| 8,83 % | Franklin Advisers, Inc. | 4.598.127 | 487.708 | 31/12/2023 |
| 8,58 % | Adage Capital Management, L.P. | 4.466.420 | 2.729.917 | 31/12/2023 |
| 7,79 % | Suvretta Capital Management, LLC | 4.056.847 | 564.700 | 31/12/2023 |
| 4,74 % | T. Rowe Price Associates, Inc. | 2.468.513 | 1.099.855 | 31/12/2023 |
| 4,49 % | EW Healthcare Partners | 2.337.786 | -1.153.135 | 31/12/2023 |
| 3,91 % | The Vanguard Group, Inc. | 2.034.060 | 593.336 | 31/12/2023 |
| 3,78 % | BlackRock Institutional Trust Company, N.A. | 1.968.721 | 371.954 | 31/12/2023 |
| 2,99 % | T. Rowe Price Investment Management, Inc. | 1.558.675 | 1.558.675 | 31/12/2023 |
| 2,80 % | Columbia Threadneedle Investments (US) | 1.458.367 | 1.448.018 | 31/12/2023 |
| 2,36 % | Citadel Advisors LLC | 1.227.278 | 168.231 | 31/12/2023 |
| 2,17 % | Millennium Management LLC | 1.128.638 | 548.009 | 31/12/2023 |
| 2,17 % | Morgan Stanley & Co. LLC | 1.128.285 | 1.060.344 | 31/12/2023 |
| 2,05 % | Jennison Associates LLC | 1.066.240 | 1.066.240 | 31/12/2023 |
| 13,24 % | Cormorant Asset Management, LP | 6.893.235 | 855.000 | 11/1/2024 |
| 1,31 % | Geode Capital Management, L.L.C. | 682.417 | 146.842 | 31/12/2023 |
| 1,30 % | Federated MDTA LLC | 674.824 | 445.289 | 31/12/2023 |
| 1,22 % | Laurion Capital Management LP | 633.409 | 633.409 | 31/12/2023 |
| 1,13 % | Perceptive Advisors LLC | 589.646 | 589.646 | 31/12/2023 |
| 1,10 % | UBS Financial Services, Inc. | 574.169 | 47.321 | 31/12/2023 |
| 1,08 % | DWS Investments UK Limited | 561.958 | 549.824 | 31/12/2023 |
| 1,06 % | State Street Global Advisors (US) | 550.609 | 17.554 | 31/12/2023 |
| 1,04 % | Goldman Sachs & Company, Inc. | 541.530 | -34.607 | 31/12/2023 |
| 0,82 % | Acuta Capital Partners, LLC | 425.128 | 125.000 | 31/12/2023 |
| 0,77 % | Oracle Investment Management, Inc. | 401.557 | 401.557 | 31/12/2023 |
| 0,77 % | Woodline Partners LP | 400.000 | 400.000 | 31/12/2023 |
| 0,71 % | Lord, Abbett & Co. LLC | 370.987 | 370.987 | 31/12/2023 |
| 0,71 % | Ikarian Capital LLC | 368.130 | 368.130 | 31/12/2023 |
| 0,61 % | First Turn Management, LLC | 317.010 | 317.010 | 31/12/2023 |
| 0,60 % | Candriam Luxembourg S.A. | 315.000 | 75.000 | 29/2/2024 |
| 0,55 % | AXA Investment Managers UK Ltd. | 287.143 | -6.948 | 31/12/2023 |
| 0,54 % | Invesco Capital Management LLC | 279.872 | 279.872 | 31/12/2023 |
| 0,53 % | Norges Bank Investment Management (NBIM) | 274.729 | 274.729 | 31/12/2023 |
| 0,51 % | Susquehanna International Group, LLP | 266.031 | 140.351 | 31/12/2023 |
| 0,48 % | VR Adviser, LLC | 250.000 | 250.000 | 31/12/2023 |
| 0,46 % | SEB Investment Management AB | 241.072 | 190.268 | 29/2/2024 |
| 0,43 % | Northern Trust Investments, Inc. | 222.705 | 29.808 | 31/12/2023 |
| 0,38 % | DWS Investment S.A. | 198.915 | 198.915 | 31/12/2023 |
| 0,36 % | Alyeska Investment Group, L.P. | 186.840 | 186.840 | 31/12/2023 |
| 0,35 % | Schroder Investment Management Ltd. (SIM) | 180.000 | 180.000 | 31/12/2023 |
| 0,34 % | Monashee Investment Management, LLC | 175.000 | 175.000 | 31/12/2023 |
| 0,33 % | Two Sigma Investments, LP | 173.682 | 77.252 | 31/12/2023 |
| 0,33 % | PFM Health Sciences, LP | 170.871 | 170.871 | 31/12/2023 |
| 0,32 % | Ghost Tree Capital, LLC | 165.000 | -160.000 | 31/12/2023 |
| 0,31 % | Barclays Bank PLC | 159.642 | 113.983 | 31/12/2023 |
| 0,28 % | Essex Investment Management Company, LLC | 147.541 | -59.619 | 31/12/2023 |
| 0,28 % | Paggiarino Dario A | 143.834 | 24.858 | 30/3/2024 |
| 0,27 % | TD Asset Management Inc. | 142.894 | 71.094 | 31/12/2023 |
| 0,27 % | Voloridge Investment Management, LLC | 140.705 | 140.705 | 31/12/2023 |
| 0,27 % | Candriam Belgium S.A. | 140.000 | 140.000 | 31/12/2023 |
| 0,27 % | EAM Investors, LLC | 138.310 | 138.310 | 31/12/2023 |
