| 7,03 % | The Vanguard Group, Inc. | 13.254.362 | 152.154 | 30/6/2023 |
| 5,10 % | Pentwater Capital Management LP | 9.629.500 | 7.874.500 | 30/6/2023 |
| 4,81 % | Capital World Investors | 9.081.409 | -3.188.031 | 30/6/2023 |
| 4,40 % | BlackRock Institutional Trust Company, N.A. | 8.300.626 | 477.794 | 30/6/2023 |
| 3,40 % | Capital International Investors | 6.417.224 | -810.641 | 30/6/2023 |
| 3,20 % | PRIMECAP Management Company | 6.038.808 | 1.144.000 | 30/6/2023 |
| 23,62 % | Baker Bros. Advisors LP | 44.554.162 | -4.088 | 30/6/2023 |
| 1,77 % | State Street Global Advisors (US) | 3.334.204 | -20.028 | 30/6/2023 |
| 1,69 % | Invesco Capital Management (QQQ Trust) | 3.197.608 | 19.941 | 30/9/2023 |
| 1,19 % | Wellington Management Company, LLP | 2.253.733 | -4.575.730 | 30/6/2023 |
| 1,16 % | Norges Bank Investment Management (NBIM) | 2.187.105 | 473.466 | 31/12/2022 |
| 1,09 % | Geode Capital Management, L.L.C. | 2.061.760 | 87.737 | 30/6/2023 |
| 1,02 % | Barclays Bank PLC | 1.929.326 | 1.775.088 | 30/6/2023 |
| 0,93 % | Avoro Capital Advisors LLC | 1.759.606 | -42.300 | 30/6/2023 |
| 0,87 % | Millennium Management LLC | 1.633.535 | 893.994 | 30/6/2023 |
| 0,85 % | JP Morgan Asset Management | 1.603.838 | -765.853 | 30/6/2023 |
| 0,70 % | Fidelity Management & Research Company LLC | 1.315.820 | -117.574 | 30/6/2023 |
| 0,60 % | BlackRock Asset Management Ireland Limited | 1.124.091 | 250.655 | 30/6/2023 |
| 0,48 % | DWS Investments UK Limited | 903.451 | 720.565 | 30/6/2023 |
| 0,47 % | Legal & General Investment Management Ltd. | 886.400 | 77.328 | 30/6/2023 |
| 0,46 % | BlackRock Investment Management (UK) Ltd. | 858.943 | 40.582 | 30/6/2023 |
| 0,45 % | Renaissance Technologies LLC | 848.513 | 837.813 | 30/6/2023 |
| 0,43 % | BlackRock Financial Management, Inc. | 802.711 | 70.701 | 30/6/2023 |
| 0,43 % | Pictet Asset Management Ltd. | 801.927 | -196.563 | 30/6/2023 |
| 0,42 % | DWS Investment GmbH | 794.495 | 530.871 | 30/6/2023 |
| 0,40 % | Citadel Advisors LLC | 761.528 | 377.582 | 30/6/2023 |
| 0,38 % | Siegall (Clay B) | 723.713 | 57.653 | 1/3/2023 |
| 0,37 % | Balyasny Asset Management LP | 696.239 | 378.859 | 30/6/2023 |
| 0,37 % | Westchester Capital Management, LLC | 694.494 | 571.207 | 30/6/2023 |
| 0,36 % | Alpine Associates Management Inc. | 674.600 | 302.000 | 30/6/2023 |
| 0,35 % | Segantii Capital Management Limited | 655.000 | 655.000 | 30/6/2023 |
| 0,35 % | TIG Advisors, L.L.C. | 654.473 | 654.473 | 30/6/2023 |
| 0,34 % | Voloridge Investment Management, LLC | 634.344 | 512.371 | 30/6/2023 |
| 0,32 % | T. Rowe Price Investment Management, Inc. | 599.076 | -1.023.147 | 30/6/2023 |
| 0,31 % | Northern Trust Investments, Inc. | 586.078 | -22.791 | 30/6/2023 |
| 0,30 % | Antipodes Partners Limited | 557.229 | -34.113 | 30/6/2023 |
| 0,28 % | Rothschild & Co Asset Management Europe SCS | 534.534 | -151 | 30/6/2023 |
| 0,28 % | Melqart Asset Management (UK) Limited | 533.093 | 318.385 | 30/6/2023 |
| 0,28 % | T. Rowe Price Associates, Inc. | 532.418 | -959.078 | 30/6/2023 |
| 0,28 % | Candriam Luxembourg S.A. | 530.215 | 762 | 31/8/2023 |
| 0,28 % | Candriam Belgium S.A. | 529.779 | -47.841 | 30/6/2023 |
| 0,28 % | PSquared Asset Management AG | 520.000 | 520.000 | 30/6/2023 |
| 0,27 % | First Trust Advisors L.P. | 510.583 | 14.792 | 30/6/2023 |
| 0,27 % | Franklin Advisers, Inc. | 507.619 | -125.300 | 30/6/2023 |
| 0,27 % | Schweizerische Nationalbank | 506.800 | -45.900 | 30/6/2023 |
| 0,26 % | Charles Schwab Investment Management, Inc. | 497.719 | 11.323 | 30/6/2023 |
| 0,26 % | Kryger Capital Limited | 494.396 | 494.396 | 30/6/2023 |
| 0,26 % | Polar Capital LLP | 489.000 | -60.392 | 30/6/2023 |
| 0,24 % | Mellon Investments Corporation | 459.395 | -53.799 | 30/6/2023 |
| 0,21 % | Rock Springs Capital Management LP | 400.200 | 0 | 30/6/2023 |
