9.29 % | Fidelity Management & Research Company LLC | 1,086,733 | -36,611 | |
31.06 % | BVF Partners L.P. | 3,633,743 | 0 | |
3.85 % | BlackRock Institutional Trust Company, N.A. | 450,491 | 31,274 | |
3.60 % | The Vanguard Group, Inc. | 421,474 | 6,841 | |
2.14 % | Stonepine Capital Management, LLC | 250,000 | -186,602 | |
2.14 % | Opaleye Management Inc. | 250,000 | -24,500 | |
1.45 % | Medical Strategy GmbH | 169,077 | 0 | |
1.38 % | Geode Capital Management, L.L.C. | 160,936 | 4,205 | |
1.17 % | Acuitas Investments LLC | 137,132 | 0 | |
1.06 % | State Street Global Advisors (US) | 124,423 | 1,990 | |
1.03 % | TLS Advisors LLC | 120,465 | -200 | |
1.02 % | HighVista Strategies LLC | 118,899 | 0 | |
0.80 % | Eversept Partners, LP | 93,727 | 3,777 | |
0.62 % | Northern Trust Investments, Inc. | 72,422 | -259 | |
0.58 % | Fidelity Institutional Asset Management | 68,300 | 7,600 | |
0.47 % | CM Management, LLC | 55,000 | 55,000 | |
0.43 % | Woodline Partners LP | 50,559 | 50,559 | |
0.31 % | Newton Investment Management North America, LLC | 36,171 | 0 | |
0.28 % | RBF Capital, LLC | 33,005 | -1,782 | |
0.24 % | Millennium Management LLC | 28,301 | 274 | |
0.23 % | Bridgeway Capital Management, LLC | 26,600 | 0 | |
0.23 % | Citadel Advisors LLC | 26,537 | -1,576 | |
0.22 % | Dimensional Fund Advisors, L.P. | 25,516 | -2,860 | |
0.19 % | BNY Mellon Asset Management | 22,143 | -70 | |
0.17 % | Knott Partners Management, LLC | 19,722 | 0 | |
0.17 % | Charles Schwab Investment Management, Inc. | 19,560 | 0 | |
0.16 % | BlackRock Investment Management, LLC | 19,001 | -276 | |
0.16 % | BlackRock Financial Management, Inc. | 18,982 | 0 | |
0.12 % | Northern Trust Global Investments | 14,546 | 19 | |
0.12 % | LUNIS Vermögensmanagement AG | 13,960 | 0 | |
0.11 % | Morgan Stanley & Co. LLC | 13,412 | 9,509 | |
0.11 % | Renaissance Technologies LLC | 12,296 | -5,909 | |
0.10 % | Squarepoint Capital LLP | 12,274 | 12,274 | |
0.10 % | Burns (Thomas M) | 12,109 | 5,554 | |
0.10 % | Perry Matthew D | 11,799 | 0 | |
0.09 % | BofA Global Research (US) | 10,610 | 4,382 | |
0.09 % | Barclays Bank PLC | 10,088 | 8,722 | |
0.09 % | Nuveen LLC | 9,988 | 0 | |
0.07 % | Rhumbline Advisers Ltd. Partnership | 8,157 | -205 | |
0.07 % | UBS Financial Services, Inc. | 7,945 | 3,970 | |
0.06 % | Sitko (Bradley J.) | 7,494 | 0 | |
0.06 % | T. Rowe Price Associates, Inc. | 6,894 | 0 | |
0.06 % | Wyszomierski (Jack L) | 6,465 | 0 | |
0.05 % | Limber (Joseph M) | 6,210 | 0 | |
0.05 % | Bailard, Inc. | 5,536 | 0 | |
0.04 % | New York State Common Retirement Fund | 5,262 | -15 | |
0.04 % | Signal Iduna Asset Management GmbH | 5,137 | -22,481 | |
0.04 % | First Manhattan Co. LLC | 5,000 | -2,500 | |
0.04 % | DWS Investments UK Limited | 4,808 | 4,808 | |
