| 9,21 % | EcoR1 Capital, LLC | 11.173.068 | 273.209 | 31/12/2023 |
| 9,15 % | Avoro Capital Advisors LLC | 11.111.111 | 0 | 31/12/2023 |
| 7,86 % | The Vanguard Group, Inc. | 9.537.719 | 85.701 | 31/12/2023 |
| 5,19 % | T. Rowe Price Investment Management, Inc. | 6.303.584 | -215.887 | 31/12/2023 |
| 3,98 % | BlackRock Institutional Trust Company, N.A. | 4.832.877 | 92.717 | 31/12/2023 |
| 2,70 % | Jennison Associates LLC | 3.275.922 | -266.287 | 31/12/2023 |
| 2,40 % | State Street Global Advisors (US) | 2.915.422 | -322.692 | 31/12/2023 |
| 2,31 % | Octagon Capital Advisors LP | 2.806.980 | -323.020 | 31/12/2023 |
| 2,30 % | Morgan Stanley & Co. LLC | 2.795.240 | 1.601.542 | 31/12/2023 |
| 13,55 % | Wellington Management Company, LLP | 16.445.290 | 1.278.246 | 31/12/2023 |
| 10,55 % | Morningside Venture Investments, Ltd. | 12.806.342 | 0 | 31/3/2023 |
| 1,98 % | T. Rowe Price Associates, Inc. | 2.398.842 | 669.759 | 31/12/2023 |
| 1,77 % | Assenagon Asset Management S.A. | 2.145.004 | 1.121.497 | 31/12/2023 |
| 1,72 % | Fidelity Management & Research Company LLC | 2.092.464 | -167.086 | 31/12/2023 |
| 1,42 % | Boxer Capital, L.L.C. | 1.726.000 | 0 | 31/12/2023 |
| 1,41 % | JP Morgan Asset Management | 1.716.070 | 70.134 | 31/12/2023 |
| 1,34 % | Geode Capital Management, L.L.C. | 1.630.642 | 75.816 | 31/12/2023 |
| 1,17 % | Invus Public Equities Advisors, LLC | 1.421.346 | -243.226 | 31/12/2023 |
| 1,11 % | Pictet Asset Management Ltd. | 1.344.563 | 610.413 | 31/12/2023 |
| 0,88 % | Deschatelets (Pascal) | 1.063.301 | 0 | 8/4/2024 |
| 0,87 % | Polar Capital LLP | 1.053.440 | -435 | 31/12/2023 |
| 0,78 % | Logos Global Management LLC | 950.000 | 200.000 | 31/12/2023 |
| 0,78 % | Norges Bank Investment Management (NBIM) | 946.213 | -101.241 | 31/12/2023 |
| 0,76 % | OrbiMed Advisors, LLC | 922.200 | -338.300 | 31/12/2023 |
| 0,76 % | Fiera Capital Corporation | 919.090 | -600 | 31/12/2023 |
| 0,75 % | Charles Schwab Investment Management, Inc. | 904.409 | 25.052 | 31/12/2023 |
| 0,73 % | Frazier Healthcare Partners | 885.165 | 271.122 | 31/12/2023 |
| 0,68 % | Bellevue Asset Management AG | 821.800 | 27.959 | 31/12/2023 |
| 0,64 % | Machiels (Alec) | 778.844 | 3.341 | 1/1/2024 |
| 0,54 % | Francois (Cedric G) | 653.418 | 0 | 1/3/2024 |
| 0,51 % | Cormorant Asset Management, LP | 625.000 | -1.375.000 | 31/12/2023 |
| 0,51 % | Victory Capital Management Inc. | 616.272 | -122.239 | 31/12/2023 |
| 0,50 % | JPMorgan Asset Management U.K. Limited | 611.840 | 137.145 | 31/12/2023 |
| 0,48 % | Macquarie Investment Management | 583.429 | -493.119 | 31/12/2023 |
| 0,41 % | Invesco Advisers, Inc. | 494.709 | 2.597 | 31/12/2023 |
| 0,40 % | Columbia Threadneedle Investments (US) | 489.522 | 213.188 | 31/12/2023 |
| 0,40 % | TD Asset Management Inc. | 483.322 | 112.465 | 31/12/2023 |
| 0,40 % | Driehaus Capital Management, LLC | 481.501 | 300.177 | 31/12/2023 |
| 0,38 % | Candriam Luxembourg S.A. | 464.507 | 95.000 | 29/2/2024 |
| 0,37 % | Eagle Asset Management, Inc. | 446.000 | -3.970 | 31/12/2023 |
| 0,36 % | Jane Street Capital, L.L.C. | 434.701 | 161.475 | 31/12/2023 |
| 0,33 % | Dunlop (Sinclair Andrew) | 402.185 | 1.500 | 12/4/2024 |
| 0,32 % | Caption Management, LLC | 393.031 | 119.781 | 31/12/2023 |
| 0,32 % | Northern Trust Investments, Inc. | 387.643 | 18.292 | 31/12/2023 |
| 0,32 % | Susquehanna International Group, LLP | 382.832 | 10.047 | 31/12/2023 |
| 0,30 % | BMO Capital Markets (US) | 368.510 | -62.000 | 31/12/2023 |
| 0,30 % | DWS Investments UK Limited | 359.928 | 356.000 | 31/12/2023 |
| 0,28 % | New York State Common Retirement Fund | 340.507 | -62.437 | 31/12/2023 |
| 0,28 % | Candriam Belgium S.A. | 337.507 | 11.000 | 31/12/2023 |
| 0,27 % | PGIM Securities Investment Trust Enterprise | 324.000 | 23.000 | 31/12/2023 |
