47.36823 % | Artal International S.C.A. | 171,231,426 | -351,744 | |
10.70213 % | Fidelity Management & Research Company LLC | 38,687,123 | 24,793,061 | |
2.48210 % | BlackRock Institutional Trust Company, N.A. | 8,972,550 | 1,982,903 | |
2.29466 % | Braidwell LP | 8,294,950 | 8,294,950 | |
2.12319 % | The Vanguard Group, Inc. | 7,675,125 | 1,273,900 | |
1.61722 % | OrbiMed Advisors, LLC | 5,846,100 | 2,304,100 | |
1.50798 % | Ulys, L.L.C. | 5,451,204 | 0 | |
1.14006 % | Point72 Asset Management, L.P. | 4,121,191 | 3,536,805 | |
0.97270 % | Invus Public Equities Advisors, LLC | 3,516,214 | 0 | |
0.89920 % | Geode Capital Management, L.L.C. | 3,250,535 | 861,398 | |
0.66653 % | Citadel Advisors LLC | 2,409,456 | 2,274,979 | |
0.65902 % | New Enterprise Associates (NEA) | 2,382,286 | 0 | |
0.63998 % | State Street Global Advisors (US) | 2,313,477 | 325,967 | |
0.63740 % | Nantahala Capital Management, LLC | 2,304,150 | 2,304,150 | |
0.57891 % | Columbia Threadneedle Investments (US) | 2,092,710 | 674,760 | |
0.51869 % | Opaleye Management Inc. | 1,875,000 | 1,875,000 | |
0.47466 % | Pinnacle Associates Ltd. | 1,715,831 | -31,999 | |
0.37598 % | Charles Schwab Investment Management, Inc. | 1,359,148 | 478,025 | |
0.37314 % | Debbane (Raymond) | 1,348,879 | 0 | |
0.34930 % | Medical Strategy GmbH | 1,262,672 | -2,030,863 | |
0.32932 % | Marshall Wace LLP | 1,190,448 | 691,276 | |
0.30376 % | Coats (Lonnel) | 1,098,068 | 0 | |
0.25407 % | Northern Trust Investments, Inc. | 918,455 | 127,543 | |
0.20433 % | Wellington Management Company, LLP | 738,628 | 52,210 | |
0.20226 % | Hennion & Walsh Asset Management, Inc. | 731,138 | 188,239 | |
0.16524 % | Millennium Management LLC | 597,321 | 63,137 | |
0.15809 % | Schonfeld Strategic Advisors LLC | 571,492 | -388,658 | |
0.09356 % | BlackRock Investment Management, LLC | 338,198 | 89,151 | |
0.08969 % | Wade (Jeffrey L) | 324,214 | 0 | |
0.08536 % | BlackRock Financial Management, Inc. | 308,581 | 55,948 | |
0.07795 % | Goldman Sachs & Company, Inc. | 281,772 | 200,893 | |
0.07553 % | AllianceBernstein L.P. | 273,041 | 53,100 | |
0.07469 % | BBR Partners LLC | 270,000 | 240,000 | |
0.07433 % | BNY Mellon Asset Management | 268,692 | 53,050 | |
0.07074 % | Main (Alan J) | 255,724 | 0 | |
0.06941 % | LifeSci Index Partners, LLC | 250,923 | 125,063 | |
0.06871 % | Amouyal (Philippe J) | 248,364 | 0 | |
0.05931 % | Nuveen LLC | 214,399 | -307,911 | |
0.05690 % | BlackRock Asset Management Ireland Limited | 205,696 | 72,496 | |
0.05690 % | BlackRock Advisors (UK) Limited | 205,688 | 4,547 | |
0.05533 % | ACCI Capital Investments SGIIC, SA | 200,000 | 20,000 | |
0.04979 % | Virtus Etf Advisers LLC | 179,972 | -113,120 | |
0.04910 % | Crum (Brian T) | 177,497 | 0 | |
0.04796 % | Morgan Stanley & Co. LLC | 173,383 | -12,196 | |
0.04621 % | Sobecki (Christopher J) | 167,055 | 0 | |
0.04500 % | Kassler-Taub (Kenneth B) | 162,672 | 43,047 | |
0.04227 % | Rhumbline Advisers Ltd. Partnership | 152,785 | 17,940 | |
0.04070 % | UBS Financial Services, Inc. | 147,111 | -19,850 | |
0.03625 % | Assenagon Asset Management S.A. | 131,042 | -720 | |
