6.98601 % | The Vanguard Group, Inc. | 8,710,158 | -109,771 | |
6.65590 % | Avidity Partners Management LP | 8,298,570 | 0 | |
6.54242 % | BlackRock Institutional Trust Company, N.A. | 8,157,094 | -580,111 | |
4.09223 % | Palo Alto Investors LP | 5,102,193 | -573,683 | |
3.52903 % | Chione, Ltd. | 4,400,000 | -600,000 | |
2.48749 % | Citadel Advisors LLC | 3,101,399 | -2,489 | |
1.91083 % | Geode Capital Management, L.L.C. | 2,382,428 | 95,282 | |
1.87519 % | GSA Capital Partners LLP | 2,337,985 | 1,769,687 | |
1.64724 % | State Street Global Advisors (US) | 2,053,773 | 10,768 | |
1.57553 % | Renaissance Technologies LLC | 1,964,377 | 1,233,977 | |
1.54538 % | Marshall Wace LLP | 1,926,782 | -256,419 | |
1.41898 % | BNP Paribas Securities Corp. North America | 1,769,184 | 108,286 | |
1.38292 % | Delphi Ventures L.P. | 1,724,222 | 0 | |
1.33406 % | Adage Capital Management, L.P. | 1,663,300 | 1,663,300 | |
1.23056 % | Millennium Management LLC | 1,534,264 | 416,356 | |
1.20308 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 1,500,000 | 0 | |
1.03874 % | BlackRock Financial Management, Inc. | 1,295,105 | -180,263 | |
0.97127 % | Goldman Sachs & Company, Inc. | 1,210,975 | -542,212 | |
0.90231 % | AlphaCentric Advisors LLC. | 1,125,000 | 0 | |
0.90231 % | LifeSci Fund Management LLC | 1,125,000 | 0 | |
0.88844 % | J.P. Morgan Securities LLC | 1,107,708 | 44,994 | |
0.82720 % | Tejara Capital Ltd. | 1,031,348 | -46,040 | |
0.80205 % | Parkwood LLC | 1,000,000 | 1,000,000 | |
0.77804 % | Barclays Bank PLC | 970,058 | -182,240 | |
0.73422 % | Northern Trust Investments, Inc. | 915,422 | 28,968 | |
0.64351 % | UBS O'Connor LLC | 802,327 | -74,383 | |
0.59352 % | Altium Capital Management LP | 740,000 | 0 | |
0.57162 % | DWS Investment S.A. | 712,696 | 712,696 | |
0.55226 % | Morgan Stanley & Co. LLC | 688,558 | -181,606 | |
0.49504 % | D. E. Shaw & Co., L.P. | 617,216 | -5,639 | |
0.49015 % | DWS Investments UK Limited | 611,116 | 556,081 | |
0.47974 % | AQR Capital Management, LLC | 598,142 | 96,343 | |
0.45072 % | SilverArc Capital Management, LLC | 561,955 | 0 | |
0.42564 % | Candriam Belgium S.A. | 530,694 | -610,000 | |
0.38880 % | Lombard Odier Asset Management (Europe) Ltd | 484,750 | -18,519 | |
0.37683 % | Birchview Capital, LP | 469,832 | -102,000 | |
0.36669 % | UBS Financial Services, Inc. | 457,185 | -449,460 | |
0.36285 % | Nuveen LLC | 452,406 | 0 | |
0.32082 % | Ikarian Capital LLC | 400,000 | 0 | |
0.31081 % | Los Angeles Capital Management LLC | 387,520 | -4,020 | |
0.30478 % | Macquarie Investment Management | 380,000 | 0 | |
0.26894 % | BlackRock Investment Management, LLC | 335,319 | 0 | |
0.24861 % | Columbia Threadneedle Investments (US) | 309,967 | -47,011 | |
0.24856 % | Charles Schwab Investment Management, Inc. | 309,909 | 51,000 | |
0.24767 % | Paulson (Richard A.) | 308,799 | -3,563 | |
0.24579 % | BofA Global Research (US) | 306,455 | -46,167 | |
0.23219 % | Bridgeway Capital Management, LLC | 289,500 | 0 | |
0.22815 % | Jacobs Levy Equity Management, Inc. | 284,457 | -2,127,871 | |
0.22381 % | BlackRock Asset Management Ireland Limited | 279,048 | -82,390 | |
0.22093 % | Jane Street Capital, L.L.C. | 275,460 | 275,460 | |
