0.98684 % | Tang Capital Management, LLC | 720,000 | 720,000 | |
0.98240 % | Suvretta Capital Management, LLC | 716,759 | 0 | |
0.85726 % | Equal Talent Investments, Ltd. | 625,455 | 0 | |
0.68887 % | Avidity Partners Management LP | 502,600 | 0 | |
0.37570 % | The Vanguard Group, Inc. | 274,111 | -35,311 | |
0.32853 % | Two Sigma Investments, LP | 239,699 | -13,706 | |
0.28121 % | Sphera Funds Management Ltd. | 205,168 | 0 | |
0.26699 % | Morningside Venture Investments, Ltd. | 194,799 | -350,000 | |
0.26412 % | OrbiMed Advisors, LLC | 192,700 | 0 | |
0.25427 % | Acadian Asset Management LLC | 185,519 | 6,435 | |
0.24147 % | Affinity Asset Advisors LLC | 176,178 | 0 | |
0.14892 % | Adar1 Capital Management LLC | 108,650 | 84,988 | |
0.14398 % | Stonepine Capital Management, LLC | 105,045 | 105,045 | |
0.13525 % | Acuitas Investments LLC | 98,679 | 29,596 | |
0.13338 % | Goldman Sachs & Company, Inc. | 97,315 | 59,281 | |
0.12208 % | Berger (Franklin Milan) | 89,069 | 0 | |
0.11910 % | Ikarian Capital LLC | 86,899 | 0 | |
0.11358 % | Qiming U.S. Ventures Management, LLC | 82,871 | 0 | |
0.11306 % | BlackRock Institutional Trust Company, N.A. | 82,491 | -334,891 | |
0.10670 % | Renaissance Technologies LLC | 77,847 | -55,960 | |
0.09647 % | International Biotechnology Trust PLC | 70,383 | 70,383 | |
0.08614 % | Millennium Management LLC | 62,851 | -18,846 | |
0.07525 % | Jane Street Capital, L.L.C. | 54,906 | 52,449 | |
0.07473 % | Geode Capital Management, L.L.C. | 54,523 | -82,846 | |
0.06623 % | Citadel Advisors LLC | 48,319 | -2,637 | |
0.06082 % | BNP Paribas Securities Corp. North America | 44,372 | 17,029 | |
0.05978 % | Fowler (John Franklin) | 43,612 | 0 | |
0.05912 % | Kirk (Christopher J) | 43,135 | 0 | |
0.05695 % | Northern Trust Investments, Inc. | 41,549 | -6,618 | |
0.04802 % | Schroder Investment Management Ltd. (SIM) | 35,039 | 0 | |
0.03971 % | Susquehanna International Group, LLP | 28,972 | 23,640 | |
0.03872 % | RBF Capital, LLC | 28,252 | 28,252 | |
0.03828 % | DWS Investments UK Limited | 27,927 | 0 | |
0.03383 % | D. E. Shaw & Co., L.P. | 24,684 | -17,259 | |
0.03121 % | Y-Intercept (Hong Kong) Ltd | 22,770 | 22,770 | |
0.02549 % | State Street Global Advisors (US) | 18,594 | -93,783 | |
0.02441 % | Marquette Wealth Management | 17,806 | 0 | |
0.02146 % | Qube Research & Technologies Ltd | 15,658 | 15,658 | |
0.02063 % | Boothbay Fund Management, LLC | 15,049 | 0 | |
0.02026 % | Centiva Capital, LP | 14,780 | 14,780 | |
0.01488 % | Bridgeway Capital Management, LLC | 10,860 | 0 | |
0.01444 % | BofA Global Research (US) | 10,539 | 7,214 | |
0.01441 % | Point72 Asia (Singapore) Pte. Ltd. | 10,511 | 10,511 | |
0.01146 % | T. Rowe Price International Ltd | 8,360 | 3,593 | |
0.01127 % | Amundi Asset Management, SAS | 8,224 | 0 | |
0.01090 % | Wells Fargo Advisors | 7,951 | 1,490 | |
0.01066 % | HRT Financial LP | 7,774 | 7,774 | |
0.00873 % | Kauffman (Michael G) | 6,369 | 0 | |
0.00868 % | Charles Schwab Investment Management, Inc. | 6,336 | -16,313 | |
