19,53354 % | BVF Partners L.P. | 8.291.988 | 0 | 31. 12. 2022. |
7,82683 % | OrbiMed Advisors, LLC | 3.322.488 | 0 | 31. 12. 2022. |
6,99094 % | Versant Ventures | 2.967.652 | −577.210 | 29. 12. 2022. |
6,59629 % | Cowen Investment Management LLC | 2.800.126 | −269.721 | 31. 12. 2022. |
6,42546 % | Deep Track Capital LP | 2.727.606 | −400.061 | 31. 12. 2022. |
6,32367 % | Redmile Group, LLC | 2.684.396 | 0 | 31. 12. 2022. |
5,71980 % | ARK Investment Management LLC | 2.428.055 | −203.973 | 31. 12. 2022. |
5,28301 % | MPM Capital Inc. | 2.242.636 | 0 | 31. 12. 2022. |
4,51832 % | T. Rowe Price Investment Management, Inc. | 1.918.026 | 155.283 | 31. 12. 2022. |
3,86301 % | BioImpact Capital LLC | 1.639.849 | 0 | 31. 12. 2022. |
1,65059 % | Fidelity Institutional Asset Management | 700.676 | 698.406 | 31. 12. 2022. |
1,64900 % | Invus Public Equities Advisors, LLC | 700.000 | 0 | 31. 12. 2022. |
1,51125 % | Medical Strategy GmbH | 641.524 | 0 | 30. 09. 2022. |
1,42588 % | Millennium Management LLC | 605.287 | 357.966 | 31. 12. 2022. |
0,66698 % | BlackRock Institutional Trust Company, N.A. | 283.131 | 30.064 | 31. 12. 2022. |
0,61457 % | BofA Global Research (US) | 260.886 | 247.926 | 31. 12. 2022. |
0,45342 % | Citadel Advisors LLC | 192.478 | −120.798 | 31. 12. 2022. |
0,42201 % | Segal (Lloyd Mitchell) | 179.143 | 78.550 | 30. 01. 2023. |
0,41452 % | Koehler (Maria) | 175.963 | 26.450 | 30. 01. 2023. |
0,41343 % | Fidelity Management & Research Company LLC | 175.502 | 542 | 31. 12. 2022. |
0,40997 % | Nikko Asset Management Co., Ltd. | 174.033 | −13.004 | 31. 12. 2022. |
0,38843 % | HighVista Strategies LLC | 164.890 | −139.291 | 31. 12. 2022. |
0,38492 % | Renaissance Technologies LLC | 163.400 | 28.279 | 31. 12. 2022. |
0,37632 % | BlackRock Advisors (UK) Limited | 159.749 | −14 | 28. 02. 2023. |
0,36844 % | BlackRock Asset Management Ireland Limited | 156.402 | 10.160 | 31. 12. 2022. |
0,31363 % | UBS Asset Management (Americas), Inc. | 133.138 | 22.986 | 31. 12. 2022. |
0,30275 % | BMO Private Investment Counsel Inc. | 128.519 | −5.000 | 31. 12. 2022. |
0,25271 % | D. E. Shaw & Co., L.P. | 107.274 | 41.890 | 31. 12. 2022. |
0,19930 % | Ensign Peak Advisors, Inc. | 84.603 | −6.200 | 31. 12. 2022. |
0,17318 % | The Vanguard Group, Inc. | 73.515 | 1.260 | 31. 12. 2022. |
0,17107 % | Trexquant Investment LP | 72.618 | −7.056 | 31. 12. 2022. |
0,16629 % | Zinda (Michael) | 70.591 | 24.550 | 30. 01. 2023. |
0,15249 % | Versant Venture Capital V (Canada), LP. | 64.731 | −80.148 | 06. 06. 2022. |
0,12563 % | State Street Global Advisors (US) | 53.330 | −145 | 31. 12. 2022. |
0,12529 % | Dimensional Fund Advisors, L.P. | 53.185 | 40.206 | 31. 12. 2022. |
0,10898 % | Parametric Portfolio Associates LLC | 46.262 | −25.315 | 31. 12. 2022. |
0,10718 % | Schweizerische Nationalbank | 45.500 | 1.200 | 31. 12. 2022. |
0,09302 % | Marshall Wace LLP | 39.489 | 39.489 | 31. 12. 2022. |
0,09156 % | Goldman Sachs & Company, Inc. | 38.867 | 10.762 | 31. 12. 2022. |
0,08144 % | Harbor Capital Advisors, Inc. | 34.572 | 32.255 | 31. 12. 2022. |
0,07229 % | Forte (Steve) | 30.687 | 24.530 | 30. 01. 2023. |
0,07112 % | Susquehanna International Group, LLP | 30.189 | 30.189 | 31. 12. 2022. |
0,06867 % | Tekla Capital Management LLC | 29.150 | 0 | 31. 12. 2022. |
0,06680 % | Algert Global LLC | 28.355 | 0 | 31. 12. 2022. |
0,06672 % | Versant Ophthalmic Affiliates Fund I, L.P. | 28.322 | −35.065 | 06. 06. 2022. |
0,06642 % | Jane Street Capital, L.L.C. | 28.197 | 28.197 | 31. 12. 2022. |
0,06596 % | Jump Financial, LLC | 28.000 | 9.800 | 31. 12. 2022. |
0,06335 % | T. Rowe Price Associates, Inc. | 26.894 | 8.567 | 31. 12. 2022. |
0,06253 % | Geode Capital Management, L.L.C. | 26.544 | 5.142 | 31. 12. 2022. |
