9.20905 % | Quogue Capital L.L.C. | 28,067,333 | 5,000,000 | |
8.50881 % | Perceptive Advisors LLC | 25,933,142 | 6,660,151 | |
8.50104 % | The Vanguard Group, Inc. | 25,909,463 | 1,035,344 | |
7.87358 % | MHR Fund Management LLC | 23,997,103 | 0 | |
6.08611 % | BlackRock Institutional Trust Company, N.A. | 18,549,238 | 992,616 | |
4.33164 % | State Street Global Advisors (US) | 13,201,978 | 576,801 | |
3.83883 % | Avoro Capital Advisors LLC | 11,700,000 | 0 | |
2.47654 % | Soleus Capital Management, L.P. | 7,548,000 | 4,043,000 | |
1.89859 % | Geode Capital Management, L.L.C. | 5,786,532 | 279,915 | |
1.67708 % | Artisan Partners Limited Partnership | 5,111,409 | -26,813 | |
1.48978 % | Balyasny Asset Management LP | 4,540,560 | 3,339,696 | |
1.35573 % | Long Focus Capital Management LLC | 4,132,000 | 2,731,688 | |
1.08918 % | T. Rowe Price Associates, Inc. | 3,319,593 | -1,798,388 | |
0.89652 % | Hood River Capital Management LLC | 2,732,427 | 108,189 | |
0.83216 % | Principal Global Investors (Equity) | 2,536,243 | 530,338 | |
0.81753 % | Voloridge Investment Management, LLC | 2,491,659 | -1,002,525 | |
0.77653 % | MPM BioImpact LLC | 2,366,714 | 166,714 | |
0.74334 % | Dimensional Fund Advisors, L.P. | 2,265,555 | -605,943 | |
0.73707 % | Goldman Sachs & Company, Inc. | 2,246,451 | -381,280 | |
0.69440 % | Palo Alto Investors LP | 2,116,403 | 3,592 | |
0.67900 % | BofA Global Research (US) | 2,069,446 | 537,142 | |
0.67278 % | T. Rowe Price Investment Management, Inc. | 2,050,500 | 737,161 | |
0.65127 % | Charles Schwab Investment Management, Inc. | 1,984,945 | 71,845 | |
0.63577 % | Eagle Asset Management, Inc. | 1,937,709 | 1,386,691 | |
0.63259 % | Northern Trust Investments, Inc. | 1,928,008 | -53,312 | |
0.62221 % | Morgan Stanley & Co. LLC | 1,896,365 | 286,603 | |
0.55607 % | UBS Asset Management (UK) Ltd. | 1,694,782 | 1,600,470 | |
0.55094 % | Rice Hall James & Associates, LLC | 1,679,157 | 43,132 | |
0.52892 % | Marshall Wace LLP | 1,612,055 | 1,612,055 | |
0.51034 % | Summit Partners Public Asset Management, LLC | 1,555,408 | -1,410,579 | |
0.49216 % | 683 Capital Management LLC | 1,500,000 | 275,000 | |
0.48120 % | Braidwell LP | 1,466,610 | 806,588 | |
0.42721 % | Nuveen LLC | 1,302,044 | -337,565 | |
0.41523 % | JPMorgan Asset Management U.K. Limited | 1,265,535 | -243,734 | |
0.41341 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 1,260,000 | 200,000 | |
0.40037 % | New York State Common Retirement Fund | 1,220,257 | 11,390 | |
0.36113 % | J.P. Morgan Securities LLC | 1,100,657 | 99,737 | |
0.33805 % | Jane Street Capital, L.L.C. | 1,030,312 | 9,245 | |
0.33188 % | Invus Public Equities Advisors, LLC | 1,011,500 | 1,011,500 | |
0.32537 % | Susquehanna International Group, LLP | 991,649 | -825,351 | |
0.30940 % | Norges Bank Investment Management (NBIM) | 942,983 | -177,474 | |
0.30188 % | Pictet Asset Management Ltd. | 920,077 | -2,330,477 | |
0.30186 % | Rhenman & Partners Asset Management AB | 920,000 | -35,000 | |
0.29573 % | BlackRock Financial Management, Inc. | 901,320 | -80,694 | |
0.29431 % | Opaleye Management Inc. | 897,000 | 0 | |
0.28331 % | Pictet Asset Management (Japan) Ltd. | 863,465 | 117,408 | |
0.26075 % | Orion Investment Company | 794,700 | 794,700 | |
0.25798 % | Two Sigma Investments, LP | 786,266 | 786,266 | |