0.22072 % | BNY Mellon Asset Management | 275,198 | -156,448 | |
0.22061 % | Acadian Asset Management LLC | 275,059 | 275,059 | |
0.21518 % | Fidelity Management & Research Company LLC | 268,286 | 1,839 | |
0.19769 % | BlackRock Advisors (UK) Limited | 246,479 | -13,680 | |
0.18242 % | PanAgora Asset Management Inc. | 227,445 | 227,445 | |
0.18051 % | Two Sigma Investments, LP | 225,060 | 189,860 | |
0.17380 % | Atom Investors LP | 216,690 | 25,865 | |
0.17055 % | Exchange Traded Concepts, LLC | 212,638 | 96,774 | |
0.15464 % | AllianceBernstein L.P. | 192,810 | 0 | |
0.15454 % | Dafna Capital Management, LLC | 192,678 | 0 | |
0.12441 % | Newton Investment Management North America, LLC | 155,120 | 0 | |
0.12039 % | Morgan Stanley Smith Barney LLC | 150,099 | -10,257 | |
0.11277 % | Mano (Michael) | 140,602 | -3,576 | |
0.11077 % | Rhumbline Advisers Ltd. Partnership | 138,107 | -50 | |
0.10622 % | Monashee Investment Management, LLC | 132,435 | 132,435 | |
0.09734 % | Mitchener (Stephen) | 121,366 | -6,357 | |
0.09361 % | Woodline Partners LP | 116,718 | -17,394 | |
0.07279 % | LSV Asset Management | 90,760 | 0 | |
0.07231 % | SEI Investments Management Corporation | 90,160 | -4,020 | |
0.06987 % | T. Rowe Price International Ltd | 87,113 | 0 | |
0.06867 % | Goldman Sachs Asset Management, L.P. | 85,618 | -76,242 | |
0.06556 % | Boothbay Fund Management, LLC | 81,736 | 0 | |
0.06475 % | Northern Trust Global Investments | 80,725 | -18,553 | |
0.06406 % | Mason (Michael P) | 79,865 | -110,622 | |
0.06304 % | Susquehanna International Group, LLP | 78,596 | -59,213 | |
0.05889 % | SG Americas Securities, L.L.C. | 73,430 | 54,839 | |
0.05888 % | JPMorgan Private Bank (United States) | 73,412 | 68,412 | |
0.05713 % | Connor, Clark & Lunn Investment Management Ltd. | 71,224 | 35,945 | |
0.05685 % | Cheng (Sohanya Roshan) | 70,884 | -125,085 | |
0.05364 % | Mellon Investments Corporation | 66,884 | 0 | |
0.05327 % | Vident Investment Advisory, LLC | 66,422 | 66,422 | |
0.04515 % | SunAmerica Asset Management, LLC | 56,295 | -228 | |
0.04138 % | Rangwala (Reshma) | 51,595 | -304,094 | |
0.03940 % | XTX Markets LLC | 49,122 | -260,943 | |
0.03647 % | Voya Investment Management LLC | 45,471 | 0 | |
0.03632 % | HSBC Global Asset Management (UK) Limited | 45,290 | 362 | |
0.03620 % | Bohlin (Garen G.) | 45,140 | 0 | |
0.03620 % | G.W. & Wade, LLC. | 45,140 | 0 | |
0.03349 % | RBC Capital Markets Wealth Management | 41,756 | -20,844 | |
0.03254 % | T. Rowe Price Associates, Inc. | 40,572 | 3,700 | |
0.03048 % | LUNIS Vermögensmanagement AG | 38,000 | 0 | |
0.03043 % | Bleakley Financial Group LLC | 37,938 | 37,938 | |
0.03043 % | Sawtooth Asset Management, Inc. | 37,938 | 37,938 | |
0.02945 % | Poulton (Stuart) | 36,723 | -145,193 | |
0.02807 % | Kennedy Investment Group | 35,000 | 0 | |
0.02522 % | Principal Global Investors (Equity) | 31,442 | -1,396 | |
0.02444 % | Group One Trading, L.P. | 30,473 | -24,040 | |
0.02385 % | Redwood Wealth Management Group, LLC | 29,730 | -3,000 | |
0.02360 % | Florida State Board of Administration | 29,422 | 29,422 | |
0.02354 % | Wells Fargo Bank, N.A. | 29,351 | 6,682 | |