8,05955 % | Vestal Point Capital, LP | 3.925.000 | 3.925.000 | 31/12/2023 |
7,14347 % | State Street Global Advisors (US) | 3.478.872 | 28.590 | 31/12/2023 |
6,07398 % | Nantahala Capital Management, LLC | 2.958.027 | -65.772 | 31/12/2023 |
4,90371 % | Bristol Myers Squibb | 2.388.108 | 0 | 15/9/2023 |
3,47639 % | 683 Capital Management LLC | 1.693.000 | 118.000 | 31/12/2023 |
3,00161 % | BlackRock Institutional Trust Company, N.A. | 1.461.782 | 206.012 | 31/12/2023 |
2,76776 % | OrbiMed Advisors, LLC | 1.347.900 | -716.555 | 31/12/2023 |
2,71919 % | Pictet Asset Management Ltd. | 1.324.246 | 320.552 | 31/12/2023 |
2,54928 % | Schroder Investment Management Ltd. (SIM) | 1.241.500 | 1.241.500 | 31/12/2023 |
2,54928 % | International Biotechnology Trust PLC | 1.241.500 | 1.226.000 | 30/9/2023 |
2,42149 % | Morgan Stanley & Co. LLC | 1.179.265 | -568.827 | 31/12/2023 |
1,97699 % | The Vanguard Group, Inc. | 962.796 | 18.348 | 31/12/2023 |
1,91255 % | Point72 Asset Management, L.P. | 931.410 | 886.584 | 31/12/2023 |
1,68431 % | Columbia Threadneedle Investments (US) | 820.260 | 445.795 | 31/12/2023 |
1,52754 % | Citi Investment Research (US) | 743.910 | -22.611 | 31/12/2023 |
1,45107 % | BNP Paribas Securities Corp. North America | 706.670 | 448.319 | 31/12/2023 |
1,45003 % | Macquarie Investment Management | 706.166 | 0 | 31/12/2023 |
1,42781 % | Goldman Sachs & Company, Inc. | 695.345 | 233.526 | 31/12/2023 |
1,23203 % | Tang Capital Management, LLC | 600.000 | -335.800 | 31/12/2023 |
1,16957 % | JPMorgan Asset Management U.K. Limited | 569.582 | 0 | 31/12/2023 |
1,15058 % | D. E. Shaw & Co., L.P. | 560.331 | 148.595 | 31/12/2023 |
1,13388 % | Morgan Stanley Investment Management Inc. (US) | 552.200 | -331.806 | 31/12/2023 |
0,99070 % | Pictet Asset Management (Japan) Ltd. | 482.473 | 168.042 | 31/10/2023 |
0,98496 % | Geode Capital Management, L.L.C. | 479.675 | 31.443 | 31/12/2023 |
0,93526 % | Millennium Management LLC | 455.472 | 75.712 | 31/12/2023 |
0,91201 % | Privium Fund Management BV | 444.148 | 162.542 | 31/12/2023 |
0,87269 % | Hudson Bay Capital Management LP | 425.000 | 34.800 | 31/12/2023 |
0,86453 % | LifeSci Fund Management LLC | 421.025 | 29.525 | 31/12/2023 |
0,86453 % | AlphaCentric Advisors LLC. | 421.025 | 29.525 | 31/12/2023 |
0,82234 % | abrdn Inc. | 400.480 | 400.480 | 31/12/2023 |
0,76972 % | Kapusta Matthew C | 374.853 | 150.000 | 1/3/2024 |
0,75725 % | Rafferty Asset Management LLC | 368.783 | -22.061 | 31/12/2023 |
0,74404 % | Bridger Management, LLC | 362.349 | 350.340 | 31/12/2023 |
0,73158 % | Tekla Capital Management LLC_NLE | 356.280 | -296.166 | 30/6/2023 |
0,62307 % | Verition Fund Management LLC | 303.435 | -340.207 | 31/12/2023 |
0,60584 % | Bank Vontobel AG | 295.042 | 242.214 | 31/12/2023 |
0,60080 % | Sectoral Asset Management Inc. | 292.592 | 292.592 | 31/12/2023 |
0,56441 % | BofA Global Research (US) | 274.869 | -79.157 | 31/12/2023 |
0,56355 % | Cubist Systematic Strategies, LLC | 274.448 | 77.286 | 31/12/2023 |
0,54315 % | Renaissance Technologies LLC | 264.513 | -184.599 | 31/12/2023 |
0,54045 % | Acadian Asset Management LLC | 263.199 | 263.199 | 31/12/2023 |
0,48297 % | Silvercrest Asset Management Group LLC | 235.205 | -18.462 | 31/12/2023 |
0,45665 % | Charles Schwab Investment Management, Inc. | 222.389 | -18.623 | 31/12/2023 |
0,42526 % | Norges Bank Investment Management (NBIM) | 207.100 | -566.394 | 31/12/2023 |
0,40041 % | Carlson Capital, L.P. | 195.000 | -100 | 31/12/2023 |
0,38646 % | Algert Global LLC | 188.205 | -226.036 | 31/12/2023 |
0,35703 % | BlackRock Investment Management (UK) Ltd. | 173.876 | -25.763 | 31/12/2023 |
0,35122 % | Citadel Advisors LLC | 171.044 | -370.868 | 31/12/2023 |
