11,89781 % | PRIMECAP Management Company | 7.312.391 | -435.200 | 30/6/2024 |
10,41062 % | Baker Bros. Advisors LP | 6.398.365 | 0 | 30/6/2024 |
9,89979 % | RA Capital Management, LP | 6.084.412 | 754.000 | 30/6/2024 |
8,50647 % | Goldman Sachs & Company, Inc. | 5.228.074 | 223.252 | 30/6/2024 |
6,41041 % | BlackRock Institutional Trust Company, N.A. | 3.939.837 | 44.398 | 30/6/2024 |
5,60784 % | Perceptive Advisors LLC | 3.446.579 | 178.001 | 30/6/2024 |
5,45234 % | The Vanguard Group, Inc. | 3.351.010 | 56.549 | 30/6/2024 |
4,73472 % | New Enterprise Associates (NEA) | 2.909.956 | 0 | 30/6/2024 |
3,85829 % | Frazier Life Sciences Management, L.P. | 2.371.304 | 181.125 | 30/6/2024 |
3,26047 % | State Street Global Advisors (US) | 2.003.882 | -1.009.956 | 30/6/2024 |
2,70661 % | BlackRock Financial Management, Inc. | 1.663.485 | 48.190 | 30/6/2024 |
2,70221 % | Federated Hermes Global Investment Management Corp. | 1.660.780 | -220 | 30/6/2024 |
2,44061 % | Polar Capital LLP | 1.500.000 | 0 | 30/6/2024 |
2,08346 % | Rock Springs Capital Management LP | 1.280.493 | -242.400 | 30/6/2024 |
2,03822 % | Geode Capital Management, L.L.C. | 1.252.689 | 71.984 | 30/6/2024 |
1,99317 % | Commodore Capital LP | 1.225.000 | 175.000 | 30/6/2024 |
1,92380 % | Driehaus Capital Management, LLC | 1.182.370 | 326.865 | 30/6/2024 |
1,57378 % | HOOPP Investment Management | 967.243 | 236.600 | 30/6/2024 |
1,50033 % | Checkpoint Capital L.P. | 922.100 | 96.600 | 30/6/2024 |
1,35163 % | Alkeon Capital Management LLC | 830.712 | 830.712 | 30/6/2024 |
1,30458 % | Pictet Asset Management Ltd. | 801.796 | -409.883 | 30/6/2024 |
1,28904 % | BlackRock Investment Management (UK) Ltd. | 792.244 | 39.968 | 30/6/2024 |
1,14683 % | OrbiMed Advisors, LLC | 704.842 | 0 | 30/6/2024 |
0,96590 % | Janus Henderson Investors | 593.642 | -27.785 | 30/6/2024 |
0,83794 % | Opaleye Management Inc. | 515.000 | 0 | 30/6/2024 |
0,80163 % | T. Rowe Price Associates, Inc. | 492.682 | 42.212 | 30/6/2024 |
0,77286 % | Cormorant Asset Management, LP | 475.000 | -75.000 | 30/6/2024 |
0,75201 % | Voloridge Investment Management, LLC | 462.188 | -11.267 | 30/6/2024 |
0,70078 % | Northern Trust Investments, Inc. | 430.698 | -14.534 | 30/6/2024 |
0,69841 % | Morgan Stanley & Co. LLC | 429.244 | 285.267 | 30/6/2024 |
0,69632 % | Charles Schwab Investment Management, Inc. | 427.958 | 21.213 | 30/6/2024 |
0,67849 % | CPP Investment Board | 417.000 | -160.000 | 30/6/2024 |
0,65773 % | National Bank of Canada | 404.242 | 36.725 | 30/6/2024 |
0,64331 % | Candriam Luxembourg S.A. | 395.377 | 0 | 30/9/2024 |
0,45434 % | Loomis, Sayles & Company, L.P. | 279.237 | 0 | 31/8/2024 |
0,44158 % | Candriam Belgium S.A. | 271.398 | 271.398 | 30/6/2024 |
0,44137 % | Artisan Partners Limited Partnership | 271.267 | -154 | 30/6/2024 |
0,34947 % | Putnam Investment Management, L.L.C. | 214.785 | 10.143 | 30/6/2024 |
0,32920 % | Wellington Management Company, LLP | 202.326 | 8803 | 30/6/2024 |
0,31141 % | Invesco Advisers, Inc. | 191.391 | 105.913 | 30/6/2024 |
0,30046 % | SilverArc Capital Management, LLC | 184.662 | 886 | 30/6/2024 |
0,28886 % | BlackRock Investment Management, LLC | 177.532 | 3820 | 30/6/2024 |
0,28410 % | Meeker (David P) | 174.605 | -986 | 22/4/2024 |
0,28091 % | Samsara BioCapital, LLC | 172.647 | 0 | 30/6/2024 |
0,27544 % | Oppenheimer Asset Management Inc. | 169.288 | 169.288 | 30/6/2024 |
0,25430 % | BlackRock Advisors (UK) Limited | 156.292 | 332 | 30/9/2024 |
0,23837 % | Jane Street Capital, L.L.C. | 146.500 | 120.182 | 30/6/2024 |
0,23799 % | Nuveen LLC | 146.270 | 6384 | 30/6/2024 |
0,23499 % | BlackRock Asset Management Ireland Limited | 144.426 | 79.800 | 30/6/2024 |
