6.59065 % | Driehaus Capital Management, LLC | 6,112,173 | 885,876 | |
5.97123 % | BlackRock Institutional Trust Company, N.A. | 5,537,719 | 678,474 | |
4.98211 % | Wellington Management Company, LLP | 4,620,413 | 1,648,831 | |
4.85250 % | The Vanguard Group, Inc. | 4,500,205 | 938,224 | |
4.65743 % | T. Rowe Price Associates, Inc. | 4,319,300 | 577,695 | |
4.48067 % | EcoR1 Capital, LLC | 4,155,375 | 0 | |
3.78798 % | Fidelity Management & Research Company LLC | 3,512,976 | -399,881 | |
3.06069 % | State Street Global Advisors (US) | 2,838,484 | 25,561 | |
2.99855 % | Point72 Asset Management, L.P. | 2,780,856 | -2,168,630 | |
2.99778 % | Jennison Associates LLC | 2,780,144 | -37,710 | |
2.71005 % | Paradigm BioCapital Advisors LP | 2,513,302 | -611,447 | |
2.64790 % | Janus Henderson Investors | 2,455,661 | 477,489 | |
1.80978 % | Geode Capital Management, L.L.C. | 1,678,387 | 276,984 | |
1.59177 % | Perceptive Advisors LLC | 1,476,203 | 0 | |
1.45568 % | Cormorant Asset Management, LP | 1,350,000 | 200,000 | |
1.45267 % | T. Rowe Price Investment Management, Inc. | 1,347,210 | -1,307,519 | |
1.38107 % | OrbiMed Advisors, LLC | 1,280,800 | -104,200 | |
1.29449 % | First Light Asset Management, LLC | 1,200,508 | -489,669 | |
1.25004 % | Struthers (Richard Scott) | 1,159,290 | 0 | |
1.14952 % | Invus Public Equities Advisors, LLC | 1,066,064 | -324,413 | |
1.07828 % | Novo Holdings A/S | 1,000,000 | 0 | |
0.95743 % | Lord, Abbett & Co. LLC | 887,921 | -76,647 | |
0.92865 % | Franklin Advisers, Inc. | 861,226 | 448,213 | |
0.86932 % | Medical Strategy GmbH | 806,205 | 46,400 | |
0.80299 % | Morgan Stanley & Co. LLC | 744,690 | 228,099 | |
0.79263 % | Eventide Asset Management, LLC | 735,088 | -324,545 | |
0.70472 % | Schonfeld Strategic Advisors LLC | 653,557 | 518,264 | |
0.66447 % | Ensign Peak Advisors, Inc. | 616,227 | -5,280 | |
0.64379 % | Charles Schwab Investment Management, Inc. | 597,049 | 118,517 | |
0.63491 % | Ikarian Capital LLC | 588,818 | -54,933 | |
0.62952 % | Fidelity Institutional Asset Management | 583,819 | 33,000 | |
0.60080 % | MPM BioImpact LLC | 557,184 | 76,596 | |
0.59424 % | StemPoint Capital LP | 551,095 | -68,694 | |
0.58956 % | Dimensional Fund Advisors, L.P. | 546,759 | -94,043 | |
0.58900 % | BNP Paribas Asset Management USA, Inc. | 546,234 | 3,526 | |
0.58217 % | Northern Trust Investments, Inc. | 539,908 | 6,577 | |
0.55532 % | Affinity Asset Advisors LLC | 515,000 | 45,000 | |
0.53591 % | Farallon Capital Management, L.L.C. | 497,000 | 492,000 | |
0.51723 % | Saturn V Capital Management LP | 479,681 | -180,462 | |
0.51017 % | Fiera Capital Inc. | 473,128 | 3,094 | |
0.47948 % | Fisher Investments | 444,670 | 8,647 | |
0.47077 % | BNP Paribas Asset Management UK Limited | 436,593 | 0 | |
0.44246 % | Hood River Capital Management LLC | 410,342 | 410,342 | |
0.43131 % | Integral Health Asset Management, LLC | 400,000 | 75,000 | |
0.42616 % | Nuveen LLC | 395,218 | -104,784 | |
0.42155 % | Qube Research & Technologies Ltd | 390,941 | 296,074 | |
0.40723 % | GW&K Investment Management, LLC | 377,663 | -10,403 | |
0.40466 % | Goldman Sachs & Company, Inc. | 375,285 | -154,533 | |
0.39821 % | First Turn Management, LLC | 369,302 | 369,302 | |
