9.37778 % | The Vanguard Group, Inc. | 15,730,075 | -849,902 | |
8.54053 % | Farallon Capital Management, L.L.C. | 14,325,692 | 791,000 | |
6.31386 % | Janus Henderson Investors | 10,590,727 | 400,656 | |
6.11654 % | Wellington Management Company, LLP | 10,259,738 | -1,528,183 | |
5.58311 % | Baker Bros. Advisors LP | 9,364,972 | 1,428,000 | |
4.96272 % | Fidelity Management & Research Company LLC | 8,324,353 | 919,012 | |
4.67582 % | BlackRock Institutional Trust Company, N.A. | 7,843,111 | -4,942,738 | |
4.53153 % | Nextech Invest, Ltd. | 7,601,087 | 0 | |
3.63263 % | Paradigm BioCapital Advisors LP | 6,093,291 | -84,820 | |
2.97034 % | BVF Partners L.P. | 4,982,384 | 0 | |
2.81326 % | State Street Global Advisors (US) | 4,718,906 | -1,086,013 | |
2.79561 % | T. Rowe Price Investment Management, Inc. | 4,689,298 | 3,015,869 | |
2.73004 % | Bellevue Asset Management AG | 4,579,300 | 205,000 | |
2.71066 % | T. Rowe Price Associates, Inc. | 4,546,792 | -888,076 | |
2.46413 % | Alphabet, Inc. | 4,133,277 | 0 | |
2.16585 % | Holocene Advisors, LP | 3,632,952 | -58,792 | |
2.01748 % | Deerfield Management Company, L.P. | 3,384,072 | 66,740 | |
1.78485 % | Geode Capital Management, L.L.C. | 2,993,866 | -1,148,548 | |
1.73817 % | Woodline Partners LP | 2,915,572 | -971,464 | |
1.72170 % | Casdin Capital, LLC | 2,887,933 | -810,000 | |
1.63858 % | Andreessen Horowitz | 2,748,523 | 0 | |
1.39184 % | Borisy (Alexis) | 2,334,636 | 3,142 | |
1.38510 % | JP Morgan Asset Management | 2,323,338 | -522,633 | |
1.30931 % | Lunate Capital LLC | 2,196,200 | 0 | |
1.01415 % | Norges Bank Investment Management (NBIM) | 1,701,111 | -40,928 | |
1.01349 % | Logos Global Management LP | 1,700,000 | 100,000 | |
0.98332 % | Westfield Capital Management Company, L.P. | 1,649,404 | 585,358 | |
0.95428 % | Charles Schwab Investment Management, Inc. | 1,600,693 | -329,775 | |
0.88094 % | Citadel Advisors LLC | 1,477,675 | 1,344,608 | |
0.88085 % | Goldman Sachs & Company, Inc. | 1,477,511 | 131,367 | |
0.82321 % | Millennium Management LLC | 1,380,841 | 1,224,488 | |
0.79348 % | Rock Springs Capital Management LP | 1,330,960 | 49,320 | |
0.76910 % | Jane Street Capital, L.L.C. | 1,290,075 | 952,673 | |
0.71540 % | Vestal Point Capital, LP | 1,200,000 | 1,200,000 | |
0.67130 % | Hood River Capital Management LLC | 1,126,020 | -591,028 | |
0.60330 % | Pictet Asset Management Ltd. | 1,011,960 | 264,400 | |
0.59465 % | Frazier Life Sciences Management, L.P. | 997,455 | 0 | |
0.59386 % | Dimensional Fund Advisors, L.P. | 996,124 | 622,370 | |
0.55966 % | Invus Public Equities Advisors, LLC | 938,755 | 375,000 | |
0.52372 % | Candriam Luxembourg S.A. | 878,484 | 142,939 | |
0.51527 % | Columbia Threadneedle Investments (UK) | 864,301 | -214,363 | |
0.47275 % | Boxer Capital Management, LLC | 792,977 | -525,000 | |
0.46860 % | Qube Research & Technologies Ltd | 786,017 | 602,877 | |
0.45097 % | Northern Trust Investments, Inc. | 756,452 | -660,570 | |
0.44811 % | Polar Capital LLP | 751,655 | 990 | |
0.43438 % | Goldsmith Mark A | 728,620 | 23,504 | |
0.42895 % | Candriam Belgium S.A. | 719,513 | 64,379 | |
0.40923 % | HRT Financial LP | 686,426 | 662,719 | |
0.40371 % | Dafna Capital Management, LLC | 677,176 | 21,000 | |
0.39751 % | Goldman Sachs Asset Management, L.P. | 666,768 | -143,764 | |