0.00854 % | Fidelity Management & Research Company LLC | 6,229 | 4,020 | |
0.00805 % | Mackenzie Investments | 5,871 | 5,345 | |
0.00769 % | Prosight Capital | 5,608 | -90,752 | |
0.00768 % | Paloma Partners Management Company | 5,606 | 5,606 | |
0.00631 % | Goldman Sachs Asset Management, L.P. | 4,603 | 2,166 | |
0.00609 % | Schonfeld Strategic Advisors LLC | 4,440 | 4,440 | |
0.00560 % | Squarepoint Capital LLP | 4,084 | 4,084 | |
0.00491 % | Mirae Asset Global Investments (USA) LLC | 3,579 | 959 | |
0.00489 % | Virtu Americas LLC | 3,566 | 1,317 | |
0.00482 % | SunAmerica Asset Management, LLC | 3,517 | -30 | |
0.00470 % | Northern Trust Global Investments | 3,429 | 60 | |
0.00452 % | Schiller (Mark C) | 3,301 | -669 | |
0.00408 % | Vaughan Nelson Investment Management, L.P. | 2,976 | 0 | |
0.00378 % | Rhumbline Advisers Ltd. Partnership | 2,755 | -8,189 | |
0.00370 % | Ironwood Investment Management, LLC | 2,701 | -100 | |
0.00326 % | RVW Wealth LLC | 2,377 | 0 | |
0.00316 % | Tower Research Capital LLC | 2,306 | 1,653 | |
0.00310 % | Jump Financial, LLC | 2,263 | 2,263 | |
0.00257 % | Belsky (Marc L) | 1,873 | 1,873 | |
0.00254 % | Prelude Capital Management, LLC | 1,855 | -8,225 | |
0.00229 % | Blackstone Alternative Investment Advisors LLC | 1,670 | 0 | |
0.00206 % | Retirement Capital Strategies, Inc | 1,500 | 0 | |
0.00205 % | Henig (Noreen) | 1,493 | 300 | |
0.00201 % | XTX Markets LLC | 1,464 | -208 | |
0.00173 % | Vanguard Personalized Indexing Management, LLC | 1,261 | 1,261 | |
0.00167 % | Occudo Quantitative Strategies LP | 1,215 | -1,962 | |
0.00163 % | Verition Fund Management LLC | 1,190 | 1,190 | |
0.00160 % | Point72 (DIFC) Ltd | 1,167 | 1,167 | |
0.00152 % | Avantax Advisory Services, Inc. | 1,111 | 0 | |
0.00148 % | Ground Swell Capital, LLC | 1,080 | 1,080 | |
0.00140 % | Citi Investment Research (US) | 1,021 | -539 | |
0.00137 % | Global Retirement Partners, LLC | 1,000 | 0 | |
0.00123 % | Federated MDTA LLC | 895 | -1,453 | |
0.00102 % | UBS Financial Services, Inc. | 742 | -6,409 | |
0.00088 % | Russell Investments Trust Company | 643 | 643 | |
0.00068 % | T. Rowe Price Associates, Inc. | 496 | -200 | |
0.00052 % | Simplex Trading, LLC | 379 | 286 | |
0.00050 % | Macquarie Investment Management Global Ltd. | 363 | 363 | |
0.00049 % | Morgan Stanley & Co. LLC | 356 | -9,056 | |
0.00047 % | RBC Wealth Management, International | 346 | 186 | |
0.00041 % | BlackRock Investment Management (UK) Ltd. | 299 | -141 | |
0.00040 % | Morgan Stanley & Co. International Plc | 294 | 253 | |
0.00034 % | Aperio Group, LLC | 246 | 0 | |
0.00033 % | Cutler Group, LP | 240 | 0 | |
0.00023 % | J.P. Morgan Securities plc | 167 | 0 | |
0.00021 % | JP Morgan Asset Management | 152 | 152 | |
0.00014 % | CIBC Private Wealth Management | 100 | 0 | |
0.00013 % | Osaic Holdings, Inc. | 98 | 90 | |
0.00013 % | ProFund Advisors LLC | 95 | -60 | |
0.00008 % | Morgan Stanley Investment Management Inc. (US) | 62 | 0 | |
0.00003 % | Barclays Bank PLC | 22 | -4,990 | |