0.37823 % | Laurion Capital Management LP | 350,766 | -279,416 | |
0.34839 % | Putnam Investment Management, L.L.C. | 323,095 | 107,200 | |
0.33990 % | Walleye Capital LLC | 315,220 | 73,858 | |
0.33319 % | Duquesne Family Office LLC | 309,000 | 0 | |
0.32442 % | Pictet Asset Management Ltd. | 300,868 | 291,501 | |
0.31206 % | Rock Springs Capital Management LP | 289,400 | 0 | |
0.29791 % | BlackRock Financial Management, Inc. | 276,286 | 72,182 | |
0.29535 % | Goldman Sachs Asset Management, L.P. | 273,905 | -60,384 | |
0.25879 % | Ghost Tree Capital, LLC | 240,000 | 40,000 | |
0.24791 % | Voya Investment Management LLC | 229,909 | 180,651 | |
0.24443 % | Victory Capital Management Inc. | 226,687 | -30,458 | |
0.24146 % | JP Morgan Asset Management | 223,928 | -89,374 | |
0.22105 % | TD Asset Management Inc. | 204,998 | -30,200 | |
0.21680 % | BlackRock Investment Management, LLC | 201,059 | 20,536 | |
0.21679 % | Adage Capital Management, L.P. | 201,048 | -431,085 | |
0.21238 % | First Trust Advisors L.P. | 196,961 | 95,224 | |
0.20448 % | BNY Mellon Asset Management | 189,636 | 39,184 | |
0.19726 % | UBS Financial Services, Inc. | 182,942 | -64,861 | |
0.19479 % | BofA Global Research (US) | 180,646 | -51,886 | |
0.19257 % | MFS Investment Management | 178,593 | -937 | |
0.18007 % | PGIM Securities Investment Trust Enterprise | 167,000 | 39,700 | |
0.17253 % | Maplelane Capital, LLC | 160,000 | 160,000 | |
0.17032 % | Decheng Capital LLC | 157,958 | 0 | |
0.16274 % | Boothbay Fund Management, LLC | 150,924 | -11,602 | |
0.15925 % | New York State Common Retirement Fund | 147,691 | -19,051 | |
0.15843 % | Mellon Investments Corporation | 146,927 | 55,025 | |
0.15244 % | Parkman Healthcare Partners LLC | 141,375 | 40,256 | |
0.15226 % | Marshall Wace LLP | 141,204 | 141,204 | |
0.15204 % | New Leaf Venture Partners LLC | 141,000 | 0 | |
0.15002 % | Moody Aldrich Partners, LLC | 139,130 | -11,053 | |
0.14949 % | BlackRock Advisors (UK) Limited | 138,637 | 2,079 | |
0.14697 % | Invesco Capital Management LLC | 136,302 | 3,848 | |
0.14572 % | Acuta Capital Partners, LLC | 135,141 | 56,738 | |
0.14557 % | Senator Investment Group LP | 135,000 | 135,000 | |
0.14233 % | DWS Investment GmbH | 132,000 | 11,099 | |
0.14230 % | UBS Asset Management (Americas), Inc. | 131,965 | -1,086 | |
0.14132 % | Manulife Investment Management (North America) Limited | 131,063 | 23,398 | |
0.14050 % | Schweizerische Nationalbank | 130,300 | 3,800 | |
0.13556 % | AHL Partners LLP | 125,714 | 125,714 | |
0.13142 % | Citadel Advisors LLC | 121,879 | -49,545 | |
0.12926 % | Jane Street Capital, L.L.C. | 119,880 | 82,956 | |
0.12543 % | ExodusPoint Capital Management, LP | 116,322 | 87,203 | |
0.12443 % | Arctic Fund Management AS | 115,400 | -47,690 | |
0.12361 % | Balyasny Asset Management LP | 114,637 | 114,637 | |
0.12111 % | Rhumbline Advisers Ltd. Partnership | 112,319 | 3,626 | |
0.12095 % | Rafferty Asset Management LLC | 112,169 | -104,680 | |
0.11928 % | Wilson (Marc) | 110,620 | 0 | |
0.11780 % | Wierenga (Wendell) | 109,246 | 3,400 | |
0.11704 % | Pier Capital, LLC | 108,545 | -8,025 | |
0.11206 % | Baker Bros. Advisors LP | 103,927 | 103,927 | |
0.10752 % | Neuberger Berman, LLC | 99,713 | 27,659 | |