| 8,16066 % | The Vanguard Group, Inc. | 9.293.363 | -1.600.786 | 31/12/2023 |
| 6,54288 % | BlackRock Institutional Trust Company, N.A. | 7.451.035 | -850.122 | 31/12/2023 |
| 5,41886 % | Boxer Capital, L.L.C. | 6.171.000 | 5.671.000 | 31/1/2024 |
| 4,26026 % | Bellevue Asset Management AG | 4.851.579 | 0 | 31/12/2023 |
| 4,15411 % | Point72 Asset Management, L.P. | 4.730.700 | 1.196.770 | 24/1/2024 |
| 3,14540 % | D. E. Shaw & Co., L.P. | 3.581.979 | -1.129.685 | 31/12/2023 |
| 3,00980 % | Two Sigma Investments, LP | 3.427.559 | -156.513 | 31/12/2023 |
| 2,96721 % | Johnson & Johnson Innovation-JJDC, Inc. | 3.379.064 | 0 | 31/12/2023 |
| 2,40701 % | Jacobs Levy Equity Management, Inc. | 2.741.104 | 224.452 | 31/12/2023 |
| 2,40012 % | BlackRock Financial Management, Inc. | 2.733.253 | -160.455 | 31/12/2023 |
| 2,34124 % | Citadel Advisors LLC | 2.666.208 | 646.576 | 31/12/2023 |
| 2,00314 % | Acadian Asset Management LLC | 2.281.171 | 131.574 | 31/12/2023 |
| 11,57393 % | Redmile Group, LLC | 13.180.388 | 11.331 | 21/3/2024 |
| 1,91713 % | Monaco asset management S.A.M. | 2.183.228 | 335.284 | 31/12/2023 |
| 1,80014 % | Casdin Capital, LLC | 2.050.000 | 0 | 31/12/2023 |
| 1,63636 % | Geode Capital Management, L.L.C. | 1.863.485 | 88.141 | 31/12/2023 |
| 1,63498 % | State Street Global Advisors (US) | 1.861.919 | -410.006 | 31/12/2023 |
| 1,62440 % | Federated MDTA LLC | 1.849.872 | -601.672 | 31/12/2023 |
| 1,49280 % | Adage Capital Management, L.P. | 1.700.000 | 1.700.000 | 31/12/2023 |
| 1,13277 % | Vestal Point Capital, LP | 1.290.000 | 1.290.000 | 31/12/2023 |
| 0,99773 % | JP Morgan Asset Management | 1.136.219 | -784.480 | 31/12/2023 |
| 0,95565 % | Morgan Stanley & Co. LLC | 1.088.296 | -20.725 | 31/12/2023 |
| 0,86321 % | Charles Schwab Investment Management, Inc. | 983.019 | 96.304 | 31/12/2023 |
| 0,79031 % | Integral Health Asset Management, LLC | 900.000 | 900.000 | 31/12/2023 |
| 0,78872 % | StemPoint Capital LP | 898.196 | 898.196 | 31/12/2023 |
| 0,78473 % | Millennium Management LLC | 893.648 | -1.170.590 | 31/12/2023 |
| 0,74449 % | Superstring Capital Management LP | 847.823 | 847.823 | 31/12/2023 |
| 0,74110 % | Citi Investment Research (US) | 843.962 | 835.245 | 31/12/2023 |
| 0,64072 % | Rafferty Asset Management LLC | 729.657 | 729.657 | 31/3/2024 |
| 0,62459 % | Jane Street Capital, L.L.C. | 711.287 | -12.986 | 31/12/2023 |
| 0,61468 % | Tang Capital Management, LLC | 700.000 | 0 | 31/12/2023 |
| 0,56709 % | Northern Trust Investments, Inc. | 645.801 | -55.686 | 31/12/2023 |
| 0,53457 % | Rastetter (William H) | 608.774 | -5.969 | 31/3/2023 |
| 0,53302 % | BofA Global Research (US) | 607.004 | 414.932 | 31/12/2023 |
| 0,46372 % | OrbiMed Advisors, LLC | 528.080 | 528.080 | 31/12/2023 |
| 0,43683 % | Schonfeld Strategic Advisors LLC | 497.457 | 478.257 | 31/12/2023 |
| 0,43547 % | GCM Grosvenor Holdings, LLC | 495.916 | 0 | 31/12/2023 |
| 0,42929 % | JPMorgan Asset Management U.K. Limited | 488.879 | 0 | 31/12/2023 |
| 0,39253 % | PGIM Quantitative Solutions LLC | 447.011 | 304.000 | 31/12/2023 |
| 0,37280 % | BlackRock Investment Management (UK) Ltd. | 424.549 | -131.942 | 31/12/2023 |
| 0,36977 % | Goldman Sachs & Company, Inc. | 421.089 | 124.084 | 31/12/2023 |
| 0,34752 % | HRT Financial LP | 395.753 | -277.537 | 31/12/2023 |
| 0,33839 % | Woodline Partners LP | 385.364 | 385.364 | 31/12/2023 |
| 0,33096 % | Nikko Asset Management Americas, Inc. | 376.900 | -72.560 | 31/12/2022 |
| 0,31499 % | Barclays Bank PLC | 358.708 | 253.823 | 31/12/2023 |
| 0,31326 % | PanAgora Asset Management Inc. | 356.740 | -69.845 | 31/12/2023 |
| 0,28168 % | Dimensional Fund Advisors, L.P. | 320.774 | -394.375 | 31/12/2023 |
| 0,26570 % | Mendlein (John D) | 302.581 | -14.619 | 31/3/2023 |
| 0,26039 % | Nuveen LLC | 296.528 | 9.578 | 31/12/2023 |
| 0,25568 % | Fidelity Management & Research Company LLC | 291.172 | -16.458 | 31/12/2023 |