| 0,26 % | HOOPP Investment Management | 137.000 | 137.000 | 31/12/2023 |
| 0,25 % | Elston (George O) | 130.609 | 7.608 | 9/2/2024 |
| 0,24 % | Connor, Clark & Lunn Investment Management Ltd. | 123.764 | 123.764 | 31/12/2023 |
| 0,24 % | Nuveen LLC | 122.997 | -52.865 | 31/12/2023 |
| 0,22 % | Jones (David Scott) | 116.079 | 6.311 | 9/2/2024 |
| 0,22 % | PGIM Securities Investment Trust Enterprise | 116.000 | 116.000 | 31/12/2023 |
| 0,21 % | Affinity Asset Advisors LLC | 109.900 | 109.900 | 31/12/2023 |
| 0,21 % | Parametric Portfolio Associates LLC | 109.790 | 43.575 | 31/12/2023 |
| 0,21 % | Ghisallo Capital Management LLC | 108.634 | 108.634 | 31/12/2023 |
| 0,20 % | BlackRock Financial Management, Inc. | 101.578 | -49.498 | 31/12/2023 |
| 0,19 % | D. E. Shaw & Co., L.P. | 100.960 | 100.960 | 31/12/2023 |
| 0,19 % | Ocumension Therapeutics | 100.222 | -1.910.500 | 11/1/2024 |
| 0,18 % | StemPoint Capital LP | 95.732 | 95.732 | 31/12/2023 |
| 0,18 % | BNY Mellon Asset Management | 94.582 | 6.394 | 31/12/2023 |
| 0,18 % | Wellington Management Company, LLP | 94.561 | 94.561 | 31/12/2023 |
| 0,17 % | Boothbay Fund Management, LLC | 88.443 | 88.443 | 31/12/2023 |
| 0,16 % | Lurker (Nancy S) | 83.351 | -52.090 | 13/2/2024 |
| 0,16 % | Sectoral Asset Management Inc. | 81.160 | -94.920 | 31/12/2023 |
| 0,16 % | PanAgora Asset Management Inc. | 80.780 | 5.541 | 31/12/2023 |
| 0,15 % | Morgan Stanley Smith Barney LLC | 80.588 | 78.199 | 31/12/2023 |
| 0,15 % | BofA Global Research (US) | 78.444 | 70.884 | 31/12/2023 |
| 0,15 % | Charles Schwab Investment Management, Inc. | 78.410 | 6.862 | 31/12/2023 |
| 0,14 % | Manulife Investment Management (North America) Limited | 74.421 | 21.482 | 31/12/2023 |
| 0,14 % | Bridgeway Capital Management, LLC | 73.000 | -44.100 | 31/12/2023 |
| 0,14 % | Legato Capital Management LLC | 71.734 | 12.387 | 31/3/2024 |
| 0,13 % | BlackRock Investment Management, LLC | 69.957 | 314 | 31/12/2023 |
| 0,13 % | Jane Street Capital, L.L.C. | 69.895 | 39.672 | 31/12/2023 |
| 0,11 % | BlackRock Advisors (UK) Limited | 55.624 | 3.006 | 31/3/2024 |
| 0,10 % | T. Rowe Price International Ltd | 54.191 | 48.503 | 31/12/2023 |
| 0,10 % | Cubist Systematic Strategies, LLC | 54.022 | -81.137 | 31/12/2023 |
| 0,10 % | Nicholas Investment Partners, L.P. | 53.236 | 53.236 | 31/12/2023 |
| 0,10 % | Artia Global Partners LP | 50.000 | 50.000 | 31/12/2023 |
| 0,09 % | Trexquant Investment LP | 48.760 | -55.858 | 31/12/2023 |
| 0,09 % | Rhumbline Advisers Ltd. Partnership | 46.140 | 4.388 | 31/12/2023 |
| 0,09 % | Ratan Capital Management LP | 45.000 | 45.000 | 31/12/2023 |
| 0,08 % | Jacobs Levy Equity Management, Inc. | 43.761 | 0 | 31/12/2023 |
| 0,08 % | Franklin Equity Group | 42.524 | 3.300 | 31/12/2023 |
| 0,07 % | Deka Vermögensmanagement GmbH | 35.000 | 35.000 | 31/12/2023 |
| 0,06 % | Assenagon Asset Management S.A. | 33.135 | 2.411 | 29/2/2024 |
| 0,06 % | Fidelity Management & Research Company LLC | 32.485 | 30.088 | 31/12/2023 |
| 0,06 % | Occudo Quantitative Strategies LP | 32.176 | 32.176 | 31/12/2023 |
| 0,06 % | Woodstock Corporation | 30.778 | 8.525 | 31/3/2024 |
| 0,06 % | Hightower Advisors, LLC | 30.007 | -222.965 | 31/12/2023 |
| 0,06 % | Dimensional Fund Advisors, L.P. | 29.610 | -20.511 | 31/12/2023 |
| 0,06 % | Duker (Jay S) | 29.420 | -14.066 | 27/2/2024 |
| 0,05 % | Victory Capital Management Inc. | 28.530 | 28.530 | 31/12/2023 |
| 0,05 % | Goldman Sachs Asset Management, L.P. | 26.456 | 2.119 | 31/12/2023 |
| 0,05 % | Exome Asset Management LLC | 26.400 | 26.400 | 31/12/2023 |
| 0,05 % | BMO Capital Markets (US) | 25.400 | 25.400 | 31/12/2023 |
| 0,05 % | Simplex Trading, LLC | 24.450 | 24.450 | 31/12/2023 |
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