12.22467 % | Cormorant Asset Management, LP | 8,325,000 | 0 | |
7.60033 % | Suvretta Capital Management, LLC | 5,175,823 | 1,411,935 | |
5.35766 % | Franklin Advisers, Inc. | 3,648,569 | 287,636 | |
5.27374 % | Adage Capital Management, L.P. | 3,591,420 | -1,564,879 | |
4.86301 % | BlackRock Institutional Trust Company, N.A. | 3,311,710 | 819,437 | |
4.06025 % | The Vanguard Group, Inc. | 2,765,031 | 378,226 | |
3.55509 % | T. Rowe Price Associates, Inc. | 2,421,017 | 14,918 | |
3.04194 % | T. Rowe Price Investment Management, Inc. | 2,071,563 | 466,800 | |
2.43666 % | Morgan Stanley & Co. LLC | 1,659,365 | 455,210 | |
2.27830 % | EW Healthcare Partners | 1,551,521 | 0 | |
1.98903 % | Citadel Advisors LLC | 1,354,532 | -20,985 | |
1.79109 % | State Street Global Advisors (US) | 1,219,729 | 187,157 | |
1.60573 % | Octagon Capital Advisors LP | 1,093,503 | 0 | |
1.57500 % | Laurion Capital Management LP | 1,072,577 | 443,181 | |
1.51594 % | Geode Capital Management, L.L.C. | 1,032,357 | 199,720 | |
1.35438 % | TCG Crossover Management, LLC | 922,335 | 922,335 | |
1.28897 % | Deerfield Management Company, L.P. | 877,790 | 298,196 | |
1.27690 % | Columbia Threadneedle Investments (US) | 869,570 | 264,475 | |
1.14053 % | Two Sigma Investments, LP | 776,702 | 660,412 | |
1.11712 % | Goldman Sachs & Company, Inc. | 760,759 | -44,365 | |
1.03877 % | Finepoint Capital LP | 707,404 | 50,804 | |
0.98031 % | Fiera Capital Inc. | 667,592 | 3,465 | |
0.94020 % | Perceptive Advisors LLC | 640,274 | 50,628 | |
0.92624 % | Point72 Asset Management, L.P. | 630,769 | 630,769 | |
0.85274 % | Millennium Management LLC | 580,716 | -1,465,722 | |
0.82876 % | DWS Investments UK Limited | 564,383 | -201,675 | |
0.77473 % | Morgan Stanley Investment Management Inc. (US) | 527,593 | 527,376 | |
0.69934 % | Cubist Systematic Strategies, LLC | 476,250 | 425,717 | |
0.56241 % | Candriam Belgium S.A. | 383,000 | 0 | |
0.54915 % | Walleye Capital LLC | 373,974 | 187,016 | |
0.43493 % | Northern Trust Investments, Inc. | 296,190 | -2,668 | |
0.43014 % | PFM Health Sciences, LP | 292,926 | 122,055 | |
0.42616 % | Federated MDTA LLC | 290,212 | -352,964 | |
0.41529 % | SEB Investment Management AB | 282,814 | 0 | |
0.39631 % | Susquehanna International Group, LLP | 269,885 | 220,808 | |
0.38691 % | AXA Investment Managers UK Ltd. | 263,483 | 148 | |
0.36909 % | Alyeska Investment Group, L.P. | 251,348 | 103,511 | |
0.36711 % | HSBC Private Bank (Suisse) S.A. | 250,000 | 0 | |
0.34047 % | Oracle Investment Management, Inc. | 231,857 | -230,000 | |
0.32970 % | Lurker (Nancy S) | 224,524 | 3,173 | |
0.29564 % | Granahan Investment Management, LLC | 201,332 | 201,332 | |
0.27886 % | UBS Financial Services, Inc. | 189,903 | -266,723 | |
0.27828 % | BofA Global Research (US) | 189,510 | 112,273 | |
0.24861 % | Trexquant Investment LP | 169,305 | 36,812 | |
0.24055 % | Nuveen LLC | 163,816 | 7,882 | |
0.22438 % | Renaissance Technologies LLC | 152,800 | 80,900 | |
0.21219 % | BlackRock Investment Management, LLC | 144,500 | 47,871 | |
0.20873 % | Essex Investment Management Company, LLC | 142,144 | 99,606 | |
0.20843 % | BlackRock Financial Management, Inc. | 141,942 | 32,920 | |