| 0,23 % | Citadel Advisors LLC | 285.117 | 270.370 | 31/12/2023 |
| 0,23 % | Medical Strategy GmbH | 282.365 | -6.200 | 31/12/2023 |
| 0,22 % | Nuveen LLC | 266.739 | -6.439 | 31/12/2023 |
| 0,21 % | Voya Investment Management LLC | 256.533 | 174.366 | 31/12/2023 |
| 0,21 % | Group One Trading, L.P. | 253.905 | 27.221 | 31/12/2023 |
| 0,20 % | Ensign Peak Advisors, Inc. | 245.566 | 60.000 | 31/12/2023 |
| 0,20 % | Fiduciary Trust Company | 242.607 | -22.600 | 31/12/2023 |
| 0,20 % | Amundi Asset Management US, Inc. | 241.371 | 135.315 | 31/12/2023 |
| 0,19 % | Marshall Wace LLP | 230.876 | 61.582 | 31/12/2023 |
| 0,19 % | Franklin Advisers, Inc. | 229.622 | 229.622 | 31/12/2023 |
| 0,17 % | Eventide Asset Management, LLC | 209.794 | 209.794 | 31/12/2023 |
| 0,17 % | Great Lakes Advisors, LLC | 208.163 | 208.163 | 31/12/2023 |
| 0,17 % | Managed Account Advisors LLC | 201.764 | -138.260 | 31/12/2023 |
| 0,16 % | Barclays Bank PLC | 194.813 | -133.008 | 31/12/2023 |
| 0,16 % | Goldman Sachs Asset Management, L.P. | 191.449 | -31.387 | 31/12/2023 |
| 0,16 % | DWS Investment S.A. | 190.889 | 190.889 | 31/12/2023 |
| 0,16 % | DWS Investment GmbH | 188.493 | -15.577 | 31/12/2023 |
| 0,15 % | BNY Mellon Asset Management | 187.210 | 3.829 | 31/12/2023 |
| 0,15 % | Woodline Partners LP | 186.224 | 186.224 | 31/12/2023 |
| 0,15 % | BlackRock Financial Management, Inc. | 184.605 | -347 | 31/12/2023 |
| 0,14 % | Tekla Capital Management LLC_NLE | 173.248 | 38.124 | 30/6/2023 |
| 0,14 % | abrdn Inc. | 169.051 | 169.051 | 31/12/2023 |
| 0,14 % | BNP Paribas Securities Corp. North America | 167.488 | -68.867 | 31/12/2023 |
| 0,13 % | Mellon Investments Corporation | 163.694 | -2.386 | 31/12/2023 |
| 0,13 % | Schweizerische Nationalbank | 162.400 | -16.800 | 31/12/2023 |
| 0,13 % | Altitude Crest Partners Inc | 152.200 | 152.200 | 31/12/2023 |
| 0,12 % | Morgan Stanley Smith Barney LLC | 151.483 | -120.351 | 31/12/2023 |
| 0,12 % | BlackRock Asset Management Ireland Limited | 150.301 | 4.920 | 31/12/2023 |
| 0,12 % | Ally Bridge Group NY LLC | 150.000 | -31.805 | 31/12/2023 |
| 0,12 % | Walleye Capital LLC | 147.674 | 13.691 | 31/12/2023 |
| 0,12 % | California Public Employees' Retirement System | 145.833 | -38.011 | 31/12/2023 |
| 0,12 % | J.P. Morgan Securities plc | 145.342 | 145.342 | 31/12/2023 |
| 0,12 % | Rafferty Asset Management LLC | 143.118 | -71.043 | 31/12/2023 |
| 0,12 % | Saturn V Capital Management LLC | 142.927 | 142.927 | 31/12/2023 |
| 0,11 % | Rhumbline Advisers Ltd. Partnership | 133.586 | 1.292 | 31/12/2023 |
| 0,11 % | Pictet Asset Management (Japan) Ltd. | 131.404 | 131.404 | 31/10/2023 |
| 0,11 % | Lombard Odier Asset Management (Europe) Ltd | 131.098 | -38.956 | 30/9/2022 |
| 0,11 % | 683 Capital Management LLC | 130.000 | -110.000 | 31/12/2023 |
| 0,10 % | Wells Fargo Advisors | 125.206 | 15.309 | 31/12/2023 |
| 0,10 % | PNC Investments LLC | 119.653 | 57 | 31/12/2023 |
| 0,10 % | BofA Global Research (US) | 119.017 | -245.914 | 31/12/2023 |
| 0,10 % | Allspring Global Investments, LLC | 115.453 | 56.178 | 31/3/2024 |
| 0,09 % | Goldman Sachs & Company, Inc. | 114.810 | 5.853 | 31/12/2023 |
| 0,09 % | LMR Partners LLP | 114.069 | 56.940 | 31/12/2023 |
| 0,09 % | Cutter Capital Management, LP | 108.000 | 108.000 | 31/12/2023 |
| 0,09 % | Manulife Investment Management (North America) Limited | 106.002 | 51.737 | 31/12/2023 |
| 0,08 % | Parametric Portfolio Associates LLC | 100.752 | 14.566 | 31/12/2023 |
| 0,08 % | Rhenman & Partners Asset Management AB | 100.400 | -114.600 | 31/12/2023 |
| 0,08 % | BMO Nesbitt Burns Inc. | 99.800 | 99.800 | 31/12/2023 |
| 0,08 % | Thrivent Asset Management, LLC | 97.716 | 18.255 | 31/12/2023 |
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