| 8,41495 % | The Vanguard Group, Inc. | 15.730.075 | -849.902 | 30/06/2025 |
| 7,66367 % | Farallon Capital Management, L.L.C. | 14.325.692 | 791.000 | 30/06/2025 |
| 5,66561 % | Janus Henderson Investors | 10.590.727 | 400.656 | 30/06/2025 |
| 5,48855 % | Wellington Management Company, LLP | 10.259.738 | -1.528.183 | 30/06/2025 |
| 5,00988 % | Baker Bros. Advisors LP | 9.364.972 | 1.428.000 | 30/06/2025 |
| 4,45319 % | Fidelity Management & Research Company LLC | 8.324.353 | 919.012 | 30/06/2025 |
| 4,19575 % | BlackRock Institutional Trust Company, N.A. | 7.843.111 | -4.942.738 | 30/06/2025 |
| 4,06627 % | Nextech Invest, Ltd. | 7.601.087 | 0 | 30/06/2025 |
| 3,25966 % | Paradigm BioCapital Advisors LP | 6.093.291 | -84.820 | 30/06/2025 |
| 2,66537 % | BVF Partners L.P. | 4.982.384 | 0 | 30/06/2025 |
| 2,52442 % | State Street Investment Management (US) | 4.718.906 | -1.086.013 | 30/06/2025 |
| 2,50859 % | T. Rowe Price Investment Management, Inc. | 4.689.298 | 3.015.869 | 30/06/2025 |
| 2,44974 % | Bellevue Asset Management AG | 4.579.300 | 205.000 | 30/06/2025 |
| 2,43235 % | T. Rowe Price Associates, Inc. | 4.546.792 | -888.076 | 30/06/2025 |
| 2,21114 % | Alphabet, Inc. | 4.133.277 | 0 | 30/06/2025 |
| 1,94348 % | Holocene Advisors, LP | 3.632.952 | -58.792 | 30/06/2025 |
| 1,81034 % | Deerfield Management Company, L.P. | 3.384.072 | 66.740 | 30/06/2025 |
| 1,60160 % | Geode Capital Management, L.L.C. | 2.993.866 | -1.148.548 | 30/06/2025 |
| 1,55971 % | Woodline Partners LP | 2.915.572 | -971.464 | 30/06/2025 |
| 1,54493 % | Casdin Capital, LLC | 2.887.933 | -810.000 | 30/06/2025 |
| 1,47035 % | Andreessen Horowitz | 2.748.523 | 0 | 30/06/2025 |
| 1,24894 % | Borisy (Alexis) | 2.334.636 | 3.142 | 26/06/2025 |
| 1,24289 % | JP Morgan Asset Management | 2.323.338 | -522.633 | 30/06/2025 |
| 1,17488 % | Lunate Capital LLC | 2.196.200 | 0 | 30/06/2025 |
| 0,91003 % | Norges Bank Investment Management (NBIM) | 1.701.111 | -40.928 | 30/06/2025 |
| 0,90943 % | Logos Global Management LP | 1.700.000 | 100.000 | 30/06/2025 |
| 0,88236 % | Westfield Capital Management Company, L.P. | 1.649.404 | 585.358 | 30/06/2025 |
| 0,85631 % | Charles Schwab Investment Management, Inc. | 1.600.693 | -329.775 | 30/06/2025 |
| 0,79050 % | Citadel Advisors LLC | 1.477.675 | 1.344.608 | 30/06/2025 |
| 0,79041 % | Goldman Sachs & Company, Inc. | 1.477.511 | 131.367 | 30/06/2025 |
| 0,73869 % | Millennium Management LLC | 1.380.841 | 1.224.488 | 30/06/2025 |
| 0,71201 % | Rock Springs Capital Management LP | 1.330.960 | 49.320 | 30/06/2025 |
| 0,69014 % | Jane Street Capital, L.L.C. | 1.290.075 | 952.673 | 30/06/2025 |
| 0,64195 % | Vestal Point Capital, LP | 1.200.000 | 1.200.000 | 30/06/2025 |
| 0,60238 % | Hood River Capital Management LLC | 1.126.020 | -591.028 | 30/06/2025 |
| 0,54136 % | Pictet Asset Management Ltd. | 1.011.960 | 264.400 | 30/06/2025 |
| 0,53712 % | Candriam Luxembourg S.A. | 1.004.033 | 89.152 | 30/09/2025 |
| 0,53360 % | Frazier Life Sciences Management, L.P. | 997.455 | 0 | 30/06/2025 |
| 0,53289 % | Dimensional Fund Advisors, L.P. | 996.124 | 622.370 | 30/06/2025 |
| 0,50220 % | Invus Public Equities Advisors, LLC | 938.755 | 375.000 | 30/06/2025 |
| 0,46237 % | Columbia Threadneedle Investments (UK) | 864.301 | -214.363 | 30/06/2025 |
| 0,42421 % | Boxer Capital Management, LLC | 792.977 | -525.000 | 30/06/2025 |
| 0,42049 % | Qube Research & Technologies Ltd | 786.017 | 602.877 | 30/06/2025 |
| 0,40467 % | Northern Trust Investments, Inc. | 756.452 | -660.570 | 30/06/2025 |
| 0,40211 % | Polar Capital LLP | 751.655 | 990 | 30/06/2025 |
| 0,38491 % | Candriam Belgium S.A. | 719.513 | 64.379 | 30/06/2025 |
| 0,38261 % | Goldsmith Mark A | 715.209 | 0 | 17/10/2025 |
| 0,36721 % | HRT Financial LP | 686.426 | 662.719 | 30/06/2025 |
| 0,36226 % | Dafna Capital Management, LLC | 677.176 | 21.000 | 30/06/2025 |
| 0,35669 % | Goldman Sachs Asset Management, L.P. | 666.768 | -143.764 | 30/06/2025 |