| 0,21 % | Capital Group Private Client Services, Inc. | 390.527 | -292.132 | 30/6/2023 |
| 0,20 % | Sumitomo Mitsui Trust Bank, Limited | 386.322 | -61.012 | 30/6/2023 |
| 0,20 % | UBS Asset Management (Switzerland) | 383.325 | -18.166 | 31/3/2023 |
| 0,20 % | Nuveen LLC | 379.475 | -1.499 | 30/6/2023 |
| 0,18 % | Marshall Wace LLP | 340.407 | 106.604 | 30/6/2023 |
| 0,18 % | Tudor Investment Corporation | 340.004 | 340.004 | 30/6/2023 |
| 0,17 % | Magnetar Capital Partners LP | 328.246 | 45.713 | 30/6/2023 |
| 0,17 % | Cercano Management LLC | 319.038 | 319.038 | 30/6/2023 |
| 0,16 % | HSBC Global Asset Management (UK) Limited | 310.565 | -780 | 30/6/2023 |
| 0,16 % | Goldman Sachs Asset Management, L.P. | 307.449 | 23.634 | 30/6/2023 |
| 0,16 % | Invesco Capital Management LLC | 306.828 | 41.386 | 30/6/2023 |
| 0,16 % | Dimensional Fund Advisors, L.P. | 305.201 | 838 | 30/6/2023 |
| 0,16 % | Hudson Bay Capital Management LP | 303.291 | 216.877 | 30/6/2023 |
| 0,16 % | Sand Grove Capital Management LLP | 303.209 | 112.813 | 30/6/2023 |
| 0,16 % | Morgan Stanley & Co. LLC | 296.961 | 43.140 | 30/6/2023 |
| 0,16 % | APG Asset Management N.V. | 296.129 | -45.294 | 30/6/2023 |
| 0,16 % | Amundi Asset Management, SAS | 294.890 | 21.120 | 30/6/2023 |
| 0,14 % | Citi Investment Research (US) | 261.282 | 96.269 | 30/6/2023 |
| 0,14 % | PFM Health Sciences, LP | 256.299 | 35.416 | 30/6/2023 |
| 0,13 % | California Public Employees' Retirement System | 254.676 | -41.662 | 30/6/2023 |
| 0,13 % | LMR Partners LLP | 252.922 | 252.922 | 30/6/2023 |
| 0,13 % | BlackRock Japan Co., Ltd. | 251.560 | -11.258 | 30/6/2023 |
| 0,13 % | Parametric Portfolio Associates LLC | 249.679 | 9.477 | 30/6/2023 |
| 0,13 % | AllianceBernstein L.P. | 241.852 | 144.450 | 30/6/2023 |
| 0,12 % | BNY Mellon Asset Management | 234.407 | 921 | 30/6/2023 |
| 0,12 % | Zevenbergen Capital Investments LLC | 234.170 | -38.406 | 30/6/2023 |
| 0,12 % | Assenagon Asset Management S.A. | 233.507 | -338.289 | 30/6/2023 |
| 0,12 % | California State Teachers Retirement System | 231.170 | -705 | 30/6/2023 |
| 0,12 % | Empyrean Capital Partners, LP | 231.000 | 231.000 | 30/6/2023 |
| 0,12 % | J.P. Morgan Securities LLC | 229.672 | -387.358 | 30/6/2023 |
| 0,12 % | Qube Research & Technologies Ltd | 225.470 | 155.804 | 30/6/2023 |
| 0,12 % | P. Schoenfeld Asset Management LP | 222.300 | 222.300 | 30/6/2023 |
| 0,12 % | Adage Capital Management, L.P. | 220.793 | -179.207 | 30/6/2023 |
| 0,12 % | UBS Asset Management (UK) Ltd. | 217.010 | 42.833 | 31/3/2023 |
| 0,11 % | HOOPP Investment Management | 211.900 | 211.900 | 30/6/2023 |
| 0,11 % | Boussard & Gavaudan Investment Management LLP | 210.427 | 210.427 | 30/6/2023 |
| 0,11 % | Credit Suisse Funds AG | 205.475 | -19.828 | 30/6/2023 |
| 0,11 % | Rhumbline Advisers Ltd. Partnership | 200.036 | 32.071 | 30/6/2023 |
| 0,10 % | BlackRock (Netherlands) B.V. | 190.689 | -18.943 | 30/6/2023 |
| 0,10 % | Medical Strategy GmbH | 189.008 | -65.003 | 31/5/2023 |
| 0,10 % | National Pension Service | 186.443 | -19.649 | 30/6/2023 |
| 0,10 % | State of Wisconsin Investment Board | 186.311 | 75.919 | 30/6/2023 |
| 0,10 % | GLG Partners LP | 186.256 | 139.665 | 30/6/2023 |
| 0,10 % | Picton Mahoney Asset Management | 185.000 | 185.000 | 30/6/2023 |
| 0,09 % | Jennison Associates LLC | 171.813 | -10 | 30/6/2023 |
| 0,09 % | BlackRock Investment Management, LLC | 171.120 | 34.616 | 30/6/2023 |
| 0,09 % | Principal Global Investors (Equity) | 169.241 | -150.357 | 30/6/2023 |
| 0,09 % | Gabelli Funds, LLC | 167.800 | 112.250 | 30/6/2023 |
| 0,09 % | Calamos Advisors LLC | 163.748 | 87.940 | 30/6/2023 |
| 0,09 % | Employees Retirement System of Texas | 162.000 | 0 | 30/6/2023 |
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