7.18876 % | Samsara BioCapital, LLC | 5,161,888 | 0 | |
6.05189 % | Frazier Healthcare Partners | 4,345,559 | 80,000 | |
4.94397 % | BlackRock Institutional Trust Company, N.A. | 3,550,018 | 273,697 | |
4.22701 % | Versant Ventures | 3,035,207 | -400,000 | |
4.17798 % | Deep Track Capital LP | 3,000,000 | 0 | |
3.87812 % | The Vanguard Group, Inc. | 2,784,681 | 392,808 | |
3.70302 % | State Street Global Advisors (US) | 2,658,956 | 193,237 | |
3.55366 % | Octagon Capital Advisors LP | 2,551,703 | 0 | |
3.52914 % | Baker Bros. Advisors LP | 2,534,102 | 0 | |
2.82613 % | OrbiMed Advisors, LLC | 2,029,300 | 0 | |
2.01216 % | Suvretta Capital Management, LLC | 1,444,830 | 54,830 | |
1.76542 % | Point72 Asset Management, L.P. | 1,267,660 | -1,173,094 | |
1.72423 % | Dimensional Fund Advisors, L.P. | 1,238,080 | 124,336 | |
1.62407 % | Pictet Asset Management Ltd. | 1,166,164 | 484,052 | |
1.62001 % | Victory Capital Management Inc. | 1,163,245 | 136,182 | |
1.28982 % | Candriam Luxembourg S.A. | 926,155 | 0 | |
1.28982 % | Candriam Belgium S.A. | 926,155 | 55,000 | |
1.27674 % | Nuveen LLC | 916,765 | -44,493 | |
1.27321 % | Geode Capital Management, L.L.C. | 914,226 | 39,669 | |
1.23703 % | Assenagon Asset Management S.A. | 888,249 | -543,145 | |
1.21461 % | Vivo Capital, LLC | 872,151 | 0 | |
1.20869 % | Federated Hermes Global Investment Management Corp. | 867,900 | 867,900 | |
1.15556 % | Laurion Capital Management LP | 829,750 | 643 | |
1.14223 % | Adage Capital Management, L.P. | 820,178 | 720,178 | |
1.13925 % | Affinity Asset Advisors LLC | 818,035 | 4,037 | |
1.12312 % | Sofinnova Investments, Inc | 806,459 | 518,558 | |
1.07611 % | Driehaus Capital Management, LLC | 772,700 | -108,984 | |
1.02925 % | Davis (Jerel C) | 739,051 | 1,646 | |
1.00245 % | Rubric Capital Management LP | 719,809 | -229,357 | |
0.96094 % | EcoR1 Capital, LLC | 690,000 | 0 | |
0.89509 % | Nicholas Investment Partners, L.P. | 642,720 | 75,305 | |
0.71188 % | Citadel Advisors LLC | 511,167 | 290,148 | |
0.70679 % | Rock Springs Capital Management LP | 507,512 | 0 | |
0.68200 % | Baillie Gifford & Co. | 489,708 | 25,394 | |
0.61380 % | Millennium Management LLC | 440,738 | 41,769 | |
0.58934 % | Saturn V Capital Management LLC | 423,177 | 423,177 | |
0.53916 % | Northern Trust Investments, Inc. | 387,144 | 11,216 | |
0.53617 % | Altium Capital Management LP | 385,000 | -140,000 | |
0.53438 % | Charles Schwab Investment Management, Inc. | 383,712 | 9,225 | |
0.52309 % | Two Sigma Investments, LP | 375,608 | -90,517 | |
0.51363 % | Eventide Asset Management, LLC | 368,811 | 368,811 | |
0.50392 % | Ensign Peak Advisors, Inc. | 361,838 | 124,933 | |
0.50106 % | D. E. Shaw & Co., L.P. | 359,785 | -119,742 | |
0.47405 % | International Biotechnology Trust PLC | 340,389 | 0 | |
0.42728 % | Fidelity Management & Research Company LLC | 306,810 | -22,429 | |
0.42382 % | Norges Bank Investment Management (NBIM) | 304,326 | 304,326 | |
0.41938 % | Dobmeier (Eric L. J.D.) | 301,138 | 12,151 | |
0.39477 % | Ikarian Capital LLC | 283,464 | 0 | |
0.32841 % | Connor, Clark & Lunn Investment Management Ltd. | 235,816 | -51,468 | |
0.26934 % | Invesco Capital Management LLC | 193,400 | 13,264 | |
