7.47976 % | Avoro Capital Advisors LLC | 5,666,666 | 766,666 | |
6.40800 % | Fidelity Management & Research Company LLC | 4,854,702 | 602,161 | |
5.73545 % | Driehaus Capital Management, LLC | 4,345,180 | -167,825 | |
5.49453 % | Wellington Management Company, LLP | 4,162,654 | 2,434,546 | |
4.04782 % | Polar Capital LLP | 3,066,628 | 62,881 | |
3.53952 % | Capital World Investors | 2,681,537 | 406,563 | |
3.24140 % | Capital International Investors | 2,455,683 | 8,863 | |
2.86140 % | Commodore Capital LP | 2,167,793 | 322,793 | |
2.80808 % | Paradigm BioCapital Advisors LP | 2,127,400 | 635,565 | |
2.69324 % | Pictet Asset Management Ltd. | 2,040,400 | 101,621 | |
2.17438 % | Braidwell LP | 1,647,311 | -456,085 | |
2.17198 % | First Light Asset Management, LLC | 1,645,490 | 1,043,420 | |
2.07836 % | AllianceBernstein L.P. | 1,574,568 | 490,231 | |
2.01775 % | Marshall Wace LLP | 1,528,648 | -625,746 | |
1.67218 % | Citadel Advisors LLC | 1,266,844 | 543,320 | |
1.65731 % | Rock Springs Capital Management LP | 1,255,577 | 77,575 | |
1.45294 % | Perceptive Advisors LLC | 1,100,748 | 483,248 | |
1.38427 % | Adage Capital Management, L.P. | 1,048,725 | 498,725 | |
1.31161 % | Baker Bros. Advisors LP | 993,679 | 242,040 | |
1.27516 % | Janus Henderson Investors | 966,065 | 583,760 | |
1.21857 % | BlackRock Financial Management, Inc. | 923,185 | 904,476 | |
1.17628 % | T. Rowe Price Investment Management, Inc. | 891,149 | 891,149 | |
1.17486 % | BVF Partners L.P. | 890,072 | -937,886 | |
1.15505 % | Point72 Asset Management, L.P. | 875,065 | -250,643 | |
1.07708 % | Avidity Partners Management LP | 815,993 | 494,593 | |
1.05758 % | Fidelity Institutional Asset Management | 801,220 | 800,895 | |
1.04799 % | TimesSquare Capital Management, LLC | 793,954 | 203,379 | |
0.97135 % | BlackRock Institutional Trust Company, N.A. | 735,897 | 118,486 | |
0.94769 % | Lord, Abbett & Co. LLC | 717,972 | -431,196 | |
0.93492 % | Loomis, Sayles & Company, L.P. | 708,295 | -22,421 | |
0.93024 % | Invesco Advisers, Inc. | 704,751 | 2,872 | |
0.89808 % | First Turn Management, LLC | 680,389 | 680,389 | |
0.79910 % | Norges Bank Investment Management (NBIM) | 605,398 | 470,940 | |
0.79197 % | Boxer Capital, L.L.C. | 600,000 | 0 | |
0.79197 % | Great Point Partners, LLC | 600,000 | 99,999 | |
0.78236 % | Two Sigma Investments, LP | 592,715 | 447,182 | |
0.74762 % | Jennison Associates LLC | 566,396 | 352,573 | |
0.72998 % | Fiera Capital Corporation | 553,030 | -7,516 | |
0.72598 % | OrbiMed Advisors, LLC | 550,000 | -408,793 | |
0.70074 % | Candriam Belgium S.A. | 530,884 | -39,000 | |
0.70074 % | Candriam Luxembourg S.A. | 530,884 | 0 | |
0.60718 % | Affinity Asset Advisors LLC | 460,000 | 159,562 | |
0.55591 % | Samlyn Capital, LLC | 421,155 | -530,600 | |
0.53150 % | Dimensional Fund Advisors, L.P. | 402,668 | -24,457 | |
0.50871 % | Medical Strategy GmbH | 385,399 | -6,400 | |
0.50350 % | BNP Paribas Asset Management USA, Inc. | 381,453 | 2,380 | |
0.46180 % | Goldman Sachs & Company, Inc. | 349,858 | 94,490 | |
0.45749 % | Federated Hermes Global Investment Management Corp. | 346,596 | 346,596 | |
0.40983 % | The Vanguard Group, Inc. | 310,486 | 52,594 | |