0,35093 % | J.P. Morgan Securities LLC | 170.904 | 156.397 | 31/12/2023 |
0,34646 % | Susquehanna International Group, LLP | 168.724 | -73.831 | 31/12/2023 |
0,34497 % | UBS Financial Services, Inc. | 168.002 | 81.533 | 31/12/2023 |
0,34253 % | Kuta (Alexander Edward III) | 166.812 | 105.581 | 15/9/2023 |
0,33881 % | Ghost Tree Capital, LLC | 165.000 | -50.000 | 31/12/2023 |
0,32313 % | Ikarian Capital LLC | 157.365 | 0 | 31/12/2023 |
0,30857 % | Two Sigma Investments, LP | 150.276 | 88.917 | 31/12/2023 |
0,29689 % | Banque Pictet & Cie S.A. | 144.585 | -16.044 | 31/12/2023 |
0,28902 % | Walleye Capital LLC | 140.755 | 14.777 | 31/12/2023 |
0,28029 % | Barclays Bank PLC | 136.502 | -56.444 | 31/12/2023 |
0,25735 % | Medical Strategy GmbH | 125.331 | 0 | 30/9/2023 |
0,25575 % | Schonfeld Strategic Advisors LLC | 124.549 | -258.080 | 31/12/2023 |
0,24943 % | BlackRock Financial Management, Inc. | 121.470 | -30.366 | 31/12/2023 |
0,23963 % | Abi-Saab (Walid) | 116.700 | 49.500 | 1/3/2024 |
0,23674 % | Squarepoint Capital LLP | 115.292 | 115.292 | 31/12/2023 |
0,22358 % | Jump Financial, LLC | 108.882 | -13.736 | 31/12/2023 |
0,21602 % | Jane Street Capital, L.L.C. | 105.202 | -187.173 | 31/12/2023 |
0,21424 % | Nomura Securities Co., Ltd. | 104.336 | 94.336 | 31/12/2023 |
0,20575 % | PDT Partners, LLC | 100.201 | -29.914 | 31/12/2023 |
0,19836 % | Potts (Jeannette) | 96.600 | 49.500 | 1/3/2024 |
0,19507 % | UBS O'Connor LLC | 95.000 | 6035 | 31/12/2023 |
0,18752 % | Klemt (Christian) | 91.321 | 49.500 | 1/3/2024 |
0,18553 % | Mirae Asset Global Investments (USA) LLC | 90.354 | -124.332 | 31/12/2023 |
0,17438 % | Northern Trust Investments, Inc. | 84.924 | -24.194 | 31/12/2023 |
0,16453 % | RBC Capital Markets Wealth Management | 80.125 | 12.595 | 31/12/2023 |
0,16285 % | SELECTRA Management Company S.A. | 79.306 | 0 | 30/6/2023 |
0,15844 % | AQR Capital Management, LLC | 77.161 | -58.289 | 31/12/2023 |
0,14130 % | Qube Research & Technologies Ltd | 68.813 | -50.098 | 31/12/2023 |
0,13977 % | Sanders Morris LLC | 68.070 | 0 | 31/3/2024 |
0,13470 % | Pale Fire Capital SE | 65.600 | 5500 | 31/12/2023 |
0,13030 % | Caloz (Pierre Alain) | 63.456 | 33.000 | 1/3/2024 |
0,12726 % | BlackRock Asset Management Ireland Limited | 61.976 | -38.270 | 31/12/2023 |
0,12320 % | Moore Capital Management, LP | 60.000 | 0 | 31/12/2023 |
0,11948 % | ProFund Advisors LLC | 58.187 | -5985 | 31/12/2023 |
0,11680 % | HRT Financial LP | 56.881 | -154.765 | 31/12/2023 |
0,11126 % | Diamond Hill Capital Management Inc. | 54.185 | 29.277 | 31/12/2023 |
0,10974 % | Florida State Board of Administration | 53.443 | 53.443 | 30/9/2022 |
0,10724 % | Raymond James & Associates, Inc. | 52.224 | 3145 | 31/12/2023 |
0,10611 % | BlackRock Advisors (UK) Limited | 51.676 | -3159 | 31/3/2024 |
0,10547 % | Bellecapital Partners AG | 51.363 | 0 | 30/9/2023 |
0,10430 % | Engineers Gate Manager, L.P. | 50.794 | 11.990 | 31/12/2023 |
0,10399 % | Allianz Global Investors GmbH | 50.642 | -131.753 | 31/12/2023 |
0,10325 % | Group One Trading, L.P. | 50.281 | 28.713 | 31/12/2023 |
0,10267 % | Sonic GP LLC | 50.000 | 0 | 31/12/2023 |
0,10017 % | Fidelity Management & Research Company LLC | 48.782 | -147.358 | 31/12/2023 |
0,09959 % | Pennant Investors, LP | 48.500 | 48.500 | 31/12/2023 |
0,09800 % | Dolmetsch (Ricardo) | 47.728 | 12.492 | 18/9/2023 |
0,09762 % | Avantis Investors | 47.540 | 14.561 | 31/3/2024 |
0,09137 % | American Century Investment Management, Inc. | 44.496 | 11.332 | 31/12/2023 |
0,08480 % | Erste Asset Management GmbH | 41.300 | 0 | 31/12/2023 |
0,08478 % | Henry James International Management, Inc. | 41.286 | -1307 | 31/12/2023 |
0,08090 % | Deka Investment GmbH | 39.400 | 39.400 | 31/12/2022 |