0,22208 % | UBS Asset Management (Americas), Inc. | 136.493 | -89 | 30/6/2024 |
0,21805 % | BNY Mellon Asset Management | 134.012 | 9007 | 30/6/2024 |
0,19100 % | Ghost Tree Capital, LLC | 117.388 | -7612 | 30/6/2024 |
0,18354 % | abrdn Inc. | 112.804 | 0 | 30/9/2024 |
0,17379 % | Marshall Wace LLP | 106.809 | 87.059 | 30/6/2024 |
0,17217 % | JGP Gest¿o de Recursos Ltda. | 105.814 | 100.126 | 31/3/2024 |
0,16943 % | Algert Global LLC | 104.132 | 35.084 | 30/6/2024 |
0,16894 % | AQR Capital Management, LLC | 103.830 | 32.831 | 30/6/2024 |
0,16692 % | Lord, Abbett & Co. LLC | 102.591 | -178.566 | 30/6/2024 |
0,16510 % | Samsung Asset Management Co., Ltd. | 101.469 | -4859 | 30/9/2024 |
0,16427 % | Hennion & Walsh Asset Management, Inc. | 100.961 | 4583 | 30/9/2024 |
0,15935 % | Smith (Hunter C) | 97.939 | 0 | 22/4/2024 |
0,15923 % | J.P. Morgan Securities plc | 97.865 | 82.413 | 30/6/2024 |
0,14808 % | First Trust Advisors L.P. | 91.010 | 91.010 | 30/6/2024 |
0,14432 % | Schweizerische Nationalbank | 88.700 | -4600 | 30/6/2024 |
0,14336 % | ClearBridge Investments, LLC | 88.108 | -1896 | 30/6/2024 |
0,14019 % | BofA Global Research (US) | 86.161 | -19.012 | 30/6/2024 |
0,13880 % | Invesco Capital Management LLC | 85.309 | 82.582 | 30/6/2024 |
0,13515 % | Rhumbline Advisers Ltd. Partnership | 83.063 | 6339 | 30/6/2024 |
0,11806 % | Rafferty Asset Management LLC | 72.562 | -146.095 | 30/6/2024 |
0,10778 % | NISA Investment Advisors, L.L.C. | 66.240 | -308.107 | 30/9/2024 |
0,10729 % | UBS Financial Services, Inc. | 65.942 | -105.623 | 30/6/2024 |
0,10113 % | Northern Trust Global Investments | 62.156 | 11.335 | 30/6/2024 |
0,09937 % | AllianceBernstein L.P. | 61.070 | 7640 | 30/6/2024 |
0,09854 % | Goldman Sachs Asset Management, L.P. | 60.561 | -46.218 | 30/6/2024 |
0,09338 % | UBS Asset Management (Switzerland) | 57.391 | 9896 | 30/6/2024 |
0,08851 % | Mellon Investments Corporation | 54.397 | 15.068 | 30/6/2024 |
0,08726 % | Barclays Bank PLC | 53.631 | -73.905 | 30/6/2024 |
0,08709 % | Legal & General Investment Management Ltd. | 53.526 | 6110 | 30/6/2024 |
0,08020 % | Manulife Investment Management (North America) Limited | 49.291 | 1667 | 30/6/2024 |
0,07992 % | Nan Fung Life Sciences | 49.120 | 0 | 30/6/2024 |
0,07947 % | WEDGE Capital Management, L.L.P. | 48.844 | -14.353 | 30/9/2024 |
0,07319 % | Caption Management, LLC | 44.984 | 44.984 | 30/6/2024 |
0,07282 % | California State Teachers Retirement System | 44.757 | -3137 | 30/6/2024 |
0,07199 % | Woodline Partners LP | 44.247 | -127.960 | 30/6/2024 |
0,07151 % | Ostrum Asset Management | 43.951 | 37.901 | 30/6/2024 |
0,07035 % | Norges Bank Investment Management (NBIM) | 43.238 | 43.238 | 30/6/2024 |
0,06731 % | Harbor Capital Advisors, Inc. | 41.368 | 6741 | 30/9/2024 |
0,06576 % | Columbia Threadneedle Investments (US) | 40.415 | 19.435 | 30/6/2024 |
0,06540 % | MFS Investment Management | 40.192 | -115 | 31/8/2024 |
0,06415 % | State of Wisconsin Investment Board | 39.427 | 6123 | 30/6/2024 |
0,06152 % | Voya Investment Management LLC | 37.811 | -131.900 | 30/6/2024 |
0,05939 % | Nomura Asset Management Co., Ltd. | 36.500 | 36.500 | 30/11/2023 |
0,05674 % | Mazabraud (Yann) | 34.870 | 10.375 | 22/4/2024 |
0,05412 % | T. Rowe Price International Ltd | 33.260 | 2197 | 30/6/2024 |
0,05361 % | UBS Fund Management (Switzerland) AG | 32.946 | -10.218 | 30/6/2024 |
0,05241 % | Mirae Asset Global Investments (USA) LLC | 32.211 | 32.211 | 30/6/2024 |
0,05150 % | MetLife Investment Management, LLC | 31.652 | 4529 | 30/6/2024 |
0,05044 % | TD Asset Management Inc. | 31.000 | 3400 | 30/6/2024 |
0,04792 % | Corebridge Financial Inc | 29.454 | 29.454 | 30/6/2024 |
0,04741 % | Fulcrum Asset Management LLP | 29.140 | -279 | 31/7/2024 |