0,06164 % | Acadian Asset Management LLC | 26.165 | 26.165 | 31. 12. 2022. |
0,06028 % | Versant Affiliates Fund V, L.P. | 25.587 | −31.677 | 06. 06. 2022. |
0,06025 % | Goldman Sachs Asset Management, L.P. | 25.577 | 4.372 | 31. 12. 2022. |
0,05920 % | Davis (Jerel C) | 25.131 | 4.254 | 29. 12. 2022. |
0,05882 % | XTX Markets LLC | 24.969 | 24.969 | 31. 12. 2022. |
0,05770 % | Assenagon Asset Management S.A. | 24.495 | −1.010 | 28. 02. 2023. |
0,05361 % | TD Asset Management Inc. | 22.758 | −6.505 | 31. 12. 2022. |
0,05323 % | The Blackstone Group | 22.595 | 3.427 | 31. 12. 2022. |
0,05307 % | HRT Financial LP | 22.529 | 22.529 | 31. 12. 2022. |
0,05095 % | Nuveen LLC | 21.630 | −188 | 31. 12. 2022. |
0,05016 % | Credit Suisse Asset Management | 21.293 | 7.043 | 31. 12. 2022. |
0,04724 % | Fred Alger Management, LLC | 20.055 | −4.256 | 31. 12. 2022. |
0,04665 % | Black (Cameron) | 19.804 | 729 | 15. 02. 2022. |
0,04615 % | Cubist Systematic Strategies, LLC | 19.590 | 19.590 | 31. 12. 2022. |
0,04369 % | Apo Asset Management GmbH | 18.545 | 0 | 31. 01. 2023. |
0,04274 % | Morgan Stanley & Co. LLC | 18.143 | −10.765 | 31. 12. 2022. |
0,04195 % | AQR Capital Management, LLC | 17.807 | 17.807 | 31. 12. 2022. |
0,04013 % | Tudor Investment Corporation | 17.034 | 17.034 | 31. 12. 2022. |
0,03860 % | California State Teachers Retirement System | 16.386 | 164 | 31. 12. 2022. |
0,03829 % | State of Wisconsin Investment Board | 16.256 | −1.141 | 31. 12. 2022. |
0,03687 % | Two Sigma Investments, LP | 15.653 | 15.653 | 31. 12. 2022. |
0,03632 % | Difesa Capital Management, LP | 15.416 | 0 | 31. 12. 2022. |
0,03626 % | Northern Trust Investments, Inc. | 15.392 | 1.046 | 31. 12. 2022. |
0,03439 % | Deka Investment GmbH | 14.600 | 1.300 | 30. 06. 2022. |
0,03439 % | Deka Vermögensmanagement GmbH | 14.600 | 0 | 31. 12. 2022. |
0,03404 % | BlackRock Financial Management, Inc. | 14.450 | 7.237 | 31. 12. 2022. |
0,02900 % | SETH KIM | 12.312 | 11.625 | 02. 12. 2021. |
0,02892 % | HarbourVest Partners, L.L.C. | 12.276 | 0 | 31. 12. 2022. |
0,02891 % | DuPont Capital Management Corporation | 12.271 | 12.271 | 31. 12. 2022. |
0,02784 % | Emerge Canada Inc | 11.816 | −1.204 | 31. 01. 2023. |
0,02659 % | UBS Asset Management (Switzerland) | 11.286 | −906 | 31. 12. 2022. |
0,02656 % | Morgan Stanley Smith Barney LLC | 11.273 | −35.203 | 31. 12. 2022. |
0,02591 % | Abaris Investment Management AG | 11.000 | 0 | 31. 12. 2021. |
0,02512 % | Qube Research & Technologies Ltd | 10.664 | −1.569 | 31. 12. 2022. |
0,02220 % | Virtus Etf Advisers LLC | 9.426 | 1.789 | 31. 12. 2022. |
0,01885 % | Schafer (Carol Anne) | 8.000 | 0 | 15. 03. 2022. |
0,01835 % | Lazard Asset Management, L.L.C. | 7.788 | 7.788 | 31. 12. 2022. |
0,01767 % | Civik (Thomas) | 7.500 | 0 | 15. 03. 2022. |
0,01601 % | Simplex Trading, LLC | 6.797 | 6.775 | 31. 12. 2022. |
0,01296 % | Handelsbanken Kapitalförvaltning AB | 5.500 | 0 | 31. 01. 2023. |
0,01188 % | UBS Financial Services, Inc. | 5.042 | 1.491 | 31. 12. 2022. |
0,01131 % | Morrison Briggs W | 4.800 | 0 | 15. 03. 2022. |
0,01091 % | Legal & General Investment Management Ltd. | 4.633 | 0 | 31. 12. 2022. |
0,01029 % | American Century Investment Management, Inc. | 4.367 | 2.848 | 31. 12. 2022. |
0,00974 % | BlackRock Investment Management (UK) Ltd. | 4.133 | 179 | 31. 12. 2022. |
0,00971 % | Dimensional Fund Advisors, Ltd. | 4.124 | 0 | 31. 01. 2023. |
0,00942 % | KLP Fondsforvaltning AS | 4.000 | 0 | 31. 01. 2023. |
0,00942 % | Rhoads (Ann D) | 4.000 | 0 | 15. 03. 2022. |
0,00937 % | Northern Trust Global Investments | 3.977 | 0 | 31. 12. 2022. |
0,00843 % | Northern Trust Global Investments Limited | 3.578 | 0 | 31. 12. 2022. |
0,00763 % | ProShare Advisors LLC | 3.239 | −345 | 28. 02. 2023. |