6.03730 % | BlackRock Institutional Trust Company, N.A. | 8,995,574 | 593,702 | |
4.75594 % | The Vanguard Group, Inc. | 7,086,345 | 60,181 | |
3.98456 % | Stonepine Capital Management, LLC | 5,937,000 | 21,628 | |
3.78652 % | Caxton Associates LP | 5,641,920 | 0 | |
2.58203 % | BioImpact Capital LLC | 3,847,232 | -140,735 | |
2.37831 % | Rosalind Advisors, Inc. | 3,543,685 | 3,543,685 | |
1.94099 % | Geode Capital Management, L.L.C. | 2,892,077 | 118,784 | |
1.82827 % | State Street Global Advisors (US) | 2,724,126 | 154,004 | |
1.68133 % | Medical Strategy GmbH | 2,505,175 | -220,231 | |
1.59276 % | Edick (Paul Raymond) | 2,373,211 | 1,500,000 | |
1.08178 % | Pieper (Steven) | 1,611,858 | 450,000 | |
1.03890 % | Millennium Management LLC | 1,547,955 | -726,189 | |
0.92728 % | Renaissance Technologies LLC | 1,381,640 | 359,600 | |
0.79495 % | Morgan Stanley & Co. LLC | 1,184,474 | 588,213 | |
0.73429 % | Shannon John Patrick Jr | 1,094,092 | 750,000 | |
0.72296 % | Northern Trust Investments, Inc. | 1,077,211 | 41,744 | |
0.70779 % | D. E. Shaw & Co., L.P. | 1,054,610 | 179,200 | |
0.70241 % | Redmile Group, LLC | 1,046,587 | 0 | |
0.61498 % | Hecht (Beth P) | 916,324 | 750,000 | |
0.55435 % | Johnson John H | 825,983 | 305,171 | |
0.48961 % | Prestrelski (Steven) | 729,524 | 150,000 | |
0.38876 % | BlackRock Financial Management, Inc. | 579,257 | 31,275 | |
0.38162 % | Invenomic Capital Management LP | 568,619 | 568,619 | |
0.37142 % | Tudor Investment Corporation | 553,411 | -88,087 | |
0.34907 % | Columbia Threadneedle Investments (US) | 520,121 | -67,817 | |
0.29657 % | Johnson (Kenneth Erland) | 441,890 | 175,000 | |
0.28159 % | Nuveen LLC | 419,567 | -293,130 | |
0.27937 % | GSA Capital Partners LLP | 416,267 | 35,036 | |
0.27102 % | Lazard Asset Management, L.L.C. | 403,813 | 88,326 | |
0.26884 % | Citadel Advisors LLC | 400,577 | 371,383 | |
0.26034 % | Knott Partners Management, LLC | 387,910 | 387,910 | |
0.24455 % | Charles Schwab Investment Management, Inc. | 364,382 | -631 | |
0.23336 % | BlackRock Investment Management, LLC | 347,708 | -3 | |
0.22227 % | BNY Mellon Asset Management | 331,188 | -42,501 | |
0.18751 % | IHT Wealth Management, LLC | 279,392 | -5,000 | |
0.18521 % | Barclays Bank PLC | 275,963 | 170,220 | |
0.18337 % | AQR Capital Management, LLC | 273,222 | 230,942 | |
0.18121 % | Alpine Global Management, LLC | 270,000 | -30,000 | |
0.17475 % | BofA Global Research (US) | 260,379 | 190,592 | |
0.15006 % | Jane Street Capital, L.L.C. | 223,584 | 79,980 | |
0.14188 % | Brown Advisory | 211,405 | -18,100 | |
0.13922 % | J.P. Morgan Securities LLC | 207,442 | 207,442 | |
0.12551 % | Commonwealth Financial Network | 187,003 | 40,769 | |
0.12120 % | Goldman Sachs & Company, Inc. | 180,585 | 102,571 | |
0.11795 % | Diversified Trust Company | 175,741 | 20,091 | |
0.11496 % | Rhumbline Advisers Ltd. Partnership | 171,292 | -2,516 | |
0.10955 % | Susquehanna International Group, LLP | 163,229 | 56,998 | |
0.10161 % | Hamblin Watsa Investment Counsel Ltd. | 151,395 | 0 | |
0.10067 % | Tang Capital Management, LLC | 150,000 | 0 | |