0.40220 % | BlackRock Advisors (UK) Limited | 304,703 | -1,012 | |
0.39939 % | Granahan Investment Management, LLC | 302,581 | 66,291 | |
0.38911 % | Parkman Healthcare Partners LLC | 294,788 | 78,144 | |
0.38784 % | Franklin Advisers, Inc. | 293,825 | 121,213 | |
0.38349 % | Altium Capital Management LP | 290,535 | 62,535 | |
0.37078 % | BlackRock Asset Management Ireland Limited | 280,900 | 1,875 | |
0.36528 % | Dafna Capital Management, LLC | 276,739 | -3,799 | |
0.33716 % | Boone Capital Management LLC | 255,432 | 255,432 | |
0.31938 % | Ally Bridge Group NY LLC | 241,961 | -25,000 | |
0.31348 % | Westfield Capital Management Company, L.P. | 237,495 | 237,495 | |
0.29968 % | State Street Global Advisors (US) | 227,040 | 14,670 | |
0.29773 % | Tri Locum Partners LP | 225,564 | 53,809 | |
0.28685 % | Algert Global LLC | 217,320 | 88,833 | |
0.28451 % | Putnam Investment Management, L.L.C. | 215,545 | 43,609 | |
0.26649 % | Morgan Stanley & Co. LLC | 201,895 | -16,922 | |
0.25931 % | Woodline Partners LP | 196,453 | 53,002 | |
0.25456 % | PFM Health Sciences, LP | 192,856 | 114,269 | |
0.25120 % | New York State Common Retirement Fund | 190,312 | 5,680 | |
0.24792 % | AXA Investment Managers UK Ltd. | 187,821 | -4,542 | |
0.23099 % | Vestal Point Capital, LP | 175,000 | 175,000 | |
0.22230 % | Russell Investments Trust Company | 168,418 | 2,930 | |
0.21815 % | ExodusPoint Capital Management, LP | 165,267 | -194,571 | |
0.21697 % | Ensign Peak Advisors, Inc. | 164,380 | 0 | |
0.21537 % | SilverArc Capital Management, LLC | 163,168 | 109,172 | |
0.19931 % | Nomura Asset Management Co., Ltd. | 151,000 | -34,400 | |
0.19799 % | Logos Global Management LLC | 150,000 | -300,000 | |
0.19377 % | Bridger Management, LLC | 146,800 | 146,800 | |
0.16664 % | DNB Asset Management AS | 126,250 | -125 | |
0.16341 % | Schweizerische Nationalbank | 123,800 | 12,100 | |
0.14526 % | Tenax Capital Ltd. | 110,047 | 0 | |
0.14500 % | Principal Global Investors (Equity) | 109,852 | -4,600 | |
0.14125 % | New Jersey Division of Investment | 107,013 | 6,559 | |
0.14081 % | Nan Fung Life Sciences | 106,680 | 0 | |
0.13638 % | UBS Switzerland AG | 103,325 | 0 | |
0.13213 % | Baron Capital Management, Inc. | 100,100 | 0 | |
0.13164 % | Assenagon Asset Management S.A. | 99,731 | -47,962 | |
0.13134 % | Barclays Capital Inc. | 99,500 | 99,300 | |
0.12647 % | MFS Investment Management | 95,813 | -2,894 | |
0.12584 % | State of Wisconsin Investment Board | 95,336 | -738 | |
0.12306 % | Atika Capital Management LLC | 93,234 | 93,234 | |
0.12078 % | Schroder Investment Management Ltd. (SIM) | 91,500 | 91,500 | |
0.12078 % | International Biotechnology Trust PLC | 91,500 | 66,000 | |
0.11583 % | Nicholas Investment Partners, L.P. | 87,752 | -766,695 | |
0.11550 % | Schonfeld Strategic Advisors LLC | 87,500 | -111,484 | |
0.11108 % | D. E. Shaw & Co., L.P. | 84,153 | 43,606 | |
0.10965 % | HRT Financial LP | 83,069 | 47,859 | |
0.10797 % | Credit Suisse Funds AG | 81,795 | 16,209 | |
0.10159 % | Millennium Management LLC | 76,965 | -18,528 | |
0.09900 % | Laurion Capital Management LP | 75,000 | 75,000 | |
0.09797 % | Azab (Mohammad) | 74,225 | 4,320 | |
0.08911 % | Tekla Capital Management LLC_NLE | 67,506 | -16,208 | |