| 8,64 % | The Vanguard Group, Inc. | 8.331.674 | 155.579 | 31/12/2023 |
| 7,89 % | BlackRock Institutional Trust Company, N.A. | 7.609.214 | 675.921 | 31/12/2023 |
| 4,91 % | State Street Global Advisors (US) | 4.735.861 | 1.002.936 | 31/12/2023 |
| 3,52 % | Nikko Asset Management Co., Ltd. | 3.399.318 | -79.244 | 31/3/2024 |
| 2,55 % | Wellington Management Company, LLP | 2.456.917 | -195.077 | 31/12/2023 |
| 2,33 % | Deep Track Capital LP | 2.250.000 | 250.000 | 31/12/2023 |
| 2,09 % | Federated Hermes Global Investment Management Corp. | 2.016.300 | 244.722 | 31/12/2023 |
| 2,05 % | Geode Capital Management, L.L.C. | 1.973.269 | 93.024 | 31/12/2023 |
| 11,39 % | ARK Investment Management LLC | 10.989.282 | -423.167 | 31/3/2024 |
| 1,81 % | T. Rowe Price Associates, Inc. | 1.746.041 | -216.717 | 31/12/2023 |
| 1,72 % | AllianceBernstein L.P. | 1.663.742 | 116.630 | 31/12/2023 |
| 1,52 % | Rokos Capital Management LLP | 1.463.630 | 74.334 | 31/12/2023 |
| 1,50 % | Casdin Capital, LLC | 1.450.000 | 271.925 | 31/12/2023 |
| 1,31 % | Citadel Advisors LLC | 1.259.292 | -710.891 | 31/12/2023 |
| 1,21 % | Dimensional Fund Advisors, L.P. | 1.170.829 | 60.748 | 31/12/2023 |
| 1,10 % | Morgan Stanley & Co. LLC | 1.064.198 | 178.956 | 31/12/2023 |
| 1,07 % | Himension Capital (Singapore) Pte. Ltd | 1.030.621 | -114.470 | 31/12/2023 |
| 1,03 % | Fidelity Management & Research Company LLC | 992.006 | -215.658 | 31/12/2023 |
| 1,03 % | Chevy Chase Trust Company | 991.175 | -11.780 | 31/12/2023 |
| 1,02 % | Morgan Stanley Investment Management Inc. (US) | 980.108 | -879.931 | 31/12/2023 |
| 1,01 % | Two Sigma Investments, LP | 971.904 | 554.297 | 31/12/2023 |
| 0,93 % | Leonard (John M) | 900.124 | 113.586 | 1/3/2024 |
| 0,92 % | Marshall Wace LLP | 890.498 | 890.498 | 31/12/2023 |
| 0,92 % | Pictet Asset Management Ltd. | 883.470 | -53.847 | 31/12/2023 |
| 0,82 % | BlackRock Financial Management, Inc. | 791.366 | 85.542 | 31/12/2023 |
| 0,76 % | Northern Trust Investments, Inc. | 731.355 | 15.586 | 31/12/2023 |
| 0,73 % | Charles Schwab Investment Management, Inc. | 700.228 | 18.987 | 31/12/2023 |
| 0,58 % | Discovery Value Fund | 561.561 | 0 | 31/12/2023 |
| 0,56 % | Norges Bank Investment Management (NBIM) | 536.172 | -321.106 | 31/12/2023 |
| 0,50 % | Goldman Sachs & Company, Inc. | 486.337 | 33.377 | 31/12/2023 |
| 0,49 % | Nuveen LLC | 472.818 | -28.152 | 31/12/2023 |
| 0,46 % | Avidity Partners Management LP | 447.434 | 68.334 | 31/12/2023 |
| 0,40 % | BioImpact Capital LLC | 382.598 | -162.041 | 31/12/2023 |
| 0,39 % | Eventide Asset Management, LLC | 372.665 | 0 | 31/12/2023 |
| 0,35 % | Goldman Sachs Asset Management, L.P. | 338.190 | -5.113 | 31/12/2023 |
| 0,35 % | JPMorgan Asset Management U.K. Limited | 335.990 | -7.416 | 31/12/2023 |
| 0,34 % | Rafferty Asset Management LLC | 328.998 | 77.873 | 31/12/2023 |
| 0,34 % | Barclays Bank PLC | 328.446 | 131.369 | 31/12/2023 |
| 0,34 % | UBS Asset Management (Switzerland) | 326.204 | 21.099 | 31/12/2023 |
| 0,33 % | Nikko Asset Management Americas, Inc. | 318.369 | -52.071 | 31/12/2022 |
| 0,31 % | Morgan Stanley Smith Barney LLC | 299.384 | 67.115 | 31/12/2023 |
| 0,31 % | HOOPP Investment Management | 298.000 | 298.000 | 31/12/2023 |
| 0,30 % | Columbia Threadneedle Investments (US) | 292.519 | 259.164 | 31/12/2023 |
| 0,30 % | Capital Advisors, Inc. (OK) | 284.738 | 73.379 | 31/12/2023 |
| 0,29 % | BlackRock Investment Management, LLC | 280.706 | 36.574 | 31/12/2023 |
| 0,29 % | Temasek Holdings Pte. Ltd. | 279.693 | 0 | 31/12/2023 |
| 0,28 % | UBS Financial Services, Inc. | 274.524 | 150.517 | 31/12/2023 |
| 0,28 % | Eagle Asset Management, Inc. | 269.558 | 26.867 | 31/12/2023 |
| 0,28 % | Vestmark Advisory Solutions, Inc | 265.981 | 265.981 | 31/12/2023 |
| 0,27 % | Granahan Investment Management, LLC | 257.791 | 52.600 | 31/12/2023 |
