
0.09223 % | Adage Capital Management, L.P. | 170,000 | -30,000 | |
0.08856 % | Readystate Asset Management LP | 163,241 | 95,941 | |
0.08591 % | Kelsey (Stephen Michael) | 158,345 | 0 | |
0.08579 % | Nicholas Investment Partners, L.P. | 158,132 | 142,044 | |
0.08358 % | T. Rowe Price International Ltd | 154,060 | 10,734 | |
0.07709 % | Neuberger Berman, LLC | 142,087 | -1,272 | |
0.07463 % | JPMorgan Private Bank (United States) | 137,559 | -1,373 | |
0.07309 % | Conestoga Capital Advisors, LLC | 134,721 | -1,296 | |
0.07216 % | Acuta Capital Partners, LLC | 133,000 | -10,777 | |
0.07158 % | J.P. Morgan Securities plc | 131,944 | 95,918 | |
0.07092 % | Legal & General Investment Management Ltd. | 130,725 | 24,596 | |