8.85216 % | The Vanguard Group, Inc. | 10,948,357 | 586,934 | |
5.72174 % | Fred Alger Management, LLC | 7,076,651 | 120,465 | |
4.59094 % | JP Morgan Asset Management | 5,678,074 | 43,087 | |
4.40831 % | BlackRock Institutional Trust Company, N.A. | 5,452,196 | 420,848 | |
3.13292 % | Samlyn Capital, LLC | 3,874,801 | -525,425 | |
2.80958 % | Farallon Capital Management, L.L.C. | 3,474,883 | 1,197,000 | |
2.57575 % | State Street Global Advisors (US) | 3,185,683 | 207,907 | |
2.41787 % | AllianceBernstein L.P. | 2,990,416 | -94,236 | |
2.16525 % | Invesco Advisers, Inc. | 2,677,978 | 280,993 | |
2.09680 % | RTW Investments L.P. | 2,593,323 | -58,460 | |
1.94049 % | Kynam Capital Management LP | 2,400,000 | -603,668 | |
1.82049 % | Eversept Partners, LP | 2,251,588 | -241,048 | |
1.51237 % | American Century Investment Management, Inc. | 1,870,496 | 216,193 | |
1.43197 % | Geode Capital Management, L.L.C. | 1,771,062 | 127,393 | |
1.37744 % | Principal Global Investors (Equity) | 1,703,615 | 112,825 | |
1.34488 % | Citadel Advisors LLC | 1,663,344 | 1,659,765 | |
1.25346 % | Sofinnova Investments, Inc | 1,550,280 | -1,550,280 | |
1.22925 % | Millennium Management LLC | 1,520,333 | -1,914,321 | |
1.20929 % | Rabinowitz (Matthew) | 1,495,648 | 3,092 | |
1.18326 % | JPMorgan Asset Management U.K. Limited | 1,463,460 | -19,463 | |
1.12227 % | Nuveen LLC | 1,388,023 | 371,948 | |
1.10171 % | Columbia Threadneedle Investments (US) | 1,362,594 | 300,667 | |
1.08386 % | Norges Bank Investment Management (NBIM) | 1,340,514 | -1,439,914 | |
1.06069 % | Botha (Roelof Frederick) | 1,311,860 | 19,924 | |
0.89748 % | Avidity Partners Management LP | 1,110,000 | 211,000 | |
0.86940 % | Holocene Advisors, LP | 1,075,274 | -141,055 | |
0.85302 % | Gilder Gagnon Howe & Co. LLC | 1,055,021 | -9,110 | |
0.83460 % | Voya Investment Management LLC | 1,032,233 | -385,269 | |
0.80685 % | Charles Schwab Investment Management, Inc. | 997,909 | 68,480 | |
0.80125 % | Credit Suisse Funds AG | 990,989 | -85,950 | |
0.77961 % | Fidelity Institutional Asset Management | 964,218 | -151,355 | |
0.77881 % | Frontier Capital Management Company, LLC | 963,228 | -53,898 | |
0.77173 % | OrbiMed Advisors, LLC | 954,481 | 33,900 | |
0.73990 % | Fidelity Management & Research Company LLC | 915,111 | -32,979 | |
0.73678 % | Pictet Asset Management Ltd. | 911,250 | 125,807 | |
0.72205 % | Duquesne Family Office LLC | 893,030 | 0 | |
0.69810 % | Allspring Global Investments, LLC | 863,406 | 143,246 | |
0.69794 % | Columbia Wanger Asset Management, LLC | 863,208 | -221,610 | |
0.68744 % | Perceptive Advisors LLC | 850,225 | 632,047 | |
0.64642 % | Lord, Abbett & Co. LLC | 799,489 | 181,362 | |
0.61224 % | Goldman Sachs Asset Management, L.P. | 757,219 | 203,467 | |
0.57090 % | Driehaus Capital Management, LLC | 706,083 | -7,030 | |
0.55859 % | Eagle Health Investments LP | 690,862 | 95,168 | |
0.55410 % | D. E. Shaw & Co., L.P. | 685,315 | -28,664 | |
0.53132 % | Parametric Portfolio Associates LLC | 657,142 | 41,791 | |
0.51303 % | Mellon Investments Corporation | 634,510 | 459,488 | |
0.49603 % | Matthew Rabinowitz Grantor Retained Annuity Trust | 613,496 | 0 | |
0.48168 % | Schroder Investment Management North America Inc. | 595,743 | -236,999 | |
0.47753 % | Loomis, Sayles & Company, L.P. | 590,612 | 35,477 | |