0.03592 % | Jane Street Capital, L.L.C. | 129,856 | -151,732 | |
0.03545 % | Mellon Investments Corporation | 128,156 | 56,852 | |
0.03375 % | Caspar Asset Management S.A. | 122,000 | 122,000 | |
0.03375 % | Altium Capital Management LP | 121,986 | 121,986 | |
0.03242 % | T. Rowe Price International Ltd | 117,179 | 11,864 | |
0.03157 % | Susquehanna International Group, LLP | 114,126 | 103,283 | |
0.03008 % | Commonwealth Financial Network | 108,734 | 7,600 | |
0.02766 % | Compagnie Lombard Odier SCmA | 100,000 | 6,000 | |
0.02536 % | Goldman Sachs Asset Management, L.P. | 91,659 | 16,324 | |
0.02527 % | Parametric Portfolio Associates LLC | 91,351 | 77,491 | |
0.02442 % | Morgan Stanley Smith Barney LLC | 88,290 | 44,572 | |
0.02425 % | Barker (Samuel L) | 87,649 | 8,032 | |
0.02412 % | BofA Global Research (US) | 87,185 | 1,313 | |
0.02341 % | Simplex Trading, LLC | 84,637 | 84,637 | |
0.02187 % | Northern Trust Global Investments | 79,073 | 3,429 | |
0.02143 % | UBS Fund Management (Switzerland) AG | 77,466 | 0 | |
0.02105 % | Dimensional Fund Advisors, L.P. | 76,086 | 26,143 | |
0.01936 % | BMO Private Investment Counsel Inc. | 70,000 | 30,000 | |
0.01923 % | China Universal Asset Management Co., Ltd. | 69,527 | 27,058 | |
0.01777 % | Aperio Group, LLC | 64,230 | -3,622 | |
0.01709 % | Corebridge Financial Inc | 61,770 | 61,770 | |
0.01690 % | LPL Financial LLC | 61,085 | -28,878 | |
0.01661 % | Pathstone | 60,038 | -2,687 | |
0.01604 % | Mirae Asset Global Investments (USA) LLC | 57,975 | 57,974 | |
0.01527 % | MetLife Investment Management, LLC | 55,182 | 22,320 | |
0.01470 % | Seth (Kiernan) | 53,136 | 31,269 | |
0.01468 % | Russell Investments Trust Company | 53,080 | 3,980 | |
0.01458 % | McDermott (Wendy) | 52,694 | 24,216 | |
0.01423 % | Stifel, Nicolaus & Company, Incorporated | 51,451 | -723 | |
0.01382 % | Manulife Investment Management (North America) Limited | 49,957 | 14,411 | |
0.01354 % | JPMorgan Private Bank (United States) | 48,931 | 12,608 | |
0.01338 % | Swain (Judith L) | 48,364 | 8,032 | |
0.01338 % | Lefkowitz (Robert J) | 48,364 | 8,032 | |
0.01328 % | Vanguard Investments Australia Ltd. | 47,993 | 47,993 | |
0.01322 % | Alexander (Kristen) | 47,800 | 17,450 | |
0.01317 % | Granowitz (Craig B. M.D., Ph.D.) | 47,626 | 0 | |
0.01281 % | T. Rowe Price Associates, Inc. | 46,297 | 0 | |
0.01275 % | SG Americas Securities, L.L.C. | 46,090 | 23,893 | |
0.01263 % | SunAmerica Asset Management, LLC | 45,658 | -391 | |
0.01254 % | Victory Capital Management Inc. | 45,341 | 13,972 | |
0.01253 % | Wells Fargo Bank, N.A. | 45,301 | 14,587 | |
0.01162 % | LUNIS Verm¿gensmanagement AG | 42,000 | 0 | |
0.01148 % | J.P. Morgan Securities plc | 41,487 | -12,326 | |
0.01135 % | Nies (Alan S) | 41,046 | 9,302 | |
0.01130 % | Wedbush Securities, Inc. | 40,850 | -800 | |
0.01124 % | KWB Wealth | 40,640 | 0 | |
0.01116 % | Palantoni (Frank P) | 40,332 | 9,302 | |
0.01097 % | Voya Investment Management LLC | 39,646 | 10,677 | |
0.01091 % | Barclays Bank PLC | 39,437 | -25,182 | |
0.01022 % | Two Sigma Investments, LP | 36,927 | -152,504 | |
0.01004 % | Invesco Capital Management LLC | 36,278 | 11,874 | |