9.96069 % | Baillie Gifford & Co. | 14,260,724 | -420,303 | |
8.90645 % | Biogen Inc | 12,751,365 | -558,878 | |
7.55056 % | The Vanguard Group, Inc. | 10,810,137 | 232,597 | |
6.61220 % | BlackRock Institutional Trust Company, N.A. | 9,466,684 | 693,719 | |
5.08117 % | Wellington Management Company, LLP | 7,274,717 | -14,243 | |
4.81665 % | Temasek Holdings Pte. Ltd. | 6,895,992 | 0 | |
3.95385 % | Crestline Investors, Inc. | 5,660,732 | -300,000 | |
3.83177 % | State Street Global Advisors (US) | 5,485,948 | 1,210,620 | |
2.03222 % | Capital Research Global Investors | 2,909,528 | 29,205 | |
1.85744 % | Geode Capital Management, L.L.C. | 2,659,296 | 127,461 | |
1.82105 % | Baker Bros. Advisors LP | 2,607,196 | 315,193 | |
1.73872 % | T. Rowe Price Associates, Inc. | 2,489,326 | -316,720 | |
1.62043 % | Flagship Ventures | 2,319,968 | -300,000 | |
1.62034 % | Watts (Ryan J) | 2,319,844 | -9,589 | |
1.47060 % | Tessier-Lavigne (Marc) | 2,105,455 | 4,216 | |
1.16463 % | Marshall Wace LLP | 1,667,397 | 1,667,397 | |
1.09444 % | Credit Suisse Funds AG | 1,566,904 | 7,868 | |
0.94426 % | Federated Hermes Global Investment Management Corp. | 1,351,900 | 0 | |
0.90801 % | Casdin Capital, LLC | 1,300,000 | 0 | |
0.85171 % | Gilder Gagnon Howe & Co. LLC | 1,219,392 | -26,807 | |
0.84901 % | Mellon Investments Corporation | 1,215,533 | -17,304 | |
0.80509 % | Norges Bank Investment Management (NBIM) | 1,152,646 | 128,440 | |
0.80372 % | Yiheng Capital Management, L.P. | 1,150,684 | 0 | |
0.78203 % | Dimensional Fund Advisors, L.P. | 1,119,628 | 146,394 | |
0.74995 % | Principal Global Investors (Equity) | 1,073,704 | 393,626 | |
0.72130 % | BlackRock Financial Management, Inc. | 1,032,692 | -17,071 | |
0.70336 % | Charles Schwab Investment Management, Inc. | 1,006,997 | 25,938 | |
0.69919 % | Northern Trust Investments, Inc. | 1,001,025 | 23,415 | |
0.60422 % | Krognes (Steve E) | 865,055 | -92,500 | |
0.56080 % | Invus Public Equities Advisors, LLC | 802,899 | 0 | |
0.45010 % | Point72 Asset Management, L.P. | 644,406 | 644,406 | |
0.44818 % | Fidelity Management & Research Company LLC | 641,653 | -416,844 | |
0.44447 % | UBS Asset Management (Switzerland) | 636,345 | 59,807 | |
0.43654 % | Cercano Management LLC | 625,000 | 0 | |
0.43389 % | Schuth (Alexander O) | 621,203 | 27,156 | |
0.40807 % | Morgan Stanley & Co. LLC | 584,237 | -14,389 | |
0.36564 % | BlackRock Advisors (UK) Limited | 523,482 | -2,250 | |
0.34852 % | T. Rowe Price Investment Management, Inc. | 498,969 | -148,044 | |
0.34568 % | BlackRock Asset Management Ireland Limited | 494,916 | -18,688 | |
0.33072 % | American Century Investment Management, Inc. | 473,494 | -842 | |
0.32253 % | Braidwell LP | 461,769 | 461,769 | |
0.31618 % | Polar Capital LLP | 452,669 | -554,417 | |
0.30678 % | Pictet Asset Management Ltd. | 439,218 | -150,281 | |
0.30028 % | BofA Global Research (US) | 429,915 | 172,486 | |
0.28391 % | BNY Mellon Asset Management | 406,476 | 6,807 | |
0.28125 % | Wasatch Global Investors Inc | 402,670 | 90,369 | |
0.27395 % | The Clarius Group, LLC | 392,218 | 13,956 | |
0.26817 % | Artisan Partners Limited Partnership | 383,942 | -22,680 | |
0.26743 % | Candriam Luxembourg S.A. | 382,878 | 25,000 | |
0.26629 % | ARCH Venture Partners | 381,249 | -312,500 | |