0.25533 % | Putnam Investment Management, L.L.C. | 183,343 | -7,200 | |
0.25299 % | Renaissance Technologies LLC | 181,662 | -37,680 | |
0.24375 % | BofA Global Research (US) | 175,023 | 35,910 | |
0.24372 % | Integral Health Asset Management, LLC | 175,000 | 175,000 | |
0.24234 % | Rafferty Asset Management LLC | 174,011 | 30,893 | |
0.22989 % | BlackRock Financial Management, Inc. | 165,075 | 1,760 | |
0.22798 % | Goldman Sachs & Company, Inc. | 163,702 | -182,336 | |
0.21260 % | BlackRock Investment Management, LLC | 152,658 | 6,369 | |
0.20998 % | Frohlich (Tom) | 150,777 | 3,103 | |
0.20834 % | Polar Asset Management Partners Inc. | 149,600 | 0 | |
0.19854 % | Woodline Partners LP | 142,563 | -166,821 | |
0.19166 % | Northern Trust Global Investments | 137,619 | 98,593 | |
0.19113 % | BNY Mellon Asset Management | 137,243 | 2,292 | |
0.19083 % | Morgan Stanley & Co. LLC | 137,025 | 5,694 | |
0.18303 % | Algert Global LLC | 131,427 | -1,430 | |
0.18296 % | Walleye Capital LLC | 131,375 | -166,009 | |
0.17959 % | ExodusPoint Capital Management, LP | 128,955 | -41,701 | |
0.17715 % | Sphera Funds Management Ltd. | 127,200 | -407,158 | |
0.15869 % | Nan Fung Group Holdings Ltd | 113,950 | 0 | |
0.14570 % | JP Morgan Asset Management | 104,622 | 15,119 | |
0.14206 % | EAM Investors, LLC | 102,007 | -21,903 | |
0.14197 % | Barclays Bank PLC | 101,941 | 9,670 | |
0.13746 % | Schweizerische Nationalbank | 98,700 | 5,200 | |
0.13620 % | UBS Asset Management (Americas), Inc. | 97,801 | -3,870 | |
0.12553 % | Balyasny Asset Management LP | 90,140 | -190,147 | |
0.12534 % | Pura Vida Investments, LLC | 90,000 | 90,000 | |
0.11379 % | Parametric Portfolio Associates LLC | 81,705 | -5,203 | |
0.11294 % | Rhumbline Advisers Ltd. Partnership | 81,093 | 4,382 | |
0.11141 % | BioImpact Capital LLC | 80,000 | 80,000 | |
0.10918 % | Nomura Asset Management Co., Ltd. | 78,400 | 78,400 | |
0.10890 % | Citi Investment Research (US) | 78,195 | -53,812 | |
0.10863 % | Soleus Capital Management, L.P. | 78,000 | 0 | |
0.09765 % | New York State Common Retirement Fund | 70,116 | 7,241 | |
0.09576 % | UBS Financial Services, Inc. | 68,764 | 45,316 | |
0.09301 % | EAM Global Investors LLC | 66,787 | -17,559 | |
0.08862 % | BlackRock Advisors (UK) Limited | 63,636 | 2,432 | |
0.08356 % | HealthCor Management, L.P. | 60,000 | -206,830 | |
0.08211 % | Baillie Gifford Overseas Ltd. | 58,957 | 0 | |
0.08168 % | Mellon Investments Corporation | 58,648 | 21,230 | |
0.08021 % | Wellington Management Company, LLP | 57,593 | 12,503 | |
0.07773 % | California State Teachers Retirement System | 55,811 | 1,952 | |
0.07584 % | BlackRock Asset Management Ireland Limited | 54,454 | 15,710 | |
0.07314 % | AllianceBernstein L.P. | 52,520 | 17,400 | |
0.06893 % | HighVista Strategies LLC | 49,495 | -34,056 | |
0.06751 % | Goldman Sachs Asset Management, L.P. | 48,474 | -8,078 | |
0.06605 % | FundLogic SAS | 47,430 | 0 | |
0.06388 % | Jump Financial, LLC | 45,868 | 2,234 | |
0.06383 % | Dimensional Fund Advisors, Ltd. | 45,833 | 0 | |
0.06341 % | Martingale Asset Management, L.P. | 45,533 | 206 | |
0.06128 % | Fisher Investments | 44,003 | -7,004 | |