5.76572 % | BlackRock Institutional Trust Company, N.A. | 6,388,419 | 467,817 | |
5.17418 % | State Street Global Advisors (US) | 5,732,990 | -678,072 | |
4.83938 % | The Vanguard Group, Inc. | 5,362,035 | 97,552 | |
4.64360 % | Viking Global Investors LP | 5,145,112 | -713,420 | |
3.31583 % | AllianceBernstein L.P. | 3,673,935 | 123,861 | |
3.26361 % | Ligand Pharmaceuticals Inc | 3,616,077 | -2,449,003 | |
2.04554 % | Lian (Brian) | 2,266,453 | 391,477 | |
2.02484 % | Balyasny Asset Management LP | 2,243,523 | 121,624 | |
2.00706 % | American Century Investment Management, Inc. | 2,223,822 | 21,594 | |
13.48486 % | Fidelity Management & Research Company LLC | 14,941,221 | 16 | |
1.92089 % | Geode Capital Management, L.L.C. | 2,128,343 | 101,555 | |
1.15433 % | Deerfield Management Company, L.P. | 1,279,000 | 0 | |
1.04843 % | Morgan Stanley & Co. LLC | 1,161,658 | 867,361 | |
0.82362 % | J O Hambro Capital Management Limited | 912,569 | 424,593 | |
0.80509 % | Medical Strategy GmbH | 892,036 | -12,241 | |
0.74702 % | Northern Trust Investments, Inc. | 827,694 | 21,171 | |
0.70009 % | Charles Schwab Investment Management, Inc. | 775,699 | 10,379 | |
0.69419 % | BofA Global Research (US) | 769,168 | 76,894 | |
0.68946 % | BlackRock Financial Management, Inc. | 763,925 | 2,264 | |
0.67690 % | Eventide Asset Management, LLC | 750,000 | 0 | |
0.66257 % | Fidelity Investments Canada ULC | 734,127 | -17,820 | |
0.62701 % | Pictet Asset Management Ltd. | 694,724 | 683,355 | |
0.59852 % | MFS Investment Management | 663,155 | 586,955 | |
0.55957 % | 683 Capital Management LLC | 620,000 | -5,000 | |
0.55259 % | Goldman Sachs & Company, Inc. | 612,274 | 260,865 | |
0.53261 % | DWS Investments UK Limited | 590,137 | 541,311 | |
0.52798 % | 5AM Ventures | 585,000 | 0 | |
0.45813 % | Goldman Sachs Asset Management, L.P. | 507,611 | 264,431 | |
0.45126 % | Integral Health Asset Management, LLC | 500,000 | -300,000 | |
0.42505 % | JP Morgan Asset Management | 470,955 | -55,530 | |
0.39368 % | Soleus Capital Management, L.P. | 436,200 | 314,000 | |
0.37299 % | Rafferty Asset Management LLC | 413,278 | -146,902 | |
0.36359 % | Millennium Management LLC | 402,856 | -1,189,838 | |
0.34619 % | Artia Global Partners LP | 383,580 | 0 | |
0.32813 % | Mancini (Marianna) | 363,566 | 207,436 | |
0.31610 % | Jane Street Capital, L.L.C. | 350,240 | 97,241 | |
0.31561 % | UBS Asset Management (Americas), Inc. | 349,700 | -4,000 | |
0.31495 % | Lisanti Capital Growth, LLC | 348,970 | 348,970 | |
0.31155 % | ClearBridge Investments, LLC | 345,200 | 345,200 | |
0.30668 % | Portolan Capital Management, L.L.C. | 339,800 | 339,800 | |
0.30661 % | UBS Financial Services, Inc. | 339,726 | 196,015 | |
0.29792 % | Macquarie Investment Management | 330,100 | 0 | |
0.29358 % | BioImpact Capital LLC | 325,284 | 284 | |
0.28128 % | Fred Alger Management, LLC | 311,653 | 141,871 | |
0.27984 % | Baron Capital Management, Inc. | 310,067 | 310,067 | |
0.27619 % | Barclays Bank PLC | 306,021 | -215,901 | |
0.27076 % | Affinity Asset Advisors LLC | 300,000 | 0 | |
0.26017 % | Ensign Peak Advisors, Inc. | 288,271 | 1,650 | |
0.24442 % | Knott Partners Management, LLC | 270,822 | 85,267 | |
0.23914 % | DWS Investment GmbH | 264,967 | 0 | |