0.24997 % | Candriam Belgium S.A. | 357,878 | 0 | |
0.24705 % | AXA Investment Managers UK Ltd. | 353,695 | 866 | |
0.24341 % | Ensign Peak Advisors, Inc. | 348,497 | 0 | |
0.24321 % | SEB Investment Management AB | 348,203 | 0 | |
0.23072 % | Flatley (Jay T) | 330,327 | 2,074 | |
0.22688 % | abrdn Inc. | 324,829 | 324,829 | |
0.22688 % | Tekla Capital Management LLC_NLE | 324,829 | 0 | |
0.22632 % | Barclays Bank PLC | 324,019 | 157,512 | |
0.22489 % | Rafferty Asset Management LLC | 321,973 | 92,660 | |
0.22070 % | Nuveen LLC | 315,981 | -47,684 | |
0.22038 % | Eagle Asset Management, Inc. | 315,520 | 26,387 | |
0.21221 % | BlackRock Investment Management, LLC | 303,825 | 2,788 | |
0.20324 % | UBS Financial Services, Inc. | 290,985 | 181,289 | |
0.19180 % | Voya Investment Management LLC | 274,607 | 19,127 | |
0.18868 % | Goldman Sachs & Company, Inc. | 270,135 | 108,858 | |
0.18201 % | Balyasny Asset Management LP | 260,587 | 260,587 | |
0.17677 % | Ho (Carole) | 253,082 | -4,189 | |
0.17196 % | Mitsubishi UFJ Trust and Banking Corporation | 246,190 | -44,770 | |
0.15171 % | Baillie Gifford Overseas Ltd. | 217,209 | 0 | |
0.15136 % | Schweizerische Nationalbank | 216,700 | -24,100 | |
0.14950 % | Morgan Stanley Smith Barney LLC | 214,042 | -42,259 | |
0.14691 % | Newton Investment Management North America, LLC | 210,334 | -72,930 | |
0.14573 % | Kentucky Teachers' Retirement System | 208,644 | -9,550 | |
0.13969 % | ACATIS Investment Kapitalverwaltungsgesellschaft GmbH | 200,000 | 0 | |
0.13801 % | Woodline Partners LP | 197,584 | -653,905 | |
0.13386 % | BNP Paribas Securities Corp. North America | 191,643 | 28,817 | |
0.12302 % | California Public Employees' Retirement System | 176,131 | 0 | |
0.12223 % | Hudson Bay Capital Management LP | 175,000 | 175,000 | |
0.12169 % | Pier Capital, LLC | 174,219 | 49,139 | |
0.11962 % | Qube Research & Technologies Ltd | 171,262 | 157,709 | |
0.11648 % | Rhumbline Advisers Ltd. Partnership | 166,763 | -2,361 | |
0.11572 % | Edmond de Rothschild Asset Management (France) S.A. | 165,680 | 65,800 | |
0.11548 % | Jefferies LLC | 165,327 | 152,527 | |
0.11311 % | Renaissance Technologies LLC | 161,946 | -305,905 | |
0.11003 % | BlackRock Investment Management (UK) Ltd. | 157,534 | -9,519 | |
0.10756 % | Schroder Investment Management Ltd. (SIM) | 154,000 | 154,000 | |
0.10756 % | International Biotechnology Trust PLC | 154,000 | -34,000 | |
0.10405 % | Jane Street Capital, L.L.C. | 148,965 | 110,226 | |
0.10321 % | Parametric Portfolio Associates LLC | 147,769 | 52,705 | |
0.10090 % | Neuberger Berman, LLC | 144,461 | 144,461 | |
0.09868 % | Citi Investment Research (US) | 141,276 | 2,967 | |
0.09776 % | AllianceBernstein L.P. | 139,960 | 3,200 | |
0.09541 % | New Jersey Division of Investment | 136,600 | 29,511 | |
0.09429 % | SELECTRA Management Company S.A. | 135,000 | 0 | |
0.09080 % | Soleus Capital Management, L.P. | 130,000 | 130,000 | |
0.08659 % | New York State Common Retirement Fund | 123,974 | -5,879 | |
0.08197 % | California State Teachers Retirement System | 117,351 | -5,553 | |
0.07827 % | Sato (Vicki Lee) | 112,057 | -1,666 | |
0.07786 % | Russell Investments Trust Company | 111,473 | -2,585 | |
0.07454 % | Legal & General Investment Management Ltd. | 106,713 | 888 | |