2.53991 % | Matrix Capital Management Company, LP | 38,974,185 | 0 | |
1.78590 % | EcoR1 Capital, LLC | 27,404,070 | 0 | |
1.11307 % | New Enterprise Associates (NEA) | 17,079,778 | 0 | |
0.98726 % | Baillie Gifford & Co. | 15,149,203 | -722,672 | |
0.80460 % | Long Focus Capital Management LLC | 12,346,417 | 1,662,184 | |
0.68559 % | PFM Health Sciences, LP | 10,520,231 | 97,096 | |
0.36204 % | MPM Capital Inc. | 5,555,461 | 0 | |
0.33210 % | MPM BioImpact LLC | 5,095,912 | 0 | |
0.30325 % | BofA Global Research (US) | 4,653,325 | -14,462 | |
0.15807 % | Rock Springs Capital Management LP | 2,425,468 | 0 | |
0.15274 % | Baker Bros. Advisors LP | 2,343,695 | -8,443,327 | |
0.11641 % | Renaissance Technologies LLC | 1,786,341 | 394,566 | |
0.11363 % | Tang Capital Management, LLC | 1,743,619 | 300,000 | |
0.11017 % | Fidelity Management & Research Company LLC | 1,690,481 | -42,084 | |
0.10347 % | Baillie Gifford Overseas Ltd. | 1,587,784 | 0 | |
0.05081 % | Millennium Management LLC | 779,615 | -45,564 | |
0.05015 % | JPMorgan Asset Management U.K. Limited | 769,586 | -144,803 | |
0.04904 % | Bellecapital AG | 752,458 | 0 | |
0.04664 % | Redmile Group, LLC | 715,607 | 0 | |
0.03527 % | Acuitas Investments LLC | 541,201 | 2,880 | |
0.02821 % | Rathbones Investment Management Limited | 432,818 | 0 | |
0.02547 % | State Street Global Advisors (US) | 390,901 | 78,363 | |
0.02301 % | Morgan Stanley Smith Barney LLC | 353,084 | 32,554 | |
0.02223 % | Dafna Capital Management, LLC | 341,064 | 0 | |
0.01740 % | J.P. Morgan Securities LLC | 267,011 | 267,011 | |
0.01732 % | Rawcliffe Adrian | 265,806 | 184,025 | |
0.01664 % | Key Client Fiduciary Advisors, LLC | 255,359 | -8,630 | |
0.01578 % | Susquehanna International Group, LLP | 242,144 | 185,806 | |
0.01442 % | ACCI Capital Investments SGIIC, SA | 221,290 | -78,710 | |
0.01368 % | Menzel (Garry E) | 209,931 | 47,702 | |
0.01296 % | LPL Financial LLC | 198,856 | 90,000 | |
0.01070 % | Bertrand William C Jr | 164,158 | 81,805 | |
0.00944 % | Marshall Wace LLP | 144,880 | -109,133 | |
0.00931 % | Citadel Advisors LLC | 142,891 | -100,800 | |
0.00887 % | Lunger (John) | 136,156 | 87,639 | |
0.00768 % | Geode Capital Management, L.L.C. | 117,909 | 0 | |
0.00617 % | Norry (Elliot) | 94,638 | 80,721 | |
0.00575 % | BlackRock Financial Management, Inc. | 88,208 | 0 | |
0.00570 % | Morgan Stanley & Co. LLC | 87,463 | 34,997 | |
0.00541 % | CAPTRUST Financial Advisors | 83,041 | -28,911 | |
0.00536 % | BlackRock Institutional Trust Company, N.A. | 82,187 | 1,160 | |
0.00516 % | Virtu Americas LLC | 79,239 | 79,239 | |
0.00493 % | Jane Street Capital, L.L.C. | 75,576 | 75,576 | |
0.00415 % | Wells Fargo Advisors | 63,672 | 9,500 | |
0.00391 % | Renta 4 Gestora, S.G.I.I.C., S.A. | 60,026 | -10,020 | |
0.00326 % | Barclays Bank PLC | 50,061 | 0 | |
0.00289 % | AllianceBernstein L.P. | 44,364 | 2,520 | |
0.00280 % | Bank Vontobel AG | 43,000 | 30,000 | |
0.00256 % | Oppenheimer Asset Management Inc. | 39,298 | -4,534 | |
