20.47890 % | RP Management, LLC | 34,471,927 | 2,638,593 | |
9.22169 % | PRIMECAP Management Company | 15,522,777 | 175,000 | |
5.51374 % | BlackRock Institutional Trust Company, N.A. | 9,281,231 | 3,008,931 | |
4.42595 % | The Vanguard Group, Inc. | 7,450,156 | 1,465,248 | |
4.31755 % | Rock Springs Capital Management LP | 7,267,696 | 3,460,034 | |
4.02458 % | Palo Alto Investors LP | 6,774,541 | 1,289,328 | |
3.92319 % | Platinum Asset Management | 6,603,870 | 3,780,934 | |
3.69504 % | Millennium Management LLC | 6,219,821 | 4,265,693 | |
3.35535 % | Goldman Sachs & Company, Inc. | 5,648,034 | 2,551,775 | |
2.72489 % | BofA Global Research (US) | 4,586,777 | 1,630,807 | |
2.49753 % | Citadel Advisors LLC | 4,204,066 | 3,427,731 | |
2.28016 % | Kleiner, Perkins, Caufield & Byers | 3,838,166 | 0 | |
2.03483 % | BioImpact Capital LLC | 3,425,202 | 0 | |
2.00854 % | Bay City Capital L.L.C. | 3,380,951 | 0 | |
1.91598 % | Assenagon Asset Management S.A. | 3,225,145 | 2,648,661 | |
1.73258 % | State Street Global Advisors (US) | 2,916,434 | 1,075,905 | |
1.55863 % | Fidelity Management & Research Company LLC | 2,623,632 | 1,758,259 | |
1.48519 % | Point72 Asset Management, L.P. | 2,500,000 | 2,500,000 | |
1.41625 % | Geode Capital Management, L.L.C. | 2,383,960 | 725,024 | |
1.37867 % | D. E. Shaw & Co., L.P. | 2,320,698 | 2,061,176 | |
0.89111 % | Woodline Partners LP | 1,500,000 | 1,500,000 | |
0.88803 % | Two Sigma Investments, LP | 1,494,816 | 156,789 | |
0.72170 % | Northern Trust Investments, Inc. | 1,214,833 | 378,581 | |
0.60662 % | Charles Schwab Investment Management, Inc. | 1,021,113 | 383,632 | |
0.59407 % | Baker Bros. Advisors LP | 1,000,000 | 1,000,000 | |
0.52019 % | BlackRock Asset Management Ireland Limited | 875,630 | 174,062 | |
0.48646 % | Norges Bank Investment Management (NBIM) | 818,853 | -86,712 | |
0.47348 % | CIBC Private Wealth Management | 797,000 | -85,000 | |
0.46115 % | Morgan Stanley & Co. LLC | 776,255 | 31,671 | |
0.43924 % | Frazier Healthcare Partners | 739,369 | 0 | |
0.39909 % | Renaissance Technologies LLC | 671,788 | 162,600 | |
0.27793 % | GSA Capital Partners LLP | 467,836 | 343,336 | |
0.27189 % | AQR Capital Management, LLC | 457,670 | 439,427 | |
0.27059 % | BNP Paribas Securities Corp. North America | 455,486 | -27,308 | |
0.26999 % | Redmile Group, LLC | 454,475 | 0 | |
0.19724 % | Hennion & Walsh Asset Management, Inc. | 332,004 | -10,823 | |
0.19432 % | Schweizerische Nationalbank | 327,100 | 170,100 | |
0.19212 % | Mott (David M) | 323,387 | 16,156 | |
0.18798 % | BlackRock Investment Management, LLC | 316,432 | 45,493 | |
0.17506 % | Acadian Asset Management LLC | 294,671 | 294,671 | |
0.17353 % | Nuveen LLC | 292,102 | 7,244 | |
0.17086 % | BNY Mellon Asset Management | 287,611 | 62,230 | |
0.15992 % | Bridgeway Capital Management, LLC | 269,200 | 269,200 | |
0.14852 % | NewGen Asset Management Limited | 250,000 | 250,000 | |
0.13093 % | BlackRock Financial Management, Inc. | 220,401 | 27,207 | |
0.12974 % | Tudor Investment Corporation | 218,384 | 75,737 | |
0.12072 % | Macquarie Investment Management | 203,200 | 0 | |
0.10779 % | California State Teachers Retirement System | 181,440 | 72,569 | |
0.10465 % | DWS Investments UK Limited | 176,158 | 121,662 | |