0.39355 % | D. E. Shaw & Co., L.P. | 660,132 | 660,132 | |
0.37966 % | Caligan Partners, LP | 636,835 | 171,835 | |
0.30319 % | MIC Capital Management UK LLP | 508,569 | 0 | |
0.30277 % | UBS Financial Services, Inc. | 507,853 | 31,246 | |
0.30262 % | TD Asset Management Inc. | 507,600 | 181,724 | |
0.28816 % | Morgan Stanley & Co. LLC | 483,345 | -489,265 | |
0.28689 % | BofA Global Research (US) | 481,221 | 131,990 | |
0.27100 % | American Century Investment Management, Inc. | 454,572 | -287,288 | |
0.27019 % | JPMorgan Asset Management U.K. Limited | 453,214 | -65,978 | |
0.24776 % | First Turn Management, LLC | 415,591 | 75,482 | |
0.23692 % | Adage Capital Management, L.P. | 397,400 | 3,400 | |
0.22191 % | Eventide Asset Management, LLC | 372,229 | 0 | |
0.22169 % | Ensign Peak Advisors, Inc. | 371,857 | -55,609 | |
0.21900 % | BNP Paribas Securities Corp. North America | 367,345 | -157,083 | |
0.21885 % | Victory Capital Management Inc. | 367,093 | 29,212 | |
0.20420 % | JPMorgan Asset Management (Europe) S.à.r.l. | 342,524 | -2,481 | |
0.20195 % | Squarepoint Capital LLP | 338,753 | 245,934 | |
0.20162 % | Partners HealthCare System, Inc | 338,191 | 0 | |
0.19375 % | Integral Health Asset Management, LLC | 325,000 | 75,000 | |
0.18822 % | MPM BioImpact LLC | 315,722 | -1,361 | |
0.18819 % | Citi Investment Research (US) | 315,662 | -293,726 | |
0.18680 % | Morgan Stanley Investment Management Inc. (US) | 313,339 | 308,858 | |
0.18110 % | Weiss Asset Management | 303,772 | 303,772 | |
0.16988 % | Comerica, Inc. | 284,959 | 91,240 | |
0.16700 % | Mellon Investments Corporation | 280,130 | 30,119 | |
0.16693 % | Checkpoint Capital L.P. | 280,000 | -112,011 | |
0.16346 % | Columbia Threadneedle Investments (US) | 274,177 | 67,783 | |
0.16058 % | BlackRock Financial Management, Inc. | 269,355 | -470,219 | |
0.15884 % | Schweizerische Nationalbank | 266,431 | -10,100 | |
0.15370 % | WCM Investment Management | 257,814 | 11,817 | |
0.15228 % | UBS Asset Management (Switzerland) | 255,423 | 133,339 | |
0.15200 % | Pzena Investment Management, LLC | 254,957 | -135,176 | |
0.15103 % | Trexquant Investment LP | 253,335 | 194,121 | |
0.14955 % | Franklin Advisers, Inc. | 250,858 | 250,858 | |
0.14521 % | Bessemer Trust Company, N.A. (US) | 243,571 | 0 | |
0.14517 % | Renaissance Technologies LLC | 243,504 | 100,700 | |
0.14465 % | Barclays Bank PLC | 242,631 | -29,155 | |
0.14238 % | Nuveen LLC | 238,822 | -220,605 | |
0.13628 % | Avidity Partners Management LP | 228,600 | 15,600 | |
0.13473 % | Decheng Capital LLC | 226,000 | 0 | |
0.12784 % | California Public Employees' Retirement System | 214,430 | 1,515 | |
0.12725 % | HSBC Global Asset Management (France) S.A. | 213,454 | 0 | |
0.12725 % | HSBC Private Bank (Suisse) S.A. | 213,454 | 0 | |
0.12442 % | BlackRock Asset Management Ireland Limited | 208,699 | -257,232 | |
0.12181 % | Edgestream Partners, L.P. | 204,313 | -11,404 | |
0.12169 % | Brevan Howard Capital Management LP | 204,120 | 204,120 | |
0.11339 % | Russell Investments Trust Company | 190,196 | -86,034 | |
0.11276 % | Columbia Wanger Asset Management, LLC | 189,147 | 0 | |
0.11079 % | Boothbay Fund Management, LLC | 185,842 | 9,981 | |
0.11069 % | Susquehanna International Group, LLP | 185,669 | -58,384 | |