7.99763 % | New Enterprise Associates (NEA) | 18,093,034 | 2,255,025 | |
5.88294 % | Invus Public Equities Advisors, LLC | 13,308,968 | 0 | |
5.19836 % | The Vanguard Group, Inc. | 11,760,251 | -3,533 | |
4.06130 % | Octagon Capital Advisors LP | 9,187,883 | 0 | |
3.56094 % | ARCH Venture Partners | 8,055,916 | 0 | |
3.50551 % | Fidelity Management & Research Company LLC | 7,930,508 | -258,639 | |
2.77465 % | Palo Alto Investors LP | 6,277,093 | -114,682 | |
2.70975 % | Samsara BioCapital, LLC | 6,130,268 | 0 | |
2.54166 % | 683 Capital Management LLC | 5,750,000 | 2,500,000 | |
2.47420 % | Millennium Management LLC | 5,597,378 | -898,042 | |
2.43115 % | SilverArc Capital Management, LLC | 5,500,000 | -630,268 | |
2.42885 % | T. Rowe Price Associates, Inc. | 5,494,794 | 2,603,789 | |
2.42564 % | Alyeska Investment Group, L.P. | 5,487,516 | 5,487,516 | |
2.42415 % | Eversept Partners, LP | 5,484,148 | -510,324 | |
2.22609 % | Hasnain's family | 5,036,073 | 540,176 | |
2.19867 % | HHLR Advisors, Ltd. | 4,974,041 | 0 | |
1.80959 % | Citadel Advisors LLC | 4,093,836 | 219,110 | |
1.72833 % | Opaleye Management Inc. | 3,910,000 | 1,469,891 | |
1.68309 % | DWS Investments UK Limited | 3,807,661 | 0 | |
1.58810 % | Acadian Asset Management LLC | 3,592,765 | 856,380 | |
1.55811 % | Platinum Asset Management | 3,524,908 | -1,169,157 | |
1.49913 % | Corient Private Wealth LLC | 3,391,483 | 119,213 | |
1.47439 % | Marshall Wace LLP | 3,335,511 | 2,103,766 | |
1.44409 % | Rock Springs Capital Management LP | 3,266,960 | 0 | |
1.35488 % | Federated Hermes Global Investment Management Corp. | 3,065,136 | 0 | |
1.24276 % | BlackRock Institutional Trust Company, N.A. | 2,811,507 | -212,140 | |
1.20501 % | Monaco asset management S.A.M. | 2,726,104 | 2,170,104 | |
1.08900 % | Laurion Capital Management LP | 2,463,647 | 162,796 | |
1.00942 % | Geode Capital Management, L.L.C. | 2,283,618 | 0 | |
0.93609 % | Goldman Sachs & Company, Inc. | 2,117,714 | -576,251 | |
0.90465 % | Renaissance Technologies LLC | 2,046,600 | 1,375,000 | |
0.63856 % | Jacobs Levy Equity Management, Inc. | 1,444,617 | -189,467 | |
0.62293 % | Dafna Capital Management, LLC | 1,409,262 | 0 | |
0.55766 % | Charles Schwab Investment Management, Inc. | 1,261,597 | 8,833 | |
0.51109 % | Schonfeld Strategic Advisors LLC | 1,156,236 | 975,678 | |
0.50121 % | Two Sigma Investments, LP | 1,133,879 | -835,592 | |
0.49847 % | Exome Asset Management LLC | 1,127,699 | 1,127,699 | |
0.38008 % | Monashee Investment Management, LLC | 859,854 | -2,600,000 | |
0.34557 % | Woodline Partners LP | 781,778 | 603,836 | |
0.34015 % | Barclays Bank PLC | 769,528 | 769,528 | |
0.31507 % | State Street Global Advisors (US) | 712,776 | 23,525 | |
0.29742 % | Nantahala Capital Management, LLC | 672,856 | 0 | |
0.28911 % | Waage (Christian) | 654,048 | 654,048 | |
0.28356 % | TD Asset Management Inc. | 641,498 | 219,238 | |
0.26420 % | Highbridge Capital Management, LLC | 597,694 | 0 | |
0.25797 % | Wellington Management Company, LLP | 583,616 | -219,179 | |
0.24400 % | Bridgeway Capital Management, LLC | 552,000 | 535,000 | |
0.23544 % | Adar1 Capital Management LLC | 532,628 | -200,000 | |
