7,18876 % | Samsara BioCapital, LLC | 5.161.888 | 0 | 31. 12. 2022. |
6,05189 % | Frazier Healthcare Partners | 4.345.559 | 80.000 | 31. 12. 2022. |
4,94397 % | BlackRock Institutional Trust Company, N.A. | 3.550.018 | 273.697 | 31. 12. 2022. |
4,22701 % | Versant Ventures | 3.035.207 | −400.000 | 01. 03. 2023. |
4,17798 % | Deep Track Capital LP | 3.000.000 | 0 | 31. 12. 2022. |
3,87812 % | The Vanguard Group, Inc. | 2.784.681 | 392.808 | 31. 12. 2022. |
3,70302 % | State Street Global Advisors (US) | 2.658.956 | 193.237 | 31. 12. 2022. |
3,55366 % | Octagon Capital Advisors LP | 2.551.703 | 0 | 31. 12. 2022. |
3,52914 % | Baker Bros. Advisors LP | 2.534.102 | 0 | 31. 12. 2022. |
2,82613 % | OrbiMed Advisors, LLC | 2.029.300 | 0 | 31. 12. 2022. |
2,01216 % | Suvretta Capital Management, LLC | 1.444.830 | 54.830 | 31. 12. 2022. |
1,76542 % | Point72 Asset Management, L.P. | 1.267.660 | −1.173.094 | 31. 12. 2022. |
1,72423 % | Dimensional Fund Advisors, L.P. | 1.238.080 | 124.336 | 31. 12. 2022. |
1,62407 % | Pictet Asset Management Ltd. | 1.166.164 | 484.052 | 31. 12. 2022. |
1,62001 % | Victory Capital Management Inc. | 1.163.245 | 136.182 | 31. 12. 2022. |
1,28982 % | Candriam Luxembourg S.A. | 926.155 | 0 | 31. 01. 2023. |
1,28982 % | Candriam Belgium S.A. | 926.155 | 55.000 | 31. 12. 2022. |
1,27674 % | Nuveen LLC | 916.765 | −44.493 | 31. 12. 2022. |
1,27321 % | Geode Capital Management, L.L.C. | 914.226 | 39.669 | 31. 12. 2022. |
1,23703 % | Assenagon Asset Management S.A. | 888.249 | −543.145 | 31. 12. 2022. |
1,21461 % | Vivo Capital, LLC | 872.151 | 0 | 31. 12. 2022. |
1,20869 % | Federated Hermes Global Investment Management Corp. | 867.900 | 867.900 | 31. 12. 2022. |
1,15556 % | Laurion Capital Management LP | 829.750 | 643 | 31. 12. 2022. |
1,14223 % | Adage Capital Management, L.P. | 820.178 | 720.178 | 31. 12. 2022. |
1,13925 % | Affinity Asset Advisors LLC | 818.035 | 4.037 | 31. 12. 2022. |
1,12312 % | Sofinnova Investments, Inc | 806.459 | 518.558 | 31. 12. 2022. |
1,07611 % | Driehaus Capital Management, LLC | 772.700 | −108.984 | 31. 12. 2022. |
1,02925 % | Davis (Jerel C) | 739.051 | 1.646 | 22. 12. 2022. |
1,00245 % | Rubric Capital Management LP | 719.809 | −229.357 | 31. 12. 2022. |
0,96094 % | EcoR1 Capital, LLC | 690.000 | 0 | 31. 12. 2022. |
0,89509 % | Nicholas Investment Partners, L.P. | 642.720 | 75.305 | 31. 12. 2022. |
0,71188 % | Citadel Advisors LLC | 511.167 | 290.148 | 31. 12. 2022. |
0,70679 % | Rock Springs Capital Management LP | 507.512 | 0 | 31. 12. 2022. |
0,68200 % | Baillie Gifford & Co. | 489.708 | 25.394 | 31. 12. 2022. |
0,61380 % | Millennium Management LLC | 440.738 | 41.769 | 31. 12. 2022. |
0,58934 % | Saturn V Capital Management LLC | 423.177 | 423.177 | 31. 12. 2022. |
0,53916 % | Northern Trust Investments, Inc. | 387.144 | 11.216 | 31. 12. 2022. |
0,53617 % | Altium Capital Management LP | 385.000 | −140.000 | 31. 12. 2022. |
0,53438 % | Charles Schwab Investment Management, Inc. | 383.712 | 9.225 | 31. 12. 2022. |
0,52309 % | Two Sigma Investments, LP | 375.608 | −90.517 | 31. 12. 2022. |
0,51363 % | Eventide Asset Management, LLC | 368.811 | 368.811 | 31. 12. 2022. |
0,50392 % | Ensign Peak Advisors, Inc. | 361.838 | 124.933 | 31. 12. 2022. |
0,50106 % | D. E. Shaw & Co., L.P. | 359.785 | −119.742 | 31. 12. 2022. |
0,47405 % | International Biotechnology Trust PLC | 340.389 | 0 | 31. 12. 2022. |
0,42728 % | Fidelity Management & Research Company LLC | 306.810 | −22.429 | 31. 12. 2022. |
0,42382 % | Norges Bank Investment Management (NBIM) | 304.326 | 304.326 | 31. 12. 2022. |
0,41938 % | Dobmeier (Eric L. J.D.) | 301.138 | 12.151 | 10. 02. 2023. |
0,39477 % | Ikarian Capital LLC | 283.464 | 0 | 31. 12. 2022. |
0,32841 % | Connor, Clark & Lunn Investment Management Ltd. | 235.816 | −51.468 | 31. 12. 2022. |
0,26934 % | Invesco Capital Management LLC | 193.400 | 13.264 | 31. 12. 2022. |