0.09686 % | NISA Investment Advisors, L.L.C. | 163,050 | 162,000 | |
0.09319 % | Susquehanna International Group, LLP | 156,867 | -158,595 | |
0.09227 % | Bazemore (Robert B) | 155,322 | 82,298 | |
0.08643 % | JP Morgan Asset Management | 145,484 | -3,308 | |
0.08540 % | Foresite Capital Management, LLC | 143,759 | -690,002 | |
0.08382 % | T. Rowe Price Associates, Inc. | 141,097 | 83,839 | |
0.08149 % | Mellon Investments Corporation | 137,165 | 51,224 | |
0.07727 % | Rhumbline Advisers Ltd. Partnership | 130,067 | 17,351 | |
0.07394 % | Northern Trust Global Investments | 124,455 | 47,395 | |
0.07362 % | Jane Street Capital, L.L.C. | 123,930 | -68,350 | |
0.07129 % | State of Wisconsin Investment Board | 120,000 | 0 | |
0.07022 % | Jennison Associates LLC | 118,200 | 97,200 | |
0.06847 % | Numeric Investors LLC | 115,254 | 115,254 | |
0.06719 % | UBS Asset Management (UK) Ltd. | 113,096 | 81,004 | |
0.06689 % | PGIM Quantitative Solutions LLC | 112,590 | 10,550 | |
0.06429 % | Credit Suisse Asset Management | 108,218 | 18,125 | |
0.06061 % | Mercer Global Investments Management Ltd | 102,029 | 0 | |
0.05906 % | Caxton Associates LP | 99,409 | 69,109 | |
0.05828 % | ExodusPoint Capital Management, LP | 98,107 | -261,365 | |
0.05727 % | AllianceBernstein L.P. | 96,400 | 297 | |
0.05644 % | LUNIS Vermögensmanagement AG | 95,000 | 0 | |
0.05591 % | Goldman Sachs Asset Management, L.P. | 94,106 | -52,966 | |
0.05416 % | Los Angeles Capital Management And Equity Research, Inc. | 91,173 | 88,793 | |
0.05186 % | Voya Investment Management LLC | 87,293 | 51,891 | |
0.05003 % | JPMorgan Private Bank (United States) | 84,209 | 33,332 | |
0.04767 % | BlackRock Advisors (UK) Limited | 80,246 | -779,015 | |
0.04456 % | Alpine Global Management, LLC | 75,000 | 25,608 | |
0.04283 % | Mirabella Financial Services LLP | 72,100 | 72,100 | |
0.04227 % | SunAmerica Asset Management, LLC | 71,149 | 22,537 | |
0.04202 % | BlackRock Investment Management (UK) Ltd. | 70,724 | 0 | |
0.04159 % | Virtu Americas LLC | 70,012 | 27,262 | |
0.04111 % | UBS Asset Management (Switzerland) | 69,197 | 0 | |
0.04105 % | XTX Markets LLC | 69,097 | 58,341 | |
0.03223 % | Conroy (Kevin T) | 54,258 | 10,204 | |
0.03203 % | Legal & General Investment Management Ltd. | 53,909 | -8,858 | |
0.03084 % | Manulife Investment Management (North America) Limited | 51,916 | 1,010 | |
0.03029 % | New York State Common Retirement Fund | 50,980 | -8 | |
0.02974 % | Agarwal (Shefali) | 50,060 | -35,753 | |
0.02970 % | FNY Investment Advisers LLC | 50,000 | 50,000 | |
0.02963 % | Lazard Asset Management, L.L.C. | 49,878 | 49,878 | |
0.02864 % | Invesco Advisers, Inc. | 48,217 | 11,068 | |
0.02806 % | Ros (Matthew) | 47,229 | -10,747 | |
0.02735 % | Beveridge (Roy A M.D.) | 46,037 | 8,928 | |
0.02710 % | Graham Capital Management, L.P. | 45,622 | -28,597 | |
0.02583 % | ProShare Advisors LLC | 43,486 | 8,868 | |
0.02562 % | Wedbush Securities, Inc. | 43,133 | 0 | |
0.02378 % | Morgan Stanley Smith Barney LLC | 40,030 | -1,597 | |
0.02234 % | Principal Global Investors (Equity) | 37,606 | 9,809 | |
0.02222 % | Arizona State Retirement System | 37,398 | 18,134 | |
0.02213 % | Florida State Board of Administration | 37,251 | -25,876 | |
0.02093 % | Northern Trust Global Investments Limited | 35,234 | 0 | |