| 8,91330 % | Wellington Management Company, LLP | 7.585.221 | -57.225 | 31/12/2023 |
| 6,73731 % | BlackRock Institutional Trust Company, N.A. | 5.733.451 | 811.058 | 31/12/2023 |
| 6,65100 % | Kynam Capital Management LP | 5.660.000 | 2.060.000 | 31/12/2023 |
| 5,89451 % | State Street Global Advisors (US) | 5.016.224 | 1.415.576 | 31/12/2023 |
| 5,07684 % | The Vanguard Group, Inc. | 4.320.388 | 712.749 | 31/12/2023 |
| 4,96148 % | Avoro Capital Advisors LLC | 4.222.222 | 1.666.667 | 31/12/2023 |
| 4,64160 % | Avidity Partners Management LP | 3.950.000 | 1.129.000 | 31/12/2023 |
| 3,97561 % | Eversept Partners, LP | 3.383.244 | 786.999 | 31/12/2023 |
| 3,33079 % | Point72 Asset Management, L.P. | 2.834.499 | -322.483 | 31/12/2023 |
| 3,18596 % | T. Rowe Price Investment Management, Inc. | 2.711.253 | 1.644.705 | 31/12/2023 |
| 2,46993 % | Marshall Wace LLP | 2.101.911 | 1.497.949 | 31/12/2023 |
| 2,20329 % | BVF Partners L.P. | 1.875.000 | 1.875.000 | 31/12/2023 |
| 2,05523 % | OrbiMed Advisors, LLC | 1.749.000 | 465.000 | 31/12/2023 |
| 1,81459 % | Woodline Partners LP | 1.544.216 | 1.510.149 | 31/12/2023 |
| 1,80382 % | Geode Capital Management, L.L.C. | 1.535.055 | 174.135 | 31/12/2023 |
| 1,64231 % | Morgan Stanley & Co. LLC | 1.397.603 | 946.055 | 31/12/2023 |
| 1,56819 % | Franklin Advisers, Inc. | 1.334.531 | 1.334.531 | 31/12/2023 |
| 1,38073 % | Cormorant Asset Management, LP | 1.175.000 | 1.175.000 | 31/12/2023 |
| 1,30121 % | Goldman Sachs & Company, Inc. | 1.107.330 | -74.741 | 31/12/2023 |
| 1,28613 % | StemPoint Capital LP | 1.094.494 | 1.094.494 | 31/12/2023 |
| 1,26414 % | Sofinnova Investments, Inc | 1.075.786 | 133.969 | 31/12/2023 |
| 1,25852 % | Candriam Luxembourg S.A. | 1.071.000 | 0 | 29/2/2024 |
| 1,20447 % | Aisling Capital Management LP | 1.025.000 | 0 | 31/12/2023 |
| 1,19980 % | Candriam Belgium S.A. | 1.021.032 | 781.022 | 31/12/2023 |
| 1,11875 % | BofA Global Research (US) | 952.057 | 759.276 | 31/12/2023 |
| 1,10769 % | Millennium Management LLC | 942.642 | 502.872 | 31/12/2023 |
| 1,05758 % | Adage Capital Management, L.P. | 900.000 | -100.000 | 31/12/2023 |
| 1,02820 % | Foresite Capital Management, LLC | 875.000 | 0 | 31/12/2023 |
| 0,98475 % | BlackRock Financial Management, Inc. | 838.023 | 258.358 | 31/12/2023 |
| 0,91657 % | HOOPP Investment Management | 780.000 | 780.000 | 31/12/2023 |
| 0,90830 % | Sphera Funds Management Ltd. | 772.964 | -97 | 31/12/2023 |
| 0,87696 % | Kingdon Capital Management, L.L.C. | 746.293 | 746.293 | 31/12/2023 |
| 0,87259 % | Dafna Capital Management, LLC | 742.574 | 284.201 | 31/12/2023 |
| 0,86791 % | Parkman Healthcare Partners LLC | 738.589 | 526.141 | 31/12/2023 |
| 0,80774 % | Two Sigma Investments, LP | 687.390 | 188.773 | 31/12/2023 |
| 0,75720 % | JP Morgan Asset Management | 644.374 | -3.761 | 31/12/2023 |
| 0,73118 % | Nuveen LLC | 622.237 | 462.635 | 31/12/2023 |
| 0,72139 % | Northern Trust Investments, Inc. | 613.904 | 72.239 | 31/12/2023 |
| 0,69979 % | PFM Health Sciences, LP | 595.523 | -2.119.712 | 31/12/2023 |
| 0,67805 % | Charles Schwab Investment Management, Inc. | 577.022 | 70.555 | 31/12/2023 |
| 0,62063 % | Algert Global LLC | 528.157 | 71.938 | 31/12/2023 |
| 0,60963 % | Saturn V Capital Management LLC | 518.799 | -289.170 | 31/12/2023 |
| 0,60500 % | Ensign Peak Advisors, Inc. | 514.852 | 0 | 31/12/2023 |
| 0,60400 % | Soleus Capital Management, L.P. | 514.000 | 394.500 | 31/12/2023 |
| 0,55893 % | Columbia Threadneedle Investments (US) | 475.648 | 4.459 | 31/12/2023 |
| 0,55535 % | Palo Alto Investors LP | 472.600 | 0 | 31/12/2023 |
| 0,55402 % | Schonfeld Strategic Advisors LLC | 471.475 | 253.062 | 31/12/2023 |
| 0,48410 % | Assenagon Asset Management S.A. | 411.965 | 21.427 | 31/12/2023 |
| 0,47401 % | Rafferty Asset Management LLC | 403.381 | 119.257 | 31/12/2023 |
| 0,42921 % | Nantahala Capital Management, LLC | 365.259 | 125.228 | 31/12/2023 |