0.04 % | JPMorgan Private Bank (United States) | 4,739 | 4,739 | |
0.04 % | Mirae Asset Global Investments (USA) LLC | 4,438 | 0 | |
0.04 % | Dimensional Fund Advisors, Ltd. | 4,342 | 0 | |
0.04 % | Mellon Investments Corporation | 4,275 | 0 | |
0.03 % | SunAmerica Asset Management, LLC | 3,634 | -15 | |
0.03 % | Hughes Owen | 3,500 | 0 | |
0.03 % | Avantis Investors | 3,472 | -5 | |
0.03 % | Macquarie Investment Management | 3,466 | 0 | |
0.02 % | Vaughan Nelson Investment Management, L.P. | 2,597 | 0 | |
0.02 % | BNP Paribas Securities Corp. North America | 2,277 | 1,234 | |
0.02 % | Wells Fargo Bank, N.A. | 2,255 | 445 | |
0.02 % | RBC Capital Partners | 2,159 | 1,978 | |
0.02 % | Voya Investment Management LLC | 2,005 | 0 | |
0.01 % | Ostrum Asset Management | 1,726 | 0 | |
0.01 % | RBC Wealth Management, International | 1,560 | 333 | |
0.01 % | Parametric Portfolio Associates LLC | 1,396 | 151 | |
0.01 % | ProShare Advisors LLC | 1,313 | 241 | |
0.01 % | California State Teachers Retirement System | 1,203 | -410 | |
0.01 % | Ajovista LLC | 1,162 | 1,162 | |
0.01 % | Citi Investment Research (US) | 1,044 | 1,040 | |
0.01 % | Horizon Kinetics LLC | 979 | 0 | |
0.01 % | AllianceBernstein L.P. | 940 | 0 | |
0.01 % | Principal Global Investors (Equity) | 860 | -62 | |
0.01 % | Mackenzie Financial Corporation | 784 | -336 | |
0.01 % | RBC Capital Markets Wealth Management | 780 | 0 | |
0.01 % | Legal & General Investment Management Ltd. | 707 | 0 | |
0.01 % | Morgan Stanley Smith Barney LLC | 677 | -100 | |
0.01 % | Tower Research Capital LLC | 651 | -131 | |
0.01 % | Amalgamated Bank Institutional Asset Management & Custody | 638 | -73 | |
0.01 % | Ameritas Investment Partners, Inc. | 604 | 0 | |
0.01 % | Global Retirement Partners, LLC | 600 | 0 | |
0.01 % | Carson Wealth Management Group | 587 | 2 | |
0.00 % | Avior Wealth Management, LLC | 501 | 0 | |
0.00 % | Aristotle Pacific Capital, LLC | 449 | 0 | |
0.00 % | Truvestments Capital LLC | 400 | 0 | |
0.00 % | Franklin Mutual Advisers, LLC | 322 | 0 | |
0.00 % | JP Morgan Asset Management | 247 | -4,873 | |
0.00 % | Manulife Investment Management (North America) Limited | 228 | 0 | |
0.00 % | DFA Australia Ltd. | 220 | 1 | |
0.00 % | Wells Fargo Advisors | 190 | 0 | |
0.00 % | Assenagon Asset Management S.A. | 182 | 7 | |
0.00 % | Scarborough Capital Management | 175 | 175 | |
0.00 % | ProFund Advisors LLC | 167 | 19 | |
0.00 % | Guggenheim Investments | 104 | 0 | |
0.00 % | GAMMA Investing LLC | 75 | 67 | |
0.00 % | Osaic Holdings, Inc. | 70 | -30 | |
0.00 % | Morgan Stanley Investment Management Inc. (US) | 62 | -15 | |
0.00 % | Northwestern Mutual Capital, LLC | 60 | 60 | |
0.00 % | L2 Asset Management, LLC | 36 | 0 | |
0.00 % | Allspring Global Investments, LLC | 15 | 0 | |
0.00 % | Aperio Group, LLC | 11 | 0 | |