0.25237 % | Schroder Investment Management Ltd. (SIM) | 769,160 | 438,377 | |
0.25215 % | BlackRock Advisors (UK) Limited | 768,513 | 14,111 | |
0.24608 % | Boxer Capital, L.L.C. | 750,000 | 0 | |
0.24316 % | JPMorgan Private Bank (United States) | 741,109 | -46,968 | |
0.24004 % | Group One Trading, L.P. | 731,607 | 243,569 | |
0.23761 % | Rafferty Asset Management LLC | 724,179 | 140,068 | |
0.23570 % | BlackRock Asset Management Ireland Limited | 718,356 | 444,162 | |
0.22752 % | Candriam Luxembourg S.A. | 693,442 | -711 | |
0.22264 % | QVT Financial LP | 678,564 | 0 | |
0.21518 % | D. E. Shaw & Co., L.P. | 655,830 | -1,696,336 | |
0.20611 % | Parametric Portfolio Associates LLC | 628,186 | -98,110 | |
0.20568 % | BlackRock Investment Management, LLC | 626,880 | 7,877 | |
0.20168 % | BNY Mellon Asset Management | 614,668 | 75,949 | |
0.18662 % | McPeak (Merrill A) | 568,783 | 10,000 | |
0.18397 % | UBS Financial Services, Inc. | 560,711 | -130,169 | |
0.17653 % | DWS Investments UK Limited | 538,013 | -15,053 | |
0.16406 % | Candriam Belgium S.A. | 500,033 | -559,109 | |
0.16405 % | Tang Capital Management, LLC | 500,000 | 0 | |
0.15585 % | Zimmer Partners, LP | 475,000 | 431,500 | |
0.15226 % | BNP Paribas Securities Corp. North America | 464,052 | 318,128 | |
0.14601 % | International Biotechnology Trust PLC | 445,000 | 380,000 | |
0.13619 % | Wells Fargo Advisors | 415,076 | 131,693 | |
0.13277 % | Mellon Investments Corporation | 404,658 | 160,785 | |
0.12614 % | Schweizerische Nationalbank | 384,456 | 5,500 | |
0.12575 % | Capital Fund Management S.A. | 383,260 | 383,260 | |
0.12101 % | Rhumbline Advisers Ltd. Partnership | 368,800 | -22,750 | |
0.11951 % | Goldman Sachs Asset Management, L.P. | 364,247 | -777,867 | |
0.11851 % | PanAgora Asset Management Inc. | 361,187 | 37,521 | |
0.11531 % | Hennion & Walsh Asset Management, Inc. | 351,449 | -16,703 | |
0.11008 % | Manulife Investment Management (North America) Limited | 335,513 | -23,475 | |
0.10829 % | AllianceBernstein L.P. | 330,032 | 14,592 | |
0.10557 % | Banque Pictet & Cie S.A. | 321,759 | -346,891 | |
0.10017 % | Nomura Asset Management Co., Ltd. | 305,301 | 9,002 | |
0.09843 % | Vestal Point Capital, LP | 300,000 | 300,000 | |
0.09839 % | Tudor Investment Corporation | 299,885 | 55,269 | |
0.09517 % | Morgan Stanley Smith Barney LLC | 290,066 | -58,167 | |
0.09347 % | TD Asset Management Inc. | 284,878 | -220,400 | |
0.09343 % | SEI Investments Management Corporation | 284,761 | -16,591 | |
0.09072 % | Abaris Investment Management AG | 276,500 | 120,000 | |
0.09066 % | Barclays Bank PLC | 276,300 | 20,947 | |
0.09020 % | Aperio Group, LLC | 274,926 | -13,782 | |
0.08567 % | Parametrica Management Ltd | 261,090 | 129,500 | |
0.08450 % | Squarepoint Capital LLP | 257,543 | 257,543 | |
0.08203 % | CM Management, LLC | 250,000 | 0 | |
0.08203 % | Hudson Bay Capital Management LP | 250,000 | 200,000 | |
0.08000 % | LPL Financial LLC | 243,839 | 3,162 | |
0.07981 % | Citadel Advisors LLC | 243,258 | -867,739 | |
0.07976 % | Arctic Fund Management AS | 243,079 | -79,000 | |
0.07970 % | Legal & General Investment Management Ltd. | 242,920 | 39,176 | |
0.07755 % | State of Wisconsin Investment Board | 236,369 | 77,089 | |
0.07595 % | Credit Suisse International | 231,493 | 54,396 | |
0.07098 % | JP Morgan Asset Management | 216,332 | -721,056 | |