0.42865 % | Amundi Asset Management US, Inc. | 530,158 | 22,311 | |
0.42626 % | Federated Hermes Global Investment Management Corp. | 527,200 | -5,824 | |
0.39482 % | T. Rowe Price Associates, Inc. | 488,314 | -84,697 | |
0.38406 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 475,000 | 0 | |
0.36655 % | Northern Trust Investments, Inc. | 453,344 | 34,312 | |
0.35658 % | MFS Investment Management | 441,024 | 185,340 | |
0.35334 % | Zevenbergen Capital Investments LLC | 437,014 | 4,122 | |
0.35325 % | Marshall Wace LLP | 436,901 | -377,249 | |
0.34208 % | Assenagon Asset Management S.A. | 423,080 | 314,935 | |
0.33304 % | AXA Investment Managers UK Ltd. | 411,904 | 70,537 | |
0.33082 % | Squarepoint Capital LLP | 409,162 | 265,627 | |
0.33010 % | Weatherbie Capital, LLC | 408,266 | 81,279 | |
0.32410 % | AHL Partners LLP | 400,846 | -518,235 | |
0.32357 % | Bain Capital Life Sciences Investors, LLC | 400,197 | -300,000 | |
0.32204 % | TwinBeech Capital LP | 398,299 | 36,790 | |
0.32134 % | Blue Water Life Science Advisors, LP. | 397,436 | -400,000 | |
0.32052 % | Capital World Investors | 396,421 | 0 | |
0.31628 % | JPMorgan Private Bank (United States) | 391,169 | 169,112 | |
0.31136 % | Columbia Threadneedle Investments (UK) | 385,084 | 210,082 | |
0.30024 % | Sheena (Jonathan) | 371,341 | -26,700 | |
0.30019 % | Nikko Asset Management Co., Ltd. | 371,271 | 371,271 | |
0.28479 % | SEI Investments Management Corporation | 352,230 | -21,774 | |
0.27193 % | Kornitzer Capital Management Inc. | 336,329 | -31,165 | |
0.26468 % | Balyasny Asset Management LP | 327,359 | -208,838 | |
0.26066 % | ARK Investment Management LLC | 322,384 | 31,059 | |
0.25026 % | Morgan Stanley & Co. LLC | 309,520 | 54,449 | |
0.24263 % | Macquarie Investment Management | 300,079 | 51,561 | |
0.23992 % | SEB Investment Management AB | 296,731 | -99,771 | |
0.23956 % | J.P. Morgan Securities LLC | 296,285 | 172,376 | |
0.23508 % | Neuberger Berman, LLC | 290,747 | -5,385 | |
0.22275 % | Chapman (Steven Leonard) | 275,495 | -6,816 | |
0.21924 % | BlackRock Asset Management Ireland Limited | 271,154 | -17,451 | |
0.20746 % | Bellevue Asset Management AG | 256,584 | -1,102 | |
0.19809 % | Rhenman & Partners Asset Management AB | 245,000 | -21,769 | |
0.19566 % | Candriam Belgium S.A. | 241,987 | -48,003 | |
0.19103 % | BlackRock Financial Management, Inc. | 236,263 | 93,993 | |
0.18928 % | Artemis Investment Management LLP | 234,096 | -156,895 | |
0.18773 % | Franklin Advisers, Inc. | 232,181 | 1,391 | |
0.18333 % | Morgan Stanley Smith Barney LLC | 226,743 | -5,566 | |
0.18192 % | Integral Health Asset Management, LLC | 225,000 | 25,000 | |
0.18153 % | BNY Mellon Asset Management | 224,521 | 28,715 | |
0.18113 % | Cubist Systematic Strategies, LLC | 224,026 | 144,212 | |
0.17958 % | Schweizerische Nationalbank | 222,100 | -16,600 | |
0.17950 % | Candriam Luxembourg S.A. | 222,000 | -15,000 | |
0.17558 % | GCM Grosvenor Holdings, LLC | 217,157 | 27,157 | |
0.17207 % | Jennison Associates LLC | 212,811 | 37,916 | |
0.16882 % | T. Rowe Price Investment Management, Inc. | 208,794 | -15,393 | |
0.16762 % | Citi Investment Research (US) | 207,312 | 32,844 | |
0.16562 % | Rabinowitz (Daniel A) | 204,839 | 621 | |
0.16333 % | BeaconLight Capital LLC | 202,001 | -57,864 | |
0.16278 % | Nomura Asset Management Co., Ltd. | 201,324 | -8,303 | |