| 0,25465 % | Davis (Aaron I) | 290.000 | 290.000 | 31/1/2024 |
| 0,24989 % | BlackRock Investment Management, LLC | 284.579 | 8.006 | 31/12/2023 |
| 0,22423 % | BlackRock Asset Management Ireland Limited | 255.355 | -120.146 | 31/12/2023 |
| 0,22188 % | Numeric Investors LLC | 252.676 | 34.473 | 31/12/2023 |
| 0,22098 % | Columbia Threadneedle Investments (US) | 251.649 | -23.843 | 31/12/2023 |
| 0,21928 % | BlackRock Advisors (UK) Limited | 249.718 | -13.647 | 31/3/2024 |
| 0,21659 % | Wolchko (John Scott) | 246.657 | -14.391 | 9/1/2024 |
| 0,21486 % | Putnam Investment Management, L.L.C. | 244.684 | 111.434 | 31/12/2023 |
| 0,20807 % | Conestoga Capital Advisors, LLC | 236.948 | 0 | 29/2/2024 |
| 0,20641 % | AQR Capital Management, LLC | 235.058 | -97.853 | 31/12/2023 |
| 0,19665 % | BNY Mellon Asset Management | 223.940 | 4.035 | 31/12/2023 |
| 0,19055 % | Parametric Portfolio Associates LLC | 217.003 | -86.089 | 31/12/2023 |
| 0,18831 % | Cubist Systematic Strategies, LLC | 214.446 | 101 | 24/1/2024 |
| 0,15659 % | BIT Capital GmbH | 178.324 | 178.324 | 31/12/2023 |
| 0,15498 % | Squarepoint Capital LLP | 176.495 | -98.306 | 31/12/2023 |
| 0,15482 % | UBS Financial Services, Inc. | 176.305 | 109.595 | 31/12/2023 |
| 0,14920 % | Goldman Sachs Asset Management, L.P. | 169.904 | 24.083 | 31/12/2023 |
| 0,14908 % | J.P. Morgan Securities LLC | 169.777 | 131.849 | 31/12/2023 |
| 0,14322 % | Assenagon Asset Management S.A. | 163.097 | -217.640 | 31/12/2023 |
| 0,14117 % | AllianceBernstein L.P. | 160.760 | -800 | 31/12/2023 |
| 0,13539 % | Ohio Public Employees Retirement System | 154.178 | 0 | 31/12/2023 |
| 0,13392 % | Susquehanna International Group, LLP | 152.509 | -282.623 | 31/12/2023 |
| 0,12829 % | Pennant Investors, LP | 146.100 | 146.100 | 31/12/2023 |
| 0,12759 % | JPMorgan Private Bank (United States) | 145.297 | -2.371 | 31/12/2023 |
| 0,12557 % | Bruce & Company, Inc. | 143.000 | -57.000 | 31/12/2023 |
| 0,12323 % | Rhumbline Advisers Ltd. Partnership | 140.335 | -7 | 31/12/2023 |
| 0,11620 % | J.P. Morgan Private Wealth Advisors LLC | 132.334 | 0 | 31/12/2023 |
| 0,10704 % | Lombard Odier Asset Management (Europe) Ltd | 121.894 | -4.657 | 30/9/2022 |
| 0,10187 % | Avantis Investors | 116.014 | 69.978 | 31/3/2024 |
| 0,09923 % | PGIM Fixed Income | 113.000 | 61.100 | 31/12/2023 |
| 0,09424 % | Royce Investment Partners | 107.318 | 76.979 | 31/12/2023 |
| 0,08761 % | Invesco Capital Management LLC | 99.773 | -1.483 | 31/12/2023 |
| 0,08535 % | Mellon Investments Corporation | 97.197 | 6.638 | 31/12/2023 |
| 0,08298 % | State of Wyoming | 94.501 | 80.242 | 31/12/2023 |
| 0,08194 % | Voya Investment Management LLC | 93.313 | 11.492 | 31/12/2023 |
| 0,07952 % | SG Americas Securities, L.L.C. | 90.553 | 16.911 | 31/12/2023 |
| 0,07082 % | Algert Global LLC | 80.654 | -11.210 | 31/12/2023 |
| 0,06915 % | HSBC Global Asset Management (UK) Limited | 78.747 | -31.645 | 31/12/2023 |
| 0,06370 % | Dimensional Fund Advisors, Ltd. | 72.545 | 31.689 | 31/1/2024 |
| 0,05514 % | Northern Trust Global Investments | 62.788 | -425.135 | 31/12/2023 |
| 0,05207 % | Shell Asset Management Company B.V. | 59.302 | -17.897 | 31/12/2023 |
| 0,05061 % | Coughlin (Timothy P) | 57.632 | -5.969 | 31/3/2023 |
| 0,04994 % | Valamehr (Bahram) | 56.877 | -11.271 | 9/1/2024 |
| 0,04917 % | Abaris Investment Management AG | 56.000 | 15.000 | 30/6/2023 |
| 0,04773 % | T. Rowe Price International Ltd | 54.357 | -30.637 | 31/12/2023 |
| 0,04652 % | American Century Investment Management, Inc. | 52.982 | 15.920 | 31/12/2023 |
| 0,04605 % | Qube Research & Technologies Ltd | 52.442 | -335.814 | 31/12/2023 |
| 0,04495 % | Russell Investments Trust Company | 51.189 | 4.237 | 31/12/2023 |
| 0,04432 % | BlackRock Japan Co., Ltd. | 50.471 | 0 | 31/12/2023 |
| 0,04114 % | Engineers Gate Manager, L.P. | 46.847 | 31.460 | 31/12/2023 |
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