0.22102 % | Citi Investment Research (US) | 500,003 | -1,787,777 | |
0.20897 % | Giraudo (Bryan M.) | 472,747 | 269,020 | |
0.19494 % | Northern Trust Investments, Inc. | 441,015 | 54,457 | |
0.14746 % | Susquehanna International Group, LLP | 333,594 | -1,478,811 | |
0.13712 % | Manulife Investment Management (North America) Limited | 310,213 | 124,913 | |
0.12420 % | Victory Capital Management Inc. | 280,975 | -6,363 | |
0.09990 % | Smith, Moore & Company | 226,000 | 100,000 | |
0.09819 % | Sphera Funds Management Ltd. | 222,134 | -805,000 | |
0.08594 % | Aranda (Richard) | 194,430 | -1,908 | |
0.08029 % | Qube Research & Technologies Ltd | 181,638 | -478,047 | |
0.06108 % | Birchview Capital, LP | 138,176 | 0 | |
0.05317 % | Hasnain (Faheem) | 120,293 | 54,166 | |
0.05238 % | Sequoia Financial Group, LLC | 118,500 | 25,000 | |
0.04716 % | Morgan Stanley Smith Barney LLC | 106,695 | -1,535 | |
0.04369 % | T. Rowe Price International Ltd | 98,843 | 16,913 | |
0.04135 % | Financial Advocates Investment Management | 93,550 | -13,300 | |
0.04127 % | Jane Street Capital, L.L.C. | 93,354 | -228,976 | |
0.03888 % | Morgan Stanley & Co. LLC | 87,969 | -4,135,196 | |
0.03693 % | Algert Global LLC | 83,543 | 83,543 | |
0.03371 % | Carter (Laura) | 76,263 | -6,029 | |
0.02583 % | LMR Partners LLP | 58,445 | 0 | |
0.02203 % | Peterson (Caryn) | 49,833 | 0 | |
0.02164 % | State Street Global Advisors Ireland Limited | 48,954 | -178 | |
0.02127 % | Choreo, LLC | 48,111 | 48,111 | |
0.02054 % | Tudor Investment Corporation | 46,464 | 0 | |
0.01869 % | BofA Global Research (US) | 42,287 | -77,679 | |
0.01768 % | Nomura Securities Co., Ltd. | 40,000 | 40,000 | |
0.01753 % | U.S. Bancorp Asset Management, Inc. | 39,655 | 39,655 | |
0.01725 % | Sivia Capital Partners, LLC | 39,018 | 4,000 | |
0.01684 % | Daniel (Thomas O) | 38,095 | 0 | |
0.01524 % | Commonwealth Financial Network | 34,471 | 3,300 | |
0.01414 % | Milligan (Sandra) | 32,000 | 32,000 | |
0.01216 % | Homrich Berg | 27,500 | 27,500 | |
0.00972 % | Clearstead Advisors LLC | 22,000 | 0 | |
0.00894 % | BNY Mellon Asset Management | 20,218 | 0 | |
0.00884 % | Stephenson National Bank and Trust | 20,000 | 20,000 | |
0.00880 % | Silvercrest Asset Management Group LLC | 19,908 | 0 | |
0.00854 % | Wolverine Trading, LLC | 19,315 | 118 | |
0.00826 % | Tower Research Capital LLC | 18,696 | 1,398 | |
0.00720 % | Vanguard Personalized Indexing Management, LLC | 16,288 | 4,073 | |
0.00707 % | Cambridge Investment Research Advisors, Inc. | 16,000 | 0 | |
0.00685 % | Blackstone Alternative Investment Advisors LLC | 15,500 | -2,800 | |
0.00619 % | Traynor Capital Management, Inc. | 14,000 | 4,000 | |
0.00554 % | Cetera Investment Advisers LLC | 12,536 | 0 | |
0.00463 % | Graham Capital Management, L.P. | 10,484 | -8,638 | |
0.00444 % | Cetera Advisors LLC | 10,036 | 10,036 | |
0.00442 % | Moors & Cabot Inc. | 10,000 | 10,000 | |
0.00442 % | Trellis Wealth Advisors LLC | 10,000 | -5,000 | |
0.00442 % | Texas Yale Capital Corp. | 10,000 | 0 | |
0.00318 % | Cox (Russell J) | 7,200 | 0 | |
0.00309 % | Cape Investment Advisory, Inc. | 7,000 | 7,000 | |
0.00157 % | Mackenzie Investments | 3,542 | -6,953 | |