0.09417 % | PanAgora Asset Management Inc. | 140,318 | -109,882 | |
0.09021 % | UBS Financial Services, Inc. | 134,412 | 59,972 | |
0.08684 % | Mariner Wealth Advisors | 129,390 | -62,354 | |
0.07852 % | Cetera Advisor Networks LLC | 116,990 | 4,704 | |
0.07718 % | T. Rowe Price International Ltd | 115,003 | 2,180 | |
0.07665 % | Two Sigma Investments, LP | 114,213 | 4,287 | |
0.07425 % | CenterBook Partners LP | 110,627 | 110,627 | |
0.06670 % | Sherman (Jeffrey W) | 99,380 | 6,502 | |
0.06654 % | Kong (Garheng) | 99,144 | 6,474 | |
0.06386 % | Assenagon Asset Management S.A. | 95,144 | 6,877 | |
0.05916 % | Northern Trust Global Investments | 88,152 | -21,598 | |
0.05907 % | JPMorgan Private Bank (United States) | 88,016 | 88,016 | |
0.05891 % | State Street Global Advisors Ireland Limited | 87,770 | -319 | |
0.05861 % | HRT Financial LP | 87,334 | 87,334 | |
0.05705 % | Fairley (Ricki Louise) | 85,000 | 85,000 | |
0.05408 % | BlackRock Advisors (UK) Limited | 80,582 | 3,885 | |
0.05397 % | AllianceBernstein L.P. | 80,420 | 0 | |
0.05299 % | Group One Trading, L.P. | 78,951 | 12,781 | |
0.05242 % | Goldman Sachs Asset Management, L.P. | 78,104 | 23,278 | |
0.05010 % | BlackRock Asset Management Ireland Limited | 74,649 | 18,323 | |
0.04781 % | MetLife Investment Management, LLC | 71,237 | 0 | |
0.04439 % | SunAmerica Asset Management, LLC | 66,140 | -267 | |
0.04315 % | State Teachers Retirement System of Ohio | 64,300 | 0 | |
0.04167 % | Soleus Capital Management, L.P. | 62,083 | -242,000 | |
0.04163 % | GPS Wealth Strategies Group, LLC | 62,025 | -2,000 | |
0.04137 % | DWS Investments UK Limited | 61,635 | -2,002 | |
0.03896 % | Invesco Advisers, Inc. | 58,050 | -252,932 | |
0.03762 % | LJI Wealth Management, LLC | 56,050 | -5,300 | |
0.03750 % | Voya Investment Management LLC | 55,877 | 2,031 | |
0.03746 % | Annandale Capital, LLC | 55,820 | 30,820 | |
0.03741 % | Manulife Investment Management (North America) Limited | 55,742 | 0 | |
0.03490 % | Deltec Asset Management, LLC | 52,000 | -207,246 | |
0.03439 % | Chevy Chase Trust Company | 51,243 | 0 | |
0.03367 % | IEQ Capital LLC | 50,169 | 0 | |
0.03232 % | Schmid (John P) | 48,159 | 42,500 | |
0.03002 % | Principal Global Investors (Equity) | 44,725 | 1,601 | |
0.02852 % | Halkuff (Dawn) | 42,500 | 42,500 | |
0.02852 % | Persky (Marla S) | 42,500 | 42,500 | |
0.02852 % | Bormann-Kennedy (Barbara-Jean Anne) | 42,500 | 42,500 | |
0.02843 % | Centiva Capital, LP | 42,368 | 42,368 | |
0.02634 % | Mellon Investments Corporation | 39,254 | 0 | |
0.02548 % | Florida State Board of Administration | 37,970 | 0 | |
0.02469 % | Graham Capital Management, L.P. | 36,784 | -20,625 | |
0.02411 % | Walleye Capital LLC | 35,927 | -88,763 | |
0.02316 % | Wells Fargo Bank, N.A. | 34,513 | 7,853 | |
0.02267 % | SG Americas Securities, L.L.C. | 33,777 | 15,414 | |
0.02240 % | LPL Financial LLC | 33,375 | 33,375 | |
0.02159 % | Cambridge Investment Research Advisors, Inc. | 32,170 | -3,500 | |
0.02112 % | PGIM Quantitative Solutions LLC | 31,475 | 0 | |
0.02070 % | ProShare Advisors LLC | 30,849 | 4,537 | |
0.01905 % | RBC Wealth Management, International | 28,385 | 11,724 | |