| 0,35314 % | D. E. Shaw & Co., L.P. | 660.132 | 660.132 | 30/06/2025 |
| 0,34068 % | Caligan Partners, LP | 636.835 | 171.835 | 30/06/2025 |
| 0,27320 % | Medical Strategy GmbH | 510.700 | 0 | 31/07/2025 |
| 0,27206 % | MIC Capital Management UK LLP | 508.569 | 0 | 30/06/2025 |
| 0,27168 % | UBS Financial Services, Inc. | 507.853 | 31.246 | 30/06/2025 |
| 0,27155 % | TD Asset Management Inc. | 507.600 | 181.724 | 30/06/2025 |
| 0,25857 % | Morgan Stanley & Co. LLC | 483.345 | -489.265 | 30/06/2025 |
| 0,25743 % | BofA Global Research (US) | 481.221 | 131.990 | 30/06/2025 |
| 0,24318 % | American Century Investment Management, Inc. | 454.572 | -287.288 | 30/06/2025 |
| 0,24245 % | JPMorgan Asset Management U.K. Limited | 453.214 | -65.978 | 30/06/2025 |
| 0,22232 % | First Turn Management, LLC | 415.591 | 75.482 | 30/06/2025 |
| 0,21259 % | Adage Capital Management, L.P. | 397.400 | 3.400 | 30/06/2025 |
| 0,20924 % | JPMorgan Asset Management (Europe) S.à.r.l. | 391.125 | 40.466 | 30/09/2025 |
| 0,19913 % | Eventide Asset Management, LLC | 372.229 | 0 | 30/06/2025 |
| 0,19893 % | Ensign Peak Advisors, Inc. | 371.857 | -55.609 | 30/06/2025 |
| 0,19651 % | BNP Paribas Securities Corp. North America | 367.345 | -157.083 | 30/06/2025 |
| 0,19638 % | Victory Capital Management Inc. | 367.093 | 29.212 | 30/06/2025 |
| 0,18122 % | Squarepoint Capital LLP | 338.753 | 245.934 | 30/06/2025 |
| 0,18092 % | Partners HealthCare System, Inc | 338.191 | 0 | 30/09/2024 |
| 0,17386 % | Integral Health Asset Management, LLC | 325.000 | 75.000 | 30/06/2025 |
| 0,16890 % | MPM BioImpact LLC | 315.722 | -1.361 | 30/06/2025 |
| 0,16887 % | Citi Investment Research (US) | 315.662 | -293.726 | 30/06/2025 |
| 0,16762 % | Morgan Stanley Investment Management Inc. (US) | 313.339 | 308.858 | 30/06/2025 |
| 0,16251 % | Weiss Asset Management | 303.772 | 303.772 | 30/06/2025 |
| 0,15244 % | Comerica, Inc. | 284.959 | 91.240 | 30/06/2025 |
| 0,14986 % | Mellon Investments Corporation | 280.130 | 30.119 | 30/06/2025 |
| 0,14979 % | Checkpoint Capital L.P. | 280.000 | -112.011 | 30/06/2025 |
| 0,14667 % | Columbia Threadneedle Investments (US) | 274.177 | 67.783 | 30/06/2025 |
| 0,14409 % | BlackRock Financial Management, Inc. | 269.355 | -470.219 | 30/06/2025 |
| 0,14253 % | Schweizerische Nationalbank | 266.431 | -10.100 | 30/06/2025 |
| 0,13792 % | WCM Investment Management | 257.814 | 11.817 | 30/06/2025 |
| 0,13664 % | UBS Asset Management (Switzerland) | 255.423 | 133.339 | 30/06/2025 |
| 0,13639 % | Pzena Investment Management, LLC | 254.957 | -135.176 | 30/06/2025 |
| 0,13552 % | Trexquant Investment LP | 253.335 | 194.121 | 30/06/2025 |
| 0,13420 % | Franklin Advisers, Inc. | 250.858 | 250.858 | 30/06/2025 |
| 0,13030 % | Bessemer Trust Company, N.A. (US) | 243.571 | 0 | 30/06/2025 |
| 0,13026 % | Renaissance Technologies LLC | 243.504 | 100.700 | 30/06/2025 |
| 0,12980 % | Barclays Bank PLC | 242.631 | -29.155 | 30/06/2025 |
| 0,12776 % | Nuveen LLC | 238.822 | -220.605 | 30/06/2025 |
| 0,12229 % | Avidity Partners Management LP | 228.600 | 15.600 | 30/06/2025 |
| 0,12090 % | Decheng Capital LLC | 226.000 | 0 | 30/06/2025 |
| 0,11471 % | California Public Employees' Retirement System | 214.430 | 1.515 | 30/06/2025 |
| 0,11419 % | HSBC Global Asset Management (France) S.A. | 213.454 | 0 | 30/06/2025 |
| 0,11327 % | HSBC Private Bank (Suisse) S.A. | 211.729 | -1.725 | 31/08/2025 |
| 0,11165 % | BlackRock Asset Management Ireland Limited | 208.699 | -257.232 | 30/06/2025 |
| 0,10930 % | Edgestream Partners, L.P. | 204.313 | -11.404 | 30/06/2025 |
| 0,10920 % | Brevan Howard Capital Management LP | 204.120 | 204.120 | 30/06/2025 |
| 0,10175 % | Russell Investments Trust Company | 190.196 | -86.034 | 30/06/2025 |
| 0,10119 % | Columbia Wanger Asset Management, LLC | 189.147 | 0 | 30/06/2025 |
| 0,09942 % | Boothbay Fund Management, LLC | 185.842 | 9.981 | 30/06/2025 |