0.23897 % | Nuveen LLC | 264,775 | 491 | |
0.23850 % | Capital Fund Management S.A. | 264,263 | -7,587 | |
0.23627 % | Eagle Asset Management, Inc. | 261,783 | 261,783 | |
0.23524 % | BNY Mellon Asset Management | 260,647 | 1,217 | |
0.23162 % | Russell Investments Trust Company | 256,633 | 256,633 | |
0.23063 % | Wasatch Global Investors Inc | 255,536 | -1,019,409 | |
0.22938 % | Adar1 Capital Management LLC | 254,151 | 254,151 | |
0.22402 % | Dafna Capital Management, LLC | 248,217 | -71,438 | |
0.21996 % | BlackRock Investment Management, LLC | 243,719 | 2,784 | |
0.21880 % | BNP Paribas Securities Corp. North America | 242,425 | -135,781 | |
0.21835 % | Parametric Portfolio Associates LLC | 241,936 | 55,967 | |
0.21598 % | First Washington Corporation | 239,310 | 239,310 | |
0.21091 % | Barclays Capital Inc. | 233,692 | 233,692 | |
0.18715 % | Zante (Gregory S) | 207,361 | 185,521 | |
0.16245 % | Rhenman & Partners Asset Management AB | 180,000 | 0 | |
0.16139 % | Citi Investment Research (US) | 178,823 | -180,762 | |
0.15256 % | EAM Investors, LLC | 169,037 | 169,037 | |
0.15126 % | Schweizerische Nationalbank | 167,600 | -29,900 | |
0.13473 % | Susquehanna International Group, LLP | 149,282 | 17,554 | |
0.13308 % | Raymond James Financial Services Advisors, Inc. | 147,452 | 13,097 | |
0.12443 % | Mirae Asset Global Investments (USA) LLC | 137,863 | 294 | |
0.12417 % | Raymond James & Associates, Inc. | 137,583 | 68,921 | |
0.11660 % | Rhumbline Advisers Ltd. Partnership | 129,192 | -1,696 | |
0.11279 % | HRT Financial LP | 124,971 | 124,971 | |
0.10735 % | Two Sigma Investments, LP | 118,946 | -509,872 | |
0.10436 % | D. E. Shaw & Co., L.P. | 115,635 | 29,655 | |
0.10041 % | Foehr (Matthew W) | 111,250 | 0 | |
0.09926 % | Cornerstone Capital, Inc. | 109,975 | -170 | |
0.09647 % | Morgan Stanley Smith Barney LLC | 106,891 | -43,958 | |
0.09612 % | Neuberger Berman, LLC | 106,499 | 22,188 | |
0.09353 % | BlackRock Advisors (UK) Limited | 103,636 | 2,161 | |
0.09283 % | Marshall Wace LLP | 102,855 | 50,297 | |
0.09178 % | Kennedy Capital Management LLC | 101,688 | 101,688 | |
0.08672 % | Profit Investments | 96,081 | -90,841 | |
0.08647 % | JPMorgan Private Bank (United States) | 95,809 | 65,441 | |
0.08620 % | Legal & General Investment Management Ltd. | 95,506 | 906 | |
0.08582 % | Samsung Asset Management Co., Ltd. | 95,092 | 95,092 | |
0.08528 % | Polen Capital Management, LLC | 94,493 | 0 | |
0.08486 % | Invesco Capital Management LLC | 94,024 | -721,195 | |
0.08265 % | California State Teachers Retirement System | 91,571 | -9,053 | |
0.08159 % | Arctic Fund Management AS | 90,400 | -74,450 | |
0.08123 % | Apis Capital Advisors LLC | 90,000 | -58,000 | |
0.07968 % | Credit Suisse Funds AG | 88,288 | -3,642 | |
0.07635 % | UBS Asset Management (Switzerland) | 84,600 | 900 | |
0.07484 % | BlackRock Asset Management Ireland Limited | 82,919 | -474 | |
0.07372 % | Knights of Columbus | 81,687 | 41,130 | |
0.07220 % | Erste Asset Management GmbH | 80,000 | 80,000 | |
0.07171 % | Cubist Systematic Strategies, LLC | 79,459 | 79,459 | |
0.07125 % | TwinBeech Capital LP | 78,947 | -133,586 | |
0.06980 % | State of Wisconsin Investment Board | 77,337 | -13,235 | |