0,25533 % | Putnam Investment Management, L.L.C. | 183.343 | −7.200 | 31. 12. 2022. |
0,25299 % | Renaissance Technologies LLC | 181.662 | −37.680 | 31. 12. 2022. |
0,24375 % | BofA Global Research (US) | 175.023 | 35.910 | 31. 12. 2022. |
0,24372 % | Integral Health Asset Management, LLC | 175.000 | 175.000 | 31. 12. 2022. |
0,24234 % | Rafferty Asset Management LLC | 174.011 | 30.893 | 31. 12. 2022. |
0,22989 % | BlackRock Financial Management, Inc. | 165.075 | 1.760 | 31. 12. 2022. |
0,22798 % | Goldman Sachs & Company, Inc. | 163.702 | −182.336 | 31. 12. 2022. |
0,21260 % | BlackRock Investment Management, LLC | 152.658 | 6.369 | 31. 12. 2022. |
0,20998 % | Frohlich (Tom) | 150.777 | 3.103 | 10. 02. 2023. |
0,20834 % | Polar Asset Management Partners Inc. | 149.600 | 0 | 31. 12. 2022. |
0,19854 % | Woodline Partners LP | 142.563 | −166.821 | 31. 12. 2022. |
0,19166 % | Northern Trust Global Investments | 137.619 | 98.593 | 31. 12. 2022. |
0,19113 % | BNY Mellon Asset Management | 137.243 | 2.292 | 31. 12. 2022. |
0,19083 % | Morgan Stanley & Co. LLC | 137.025 | 5.694 | 31. 12. 2022. |
0,18303 % | Algert Global LLC | 131.427 | −1.430 | 31. 12. 2022. |
0,18296 % | Walleye Capital LLC | 131.375 | −166.009 | 31. 12. 2022. |
0,17959 % | ExodusPoint Capital Management, LP | 128.955 | −41.701 | 31. 12. 2022. |
0,17715 % | Sphera Funds Management Ltd. | 127.200 | −407.158 | 31. 12. 2022. |
0,15869 % | Nan Fung Group Holdings Ltd | 113.950 | 0 | 31. 12. 2022. |
0,14570 % | JP Morgan Asset Management | 104.622 | 15.119 | 31. 12. 2022. |
0,14206 % | EAM Investors, LLC | 102.007 | −21.903 | 31. 12. 2022. |
0,14197 % | Barclays Bank PLC | 101.941 | 9.670 | 31. 12. 2022. |
0,13746 % | Schweizerische Nationalbank | 98.700 | 5.200 | 31. 12. 2022. |
0,13620 % | UBS Asset Management (Americas), Inc. | 97.801 | −3.870 | 31. 01. 2023. |
0,12553 % | Balyasny Asset Management LP | 90.140 | −190.147 | 31. 12. 2022. |
0,12534 % | Pura Vida Investments, LLC | 90.000 | 90.000 | 31. 12. 2022. |
0,11379 % | Parametric Portfolio Associates LLC | 81.705 | −5.203 | 31. 12. 2022. |
0,11294 % | Rhumbline Advisers Ltd. Partnership | 81.093 | 4.382 | 31. 12. 2022. |
0,11141 % | BioImpact Capital LLC | 80.000 | 80.000 | 31. 12. 2022. |
0,10918 % | Nomura Asset Management Co., Ltd. | 78.400 | 78.400 | 30. 11. 2022. |
0,10890 % | Citi Investment Research (US) | 78.195 | −53.812 | 31. 12. 2022. |
0,10863 % | Soleus Capital Management, L.P. | 78.000 | 0 | 31. 12. 2022. |
0,09765 % | New York State Common Retirement Fund | 70.116 | 7.241 | 31. 12. 2022. |
0,09576 % | UBS Financial Services, Inc. | 68.764 | 45.316 | 31. 12. 2022. |
0,09301 % | EAM Global Investors LLC | 66.787 | −17.559 | 31. 12. 2022. |
0,08862 % | BlackRock Advisors (UK) Limited | 63.636 | 2.432 | 28. 02. 2023. |
0,08356 % | HealthCor Management, L.P. | 60.000 | −206.830 | 31. 12. 2022. |
0,08211 % | Baillie Gifford Overseas Ltd. | 58.957 | 0 | 31. 01. 2023. |
0,08168 % | Mellon Investments Corporation | 58.648 | 21.230 | 31. 12. 2022. |
0,08021 % | Wellington Management Company, LLP | 57.593 | 12.503 | 31. 12. 2022. |
0,07773 % | California State Teachers Retirement System | 55.811 | 1.952 | 31. 12. 2022. |
0,07584 % | BlackRock Asset Management Ireland Limited | 54.454 | 15.710 | 31. 12. 2022. |
0,07314 % | AllianceBernstein L.P. | 52.520 | 17.400 | 31. 12. 2022. |
0,06893 % | HighVista Strategies LLC | 49.495 | −34.056 | 31. 12. 2022. |
0,06751 % | Goldman Sachs Asset Management, L.P. | 48.474 | −8.078 | 31. 12. 2022. |
0,06605 % | FundLogic SAS | 47.430 | 0 | 31. 12. 2022. |
0,06388 % | Jump Financial, LLC | 45.868 | 2.234 | 31. 12. 2022. |
0,06383 % | Dimensional Fund Advisors, Ltd. | 45.833 | 0 | 31. 01. 2023. |
0,06341 % | Martingale Asset Management, L.P. | 45.533 | 206 | 31. 12. 2022. |
0,06128 % | Fisher Investments | 44.003 | −7.004 | 31. 12. 2022. |