0.00228 % | FullCircle Wealth LLC | 35,000 | 35,000 | |
0.00228 % | Northern Trust Investments, Inc. | 34,969 | -1,710 | |
0.00226 % | Invesco Capital Management LLC | 34,743 | 34,743 | |
0.00222 % | Group One Trading, L.P. | 34,037 | 11,670 | |
0.00217 % | Two Sigma Investments, LP | 33,337 | -27,274 | |
0.00205 % | COLUMBIA ADVISORY PARTNERS LLC | 31,420 | 3,333 | |
0.00203 % | Main Street Financial Solutions, LLC | 31,190 | 0 | |
0.00200 % | CSS, LLC | 30,702 | 0 | |
0.00199 % | DLK Investment Management, LLC | 30,512 | 0 | |
0.00198 % | Simon Quick Advisors, LLC | 30,452 | 452 | |
0.00196 % | Janney Montgomery Scott LLC | 30,000 | 0 | |
0.00194 % | Piccina (Cintia) | 29,828 | -24,531 | |
0.00180 % | Stifel, Nicolaus & Company, Incorporated | 27,619 | 3,822 | |
0.00173 % | Prosperity Wealth Management, Inc. | 26,620 | 0 | |
0.00170 % | HSBC Global Asset Management (UK) Limited | 26,064 | 0 | |
0.00156 % | Alleva (Lawrence M) | 23,894 | 0 | |
0.00150 % | Hunter Associates Investment Management LLC | 23,000 | 0 | |
0.00110 % | Northern Trust Global Investments | 16,892 | -3,929 | |
0.00109 % | Ballentine Partners, LLC | 16,758 | 16,758 | |
0.00109 % | Rhumbline Advisers Ltd. Partnership | 16,721 | 9,599 | |
0.00105 % | Goldman Sachs & Company, Inc. | 16,119 | -91,443 | |
0.00104 % | Wood (Gavin) | 16,000 | 0 | |
0.00104 % | Aperio Group, LLC | 15,939 | -97,091 | |
0.00099 % | Osaic Holdings, Inc. | 15,258 | -4,000 | |
0.00088 % | Commonwealth Financial Network | 13,433 | -6,762 | |
0.00081 % | Brewer (Joanna Elizabeth) | 12,442 | 0 | |
0.00081 % | XTX Markets LLC | 12,399 | -3,553 | |
0.00077 % | Greenleaf Trust | 11,856 | 11,856 | |
0.00073 % | X-Square Capital, LLC | 11,180 | -12 | |
0.00070 % | Wealth Enhancement Advisory Services, LLC | 10,816 | -24,286 | |
0.00065 % | Sigal Family Investments, LLC | 10,000 | 0 | |
0.00048 % | BlackRock Investment Management (UK) Ltd. | 7,423 | 0 | |
0.00045 % | BlackRock Fund Advisors | 6,958 | 6,958 | |
0.00043 % | Signaturefd, LLC | 6,620 | 6,620 | |
0.00043 % | Goldman Sachs Asset Management International | 6,547 | 0 | |
0.00039 % | Global Retirement Partners, LLC | 6,000 | 0 | |
0.00038 % | Putnam Investment Management, L.L.C. | 5,801 | -19,595 | |
0.00030 % | Lindbrook Capital, LLC | 4,610 | -2,135 | |
0.00021 % | Quadrant Family Wealth Advisors | 3,218 | -3,035 | |
0.00020 % | Independent Financial Partners | 3,023 | 3,023 | |
0.00020 % | CIBC Private Wealth Management | 3,023 | -73,698 | |
0.00012 % | UBS Financial Services, Inc. | 1,817 | -3,879 | |
0.00007 % | Sandy Spring Bank | 1,050 | 0 | |
0.00005 % | Desjardins Securities Inc. | 785 | 0 | |
0.00004 % | J.P. Morgan Securities plc | 641 | 0 | |
0.00003 % | Carmichael Hill & Associates Inc | 525 | 0 | |
0.00002 % | HighMark Wealth Management LLC | 287 | 0 | |
0.00002 % | Parametric Portfolio Associates LLC | 285 | 0 | |
0.00002 % | Guggenheim Investments | 273 | 0 | |
0.00002 % | Parallel Advisors, LLC | 250 | 250 | |
0.00001 % | BNP Paribas Securities Corp. North America | 213 | 0 | |