| 0,41510 % | ExodusPoint Capital Management, LP | 353.252 | 197.538 | 31/12/2023 |
| 0,37710 % | Granahan Investment Management, LLC | 320.911 | 307.862 | 31/12/2023 |
| 0,34172 % | UBS Financial Services, Inc. | 290.801 | 215.444 | 31/12/2023 |
| 0,32327 % | Zimmer Partners, LP | 275.100 | 275.100 | 31/12/2023 |
| 0,29854 % | Barclays Bank PLC | 254.061 | 67.076 | 31/12/2023 |
| 0,28683 % | Macquarie Investment Management | 244.090 | 11.624 | 31/12/2023 |
| 0,28553 % | Citadel Advisors LLC | 242.985 | -192.508 | 31/12/2023 |
| 0,26901 % | Parametric Portfolio Associates LLC | 228.924 | 168.149 | 31/12/2023 |
| 0,23036 % | Peregrine Capital Management, LLC | 196.033 | -23.941 | 31/12/2023 |
| 0,22268 % | BlackRock Investment Management, LLC | 189.497 | 13.104 | 31/12/2023 |
| 0,21834 % | BNY Mellon Asset Management | 185.810 | 2.784 | 31/12/2023 |
| 0,20463 % | PanAgora Asset Management Inc. | 174.144 | 82.645 | 31/12/2023 |
| 0,19510 % | Voya Investment Management LLC | 166.033 | 117.144 | 31/12/2023 |
| 0,19391 % | Balyasny Asset Management LP | 165.018 | 16.494 | 31/12/2023 |
| 0,19261 % | Metzger (Michael A) | 163.909 | 3.750 | 8/3/2024 |
| 0,19143 % | BNP Paribas Securities Corp. North America | 162.905 | 44.906 | 31/12/2023 |
| 0,19084 % | Citi Investment Research (US) | 162.406 | 42.174 | 31/12/2023 |
| 0,18778 % | New Jersey Division of Investment | 159.803 | 26.769 | 31/12/2023 |
| 0,17626 % | Casdin Capital, LLC | 150.000 | 150.000 | 31/12/2023 |
| 0,16864 % | Trexquant Investment LP | 143.514 | 143.514 | 31/12/2023 |
| 0,16835 % | Verition Fund Management LLC | 143.266 | 128.266 | 31/12/2023 |
| 0,16733 % | Schweizerische Nationalbank | 142.400 | 21.400 | 31/12/2023 |
| 0,16427 % | Allianz Global Investors GmbH | 139.790 | 0 | 31/1/2024 |
| 0,16041 % | JPMorgan Private Bank (United States) | 136.509 | 55.546 | 31/12/2023 |
| 0,15520 % | BlackRock Advisors (UK) Limited | 132.075 | 6.237 | 31/3/2024 |
| 0,15228 % | Goldman Sachs Asset Management, L.P. | 129.590 | 58.629 | 31/12/2023 |
| 0,15033 % | Walleye Capital LLC | 127.932 | 127.932 | 31/12/2023 |
| 0,13458 % | Yelin Lapidot Mutual Funds Management Ltd | 114.530 | 114.530 | 30/9/2023 |
| 0,13458 % | Yelin Lapidot Provident Funds Management Ltd | 114.530 | 0 | 31/12/2023 |
| 0,12844 % | Dimensional Fund Advisors, L.P. | 109.303 | 3.163 | 31/12/2023 |
| 0,12581 % | Jane Street Capital, L.L.C. | 107.066 | -43.065 | 31/12/2023 |
| 0,12067 % | Victory Capital Management Inc. | 102.687 | 102.687 | 31/12/2023 |
| 0,11827 % | Crestline Investors, Inc. | 100.649 | -33.815 | 31/12/2023 |
| 0,11275 % | UBS O'Connor LLC | 95.949 | 95.949 | 31/12/2023 |
| 0,11201 % | Rhumbline Advisers Ltd. Partnership | 95.317 | -3.652 | 31/12/2023 |
| 0,10967 % | Podlesak (Dennis G) | 93.333 | -2.000 | 8/3/2024 |
| 0,10818 % | Sectoral Asset Management Inc. | 92.060 | 6.060 | 31/12/2023 |
| 0,10448 % | BlackRock Asset Management Ireland Limited | 88.910 | 4.125 | 31/12/2023 |
| 0,10126 % | Axiom Investors | 86.175 | 75.355 | 31/12/2023 |
| 0,10012 % | Wellington Management Japan Pte Ltd | 85.200 | -54.891 | 30/6/2023 |
| 0,09807 % | TwinBeech Capital LP | 83.456 | -104.654 | 31/12/2023 |
| 0,09255 % | State of Wisconsin Investment Board | 78.758 | 24.302 | 31/12/2023 |
| 0,09102 % | AllianceBernstein L.P. | 77.460 | 0 | 31/12/2023 |
| 0,08861 % | California State Teachers Retirement System | 75.407 | 12.215 | 31/12/2023 |
| 0,08552 % | Credit Suisse Funds AG | 72.775 | 3.606 | 31/12/2023 |
| 0,08226 % | HealthCor Management, L.P. | 70.000 | -789.240 | 31/12/2022 |
| 0,08106 % | Tudor Investment Corporation | 68.981 | 39.042 | 31/12/2023 |
| 0,08047 % | Aperio Group, LLC | 68.479 | 37.344 | 31/12/2023 |
| 0,08014 % | Gyon Technologies Capital Management, LP | 68.195 | 35.226 | 31/12/2022 |
| 0,07885 % | Polar Asset Management Partners Inc. | 67.100 | 67.100 | 31/12/2023 |
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