0.20488 % | State of Wisconsin Investment Board | 139,526 | 82,142 | |
0.19794 % | Charles Schwab Investment Management, Inc. | 134,796 | 34,946 | |
0.19599 % | BNY Mellon Asset Management | 133,472 | 32,356 | |
0.18751 % | TD Asset Management Inc. | 127,694 | -15,200 | |
0.18734 % | Corient Private Wealth LLC | 127,579 | 74,681 | |
0.18373 % | Schroder Investment Management Ltd. (SIM) | 125,122 | -181,084 | |
0.17727 % | PanAgora Asset Management Inc. | 120,721 | 81,201 | |
0.17707 % | Connor, Clark & Lunn Investment Management Ltd. | 120,587 | -44,525 | |
0.17662 % | BlackRock Advisors (UK) Limited | 120,280 | 962 | |
0.17062 % | Balyasny Asset Management LP | 116,195 | 116,195 | |
0.17045 % | Jones (David Scott) | 116,079 | 6,311 | |
0.16892 % | Qube Research & Technologies Ltd | 115,037 | 109,088 | |
0.16740 % | Medical Strategy GmbH | 114,000 | -16,200 | |
0.15889 % | BlackRock Asset Management Ireland Limited | 108,205 | 52,581 | |
0.15823 % | Wellington Management Company, LLP | 107,756 | 13,195 | |
0.15040 % | Jump Financial, LLC | 102,422 | 102,422 | |
0.14947 % | Jane Street Capital, L.L.C. | 101,787 | -112,907 | |
0.14944 % | Schonfeld Strategic Advisors LLC | 101,772 | 101,772 | |
0.14905 % | Artia Global Partners LP | 101,500 | 50,000 | |
0.14717 % | Ocumension Therapeutics | 100,221 | -1 | |
0.14684 % | SilverArc Capital Management, LLC | 100,000 | -147,968 | |
0.14684 % | MYDA Advisors LLC | 100,000 | -15,000 | |
0.13671 % | Schweizerische Nationalbank | 93,100 | 6,400 | |
0.11946 % | T. Rowe Price International Ltd | 81,354 | 21,638 | |
0.11815 % | Graham Capital Management, L.P. | 80,459 | -3,900 | |
0.11282 % | Rhumbline Advisers Ltd. Partnership | 76,833 | 18,897 | |
0.10496 % | Woodstock Corporation | 71,480 | 16,093 | |
0.10152 % | DWS Investment Management Americas, Inc. | 69,136 | -528 | |
0.09992 % | Manulife Investment Management (North America) Limited | 68,043 | -8,496 | |
0.09850 % | Paggiarino Dario A | 67,080 | -76,754 | |
0.09542 % | Managed Account Advisors LLC | 64,982 | 1,714 | |
0.09241 % | Zaderej (Karen L) | 62,933 | 12,500 | |
0.08888 % | Duker (Jay S) | 60,527 | 8,607 | |
0.08777 % | Parametric Portfolio Associates LLC | 59,769 | -3,767 | |
0.08306 % | Mellon Investments Corporation | 56,562 | 20,098 | |
0.08232 % | Wells Fargo Advisors | 56,059 | -2,833 | |
0.07810 % | Dynamic Technology Lab Pte. Ltd. | 53,188 | 38,479 | |
0.07601 % | AllianceBernstein L.P. | 51,760 | 24,160 | |
0.07443 % | BlackRock Investment Management (UK) Ltd. | 50,687 | 21,869 | |
0.07406 % | Adamis (Anthony P) | 50,433 | 2,000 | |
0.07342 % | 5AM Ventures | 50,000 | 50,000 | |
0.07328 % | Corton Capital Inc | 49,905 | 38,126 | |
0.07240 % | Envestnet Asset Management, Inc. | 49,301 | 970 | |
0.07189 % | D. E. Shaw & Co., L.P. | 48,959 | 48,959 | |
0.07050 % | Barclays Bank PLC | 48,012 | -117,675 | |
0.07048 % | Bridgeway Capital Management, LLC | 48,000 | -6,100 | |
0.06972 % | Elston (George O) | 47,480 | 3,873 | |
0.06822 % | Squarepoint Capital LLP | 46,456 | -92,203 | |
0.06810 % | California State Teachers Retirement System | 46,374 | 3,099 | |
0.06510 % | Legal & General Investment Management Ltd. | 44,331 | 7,416 | |
0.06493 % | UBS Asset Management (Switzerland) | 44,216 | 44,216 | |