| 0,26 % | American Century Investment Management, Inc. | 248.529 | -18.684 | 31/12/2023 |
| 0,25 % | Qube Research & Technologies Ltd | 240.691 | 195.432 | 31/12/2023 |
| 0,25 % | BNY Mellon Asset Management | 239.887 | 6.972 | 31/12/2023 |
| 0,25 % | Hudson Bay Capital Management LP | 237.500 | 52.300 | 31/12/2023 |
| 0,22 % | Contrarius Investment Management Ltd. | 214.401 | -17.461 | 31/12/2023 |
| 0,22 % | BofA Global Research (US) | 211.174 | 15.051 | 31/12/2023 |
| 0,22 % | BNP Paribas Securities Corp. North America | 210.161 | 1.930 | 31/12/2023 |
| 0,21 % | Jane Street Capital, L.L.C. | 204.285 | 116.308 | 31/12/2023 |
| 0,21 % | Frazier Healthcare Partners | 203.684 | 0 | 31/12/2023 |
| 0,21 % | Walleye Capital LLC | 203.327 | 19.872 | 31/12/2023 |
| 0,21 % | Tang Capital Management, LLC | 200.000 | -197.600 | 31/12/2023 |
| 0,20 % | Susquehanna International Group, LLP | 195.499 | 87.710 | 31/12/2023 |
| 0,20 % | Fidelity Institutional Asset Management | 194.597 | -90.767 | 31/12/2023 |
| 0,20 % | Medical Strategy GmbH | 194.224 | 0 | 31/12/2023 |
| 0,19 % | Mirae Asset Global Investments (USA) LLC | 185.858 | -100.885 | 31/12/2023 |
| 0,18 % | Wells Fargo Advisors | 175.589 | 13.389 | 31/12/2023 |
| 0,18 % | Orchard Capital Management LLC | 170.006 | 10.851 | 31/12/2023 |
| 0,17 % | Citi Investment Research (US) | 167.606 | -97.798 | 31/12/2023 |
| 0,17 % | Parametric Portfolio Associates LLC | 166.998 | 85.511 | 31/12/2023 |
| 0,17 % | Schweizerische Nationalbank | 165.700 | -8.700 | 31/12/2023 |
| 0,17 % | Rhumbline Advisers Ltd. Partnership | 163.358 | -627 | 31/12/2023 |
| 0,17 % | PDT Partners, LLC | 160.997 | 123.920 | 31/12/2023 |
| 0,16 % | abrdn Inc. | 154.269 | 154.269 | 31/12/2023 |
| 0,16 % | Tekla Capital Management LLC_NLE | 154.269 | 0 | 30/6/2023 |
| 0,16 % | Managed Account Advisors LLC | 154.197 | -63.554 | 31/12/2023 |
| 0,16 % | Coho Partners, Ltd. | 151.803 | 151.803 | 30/4/2023 |
| 0,16 % | Wanjia Asset Management Co., Ltd. | 150.000 | 30.000 | 30/6/2023 |
| 0,15 % | BlackRock Advisors (UK) Limited | 148.072 | 7.181 | 31/3/2024 |
| 0,15 % | AHL Partners LLP | 146.072 | 137.709 | 31/12/2023 |
| 0,15 % | Mellon Investments Corporation | 144.771 | 1.366 | 31/12/2023 |
| 0,15 % | Northern Trust Global Investments | 140.380 | -30.466 | 31/12/2023 |
| 0,14 % | Neuberger Berman, LLC | 135.637 | -10.784 | 31/12/2023 |
| 0,14 % | Raymond James & Associates, Inc. | 134.371 | 29.997 | 31/12/2023 |
| 0,14 % | DWS Investments UK Limited | 132.813 | 90.332 | 31/12/2023 |
| 0,13 % | JP Morgan Asset Management | 129.655 | -60.765 | 31/12/2023 |
| 0,13 % | California Public Employees' Retirement System | 126.624 | 0 | 31/12/2023 |
| 0,13 % | Credit Suisse Funds AG | 125.339 | 12.056 | 31/12/2023 |
| 0,13 % | BlackRock Investment Management (UK) Ltd. | 123.970 | 54.379 | 31/12/2023 |
| 0,12 % | RBC Capital Markets Wealth Management | 120.290 | 63.835 | 31/12/2023 |
| 0,12 % | The Regents of the University of California | 117.315 | 5.875 | 31/12/2023 |
| 0,12 % | BlackRock Asset Management Ireland Limited | 114.844 | 4.818 | 31/12/2023 |
| 0,11 % | Russell Investments Trust Company | 108.404 | -18.863 | 31/12/2023 |
| 0,11 % | JPMorgan Private Bank (United States) | 102.414 | 82.807 | 31/12/2023 |
| 0,11 % | Lazard Asset Management, L.L.C. | 102.233 | -3.917 | 31/12/2023 |
| 0,10 % | Opaleye Management Inc. | 99.000 | 99.000 | 31/12/2023 |
| 0,10 % | DWS Investment GmbH | 95.330 | -2.475 | 31/12/2023 |
| 0,10 % | Voya Investment Management LLC | 94.720 | 38.170 | 31/12/2023 |
| 0,09 % | Candriam Luxembourg S.A. | 91.275 | 0 | 29/2/2024 |
| 0,09 % | Candriam Belgium S.A. | 91.275 | 40.000 | 31/12/2023 |
| 0,09 % | SELECTRA Management Company S.A. | 90.627 | 1.060 | 30/6/2023 |
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